Evaluation of the Biocompatibility of Water-Soluble Pristine С60 Fullerenes in Rabbit View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-06-19

AUTHORS

Tetiana Halenova, Nataliia Raksha, Olexiy Savchuk, Ludmila Ostapchenko, Yuriy Prylutskyy, Uwe Ritter, Peter Scharff

ABSTRACT

C60 fullerenes have proved their therapeutic effects and efficacy by the results of countless experiments. For further usage of these nanoparticles, the systematic toxicological investigations are required. Blood compatibility should be studied for C60 fullerenes due to the potential blood contact. Currently, available data is not systematic and has not provided insights into possible side effects of C60 fullerenes on blood components. In this study, water-soluble pristine C60 fullerenes were tested in vitro to assess their biocompatibility in rabbit. The blood compatibility has been evaluated looking at the impact of C60 fullerenes on erythrocyte integrity, platelet aggregation, and some blood factors involved in coagulation. Our results revealed that C60 fullerenes cannot elicit hemolysis at studied concentrations and did not show any effect on coagulation process. C60 fullerenes in concentration-dependent manner increased ADP-dependent platelet aggregation and changed the key kinetic parameters of these processes. C60 fullerenes inhibited thrombin amidolytic activity but did not affect the activities of other studied coagulation factors. The prothrombotic property of C60 fullerenes could be the potential risk factor that leads to enhancement of vascular thrombosis. The ability of fullerene to inhibit thrombin activity is important for the pharmacological use of these carbon nanoparticles as anticoagulant agents. More... »

PAGES

721-730

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12668-020-00762-w

DOI

http://dx.doi.org/10.1007/s12668-020-00762-w

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