Efficacy of statin treatment after endovascular therapy for isolated below-the-knee disease in patients with critical limb ischemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06-12

AUTHORS

Yusuke Tomoi, Yoshimitsu Soga, Osamu Iida, Keisuke Hirano, Kenji Suzuki, Daizo Kawasaki, Yasutaka Yamauchi, Yusuke Miyashita, Junichi Tazaki, Masakiyo Nobuyoshi

ABSTRACT

To investigate the efficacy of statin treatment after endovascular therapy (EVT) for isolated below-the-knee (BTK) lesions in patients with critical limb ischemia (CLI). From March 2004 to June 2011, 812 patients (984 limbs, 69.0 % male, 71.6 ± 10.0 years old) with CLI underwent successful EVT for de novo isolated BTK lesions at 11 cardiovascular centers in Japan. Of these patients, 169 patients were treated with statins. Successful EVT was defined as direct-line flow to the pedal arch with <30 % residual stenosis. The multicenter data were analyzed retrospectively for outcomes of overall survival, amputation-free survival (AFS), cardiovascular death, limb salvage, freedom from repeat revascularization, and major adverse limb events [MALE: repeat revascularization for the limb or major amputation (defined as above-the-ankle amputation)]. The mean follow-up period was 19.4 ± 17.6 months. Overall survival, AFS and freedom from repeat revascularization at 4 years were significantly higher in patients treated with statins (64.5 vs. 45.9 %, P = 0.004; 64.1 vs. 43.0 %, P = 0.003; and 56.4 vs. 45.4 %, P = 0.03, respectively). However, rates of cardiovascular death, limb salvage, and MALE at 4 years did not differ significantly between the two groups (86.0 vs. 75.2 %, P = 0.11; 87.2 vs. 87.7 %, P = 0.39; and 84.4 vs. 82.9 %, P = 0.64, respectively). After adjusting all outcomes against differences in prespecified baseline variables, there was no significant difference in overall survival, AFS, cardiovascular death, limb salvage, repeat revascularization, and MALE between the groups. In a subgroup of 513 patients who were ambulatory at baseline, statin treatment significantly improved overall survival [hazard ratio (HR) 0.54, 95 % confidential interval (CI) 0.29–0.97, adjusted P = 0.04] and numerically improved AFS (HR 0.63, 95 % CI 0.35–1.07, adjusted P = 0.086). In this subgroup analysis, there was no significant difference in the rates of repeat revascularization, cardiovascular death, limb salvage, and MALE between patients treated with and without statins. In this retrospective study, the statin treatment after successful EVT establishing one straight line for isolated BTK lesions with CLI do not influence overall survival, AFS, and the rates of cardiovascular death, limb salvage, and MALE. However, in ambulatory patients, the statins may improve overall survival and AFS after successful EVT establishing one straight line for isolated BTK lesions. More... »

PAGES

374-382

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12928-013-0188-6

DOI

http://dx.doi.org/10.1007/s12928-013-0188-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011046092

