Treatment of chronic genotype-3 hepatitis C virus infection using direct-acting antiviral agents: An Indian experience View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05

AUTHORS

Amit Goel, Rajat Bhargava, Praveer Rai, Rakesh Aggarwal

ABSTRACT

BackgroundDirect-acting antiviral drugs (DAAs) are favored for the treatment of hepatitis C virus (HCV) infection. However, the experience with the DAAs currently available in India in the treatment of genotype-3 HCV is limited. We therefore reviewed our experience with these drugs in treating patients with chronic genotype-3 HCV infection, including those with cirrhosis.MethodsWe prospectively followed adult patients with genotype-3 HCV infection who had received treatment regimens containing sofosbuvir with/without daclatasvir. Patients were categorized as chronic hepatitis C (CHC), compensated cirrhosis (CC), and decompensated cirrhosis (DC). They received either (i) sofosbuvir and ribavirin, with or without pegylated interferon (Peg-IFN) for 12 or 24 weeks, or (ii) sofosbuvir and daclatasvir, with or without ribavirin for 12 or 24 weeks. Response was assessed using HCV RNA testing after 2 or 4 weeks of treatment (rapid virological response [RVR]), at treatment completion (end-of-treatment response [ETR]) or 12 weeks after treatment completion (sustained virological response [SVR12]).ResultsOf the 160 patients (90% treatment-naïve; CHC 49%, CC 32%, and DC 19%), 39 (24%) received Peg-IFN, sofosbuvir and ribavirin, 21 (13%) received sofosbuvir and ribavirin, and 100 (63%) received sofosbuvir and daclatasvir, with or without ribavirin. On intention-to-treat basis, RVR, ETR, and SVR12 in the entire cohort were 146/160 (91.3%), 151/160 (94.4%), and 147/160 (91.9%), respectively. Seven patients died (CC 2, DC 5) during treatment; four (2 CHC, 2 DC) patients discontinued treatment; and two patients with CC relapsed.ConclusionsDual-DAA-based regimens were safe and highly effective in treating genotype-3 HCV infection in CHC and CC patients. More... »

PAGES

227-234

References to SciGraph publications

  • 2008-05-01. Acute Hepatitis C: A Systematic Review in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2016-11-08. Efficacy and safety of sofosbuvir-based therapy for chronic hepatitis C infection in “real-life” cohort in INDIAN JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12664-017-0763-3

    DOI

    http://dx.doi.org/10.1007/s12664-017-0763-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090276888

