Outcomes of the largest multi-center trial stratified by the presence of diabetes mellitus comparing sirolimus-eluting stents (SES) and paclitaxel-eluting stents ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06-27

AUTHORS

Masato Nakamura, Toshiya Muramatsu, Hiroyoshi Yokoi, Hisayuki Okada, Masahiko Ochiai, Satoru Suwa, Hidenari Hozawa, Kazuya Kawai, Masaki Awata, Hiroaki Mukawa, Hiroshi Fujita, Nobuo Shiode, Ryuta Asano, Yoshiaki Tsukamoto, Takahisa Yamada, Yoshio Yasumura, Hiroshi Ohira, Akira Miyamoto, Hiroaki Takashima, Takayuki Ogawa, Yutaka Matsuyama, Shinsuke Nanto, On behalf of the J-DESsERT investigators

ABSTRACT

The Japan drug-eluting stents evaluation: a randomized trial (J-DESsERT) was conducted to compare the effectiveness of 2 different drug-eluting stents (DES). It remains uncertain which is more efficacious in diabetic patients, sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES). In this trial, the largest of its kind, 3,533 patients including 1,724 diabetes mellitus (DM) patients were randomized to either SES or PES. Stratification was based on the presence or absence of DM. PES target vessel failure (TVF) non-inferiority at 8 months (primary endpoint) was not demonstrated when compared to SES (SES 4.5 % vs. PES 6.4 %, p = 0.23). In addition, PES TVF superiority at 8 months in the DM subset (secondary endpoint) was not shown (SES 5.6 % vs. PES 7.6 %, p = 0.10). Insulin treatment was associated with increased TVF rates, however, this was less pronounced in the PES group. At 8 months, the similar TVF rates for SES and PES up to that point diverged significantly, favoring SES out to 12 months. Patients undergoing routine angiographic follow-up demonstrated lower TVF prior to the 8-month point, and higher TVF after 8 months, as compared to those followed clinically. In conclusion, the current study failed to demonstrate the proposed superiority of PES for DM patients. In addition, the diversion of TVF at 8 months may reflect an “oculo-stenotic reflex” bias (the tendency to treat lesions found during routine, rather than clinically driven, angiographic follow-up), which could constitute an obstacle for evaluating the true clinical effect of new devices. More... »

PAGES

103-114

Journal

Author Affiliations

  • Division of Cardiovascular Medicine, Toho University School of Medicine, Ohashi Medical Center, 2-17-6 Ohashi, 153-8515, Meguro-ku, Tokyo, Japan
  • Division of Cardiology, Saiseikai Yokohama-City Eastern Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, 230-8765, Yokohama-shi, Kanagawa, Japan
  • Cardiovascular Medicine Center, Fukuoka Sanno Hospital, 3-6-45 Momochihama, Sawara-ku, 814-0001, Fukuoka-shi, Fukuoka, Japan
  • Department of Cardiology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, 430-8558, Hamamatsu-shi, Shizuoka, Japan
  • Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, 224-8503, Yokohama-shi, Kanagawa, Japan
  • Department of Cardiology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, 410-2295, Izunokuni-shi, Shizuoka, Japan
  • Division of Cardiology, Ayase Heart Hospital, 3-12-10 Yanaka, 120-0006, Adachi-ku, Tokyo, Japan
  • Division of Cardiology, Chikamori Hospital, 1-1-16 Okawasuji, 780-8522, Kochi-shi, Kochi, Japan
  • Kansai Rosai Hospital Cardiovascular Center, 3-1-69 Inabaso, 660-8511, Amagasaki-shi, Hyogo, Japan
  • Department of Cardiology, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, 503-8502, Ogaki-shi, Gifu, Japan
  • Division of Cardiology, Japanese Red Cross Kyoto Daini Hospital, 355-5 Kamanzadorimarutamachiagaruharuobi-cho, Kamigyo-ku, 602-8026, Kyoto-shi, Kyoto, Japan
  • Division of Cardiology, Tsuchiya General Hospital, 3-30 Nakajima-cho, Naka-ku, 730-8655, Hiroshima-shi, Hiroshima, Japan
  • Department of Cardiology, Sakakibara Heart Institute, 3-16-1 Asahi-cho, 183-0003, Fuchu-shi, Tokyo, Japan
  • Department of Cardiology, Kawasaki Saiwai Hospital, 31-27 Omiya-cho, Saiwai-ku, 212-0014, Kawasaki-shi, Kanagawa, Japan
  • Division of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, 558-8558, Osaka-shi, Osaka, Japan
  • Cardiovascular Division, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, 540-0006, Osaka-shi, Osaka, Japan
  • Department of Cardiology, Edogawa Hospital, 2-24-18 Higashikoiwa, 133-0052, Edogawa-ku, Tokyo, Japan
  • Department of Cardiology, Kikuna Memorial Hospital, 4-4-27 Kikuna, Kohoku-ku, 222-0011, Yokohama-shi, Japan
  • Department of Cardiology, Aichi Medical University, 1-1 Yazakokarimata, 480-1195, Nagakute-shi, Aichi, Japan
  • Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, 105-8461, Minato-ku, Tokyo, Japan
  • Department of Biostatistics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, 111-0033, Bunkyo-ku, Tokyo, Japan
  • Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita-shi, Osaka, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z

    DOI

    http://dx.doi.org/10.1007/s12928-014-0279-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029364812

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24969222


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Bacterial Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coronary Artery Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coronary Restenosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetes Mellitus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug-Eluting Stents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Japan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Paclitaxel", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sirolimus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tubulin Modulators", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Cardiovascular Medicine, Toho University School of Medicine, Ohashi Medical Center, 2-17-6 Ohashi, 153-8515, Meguro-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265050.4", 
              "name": [
                "Division of Cardiovascular Medicine, Toho University School of Medicine, Ohashi Medical Center, 2-17-6 Ohashi, 153-8515, Meguro-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamura", 