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23756936


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endovascular Procedures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxymethylglutaryl-CoA Reductase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leg", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Limb Salvage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peripheral Arterial Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kokura Memorial Hospital, 1-1 Asano, Kokurakita-ku, 802-0001, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415432.5", 
          "name": [
            "Department of Cardiology, Kokura Memorial Hospital, 1-1 Asano, Kokurakita-ku, 802-0001, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomoi", 
        "givenName": "Yusuke", 
        "id": "sg:person.01104331243.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104331243.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kokura Memorial Hospital, 1-1 Asano, Kokurakita-ku, 802-0001, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415432.5", 
          "name": [
            "Department of Cardiology, Kokura Memorial Hospital, 1-1 Asano, Kokurakita-ku, 802-0001, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soga", 
        "givenName": "Yoshimitsu", 
        "id": "sg:person.01276714415.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276714415.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414976.9", 
          "name": [
            "Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iida", 
        "givenName": "Osamu", 
        "id": "sg:person.01016335235.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016335235.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Saiseikai Yokohama-city Eastern Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.461876.a", 
          "name": [
            "Department of Cardiology, Saiseikai Yokohama-city Eastern Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirano", 
        "givenName": "Keisuke", 
        "id": "sg:person.01114053446.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114053446.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415501.4", 
          "name": [
            "Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Kenji", 
        "id": "sg:person.0665160503.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665160503.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawasaki", 
        "givenName": "Daizo", 
        "id": "sg:person.01262107455.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262107455.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Advanced PAD Therapeutics, Shinshu University, Matsumoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263518.b", 
          "name": [
            "Department of Advanced PAD Therapeutics, Shinshu University, Matsumoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamauchi", 
        "givenName": "Yasutaka", 
        "id": "sg:person.01064254650.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064254650.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kikuna Memorial Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Kikuna Memorial Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyashita", 
        "givenName": "Yusuke", 
        "id": "sg:person.0713436542.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713436542.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Graduates School of Medicine, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiovascular Medicine, Graduates School of Medicine, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tazaki", 
        "givenName": "Junichi", 
        "id": "sg:person.01104142451.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104142451.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kokura Memorial Hospital, 1-1 Asano, Kokurakita-ku, 802-0001, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415432.5", 
          "name": [
            "Department of Cardiology, Kokura Memorial Hospital, 1-1 Asano, Kokurakita-ku, 802-0001, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nobuyoshi", 
        "givenName": "Masakiyo", 
        "id": "sg:person.01275721512.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275721512.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12928-010-0018-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010372438", 
          "https://doi.org/10.1007/s12928-010-0018-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12928-013-0173-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009175457", 
          "https://doi.org/10.1007/s12928-013-0173-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06-12", 
    "datePublishedReg": "2013-06-12", 
