Ontology type: schema:ScholarlyArticle Open Access: True
2017-04
AUTHORSMasakatsu Nishikawa, Takaaki Isshiki, Takeshi Kimura, Hisao Ogawa, Hiroyoshi Yokoi, Shunichi Miyazaki, Yasuo Ikeda, Masato Nakamura, Yuko Tanaka, Shigeru Saito
ABSTRACTPrasugrel is a third-generation thienopyridine that achieves potent platelet inhibition with less pharmacological variability than other thienopyridines. However, clinical experience suggests that prasugrel may be associated with a higher risk of de novo and recurrent bleeding events compared with clopidogrel in Japanese patients undergoing percutaneous coronary intervention (PCI). In this review, we evaluate the risk of bleeding in Japanese patients treated with prasugrel at the doses (loading/maintenance doses: 20/3.75 mg) adjusted for Japanese patients, evaluate the risk factors for bleeding in Japanese patients, and examine whether patients with a bleeding event are at increased risk of recurrent bleeding. This review covers published data and new analyses of the PRASFIT (PRASugrel compared with clopidogrel For Japanese patIenTs) trials of patients undergoing PCI for acute coronary syndrome or elective reasons. The bleeding risk with prasugrel was similar to that observed with the standard dose of clopidogrel (300/75 mg), including when bleeding events were re-classified using the Bleeding Academic Research Consortium criteria. The pharmacodynamics of prasugrel was not associated with the risk of bleeding events. The main risk factors for bleeding events were female sex, low body weight, advanced age, and presence of diabetes mellitus. Use of a radial puncture site was associated with a lower risk of bleeding during PCI than a femoral puncture site. Finally, the frequency and severity of recurrent bleeding events during continued treatment were similar between prasugrel and clopidogrel. In summary, this review provides important insights into the risk and types of bleeding events in prasugrel-treated patients.Trial registration numbers: JapicCTI-101339 and JapicCTI-111550. More... »
PAGES93-105
http://scigraph.springernature.com/pub.10.1007/s12928-016-0452-7
DOIhttp://dx.doi.org/10.1007/s12928-016-0452-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1022456997
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28097639
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Acute Coronary Syndrome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Coronary Restenosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hemorrhage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Incidence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Japan",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Percutaneous Coronary Intervention",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Platelet Aggregation Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Postoperative Hemorrhage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prasugrel Hydrochloride",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recurrence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Mie University Hospital",
"id": "https://www.grid.ac/institutes/grid.412075.5",
"name": [
"Clinical Research Support Center, Mie University Hospital, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan"
],
"type": "Organization"
},
"familyName": "Nishikawa",
"givenName": "Masakatsu",
"id": "sg:person.011464732752.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464732752.46"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Division of Cardiology, Ageo Central General Hospital, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Isshiki",
"givenName": "Takaaki",
"id": "sg:person.0736052024.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736052024.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Kimura",
"givenName": "Takeshi",
"id": "sg:person.012173163322.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012173163322.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Cerebral and Cardiovascular Center",
"id": "https://www.grid.ac/institutes/grid.410796.d",
"name": [
"National Cerebral and Cardiovascular Center, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Ogawa",
"givenName": "Hisao",
"id": "sg:person.01301470144.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301470144.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "International University of Health and Welfare",
"id": "https://www.grid.ac/institutes/grid.411731.1",
"name": [
"Cardiovascular Medicine Center, Fukuoka Sanno Hospital, Fukuoka, Japan",
"International University of Health and Welfare, Tochigi, Japan"
],
"type": "Organization"
},
"familyName": "Yokoi",
"givenName": "Hiroyoshi",
"id": "sg:person.01052603744.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052603744.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kindai University",
"id": "https://www.grid.ac/institutes/grid.258622.9",
"name": [
"Saiseikai Tondabayashi Hospital, Osaka, Japan",
"Division of Cardiology, Department of Medicine, Faculty of Medicine, Kinki University, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Miyazaki",
"givenName": "Shunichi",
"id": "sg:person.0612075436.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612075436.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Waseda University",
"id": "https://www.grid.ac/institutes/grid.5290.e",
"name": [
"Waseda University, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Ikeda",
"givenName": "Yasuo",
"id": "sg:person.0675044622.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675044622.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Toho University",
"id": "https://www.grid.ac/institutes/grid.265050.4",
"name": [
"Division of Cardiovascular Medicine, Ohashi Medical Center, Toho University, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Nakamura",
"givenName": "Masato",
"id": "sg:person.01031752616.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031752616.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Daiichi-Sankyo (Japan)",
"id": "https://www.grid.ac/institutes/grid.410844.d",
"name": [
"R&D Division, Biostatistics & Data Management Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Yuko",
"id": "sg:person.0663322573.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663322573.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shonan Kamakura General Hospital",
"id": "https://www.grid.ac/institutes/grid.415816.f",
"name": [
"Division of Cardiology, Shonan Kamakura General Hospital, Kamakura, Japan"
],
"type": "Organization"
},
"familyName": "Saito",
"givenName": "Shigeru",
"id": "sg:person.01304041652.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304041652.36"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1056/nejmoa0706482",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000755110"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.109.192663",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002476458"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1253/circj.cj-13-0702",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006131162"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.clpt.6100139",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006304268",
"https://doi.org/10.1038/sj.clpt.6100139"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.clpt.6100139",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006304268",
