Prospective multi-center registry to evaluate efficacy and safety of the newly developed diamond-like carbon-coated cobalt–chromium coronary stent system View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07

AUTHORS

Kenji Ando, Katsuhisa Ishii, Eiji Tada, Kazuaki Kataoka, Atsushi Hirohata, Kenji Goto, Katsuyuki Kobayashi, Hiroshi Tsutsui, Makoto Nakahama, Hitoshi Nakashima, Shinichiroh Uchikawa, Junji Kanda, Satoshi Yasuda, Junji Yajima, Hiroshi Kitabayashi, Shumpei Sakurai, Keita Nakanishi, Naoto Inoue, Hirofumi Noike, Terumitsu Hasebe, Tetsuya Sato, Masao Yamasaki, Takeshi Kimura

ABSTRACT

The purpose of this multi-center, non-randomized, and open-label clinical trial was to determine the non-inferiority of diamond-like carbon (DLC)-coated cobalt-chromium coronary stent, the MOMO DLC coronary stent, relative to commercially available bare-metal stents (MULTI-LINK VISION®). Nineteen centers in Japan participated. The study cohort consisted of 99 patients from 19 Japanese centers with single or double native coronary vessel disease with de novo and restenosis lesions who met the study eligibility criteria. This cohort formed the safety analysis set. The efficacy analysis set consisted of 98 patients (one case was excluded for violating the eligibility criteria). The primary endpoint was target vessel failure (TVF) rate at 9 months after stent placement. Of the 98 efficacy analysis set patients, TVF occurred in 11 patients (11.2 %, 95 % confidence interval 5.7-19.2 %) at 9 months after the index stent implantation. The upper 95 % confidence interval for TVF of the study stent was lower than that previously reported for the commercially available MULTI-LINK VISION® (19.6 %), demonstrating non-inferiority of the study stent to MULTI-LINK VISION®. All the TVF cases were related to target vascular revascularization. None of the cases developed in-stent thrombosis or myocardial infarction. The average in-stent late loss and binary restenosis rate at the 6-month follow-up angiography were 0.69 mm and 10.5 %, respectively, which are lower than the reported values for commercially available bare-metal stents. In conclusion, the current pivotal clinical study evaluating the new MOMO DLC-coated coronary stent suggested its low rates of TVF and angiographic binary restenosis, and small in-stent late loss, although the data were considered preliminary considering the small sample size and single arm study design. More... »

PAGES

225-232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12928-016-0407-z

DOI

http://dx.doi.org/10.1007/s12928-016-0407-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013212263

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27448025


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12928-016-0407-z'

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12928-016-0407-z'


 

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