    "description": "To investigate the efficacy of statin treatment after endovascular therapy (EVT) for isolated below-the-knee (BTK) lesions in patients with critical limb ischemia (CLI). From March 2004 to June 2011, 812 patients (984 limbs, 69.0\u00a0% male, 71.6\u00a0\u00b1\u00a010.0\u00a0years old) with CLI underwent successful EVT for de novo isolated BTK lesions at 11 cardiovascular centers in Japan. Of these patients, 169 patients were treated with statins. Successful EVT was defined as direct-line flow to the pedal arch with <30\u00a0% residual stenosis. The multicenter data were analyzed retrospectively for outcomes of overall survival, amputation-free survival (AFS), cardiovascular death, limb salvage, freedom from repeat revascularization, and major adverse limb events [MALE: repeat revascularization for the limb or major amputation (defined as above-the-ankle amputation)]. The mean follow-up period was 19.4\u00a0\u00b1\u00a017.6\u00a0months. Overall survival, AFS and freedom from repeat revascularization at 4\u00a0years were significantly higher in patients treated with statins (64.5 vs. 45.9\u00a0%, P\u00a0=\u00a00.004; 64.1 vs. 43.0\u00a0%, P\u00a0=\u00a00.003; and 56.4 vs. 45.4\u00a0%, P\u00a0=\u00a00.03, respectively). However, rates of cardiovascular death, limb salvage, and MALE at 4\u00a0years did not differ significantly between the two groups (86.0 vs. 75.2\u00a0%, P\u00a0=\u00a00.11; 87.2 vs. 87.7\u00a0%, P\u00a0=\u00a00.39; and 84.4 vs. 82.9\u00a0%, P\u00a0=\u00a00.64, respectively). After adjusting all outcomes against differences in prespecified baseline variables, there was no significant difference in overall survival, AFS, cardiovascular death, limb salvage, repeat revascularization, and MALE between the groups. In a subgroup of 513 patients who were ambulatory at baseline, statin treatment significantly improved overall survival [hazard ratio (HR) 0.54, 95\u00a0% confidential interval (CI) 0.29\u20130.97, adjusted P\u00a0=\u00a00.04] and numerically improved AFS (HR 0.63, 95\u00a0% CI 0.35\u20131.07, adjusted P\u00a0=\u00a00.086). In this subgroup analysis, there was no significant difference in the rates of repeat revascularization, cardiovascular death, limb salvage, and MALE between patients treated with and without statins. In this retrospective study, the statin treatment after successful EVT establishing one straight line for isolated BTK lesions with CLI do not influence overall survival, AFS, and the rates of cardiovascular death, limb salvage, and MALE. However, in ambulatory patients, the statins may improve overall survival and AFS after successful EVT establishing one straight line for isolated BTK lesions.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12928-013-0188-6", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1042779", 
        "issn": [
          "1868-4300", 
          "1868-4297"
        ], 
        "name": "Cardiovascular Intervention and Therapeutics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "keywords": [
      "amputation-free survival", 
      "critical limb ischemia", 
      "successful endovascular therapy", 
      "endovascular therapy", 
      "overall survival", 
      "cardiovascular death", 
      "limb salvage", 
      "statin treatment", 
      "BTK lesions", 
      "repeat revascularization", 
      "limb ischemia", 
      "major adverse limb events", 
      "adverse limb events", 
      "prespecified baseline variables", 
      "significant differences", 
      "mean follow", 
      "residual stenosis", 
      "ambulatory patients", 
      "retrospective study", 
      "Cardiovascular Center", 
      "baseline variables", 
      "subgroup analysis", 
      "pedal arch", 
      "knee lesions", 
      "multicenter data", 
      "limb events", 
      "knee disease", 
      "patients", 
      "revascularization", 
      "statins", 
      "lesions", 
      "salvage", 
      "death", 
      "survival", 
      "ischemia", 
      "treatment", 
      "therapy", 
      "males", 
      "efficacy", 
      "outcomes", 
      "de novo", 
      "stenosis", 
      "group", 
      "follow", 
      "years", 
      "differences", 
      "disease", 
      "baseline", 
      "months", 
      "subgroups", 
      "rate", 
      "arch", 
      "novo", 
      "period", 
      "center", 
      "lines", 
      "study", 
      "events", 
      "data", 
      "variables", 
      "Japan", 
      "analysis", 
      "flow", 
      "freedom", 
      "straight line"
    ], 
    "name": "Efficacy of statin treatment after endovascular therapy for isolated below-the-knee disease in patients with critical limb ischemia", 
    "pagination": "374-382", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011046092"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12928-013-0188-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23756936"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12928-013-0188-6", 
