Long-term outcomes of three-vessel coronary artery disease after coronary revascularization by percutaneous coronary intervention using second-generation drug-eluting stents versus coronary ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-07-10

AUTHORS

Reo Hata, Shunsuke Kubo, Hiroshi Tsuneyoshi, Takeshi Shimamoto, Akimune Kuwayama, Masanobu Ohya, Takenobu Shimada, Katsuya Miura, Hidewo Amano, Suguru Otsuru, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Tatsuhiko Komiya, Kazushige Kadota

ABSTRACT

Studies on the outcomes of de novo three-vessel coronary artery disease (3VD) are limited. This study evaluated the outcomes after coronary revascularization in patients with 3VD treated by percutaneous coronary intervention (PCI) using second-generation drug-eluting stents (2ndDES) in comparison with coronary artery bypass grafting (CABG). We analyzed 853 patients undergoing either PCI or CABG for 3VD between 2010 and 2014. Of them, this study included 298 undergoing PCI with 2ndDES alone (PCI group) and 171 undergoing CABG (CABG group). The primary outcome measure was a composite of all-cause death, non-fatal myocardial infarction (MI), or stroke. The secondary outcome measures were cardiac death, MI, stroke, and target vessel revascularization (TVR). Propensity matching was used to adjust a cohort of patients with similar baseline characteristics. Between the PCI and CABG groups, no significant differences were found in the 3-year cumulative incidence of the primary outcome measure (14.9% vs. 12.9%, p = 0.60). After propensity score matching, no significant differences were found in the incidences of primary outcome measure (13.0% vs. 12.8%, p = 0.95), cardiac death, MI, and stroke (3.5% vs. 2.7%, p = 0.72; 1.2% vs. 0.0%, p = 0.31; and 4.9% vs. 3.1%, p = 0.35), whereas that of TVR was significantly higher in the PCI group (24.5 vs. 7.1%, p < 0.01). Compared with CABG, PCI with second-generation DES was not associated with higher risk of clinical outcomes, but was associated with a higher risk of TVR in the treatment of 3VD. More... »

PAGES

194-202

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12928-019-00599-5

DOI

http://dx.doi.org/10.1007/s12928-019-00599-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117919379

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31292929


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19 schema:description Studies on the outcomes of de novo three-vessel coronary artery disease (3VD) are limited. This study evaluated the outcomes after coronary revascularization in patients with 3VD treated by percutaneous coronary intervention (PCI) using second-generation drug-eluting stents (2ndDES) in comparison with coronary artery bypass grafting (CABG). We analyzed 853 patients undergoing either PCI or CABG for 3VD between 2010 and 2014. Of them, this study included 298 undergoing PCI with 2ndDES alone (PCI group) and 171 undergoing CABG (CABG group). The primary outcome measure was a composite of all-cause death, non-fatal myocardial infarction (MI), or stroke. The secondary outcome measures were cardiac death, MI, stroke, and target vessel revascularization (TVR). Propensity matching was used to adjust a cohort of patients with similar baseline characteristics. Between the PCI and CABG groups, no significant differences were found in the 3-year cumulative incidence of the primary outcome measure (14.9% vs. 12.9%, p = 0.60). After propensity score matching, no significant differences were found in the incidences of primary outcome measure (13.0% vs. 12.8%, p = 0.95), cardiac death, MI, and stroke (3.5% vs. 2.7%, p = 0.72; 1.2% vs. 0.0%, p = 0.31; and 4.9% vs. 3.1%, p = 0.35), whereas that of TVR was significantly higher in the PCI group (24.5 vs. 7.1%, p < 0.01). Compared with CABG, PCI with second-generation DES was not associated with higher risk of clinical outcomes, but was associated with a higher risk of TVR in the treatment of 3VD.
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28 PCI group
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30 TVR
31 artery bypass
32 artery bypass graft surgery
33 artery disease
34 baseline characteristics
35 bypass
36 bypass graft surgery
37 cardiac death
38 cause death
39 characteristics
40 clinical outcomes
41 cohort
42 cohort of patients
43 comparison
44 composites
45 coronary artery bypass
46 coronary artery bypass graft surgery
47 coronary artery disease
48 coronary intervention
49 coronary revascularization
50 cumulative incidence
51 de novo
52 death
53 differences
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55 drug-eluting stents
56 graft surgery
57 group
58 high risk
59 incidence
60 infarction
61 intervention
62 long-term outcomes
63 matching
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65 myocardial infarction
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67 novo
68 outcome measures
69 outcomes
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71 percutaneous coronary intervention
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73 propensity matching
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76 risk
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