"https://doi.org/10.1038/sj.clpt.6100139"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5551/jat.26013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006773540"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.110.002683",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012123607"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(11)60404-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012188899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/0897190015615900",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013216679"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/0897190015615900",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013216679"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.113.002303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013620432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.113.002303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013620432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.113.002303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013620432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.thromres.2015.09.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013975305"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2012.07.050",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014978340"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.amjcard.2014.02.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016452297"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/heartjnl-2014-306925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016942641"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ahj.2006.04.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017631304"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2013.07.101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020743254"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.110.009449",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025074445"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2012.06.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025499309"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4172/2329-6607.1000162",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029463679"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1253/circj.cj-14-0266",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031368573"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1538-7836.2012.04875.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034162613"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ahj.2008.11.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034670494"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2012.06.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034793358"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jcin.2013.04.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037957326"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/dmd.105.007989",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038051799"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1253/circj.cj-15-0276",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039842599"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.amjcard.2009.06.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043999815"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/11537820-000000000-00000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044550109",
"https://doi.org/10.2165/11537820-000000000-00000"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/11537820-000000000-00000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044550109",
"https://doi.org/10.2165/11537820-000000000-00000"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/11537820-000000000-00000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044550109",
"https://doi.org/10.2165/11537820-000000000-00000"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.amjcard.2013.09.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044745422"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ahj.2015.06.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045580870"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1253/circj.cj-13-0786",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046621345"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.amjcard.2008.11.049",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048986245"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijcard.2015.01.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050559080"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2013.08.1651",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051270123"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1253/circj.cj-13-1482",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051285887"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1185/03007995.2014.944638",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051319860"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/heartjnl-2011-300558",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052285582"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jcin.2013.08.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053498152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th07-05-0324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063291261"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th13-10-0891",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063293578"
],
"type": "CreativeWork"
}
],
"datePublished": "2017-04",
"datePublishedReg": "2017-04-01",
"description": "Prasugrel is a third-generation thienopyridine that achieves potent platelet inhibition with less pharmacological variability than other thienopyridines. However, clinical experience suggests that prasugrel may be associated with a higher risk of de novo and recurrent bleeding events compared with clopidogrel in Japanese patients undergoing percutaneous coronary intervention (PCI). In this review, we evaluate the risk of bleeding in Japanese patients treated with prasugrel at the doses (loading/maintenance doses: 20/3.75\u00a0mg) adjusted for Japanese patients, evaluate the risk factors for bleeding in Japanese patients, and examine whether patients with a bleeding event are at increased risk of recurrent bleeding. This review covers published data and new analyses of the PRASFIT (PRASugrel compared with clopidogrel For Japanese patIenTs) trials of patients undergoing PCI for acute coronary syndrome or elective reasons. The bleeding risk with prasugrel was similar to that observed with the standard dose of clopidogrel (300/75\u00a0mg), including when bleeding events were re-classified using the Bleeding Academic Research Consortium criteria. The pharmacodynamics of prasugrel was not associated with the risk of bleeding events. The main risk factors for bleeding events were female sex, low body weight, advanced age, and presence of diabetes mellitus. Use of a radial puncture site was associated with a lower risk of bleeding during PCI than a femoral puncture site. Finally, the frequency and severity of recurrent bleeding events during continued treatment were similar between prasugrel and clopidogrel. In summary, this review provides important insights into the risk and types of bleeding events in prasugrel-treated patients.Trial registration numbers: JapicCTI-101339 and JapicCTI-111550.",
"genre": "research_article",
"id": "sg:pub.10.1007/s12928-016-0452-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1042779",
"issn": [
"1868-4300",
"1868-4297"
],
"name": "Cardiovascular Intervention and Therapeutics",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "32"
}
],
"name": "Risk of bleeding and repeated bleeding events in prasugrel-treated patients: a review of data from the Japanese PRASFIT studies",
"pagination": "93-105",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"6afd4d842c86b30dd490531ce9c4a6f516bcb77af57d4aca43c3086a47d6bf6b"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"28097639"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101522043"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s12928-016-0452-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1022456997"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s12928-016-0452-7",
"https://app.dimensions.ai/details/publication/pub.1022456997"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:52",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89790_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs12928-016-0452-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12928-016-0452-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12928-016-0452-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12928-016-0452-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12928-016-0452-7'
This table displays all metadata directly associated to this object as RDF triples.
327 TRIPLES
21 PREDICATES
80 URIs
33 LITERALS
21 BLANK NODES