      "https://app.dimensions.ai/details/publication/pub.1011046092"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_601.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12928-013-0188-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12928-013-0188-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12928-013-0188-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12928-013-0188-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12928-013-0188-6'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      21 PREDICATES      109 URIs      99 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12928-013-0188-6 schema:about N18b258bf45d140d08c9293310adbbfb6
2 N27606eed8193438cb45a44f8363b1a58
3 N38921f606b264fcb9e0404c00d19d0ec
4 N43838c0933d248b2907c457b90f6aaca
5 N4e45e8c1115b4527ae7246d6d222e6c9
6 N510b6094e63c4a6296a0c8b450d953c6
7 N6cf1e5dbec1e404cb423164af08d3d1f
8 N878bc15a7da24f709037cfcff6a649d8
9 N9183056c5dea40e499f2b8e43276d992
10 N9ec1bcfbd9124ddfb94fccb1eba760a3
11 Na0981b939a2a4bca9c8a0865413eeda9
12 Nac76a0b9dcfd421381c0e68d95852c9c
13 Nd0db4aa9a83142dd9f6e3594e15f22af
14 Nde956d005873498f80d8ba9d39adf0d2
15 Ne063eb0758e340a1a30b17e54d9fde0a
16 Nf6713ac2c9924247b856f2a9092dc260
17 Nfdf314eab4494c2094989b1a206ec01a
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N9b761e3352eb45d0b4730a9472d3b1fe
21 schema:citation sg:pub.10.1007/s12928-010-0018-z
22 sg:pub.10.1007/s12928-013-0173-0
23 schema:datePublished 2013-06-12
24 schema:datePublishedReg 2013-06-12
25 schema:description To investigate the efficacy of statin treatment after endovascular therapy (EVT) for isolated below-the-knee (BTK) lesions in patients with critical limb ischemia (CLI). From March 2004 to June 2011, 812 patients (984 limbs, 69.0 % male, 71.6 ± 10.0 years old) with CLI underwent successful EVT for de novo isolated BTK lesions at 11 cardiovascular centers in Japan. Of these patients, 169 patients were treated with statins. Successful EVT was defined as direct-line flow to the pedal arch with <30 % residual stenosis. The multicenter data were analyzed retrospectively for outcomes of overall survival, amputation-free survival (AFS), cardiovascular death, limb salvage, freedom from repeat revascularization, and major adverse limb events [MALE: repeat revascularization for the limb or major amputation (defined as above-the-ankle amputation)]. The mean follow-up period was 19.4 ± 17.6 months. Overall survival, AFS and freedom from repeat revascularization at 4 years were significantly higher in patients treated with statins (64.5 vs. 45.9 %, P = 0.004; 64.1 vs. 43.0 %, P = 0.003; and 56.4 vs. 45.4 %, P = 0.03, respectively). However, rates of cardiovascular death, limb salvage, and MALE at 4 years did not differ significantly between the two groups (86.0 vs. 75.2 %, P = 0.11; 87.2 vs. 87.7 %, P = 0.39; and 84.4 vs. 82.9 %, P = 0.64, respectively). After adjusting all outcomes against differences in prespecified baseline variables, there was no significant difference in overall survival, AFS, cardiovascular death, limb salvage, repeat revascularization, and MALE between the groups. In a subgroup of 513 patients who were ambulatory at baseline, statin treatment significantly improved overall survival [hazard ratio (HR) 0.54, 95 % confidential interval (CI) 0.29–0.97, adjusted P = 0.04] and numerically improved AFS (HR 0.63, 95 % CI 0.35–1.07, adjusted P = 0.086). In this subgroup analysis, there was no significant difference in the rates of repeat revascularization, cardiovascular death, limb salvage, and MALE between patients treated with and without statins. In this retrospective study, the statin treatment after successful EVT establishing one straight line for isolated BTK lesions with CLI do not influence overall survival, AFS, and the rates of cardiovascular death, limb salvage, and MALE. However, in ambulatory patients, the statins may improve overall survival and AFS after successful EVT establishing one straight line for isolated BTK lesions.
26 schema:genre article
27 schema:isAccessibleForFree false
28 schema:isPartOf N57c2f3646ea54ffc8149f4146be76a0a
29 Nb6278e12ca2b436e8ff27ddc9c0c08a9
30 sg:journal.1042779
31 schema:keywords BTK lesions
32 Cardiovascular Center
33 Japan
34 adverse limb events
35 ambulatory patients
36 amputation-free survival
37 analysis
38 arch
39 baseline
40 baseline variables
41 cardiovascular death
42 center
43 critical limb ischemia
44 data
45 de novo
46 death
47 differences
48 disease
49 efficacy
50 endovascular therapy
51 events
52 flow
53 follow
54 freedom
55 group
56 ischemia
57 knee disease
58 knee lesions
59 lesions
60 limb events
61 limb ischemia
62 limb salvage
63 lines
64 major adverse limb events
65 males
66 mean follow
67 months
68 multicenter data
69 novo
70 outcomes
71 overall survival
72 patients
73 pedal arch
74 period
75 prespecified baseline variables
76 rate
77 repeat revascularization
78 residual stenosis
79 retrospective study
80 revascularization
81 salvage
82 significant differences
83 statin treatment
84 statins
85 stenosis