            "givenName": "Masato", 
            "id": "sg:person.01031752616.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031752616.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Saiseikai Yokohama-City Eastern Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, 230-8765, Yokohama-shi, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.461876.a", 
              "name": [
                "Division of Cardiology, Saiseikai Yokohama-City Eastern Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, 230-8765, Yokohama-shi, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muramatsu", 
            "givenName": "Toshiya", 
            "id": "sg:person.01225552506.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cardiovascular Medicine Center, Fukuoka Sanno Hospital, 3-6-45 Momochihama, Sawara-ku, 814-0001, Fukuoka-shi, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Cardiovascular Medicine Center, Fukuoka Sanno Hospital, 3-6-45 Momochihama, Sawara-ku, 814-0001, Fukuoka-shi, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yokoi", 
            "givenName": "Hiroyoshi", 
            "id": "sg:person.01052603744.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052603744.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, 430-8558, Hamamatsu-shi, Shizuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415466.4", 
              "name": [
                "Department of Cardiology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, 430-8558, Hamamatsu-shi, Shizuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okada", 
            "givenName": "Hisayuki", 
            "id": "sg:person.0707402413.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707402413.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, 224-8503, Yokohama-shi, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.482675.a", 
              "name": [
                "Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, 224-8503, Yokohama-shi, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ochiai", 
            "givenName": "Masahiko", 
            "id": "sg:person.01240612333.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240612333.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, 410-2295, Izunokuni-shi, Shizuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.482667.9", 
              "name": [
                "Department of Cardiology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, 410-2295, Izunokuni-shi, Shizuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suwa", 
            "givenName": "Satoru", 
            "id": "sg:person.01073706066.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073706066.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Ayase Heart Hospital, 3-12-10 Yanaka, 120-0006, Adachi-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Division of Cardiology, Ayase Heart Hospital, 3-12-10 Yanaka, 120-0006, Adachi-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hozawa", 
            "givenName": "Hidenari", 
            "id": "sg:person.01252571314.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252571314.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Chikamori Hospital, 1-1-16 Okawasuji, 780-8522, Kochi-shi, Kochi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.452236.4", 
              "name": [
                "Division of Cardiology, Chikamori Hospital, 1-1-16 Okawasuji, 780-8522, Kochi-shi, Kochi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kawai", 
            "givenName": "Kazuya", 
            "id": "sg:person.0665632664.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665632664.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kansai Rosai Hospital Cardiovascular Center, 3-1-69 Inabaso, 660-8511, Amagasaki-shi, Hyogo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414976.9", 
              "name": [
                "Kansai Rosai Hospital Cardiovascular Center, 3-1-69 Inabaso, 660-8511, Amagasaki-shi, Hyogo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Awata", 
            "givenName": "Masaki", 
            "id": "sg:person.0720647077.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720647077.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, 503-8502, Ogaki-shi, Gifu, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416762.0", 
              "name": [
                "Department of Cardiology, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, 503-8502, Ogaki-shi, Gifu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mukawa", 
            "givenName": "Hiroaki", 
            "id": "sg:person.0750766550.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750766550.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Japanese Red Cross Kyoto Daini Hospital, 355-5 Kamanzadorimarutamachiagaruharuobi-cho, Kamigyo-ku, 602-8026, Kyoto-shi, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Division of Cardiology, Japanese Red Cross Kyoto Daini Hospital, 355-5 Kamanzadorimarutamachiagaruharuobi-cho, Kamigyo-ku, 602-8026, Kyoto-shi, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujita", 
            "givenName": "Hiroshi", 
            "id": "sg:person.07625025041.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07625025041.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Tsuchiya General Hospital, 3-30 Nakajima-cho, Naka-ku, 730-8655, Hiroshima-shi, Hiroshima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.513487.c", 
              "name": [
                "Division of Cardiology, Tsuchiya General Hospital, 3-30 Nakajima-cho, Naka-ku, 730-8655, Hiroshima-shi, Hiroshima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiode", 
            "givenName": "Nobuo", 
            "id": "sg:person.01301076173.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301076173.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Sakakibara Heart Institute, 3-16-1 Asahi-cho, 183-0003, Fuchu-shi, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413411.2", 