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28656492


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antiviral Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carbamates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Therapy, Combination", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepacivirus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatitis C, Chronic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Imidazoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "India", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon alpha-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-alpha", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Cirrhosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polyethylene Glycols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyrrolidines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombinant Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ribavirin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sofosbuvir", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Valine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India", 
              "id": "http://www.grid.ac/institutes/grid.263138.d", 
              "name": [
                "Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goel", 
            "givenName": "Amit", 
            "id": "sg:person.0633741372.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633741372.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India", 
              "id": "http://www.grid.ac/institutes/grid.263138.d", 
              "name": [
                "Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhargava", 
            "givenName": "Rajat", 
            "id": "sg:person.011650233217.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011650233217.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India", 
              "id": "http://www.grid.ac/institutes/grid.263138.d", 
              "name": [
                "Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rai", 
            "givenName": "Praveer", 
            "id": "sg:person.01336570760.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336570760.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India", 
              "id": "http://www.grid.ac/institutes/grid.263138.d", 
              "name": [
                "Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aggarwal", 
            "givenName": "Rakesh", 
            "id": "sg:person.01227657050.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227657050.94"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1111/j.1572-0241.2008.01825.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001725308", 
              "https://doi.org/10.1111/j.1572-0241.2008.01825.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12664-016-0713-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044521490", 
              "https://doi.org/10.1007/s12664-016-0713-5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-05", 
        "datePublishedReg": "2017-05-01", 
        "description": "BackgroundDirect-acting antiviral drugs (DAAs) are favored for the treatment of hepatitis C virus (HCV) infection. However, the experience with the DAAs currently available in India in the treatment of genotype-3 HCV is limited. We therefore reviewed our experience with these drugs in treating patients with chronic genotype-3 HCV infection, including those with cirrhosis.MethodsWe prospectively followed adult patients with genotype-3 HCV infection who had received treatment regimens containing sofosbuvir with/without daclatasvir. Patients were categorized as chronic hepatitis C (CHC), compensated cirrhosis (CC), and decompensated cirrhosis (DC). They received either (i) sofosbuvir and ribavirin, with or without pegylated interferon (Peg-IFN) for 12 or 24\u00a0weeks, or (ii) sofosbuvir and daclatasvir, with or without ribavirin for 12 or 24\u00a0weeks. Response was assessed using HCV RNA testing after 2 or 4\u00a0weeks of treatment (rapid virological response [RVR]), at treatment completion (end-of-treatment response [ETR]) or 12\u00a0weeks after treatment completion (sustained virological response [SVR12]).ResultsOf the 160 patients (90% treatment-na\u00efve; CHC 49%, CC 32%, and DC 19%), 39 (24%) received Peg-IFN, sofosbuvir and ribavirin, 21 (13%) received sofosbuvir and ribavirin, and 100 (63%) received sofosbuvir and daclatasvir, with or without ribavirin. On intention-to-treat basis, RVR, ETR, and SVR12 in the entire cohort were 146/160 (91.3%), 151/160 (94.4%), and 147/160 (91.9%), respectively. Seven patients died (CC 2, DC 5) during treatment; four (2 CHC, 2 DC) patients discontinued treatment; and two patients with CC relapsed.ConclusionsDual-DAA-based regimens were safe and highly effective in treating genotype-3 HCV infection in CHC and CC patients.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12664-017-0763-3", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1094828", 
            "issn": [
              "0254-8860", 
              "0975-0711"
            ], 
            "name": "Indian Journal of Gastroenterology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "36"
          }
        ], 
        "keywords": [
          "genotype 3 HCV infection", 
          "chronic hepatitis C", 
          "hepatitis C virus infection", 
          "C virus infection", 
          "HCV infection", 
          "treatment completion", 
          "virus infection", 
          "genotype 3 hepatitis C virus (HCV) infection", 
          "genotype 3 HCV", 
          "HCV RNA testing", 
          "weeks of treatment", 
          "hepatitis C", 
          "PEG-IFN", 
          "treat basis", 
          "adult patients", 
          "RNA testing", 
          "treatment regimens", 
          "entire cohort", 
          "CC patients", 
          "antiviral drugs", 
          "patients", 
          "ribavirin", 
          "antiviral agents", 
          "sofosbuvir", 
          "cirrhosis", 
          "infection", 
          "weeks", 
          "treatment", 
          "regimens", 
          "drugs", 
          "BackgroundDirect", 
          "SVR12", 
          "HCV", 
          "ResultsOf", 
          "daclatasvir", 
          "interferon", 
          "cohort", 
          "Indian experience", 
          "MethodsWe", 
          "RVR", 
          "completion", 
          "DAA", 
          "experience", 
          "agents", 
          "CC", 
          "response", 