86 straight line
87 study
88 subgroup analysis
89 subgroups
90 successful endovascular therapy
91 survival
92 therapy
93 treatment
94 variables
95 years
96 schema:name Efficacy of statin treatment after endovascular therapy for isolated below-the-knee disease in patients with critical limb ischemia
97 schema:pagination 374-382
98 schema:productId N07f6eb26e4ec479ca1504c2872ae2b31
99 N6822c8e9a040433db08b80fba873b217
100 Nd1967c5987db48658853c8d48c4e9a79
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011046092
102 https://doi.org/10.1007/s12928-013-0188-6
103 schema:sdDatePublished 2022-10-01T06:38
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher Nd2af769aea6142929d3ed36aa7d9a04e
106 schema:url https://doi.org/10.1007/s12928-013-0188-6
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N07f6eb26e4ec479ca1504c2872ae2b31 schema:name doi
111 schema:value 10.1007/s12928-013-0188-6
112 rdf:type schema:PropertyValue
113 N10db45c1e9824b83bc7a106e9635e80a rdf:first sg:person.01114053446.21
114 rdf:rest Nab23cd0843dd4c37a29c2526b9cdd35e
115 N18b258bf45d140d08c9293310adbbfb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Follow-Up Studies
117 rdf:type schema:DefinedTerm
118 N1ad7d44d283a4d0598537558d413e0a0 rdf:first sg:person.01104142451.94
119 rdf:rest Nc4c5ba44a2344094a299399c65bc2dc4
120 N27606eed8193438cb45a44f8363b1a58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Ischemia
122 rdf:type schema:DefinedTerm
123 N38921f606b264fcb9e0404c00d19d0ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Limb Salvage
125 rdf:type schema:DefinedTerm
126 N43838c0933d248b2907c457b90f6aaca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 N4c713ccc9f1f48f1ab880239047d3968 rdf:first sg:person.0713436542.12
130 rdf:rest N1ad7d44d283a4d0598537558d413e0a0
131 N4d2c8fd5b829465787cb75c9d7cc4fc9 rdf:first sg:person.01276714415.24
132 rdf:rest Nfc1dc0d29fb94b21a7832b0d9f86ef5b
133 N4e45e8c1115b4527ae7246d6d222e6c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Female
135 rdf:type schema:DefinedTerm
136 N510b6094e63c4a6296a0c8b450d953c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Hydroxymethylglutaryl-CoA Reductase Inhibitors
138 rdf:type schema:DefinedTerm
139 N57c2f3646ea54ffc8149f4146be76a0a schema:volumeNumber 28
140 rdf:type schema:PublicationVolume
141 N6822c8e9a040433db08b80fba873b217 schema:name pubmed_id
142 schema:value 23756936
143 rdf:type schema:PropertyValue
144 N6cf1e5dbec1e404cb423164af08d3d1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Aged, 80 and over
146 rdf:type schema:DefinedTerm
147 N7d7488d8383b4335896f00300f3f111a rdf:first sg:person.01064254650.86
148 rdf:rest N4c713ccc9f1f48f1ab880239047d3968
149 N7e6fdd81a84345c9bd7be085c9171ead rdf:first sg:person.01262107455.48
150 rdf:rest N7d7488d8383b4335896f00300f3f111a
151 N878bc15a7da24f709037cfcff6a649d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 N9183056c5dea40e499f2b8e43276d992 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Middle Aged
156 rdf:type schema:DefinedTerm
157 N9b761e3352eb45d0b4730a9472d3b1fe rdf:first sg:person.01104331243.48
158 rdf:rest N4d2c8fd5b829465787cb75c9d7cc4fc9
159 N9ec1bcfbd9124ddfb94fccb1eba760a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Aged
161 rdf:type schema:DefinedTerm
162 Na0981b939a2a4bca9c8a0865413eeda9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Retrospective Studies
164 rdf:type schema:DefinedTerm
165 Nab23cd0843dd4c37a29c2526b9cdd35e rdf:first sg:person.0665160503.74
166 rdf:rest N7e6fdd81a84345c9bd7be085c9171ead
167 Nac76a0b9dcfd421381c0e68d95852c9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Peripheral Arterial Disease
169 rdf:type schema:DefinedTerm
170 Nb6278e12ca2b436e8ff27ddc9c0c08a9 schema:issueNumber 4
171 rdf:type schema:PublicationIssue
172 Nc4c5ba44a2344094a299399c65bc2dc4 rdf:first sg:person.01275721512.32
173 rdf:rest rdf:nil
174 Nd0db4aa9a83142dd9f6e3594e15f22af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Japan
176 rdf:type schema:DefinedTerm
177 Nd1967c5987db48658853c8d48c4e9a79 schema:name dimensions_id
178 schema:value pub.1011046092
179 rdf:type schema:PropertyValue
180 Nd2af769aea6142929d3ed36aa7d9a04e schema:name Springer Nature - SN SciGraph project
181 rdf:type schema:Organization
182 Nde956d005873498f80d8ba9d39adf0d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Survival Analysis
184 rdf:type schema:DefinedTerm
185 Ne063eb0758e340a1a30b17e54d9fde0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Treatment Outcome
187 rdf:type schema:DefinedTerm
188 Nf6713ac2c9924247b856f2a9092dc260 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Endovascular Procedures
190 rdf:type schema:DefinedTerm
191 Nfc1dc0d29fb94b21a7832b0d9f86ef5b rdf:first sg:person.01016335235.39
192 rdf:rest N10db45c1e9824b83bc7a106e9635e80a
193 Nfdf314eab4494c2094989b1a206ec01a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Leg
195 rdf:type schema:DefinedTerm