              "name": [
                "Department of Cardiology, Sakakibara Heart Institute, 3-16-1 Asahi-cho, 183-0003, Fuchu-shi, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Asano", 
            "givenName": "Ryuta", 
            "id": "sg:person.01004616343.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004616343.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Kawasaki Saiwai Hospital, 31-27 Omiya-cho, Saiwai-ku, 212-0014, Kawasaki-shi, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Cardiology, Kawasaki Saiwai Hospital, 31-27 Omiya-cho, Saiwai-ku, 212-0014, Kawasaki-shi, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsukamoto", 
            "givenName": "Yoshiaki", 
            "id": "sg:person.013743505730.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013743505730.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, 558-8558, Osaka-shi, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416985.7", 
              "name": [
                "Division of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, 558-8558, Osaka-shi, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamada", 
            "givenName": "Takahisa", 
            "id": "sg:person.01177767704.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177767704.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cardiovascular Division, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, 540-0006, Osaka-shi, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416803.8", 
              "name": [
                "Cardiovascular Division, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, 540-0006, Osaka-shi, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yasumura", 
            "givenName": "Yoshio", 
            "id": "sg:person.01233704217.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233704217.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Edogawa Hospital, 2-24-18 Higashikoiwa, 133-0052, Edogawa-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.452399.0", 
              "name": [
                "Department of Cardiology, Edogawa Hospital, 2-24-18 Higashikoiwa, 133-0052, Edogawa-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohira", 
            "givenName": "Hiroshi", 
            "id": "sg:person.01232754001.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232754001.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Kikuna Memorial Hospital, 4-4-27 Kikuna, Kohoku-ku, 222-0011, Yokohama-shi, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Cardiology, Kikuna Memorial Hospital, 4-4-27 Kikuna, Kohoku-ku, 222-0011, Yokohama-shi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyamoto", 
            "givenName": "Akira", 
            "id": "sg:person.01211105620.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211105620.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Aichi Medical University, 1-1 Yazakokarimata, 480-1195, Nagakute-shi, Aichi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411234.1", 
              "name": [
                "Department of Cardiology, Aichi Medical University, 1-1 Yazakokarimata, 480-1195, Nagakute-shi, Aichi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takashima", 
            "givenName": "Hiroaki", 
            "id": "sg:person.0747647173.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747647173.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, 105-8461, Minato-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, 105-8461, Minato-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogawa", 
            "givenName": "Takayuki", 
            "id": "sg:person.01123036421.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123036421.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, 111-0033, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Biostatistics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, 111-0033, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuyama", 
            "givenName": "Yutaka", 
            "id": "sg:person.01044204653.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044204653.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita-shi, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita-shi, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nanto", 
            "givenName": "Shinsuke", 
            "id": "sg:person.01311264335.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311264335.91"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "On behalf of the J-DESsERT investigators", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00894-009-0539-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052226488", 
              "https://doi.org/10.1007/s00894-009-0539-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/molmed.2010.00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965260", 
              "https://doi.org/10.2119/molmed.2010.00023"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-06-27", 
        "datePublishedReg": "2014-06-27", 
        "description": "The Japan drug-eluting stents evaluation: a randomized trial (J-DESsERT) was conducted to compare the effectiveness of 2 different drug-eluting stents (DES). It remains uncertain which is more efficacious in diabetic patients, sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES). In this trial, the largest of its kind, 3,533 patients including 1,724 diabetes mellitus (DM) patients were randomized to either SES or PES. Stratification was based on the presence or absence of DM. PES target vessel failure (TVF) non-inferiority at 8\u00a0months (primary endpoint) was not demonstrated when compared to SES (SES 4.5\u00a0% vs. PES 6.4\u00a0%, p\u00a0=\u00a00.23). In addition, PES TVF superiority at 8\u00a0months in the DM subset (secondary endpoint) was not shown (SES 5.6\u00a0% vs. PES 7.6\u00a0%, p\u00a0=\u00a00.10). Insulin treatment was associated with increased TVF rates, however, this was less pronounced in the PES group. At 8\u00a0months, the similar TVF rates for SES and PES up to that point diverged significantly, favoring SES out to 12\u00a0months. Patients undergoing routine angiographic follow-up demonstrated lower TVF prior to the 8-month point, and higher TVF after 8\u00a0months, as compared to those followed clinically. In conclusion, the current study failed to demonstrate the proposed superiority of PES for DM patients. In addition, the diversion of TVF at 8\u00a0months may reflect an \u201coculo-stenotic reflex\u201d bias (the tendency to treat lesions found during routine, rather than clinically driven, angiographic follow-up), which could constitute an obstacle for evaluating the true clinical effect of new devices.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12928-014-0279-z", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1042779", 
