Second-generation versus first-generation drug-eluting stents in patients with and without diabetes mellitus: pooled analysis from the RESET and NEXT trials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

Kenji Nakatsuma, Hiroki Shiomi, Masahiro Natsuaki, Takeshi Morimoto, Keiichi Igarashi, Kazushige Kadota, Toshiya Muramatsu, Kengo Tanabe, Yoshihiro Morino, Takashi Akasaka, Yoshihisa Nakagawa, Ken Kozuma, Takeshi Kimura, On behalf of the RESET and NEXT investigators

ABSTRACT

The impact of second-generation drug-eluting stent (G2-DES) implantations compared with first-generation drug-eluting stents (G1-DES) implantations on long-term clinical outcomes after percutaneous coronary intervention in patients with and without diabetes mellitus (DM) has not yet been adequately assessed. This pooled analysis compared 3-year clinical outcomes between G1- and G2-DES according to the presence or absence of DM, using individual patient-level data from the RESET and NEXT trials. Among 6431 patients, G1-DES and G2-DES were used in 713 and 2211 patients, respectively, in the DM stratum, and 887 and 2620 patients, respectively, in the non-DM stratum. Cumulative incidence of and adjusted hazard ratio (HR) for target-lesion revascularization (TLR) were not significantly different between G2- and G1-DES in both strata [DM, 8.7 versus 10.1%, adjusted HR: 0.80, 95% confidence interval (CI) 0.59-1.10, P = 0.17; non-DM, 5.7 versus 6.2%, adjusted HR: 0.86, 95% CI 0.62-1.22, P = 0.38]. In the insulin-treated DM (ITDM), G2-DES had a significantly lower adjusted HR for TLR compared with G1-DES, although there was no significant difference in the non-ITDM (ITDM, adjusted HR: 0.54, 95% CI 0.32-0.96, P = 0.04; non-ITDM, adjusted HR: 0.95, 95% CI 0.66-1.42, P = 0.81). G2-DES provided similar risk for TLR in non-ITDM and non-DM patients compared with G1-DES. However, G2-DES compared with G1-DES had a lower risk for TLR among ITDM patients. More... »

PAGES

125-134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12928-017-0458-9

DOI

http://dx.doi.org/10.1007/s12928-017-0458-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083404077

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28150119


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