196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medical and Health Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
200 schema:name Clinical Sciences
201 rdf:type schema:DefinedTerm
202 sg:journal.1042779 schema:issn 1868-4297
203 1868-4300
204 schema:name Cardiovascular Intervention and Therapeutics
205 schema:publisher Springer Nature
206 rdf:type schema:Periodical
207 sg:person.01016335235.39 schema:affiliation grid-institutes:grid.414976.9
208 schema:familyName Iida
209 schema:givenName Osamu
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016335235.39
211 rdf:type schema:Person
212 sg:person.01064254650.86 schema:affiliation grid-institutes:grid.263518.b
213 schema:familyName Yamauchi
214 schema:givenName Yasutaka
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064254650.86
216 rdf:type schema:Person
217 sg:person.01104142451.94 schema:affiliation grid-institutes:None
218 schema:familyName Tazaki
219 schema:givenName Junichi
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104142451.94
221 rdf:type schema:Person
222 sg:person.01104331243.48 schema:affiliation grid-institutes:grid.415432.5
223 schema:familyName Tomoi
224 schema:givenName Yusuke
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104331243.48
226 rdf:type schema:Person
227 sg:person.01114053446.21 schema:affiliation grid-institutes:grid.461876.a
228 schema:familyName Hirano
229 schema:givenName Keisuke
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114053446.21
231 rdf:type schema:Person
232 sg:person.01262107455.48 schema:affiliation grid-institutes:grid.272264.7
233 schema:familyName Kawasaki
234 schema:givenName Daizo
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262107455.48
236 rdf:type schema:Person
237 sg:person.01275721512.32 schema:affiliation grid-institutes:grid.415432.5
238 schema:familyName Nobuyoshi
239 schema:givenName Masakiyo
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275721512.32
241 rdf:type schema:Person
242 sg:person.01276714415.24 schema:affiliation grid-institutes:grid.415432.5
243 schema:familyName Soga
244 schema:givenName Yoshimitsu
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276714415.24
246 rdf:type schema:Person
247 sg:person.0665160503.74 schema:affiliation grid-institutes:grid.415501.4
248 schema:familyName Suzuki
249 schema:givenName Kenji
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665160503.74
251 rdf:type schema:Person
252 sg:person.0713436542.12 schema:affiliation grid-institutes:None
253 schema:familyName Miyashita
254 schema:givenName Yusuke
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713436542.12
256 rdf:type schema:Person
257 sg:pub.10.1007/s12928-010-0018-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1010372438
258 https://doi.org/10.1007/s12928-010-0018-z
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/s12928-013-0173-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009175457
261 https://doi.org/10.1007/s12928-013-0173-0
262 rdf:type schema:CreativeWork
263 grid-institutes:None schema:alternateName Department of Cardiology, Kikuna Memorial Hospital, Yokohama, Japan
264 Department of Cardiovascular Medicine, Graduates School of Medicine, Kyoto, Japan
265 schema:name Department of Cardiology, Kikuna Memorial Hospital, Yokohama, Japan
266 Department of Cardiovascular Medicine, Graduates School of Medicine, Kyoto, Japan
267 rdf:type schema:Organization
268 grid-institutes:grid.263518.b schema:alternateName Department of Advanced PAD Therapeutics, Shinshu University, Matsumoto, Japan
269 schema:name Department of Advanced PAD Therapeutics, Shinshu University, Matsumoto, Japan
270 rdf:type schema:Organization
271 grid-institutes:grid.272264.7 schema:alternateName Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
272 schema:name Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
273 rdf:type schema:Organization
274 grid-institutes:grid.414976.9 schema:alternateName Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan
275 schema:name Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan
276 rdf:type schema:Organization
277 grid-institutes:grid.415432.5 schema:alternateName Department of Cardiology, Kokura Memorial Hospital, 1-1 Asano, Kokurakita-ku, 802-0001, Kitakyushu, Japan
278 schema:name Department of Cardiology, Kokura Memorial Hospital, 1-1 Asano, Kokurakita-ku, 802-0001, Kitakyushu, Japan
279 rdf:type schema:Organization
280 grid-institutes:grid.415501.4 schema:alternateName Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan
281 schema:name Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan
282 rdf:type schema:Organization
283 grid-institutes:grid.461876.a schema:alternateName Department of Cardiology, Saiseikai Yokohama-city Eastern Hospital, Yokohama, Japan
284 schema:name Department of Cardiology, Saiseikai Yokohama-city Eastern Hospital, Yokohama, Japan
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...