            "issn": [
              "1868-4300", 
              "1868-4297"
            ], 
            "name": "Cardiovascular Intervention and Therapeutics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "30"
          }
        ], 
        "keywords": [
          "target vessel failure", 
          "paclitaxel-eluting stents", 
          "sirolimus-eluting stents", 
          "different drug-eluting stents", 
          "TVF rate", 
          "stent evaluation", 
          "large multi-centre trial", 
          "true clinical effect", 
          "diabetes mellitus patients", 
          "coronary artery disease", 
          "multi-center trial", 
          "drug-eluting stents", 
          "absence of DM", 
          "diabetic patients", 
          "mellitus patients", 
          "PES group", 
          "DM patients", 
          "diabetes mellitus", 
          "artery disease", 
          "clinical effects", 
          "insulin treatment", 
          "patients", 
          "stents", 
          "months", 
          "trials", 
          "vessel failure", 
          "current study", 
          "mellitus", 
          "reflex", 
          "disease", 
          "outcomes", 
          "treatment", 
          "evaluation", 
          "new device", 
          "rate", 
          "conclusion", 
          "diversion", 
          "failure", 
          "group", 
          "presence", 
          "stratification", 
          "subset", 
          "DM", 
          "absence", 
          "addition", 
          "study", 
          "effect", 
          "effectiveness", 
          "bias", 
          "superiority", 
          "point", 
          "obstacles", 
          "devices", 
          "kind"
        ], 
        "name": "Outcomes of the largest multi-center trial stratified by the presence of diabetes mellitus comparing sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in patients with coronary artery disease. The Japan drug-eluting stents evaluation: a randomized trial (J-DESsERT)", 
        "pagination": "103-114", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1029364812"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12928-014-0279-z"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24969222"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12928-014-0279-z", 
          "https://app.dimensions.ai/details/publication/pub.1029364812"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:02", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_638.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12928-014-0279-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    393 TRIPLES      21 PREDICATES      96 URIs      86 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12928-014-0279-z schema:about N2bc027b6373b455a91a1b5041f23a286
    2 N3ddc9f17d1a745ebb6a4d924376765f5
    3 N584e78b25710490a954989b0a9017577
    4 N60caafa1fd0e45b0bbdada5816347ba0
    5 N6474dec6ba214c0cb3a1f2657a2e27c2
    6 N7044c5a418bf423db553434f898577c6
    7 N88ad03200b2a43f496d422dbb509d8aa
    8 N8a4d1cc8eaaa47bd89b8c6f3fa722cdb
    9 Nabc05c435a15475b9acac93cb6adf493
    10 Nb2d62b92a0b34cc6aa52775334d092cf
    11 Ncc83b5f7fbba4ffe97472420616f7428
    12 Ncf9b723b3363494385fa849b763c9249
    13 Nd433bc6f41c249fb973e0ddabceb9f01
    14 Ne43914baaaae4267aa4286a7d5adf742
    15 Nfbe2a2ea5baa4abfa68accd51fcd7347
    16 anzsrc-for:11
    17 anzsrc-for:1117
    18 schema:author N201b323b06bb4ae6a83f6418a7563bda
    19 schema:citation sg:pub.10.1007/s00894-009-0539-5
    20 sg:pub.10.2119/molmed.2010.00023
    21 schema:datePublished 2014-06-27
    22 schema:datePublishedReg 2014-06-27
    23 schema:description The Japan drug-eluting stents evaluation: a randomized trial (J-DESsERT) was conducted to compare the effectiveness of 2 different drug-eluting stents (DES). It remains uncertain which is more efficacious in diabetic patients, sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES). In this trial, the largest of its kind, 3,533 patients including 1,724 diabetes mellitus (DM) patients were randomized to either SES or PES. Stratification was based on the presence or absence of DM. PES target vessel failure (TVF) non-inferiority at 8 months (primary endpoint) was not demonstrated when compared to SES (SES 4.5 % vs. PES 6.4 %, p = 0.23). In addition, PES TVF superiority at 8 months in the DM subset (secondary endpoint) was not shown (SES 5.6 % vs. PES 7.6 %, p = 0.10). Insulin treatment was associated with increased TVF rates, however, this was less pronounced in the PES group. At 8 months, the similar TVF rates for SES and PES up to that point diverged significantly, favoring SES out to 12 months. Patients undergoing routine angiographic follow-up demonstrated lower TVF prior to the 8-month point, and higher TVF after 8 months, as compared to those followed clinically. In conclusion, the current study failed to demonstrate the proposed superiority of PES for DM patients. In addition, the diversion of TVF at 8 months may reflect an “oculo-stenotic reflex” bias (the tendency to treat lesions found during routine, rather than clinically driven, angiographic follow-up), which could constitute an obstacle for evaluating the true clinical effect of new devices.
