Kinetical Release Study of Copper Ferrite Nanoparticle Incorporated on PCL/Collagen Nanofiber for Naproxen Delivery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-02

AUTHORS

Tri Prasetyo Armedya, Muhammad Fathan Dzikri, Satya Candra Wibawa Sakti, Abdulloh Abdulloh, Yanuardi Raharjo, Siti Wafiroh, Purwati, Mochamad Zakki Fahmi

ABSTRACT

Nanofiber has become one of tissue engineering examples and has extensive application on medical field, particularly as a wound healing and wound dressing. In this research, nanofiber composite based on polycaprolactone and collagen was successfully obtained via electrospinning process and further developed as host of naproxen as anti-inflammatory agents. Addition of copper ferrite (CuFe2O4) nanoparticles on the nanocomposite becomes an advance part on this study to control of naproxen release. Several characterizations were furnished to prove the design composite nanofiber and its drug release analysis performed to find out the kinetic model and naproxen release mechanism from nanofibers. CuFe2O4 nanoparticles have potential to be used to control naproxen release in nanofiber that lead to decrease level of drug released, where mostly follow the Korsmeyer-Peppas model. The release of naproxen was certainly influenced by pH value, in which the drug was easier to release on base, instead of acid or neutral condition. Varied naproxen and nanoparticle compositions were prepared to reach optimum formulation of the release. This study provides fundamental data for the effect of magnetic nanoparticle on drug release process. More... »

PAGES

274-284

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12668-019-00618-y

DOI

http://dx.doi.org/10.1007/s12668-019-00618-y

DIMENSIONS

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195 Stem Cell Research and Development Center, Universitas Airlangga, 61115, Surabaya, Indonesia
196 rdf:type schema:Organization
 




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