Ontology type: schema:ScholarlyArticle
2014-06-27
AUTHORSMasato Nakamura, Toshiya Muramatsu, Hiroyoshi Yokoi, Hisayuki Okada, Masahiko Ochiai, Satoru Suwa, Hidenari Hozawa, Kazuya Kawai, Masaki Awata, Hiroaki Mukawa, Hiroshi Fujita, Nobuo Shiode, Ryuta Asano, Yoshiaki Tsukamoto, Takahisa Yamada, Yoshio Yasumura, Hiroshi Ohira, Akira Miyamoto, Hiroaki Takashima, Takayuki Ogawa, Yutaka Matsuyama, Shinsuke Nanto, On behalf of the J-DESsERT investigators
ABSTRACTThe Japan drug-eluting stents evaluation: a randomized trial (J-DESsERT) was conducted to compare the effectiveness of 2 different drug-eluting stents (DES). It remains uncertain which is more efficacious in diabetic patients, sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES). In this trial, the largest of its kind, 3,533 patients including 1,724 diabetes mellitus (DM) patients were randomized to either SES or PES. Stratification was based on the presence or absence of DM. PES target vessel failure (TVF) non-inferiority at 8 months (primary endpoint) was not demonstrated when compared to SES (SES 4.5 % vs. PES 6.4 %, p = 0.23). In addition, PES TVF superiority at 8 months in the DM subset (secondary endpoint) was not shown (SES 5.6 % vs. PES 7.6 %, p = 0.10). Insulin treatment was associated with increased TVF rates, however, this was less pronounced in the PES group. At 8 months, the similar TVF rates for SES and PES up to that point diverged significantly, favoring SES out to 12 months. Patients undergoing routine angiographic follow-up demonstrated lower TVF prior to the 8-month point, and higher TVF after 8 months, as compared to those followed clinically. In conclusion, the current study failed to demonstrate the proposed superiority of PES for DM patients. In addition, the diversion of TVF at 8 months may reflect an “oculo-stenotic reflex” bias (the tendency to treat lesions found during routine, rather than clinically driven, angiographic follow-up), which could constitute an obstacle for evaluating the true clinical effect of new devices. More... »
PAGES103-114
http://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z
DOIhttp://dx.doi.org/10.1007/s12928-014-0279-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1029364812
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24969222
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"description": "The Japan drug-eluting stents evaluation: a randomized trial (J-DESsERT) was conducted to compare the effectiveness of 2 different drug-eluting stents (DES). It remains uncertain which is more efficacious in diabetic patients, sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES). In this trial, the largest of its kind, 3,533 patients including 1,724 diabetes mellitus (DM) patients were randomized to either SES or PES. Stratification was based on the presence or absence of DM. PES target vessel failure (TVF) non-inferiority at 8\u00a0months (primary endpoint) was not demonstrated when compared to SES (SES 4.5\u00a0% vs. PES 6.4\u00a0%, p\u00a0=\u00a00.23). In addition, PES TVF superiority at 8\u00a0months in the DM subset (secondary endpoint) was not shown (SES 5.6\u00a0% vs. PES 7.6\u00a0%, p\u00a0=\u00a00.10). Insulin treatment was associated with increased TVF rates, however, this was less pronounced in the PES group. At 8\u00a0months, the similar TVF rates for SES and PES up to that point diverged significantly, favoring SES out to 12\u00a0months. Patients undergoing routine angiographic follow-up demonstrated lower TVF prior to the 8-month point, and higher TVF after 8\u00a0months, as compared to those followed clinically. In conclusion, the current study failed to demonstrate the proposed superiority of PES for DM patients. In addition, the diversion of TVF at 8\u00a0months may reflect an \u201coculo-stenotic reflex\u201d bias (the tendency to treat lesions found during routine, rather than clinically driven, angiographic follow-up), which could constitute an obstacle for evaluating the true clinical effect of new devices.",
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12928-014-0279-z'
This table displays all metadata directly associated to this object as RDF triples.
393 TRIPLES
22 PREDICATES
97 URIs
87 LITERALS
22 BLANK NODES