    24 schema:genre article
    25 schema:isAccessibleForFree false
    26 schema:isPartOf N48eee0a550f2464fa7f8d87d5ae7f914
    27 N6fc0dfbc57214a8a84b632f9851afd91
    28 sg:journal.1042779
    29 schema:keywords DM
    30 DM patients
    31 PES group
    32 TVF rate
    33 absence
    34 absence of DM
    35 addition
    36 artery disease
    37 bias
    38 clinical effects
    39 conclusion
    40 coronary artery disease
    41 current study
    42 devices
    43 diabetes mellitus
    44 diabetes mellitus patients
    45 diabetic patients
    46 different drug-eluting stents
    47 disease
    48 diversion
    49 drug-eluting stents
    50 effect
    51 effectiveness
    52 evaluation
    53 failure
    54 group
    55 insulin treatment
    56 kind
    57 large multi-centre trial
    58 mellitus
    59 mellitus patients
    60 months
    61 multi-center trial
    62 new device
    63 obstacles
    64 outcomes
    65 paclitaxel-eluting stents
    66 patients
    67 point
    68 presence
    69 rate
    70 reflex
    71 sirolimus-eluting stents
    72 stent evaluation
    73 stents
    74 stratification
    75 study
    76 subset
    77 superiority
    78 target vessel failure
    79 treatment
    80 trials
    81 true clinical effect
    82 vessel failure
    83 schema:name Outcomes of the largest multi-center trial stratified by the presence of diabetes mellitus comparing sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in patients with coronary artery disease. The Japan drug-eluting stents evaluation: a randomized trial (J-DESsERT)
    84 schema:pagination 103-114
    85 schema:productId N5c4eae04265b4a19a06329bbeea67f8e
    86 Nac5e17d03107469888e34b8d2eefe681
    87 Nb2181825bc7a4594a10368085c5c2cfa
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029364812
    89 https://doi.org/10.1007/s12928-014-0279-z
    90 schema:sdDatePublished 2022-08-04T17:02
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher N3814e2a5552244848eff09cc359a21d8
    93 schema:url https://doi.org/10.1007/s12928-014-0279-z
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N01777926058d4e828879f774236e7b9f rdf:first sg:person.01004616343.42
    98 rdf:rest Ned5c60484d234990a10551d7725973f8
    99 N08c517e620054577ac601a6b2c4c606e rdf:first sg:person.01052603744.16
    100 rdf:rest N35bd8c4d8136496f87a45229810a166b
    101 N201b323b06bb4ae6a83f6418a7563bda rdf:first sg:person.01031752616.54
    102 rdf:rest Nd27d2a75286043898f2b57432ff27def
    103 N223815ac5ff04c0b853587ddbb518a94 rdf:first sg:person.01044204653.16
    104 rdf:rest N66a0bee342764d639031d139e3164a89
    105 N2bc027b6373b455a91a1b5041f23a286 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Japan
    107 rdf:type schema:DefinedTerm
    108 N312484f7ea7c4fef98250552871be2fa rdf:first sg:person.01240612333.96
    109 rdf:rest Nb862cb5df9cd40cb9150f7f411044221
    110 N34cb458917914a85b55f704f7c82f567 rdf:first Ncc23d86c381a478082bc0436ca31a036
    111 rdf:rest rdf:nil
    112 N35bd8c4d8136496f87a45229810a166b rdf:first sg:person.0707402413.51
    113 rdf:rest N312484f7ea7c4fef98250552871be2fa
    114 N370b4b9d30044bf3baa8304c8a1a4723 rdf:first sg:person.0665632664.22
    115 rdf:rest Nf27f254a3ec64513a53f87b810c84415
    116 N3814e2a5552244848eff09cc359a21d8 schema:name Springer Nature - SN SciGraph project
    117 rdf:type schema:Organization
    118 N3ddc9f17d1a745ebb6a4d924376765f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Treatment Outcome
    120 rdf:type schema:DefinedTerm
    121 N449b5185562d42e38c52b90140acb24d rdf:first sg:person.01301076173.92
    122 rdf:rest N01777926058d4e828879f774236e7b9f
    123 N48eee0a550f2464fa7f8d87d5ae7f914 schema:issueNumber 2
    124 rdf:type schema:PublicationIssue
    125 N54a854c912e04d43ba7aa11e91e59321 rdf:first sg:person.07625025041.03
    126 rdf:rest N449b5185562d42e38c52b90140acb24d
    127 N584e78b25710490a954989b0a9017577 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Tubulin Modulators
    129 rdf:type schema:DefinedTerm
    130 N5c4eae04265b4a19a06329bbeea67f8e schema:name dimensions_id
    131 schema:value pub.1029364812
    132 rdf:type schema:PropertyValue
    133 N60caafa1fd0e45b0bbdada5816347ba0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Coronary Restenosis
    135 rdf:type schema:DefinedTerm
    136 N6474dec6ba214c0cb3a1f2657a2e27c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Middle Aged
    138 rdf:type schema:DefinedTerm
    139 N66a0bee342764d639031d139e3164a89 rdf:first sg:person.01311264335.91
    140 rdf:rest N34cb458917914a85b55f704f7c82f567
    141 N6fc0dfbc57214a8a84b632f9851afd91 schema:volumeNumber 30
    142 rdf:type schema:PublicationVolume
    143 N7044c5a418bf423db553434f898577c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Male
    145 rdf:type schema:DefinedTerm
    146 N76b10fe681374a93a69389250ed7301f rdf:first sg:person.01177767704.09
    147 rdf:rest Na52f7ad81ac64912b164d8b2b44da272
    148 N88ad03200b2a43f496d422dbb509d8aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Paclitaxel
    150 rdf:type schema:DefinedTerm
    151 N8a4d1cc8eaaa47bd89b8c6f3fa722cdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Drug-Eluting Stents
    153 rdf:type schema:DefinedTerm
    154 N8b0e027395d8460383e6de9c919d2f5d rdf:first sg:person.01232754001.79
    155 rdf:rest N9febdded56dd41489f5e3efb385ac45c
    156 N9febdded56dd41489f5e3efb385ac45c rdf:first sg:person.01211105620.70
    157 rdf:rest Nc6f6b555a8444bdc979ceb8db60bde3a
    158 Na52f7ad81ac64912b164d8b2b44da272 rdf:first sg:person.01233704217.96
    159 rdf:rest N8b0e027395d8460383e6de9c919d2f5d
    160 Nabc05c435a15475b9acac93cb6adf493 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Diabetes Mellitus
    162 rdf:type schema:DefinedTerm
    163 Nac5e17d03107469888e34b8d2eefe681 schema:name doi
    164 schema:value 10.1007/s12928-014-0279-z
    165 rdf:type schema:PropertyValue
    166 Nb2181825bc7a4594a10368085c5c2cfa schema:name pubmed_id
    167 schema:value 24969222
    168 rdf:type schema:PropertyValue
    169 Nb2d62b92a0b34cc6aa52775334d092cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Female
    171 rdf:type schema:DefinedTerm
    172 Nb862cb5df9cd40cb9150f7f411044221 rdf:first sg:person.01073706066.34
    173 rdf:rest Neb94f09e0929473195c69405a69fa67b
    174 Nbf2eee6a9c5148fcae42cd7938c12862 rdf:first sg:person.0750766550.50
    175 rdf:rest N54a854c912e04d43ba7aa11e91e59321
    176 Nc6f6b555a8444bdc979ceb8db60bde3a rdf:first sg:person.0747647173.26
    177 rdf:rest Nfb13875d20484f7b93407f354b8d3d86
    178 Ncc23d86c381a478082bc0436ca31a036 schema:familyName On behalf of the J-DESsERT investigators
    179 rdf:type schema:Person
    180 Ncc83b5f7fbba4ffe97472420616f7428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Humans
    182 rdf:type schema:DefinedTerm
    183 Ncf9b723b3363494385fa849b763c9249 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Coronary Artery Disease
    185 rdf:type schema:DefinedTerm
    186 Nd27d2a75286043898f2b57432ff27def rdf:first sg:person.01225552506.20
    187 rdf:rest N08c517e620054577ac601a6b2c4c606e
    188 Nd433bc6f41c249fb973e0ddabceb9f01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Sirolimus
    190 rdf:type schema:DefinedTerm
    191 Ne43914baaaae4267aa4286a7d5adf742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Anti-Bacterial Agents
    193 rdf:type schema:DefinedTerm
    194 Neb94f09e0929473195c69405a69fa67b rdf:first sg:person.01252571314.42
    195 rdf:rest N370b4b9d30044bf3baa8304c8a1a4723
    196 Ned5c60484d234990a10551d7725973f8 rdf:first sg:person.013743505730.28
    197 rdf:rest N76b10fe681374a93a69389250ed7301f
    198 Nf27f254a3ec64513a53f87b810c84415 rdf:first sg:person.0720647077.34
    199 rdf:rest Nbf2eee6a9c5148fcae42cd7938c12862
    200 Nfb13875d20484f7b93407f354b8d3d86 rdf:first sg:person.01123036421.13
    201 rdf:rest N223815ac5ff04c0b853587ddbb518a94
    202 Nfbe2a2ea5baa4abfa68accd51fcd7347 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Aged
    204 rdf:type schema:DefinedTerm
    205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    206 schema:name Medical and Health Sciences
    207 rdf:type schema:DefinedTerm
    208 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    209 schema:name Public Health and Health Services
    210 rdf:type schema:DefinedTerm
    211 sg:journal.1042779 schema:issn 1868-4297
    212 1868-4300
    213 schema:name Cardiovascular Intervention and Therapeutics
    214 schema:publisher Springer Nature
    215 rdf:type schema:Periodical
    216 sg:person.01004616343.42 schema:affiliation grid-institutes:grid.413411.2
    217 schema:familyName Asano
    218 schema:givenName Ryuta
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004616343.42
    220 rdf:type schema:Person
    221 sg:person.01031752616.54 schema:affiliation grid-institutes:grid.265050.4
    222 schema:familyName Nakamura
    223 schema:givenName Masato
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031752616.54
    225 rdf:type schema:Person
    226 sg:person.01044204653.16 schema:affiliation grid-institutes:grid.26999.3d
    227 schema:familyName Matsuyama
    228 schema:givenName Yutaka
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044204653.16
    230 rdf:type schema:Person
    231 sg:person.01052603744.16 schema:affiliation grid-institutes:None
    232 schema:familyName Yokoi
    233 schema:givenName Hiroyoshi
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052603744.16
    235 rdf:type schema:Person
    236 sg:person.01073706066.34 schema:affiliation grid-institutes:grid.482667.9
    237 schema:familyName Suwa
    238 schema:givenName Satoru
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073706066.34
    240 rdf:type schema:Person
    241 sg:person.01123036421.13 schema:affiliation grid-institutes:grid.411898.d
    242 schema:familyName Ogawa
    243 schema:givenName Takayuki
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123036421.13
    245 rdf:type schema:Person
    246 sg:person.01177767704.09 schema:affiliation grid-institutes:grid.416985.7
    247 schema:familyName Yamada
    248 schema:givenName Takahisa
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177767704.09
    250 rdf:type schema:Person
    251 sg:person.01211105620.70 schema:affiliation grid-institutes:None
    252 schema:familyName Miyamoto
    253 schema:givenName Akira
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211105620.70
    255 rdf:type schema:Person
    256 sg:person.01225552506.20 schema:affiliation grid-institutes:grid.461876.a
    257 schema:familyName Muramatsu
    258 schema:givenName Toshiya
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20
    260 rdf:type schema:Person
    261 sg:person.01232754001.79 schema:affiliation grid-institutes:grid.452399.0
    262 schema:familyName Ohira
    263 schema:givenName Hiroshi
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232754001.79
    265 rdf:type schema:Person
    266 sg:person.01233704217.96 schema:affiliation grid-institutes:grid.416803.8
    267 schema:familyName Yasumura
    268 schema:givenName Yoshio
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233704217.96
    270 rdf:type schema:Person
    271 sg:person.01240612333.96 schema:affiliation grid-institutes:grid.482675.a
    272 schema:familyName Ochiai
    273 schema:givenName Masahiko
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240612333.96
    275 rdf:type schema:Person
    276 sg:person.01252571314.42 schema:affiliation grid-institutes:None
    277 schema:familyName Hozawa
    278 schema:givenName Hidenari
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252571314.42
    280 rdf:type schema:Person
    281 sg:person.01301076173.92 schema:affiliation grid-institutes:grid.513487.c
    282 schema:familyName Shiode
    283 schema:givenName Nobuo
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301076173.92
    285 rdf:type schema:Person
    286 sg:person.01311264335.91 schema:affiliation grid-institutes:grid.136593.b
    287 schema:familyName Nanto
    288 schema:givenName Shinsuke
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311264335.91
    290 rdf:type schema:Person
    291 sg:person.013743505730.28 schema:affiliation grid-institutes:None
    292 schema:familyName Tsukamoto
    293 schema:givenName Yoshiaki
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013743505730.28
    295 rdf:type schema:Person
    296 sg:person.0665632664.22 schema:affiliation grid-institutes:grid.452236.4
    297 schema:familyName Kawai
    298 schema:givenName Kazuya
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665632664.22
    300 rdf:type schema:Person
    301 sg:person.0707402413.51 schema:affiliation grid-institutes:grid.415466.4
    302 schema:familyName Okada
    303 schema:givenName Hisayuki
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707402413.51
    305 rdf:type schema:Person
    306 sg:person.0720647077.34 schema:affiliation grid-institutes:grid.414976.9
    307 schema:familyName Awata
    308 schema:givenName Masaki
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720647077.34
    310 rdf:type schema:Person
    311 sg:person.0747647173.26 schema:affiliation grid-institutes:grid.411234.1
    312 schema:familyName Takashima
    313 schema:givenName Hiroaki
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747647173.26
    315 rdf:type schema:Person
    316 sg:person.0750766550.50 schema:affiliation grid-institutes:grid.416762.0
    317 schema:familyName Mukawa
    318 schema:givenName Hiroaki
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750766550.50
    320 rdf:type schema:Person
    321 sg:person.07625025041.03 schema:affiliation grid-institutes:None
    322 schema:familyName Fujita
    323 schema:givenName Hiroshi
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07625025041.03
    325 rdf:type schema:Person
    326 sg:pub.10.1007/s00894-009-0539-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052226488
    327 https://doi.org/10.1007/s00894-009-0539-5
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.2119/molmed.2010.00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965260
    330 https://doi.org/10.2119/molmed.2010.00023
    331 rdf:type schema:CreativeWork
    332 grid-institutes:None schema:alternateName Cardiovascular Medicine Center, Fukuoka Sanno Hospital, 3-6-45 Momochihama, Sawara-ku, 814-0001, Fukuoka-shi, Fukuoka, Japan
    333 Department of Cardiology, Kawasaki Saiwai Hospital, 31-27 Omiya-cho, Saiwai-ku, 212-0014, Kawasaki-shi, Kanagawa, Japan
    334 Department of Cardiology, Kikuna Memorial Hospital, 4-4-27 Kikuna, Kohoku-ku, 222-0011, Yokohama-shi, Japan
    335 Division of Cardiology, Ayase Heart Hospital, 3-12-10 Yanaka, 120-0006, Adachi-ku, Tokyo, Japan
    336 Division of Cardiology, Japanese Red Cross Kyoto Daini Hospital, 355-5 Kamanzadorimarutamachiagaruharuobi-cho, Kamigyo-ku, 602-8026, Kyoto-shi, Kyoto, Japan
    337 schema:name Cardiovascular Medicine Center, Fukuoka Sanno Hospital, 3-6-45 Momochihama, Sawara-ku, 814-0001, Fukuoka-shi, Fukuoka, Japan
    338 Department of Cardiology, Kawasaki Saiwai Hospital, 31-27 Omiya-cho, Saiwai-ku, 212-0014, Kawasaki-shi, Kanagawa, Japan
    339 Department of Cardiology, Kikuna Memorial Hospital, 4-4-27 Kikuna, Kohoku-ku, 222-0011, Yokohama-shi, Japan
    340 Division of Cardiology, Ayase Heart Hospital, 3-12-10 Yanaka, 120-0006, Adachi-ku, Tokyo, Japan
    341 Division of Cardiology, Japanese Red Cross Kyoto Daini Hospital, 355-5 Kamanzadorimarutamachiagaruharuobi-cho, Kamigyo-ku, 602-8026, Kyoto-shi, Kyoto, Japan
    342 rdf:type schema:Organization
    343 grid-institutes:grid.136593.b schema:alternateName Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita-shi, Osaka, Japan
    344 schema:name Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita-shi, Osaka, Japan
    345 rdf:type schema:Organization
    346 grid-institutes:grid.265050.4 schema:alternateName Division of Cardiovascular Medicine, Toho University School of Medicine, Ohashi Medical Center, 2-17-6 Ohashi, 153-8515, Meguro-ku, Tokyo, Japan
    347 schema:name Division of Cardiovascular Medicine, Toho University School of Medicine, Ohashi Medical Center, 2-17-6 Ohashi, 153-8515, Meguro-ku, Tokyo, Japan
    348 rdf:type schema:Organization
    349 grid-institutes:grid.26999.3d schema:alternateName Department of Biostatistics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, 111-0033, Bunkyo-ku, Tokyo, Japan
    350 schema:name Department of Biostatistics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, 111-0033, Bunkyo-ku, Tokyo, Japan
    351 rdf:type schema:Organization
    352 grid-institutes:grid.411234.1 schema:alternateName Department of Cardiology, Aichi Medical University, 1-1 Yazakokarimata, 480-1195, Nagakute-shi, Aichi, Japan
    353 schema:name Department of Cardiology, Aichi Medical University, 1-1 Yazakokarimata, 480-1195, Nagakute-shi, Aichi, Japan
    354 rdf:type schema:Organization
    355 grid-institutes:grid.411898.d schema:alternateName Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, 105-8461, Minato-ku, Tokyo, Japan
    356 schema:name Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, 105-8461, Minato-ku, Tokyo, Japan
    357 rdf:type schema:Organization
    358 grid-institutes:grid.413411.2 schema:alternateName Department of Cardiology, Sakakibara Heart Institute, 3-16-1 Asahi-cho, 183-0003, Fuchu-shi, Tokyo, Japan
    359 schema:name Department of Cardiology, Sakakibara Heart Institute, 3-16-1 Asahi-cho, 183-0003, Fuchu-shi, Tokyo, Japan
    360 rdf:type schema:Organization
    361 grid-institutes:grid.414976.9 schema:alternateName Kansai Rosai Hospital Cardiovascular Center, 3-1-69 Inabaso, 660-8511, Amagasaki-shi, Hyogo, Japan
    362 schema:name Kansai Rosai Hospital Cardiovascular Center, 3-1-69 Inabaso, 660-8511, Amagasaki-shi, Hyogo, Japan
    363 rdf:type schema:Organization
    364 grid-institutes:grid.415466.4 schema:alternateName Department of Cardiology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, 430-8558, Hamamatsu-shi, Shizuoka, Japan
    365 schema:name Department of Cardiology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, 430-8558, Hamamatsu-shi, Shizuoka, Japan
    366 rdf:type schema:Organization
    367 grid-institutes:grid.416762.0 schema:alternateName Department of Cardiology, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, 503-8502, Ogaki-shi, Gifu, Japan
    368 schema:name Department of Cardiology, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, 503-8502, Ogaki-shi, Gifu, Japan
    369 rdf:type schema:Organization
    370 grid-institutes:grid.416803.8 schema:alternateName Cardiovascular Division, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, 540-0006, Osaka-shi, Osaka, Japan
    371 schema:name Cardiovascular Division, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, 540-0006, Osaka-shi, Osaka, Japan
    372 rdf:type schema:Organization
    373 grid-institutes:grid.416985.7 schema:alternateName Division of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, 558-8558, Osaka-shi, Osaka, Japan
    374 schema:name Division of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, 558-8558, Osaka-shi, Osaka, Japan
    375 rdf:type schema:Organization
    376 grid-institutes:grid.452236.4 schema:alternateName Division of Cardiology, Chikamori Hospital, 1-1-16 Okawasuji, 780-8522, Kochi-shi, Kochi, Japan
    377 schema:name Division of Cardiology, Chikamori Hospital, 1-1-16 Okawasuji, 780-8522, Kochi-shi, Kochi, Japan
    378 rdf:type schema:Organization
    379 grid-institutes:grid.452399.0 schema:alternateName Department of Cardiology, Edogawa Hospital, 2-24-18 Higashikoiwa, 133-0052, Edogawa-ku, Tokyo, Japan
    380 schema:name Department of Cardiology, Edogawa Hospital, 2-24-18 Higashikoiwa, 133-0052, Edogawa-ku, Tokyo, Japan
    381 rdf:type schema:Organization
    382 grid-institutes:grid.461876.a schema:alternateName Division of Cardiology, Saiseikai Yokohama-City Eastern Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, 230-8765, Yokohama-shi, Kanagawa, Japan
    383 schema:name Division of Cardiology, Saiseikai Yokohama-City Eastern Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, 230-8765, Yokohama-shi, Kanagawa, Japan
    384 rdf:type schema:Organization
    385 grid-institutes:grid.482667.9 schema:alternateName Department of Cardiology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, 410-2295, Izunokuni-shi, Shizuoka, Japan
    386 schema:name Department of Cardiology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, 410-2295, Izunokuni-shi, Shizuoka, Japan
    387 rdf:type schema:Organization
    388 grid-institutes:grid.482675.a schema:alternateName Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, 224-8503, Yokohama-shi, Kanagawa, Japan
    389 schema:name Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, 224-8503, Yokohama-shi, Kanagawa, Japan
    390 rdf:type schema:Organization
    391 grid-institutes:grid.513487.c schema:alternateName Division of Cardiology, Tsuchiya General Hospital, 3-30 Nakajima-cho, Naka-ku, 730-8655, Hiroshima-shi, Hiroshima, Japan
    392 schema:name Division of Cardiology, Tsuchiya General Hospital, 3-30 Nakajima-cho, Naka-ku, 730-8655, Hiroshima-shi, Hiroshima, Japan
    393 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...