          "testing", 
          "ETR", 
          "India", 
          "intention", 
          "basis"
        ], 
        "name": "Treatment of chronic genotype-3 hepatitis C virus infection using direct-acting antiviral agents: An Indian experience", 
        "pagination": "227-234", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1090276888"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12664-017-0763-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28656492"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12664-017-0763-3", 
          "https://app.dimensions.ai/details/publication/pub.1090276888"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_723.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12664-017-0763-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12664-017-0763-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12664-017-0763-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12664-017-0763-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12664-017-0763-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    257 TRIPLES      21 PREDICATES      108 URIs      97 LITERALS      35 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12664-017-0763-3 schema:about N0f60f404c48348dbb14b9c7cb7c35b4b
    2 N1426097cad64427fa96098ee3fb44be0
    3 N183a1317e0fb4f7a8f7ec45ab5224ec3
    4 N1c9ebb54bf554e4c86cc85acd7ea934a
    5 N2ce081d12420415f826571c793571518
    6 N41c0fe11e0ef45a7b2ae33235b98ce0a
    7 N4461ccb181f347dcaca0581561412961
    8 N5a82bafc956a4f1cb9aa226d7da7eff6
    9 N62f200da0adb427dba21514778ffd4b9
    10 N67c15cf9ee9a4017b99eaac29826c8bc
    11 N6ef538a5a9f84580b5ac57436396bf59
    12 N7163f9202b8043c88ea3bccef34525d4
    13 N8f750f670d554892a262867ada120fba
    14 N92cf6570a58a4f25bb702398edfd9e00
    15 N9581d8e1fea7448490ff61297b936d06
    16 N9bfc4a8090cd4e398009aa368f8893db
    17 N9e17b312d9554169b4d1e87b0071f9fc
    18 Na32cfa803e1e4999b774eeafb1f2c2f4
    19 Na632523ef18349fd9343fdb7c294e2c7
    20 Nad3a9832c248484a9e038019b14129f8
    21 Nb39121cab907450cacbd88ab64b95d79
    22 Nbd8a380e986143c088d239a3b78e5ecd
    23 Nc24790bf335e4bb5b1a8765a0993d185
    24 Nc60f9edab5324cc1952bcc4b6e71fda8
    25 Nd4a83641c59a4a149bdd06db538d435e
    26 Ndfa0b84653e9496ead487527fc6ecb5b
    27 Neba70a55375f49fc817fb3d6d4aa7341
    28 Nfd8cdb45c6cd4c19b58fb88affa56b45
    29 anzsrc-for:11
    30 anzsrc-for:1103
    31 anzsrc-for:1108
    32 schema:author N56f80b0eafef4e1caeb59bc55480d817
    33 schema:citation sg:pub.10.1007/s12664-016-0713-5
    34 sg:pub.10.1111/j.1572-0241.2008.01825.x
    35 schema:datePublished 2017-05
    36 schema:datePublishedReg 2017-05-01
    37 schema:description BackgroundDirect-acting antiviral drugs (DAAs) are favored for the treatment of hepatitis C virus (HCV) infection. However, the experience with the DAAs currently available in India in the treatment of genotype-3 HCV is limited. We therefore reviewed our experience with these drugs in treating patients with chronic genotype-3 HCV infection, including those with cirrhosis.MethodsWe prospectively followed adult patients with genotype-3 HCV infection who had received treatment regimens containing sofosbuvir with/without daclatasvir. Patients were categorized as chronic hepatitis C (CHC), compensated cirrhosis (CC), and decompensated cirrhosis (DC). They received either (i) sofosbuvir and ribavirin, with or without pegylated interferon (Peg-IFN) for 12 or 24 weeks, or (ii) sofosbuvir and daclatasvir, with or without ribavirin for 12 or 24 weeks. Response was assessed using HCV RNA testing after 2 or 4 weeks of treatment (rapid virological response [RVR]), at treatment completion (end-of-treatment response [ETR]) or 12 weeks after treatment completion (sustained virological response [SVR12]).ResultsOf the 160 patients (90% treatment-naïve; CHC 49%, CC 32%, and DC 19%), 39 (24%) received Peg-IFN, sofosbuvir and ribavirin, 21 (13%) received sofosbuvir and ribavirin, and 100 (63%) received sofosbuvir and daclatasvir, with or without ribavirin. On intention-to-treat basis, RVR, ETR, and SVR12 in the entire cohort were 146/160 (91.3%), 151/160 (94.4%), and 147/160 (91.9%), respectively. Seven patients died (CC 2, DC 5) during treatment; four (2 CHC, 2 DC) patients discontinued treatment; and two patients with CC relapsed.ConclusionsDual-DAA-based regimens were safe and highly effective in treating genotype-3 HCV infection in CHC and CC patients.
    38 schema:genre article
    39 schema:isAccessibleForFree false
    40 schema:isPartOf N7c61f66fe317405db6350afef67cb535
    41 Nada229f72b26400797d443cc3d24a1a4
    42 sg:journal.1094828
    43 schema:keywords BackgroundDirect
    44 C virus infection
    45 CC
    46 CC patients
    47 DAA
    48 ETR
    49 HCV
    50 HCV RNA testing
    51 HCV infection
    52 India
    53 Indian experience
    54 MethodsWe
    55 PEG-IFN
    56 RNA testing
    57 RVR
    58 ResultsOf
    59 SVR12
    60 adult patients
    61 agents
    62 antiviral agents
    63 antiviral drugs
    64 basis
    65 chronic hepatitis C
    66 cirrhosis
    67 cohort
    68 completion
    69 daclatasvir
    70 drugs
    71 entire cohort
    72 experience
    73 genotype 3 HCV
    74 genotype 3 HCV infection
    75 genotype 3 hepatitis C virus (HCV) infection
    76 hepatitis C
    77 hepatitis C virus infection
    78 infection
    79 intention
    80 interferon
    81 patients
    82 regimens
    83 response
    84 ribavirin
    85 sofosbuvir
    86 testing
    87 treat basis
    88 treatment
    89 treatment completion
    90 treatment regimens
    91 virus infection
    92 weeks
    93 weeks of treatment
    94 schema:name Treatment of chronic genotype-3 hepatitis C virus infection using direct-acting antiviral agents: An Indian experience
    95 schema:pagination 227-234
    96 schema:productId N3051550223144b0291c3b8135c2e3023
    97 N9ca7e22fe14045eb8f3a44b94c5ac678
    98 Nda82af29deaa477b8e275efeb3b655a2
    99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090276888
    100 https://doi.org/10.1007/s12664-017-0763-3
    101 schema:sdDatePublished 2022-12-01T06:35
    102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    103 schema:sdPublisher N4559b404868646e8b9e48798532f35f3
    104 schema:url https://doi.org/10.1007/s12664-017-0763-3
    105 sgo:license sg:explorer/license/
    106 sgo:sdDataset articles
    107 rdf:type schema:ScholarlyArticle
    108 N0218fac2b6f646d8a407cb9701ddc360 rdf:first sg:person.01336570760.60
    109 rdf:rest N1faed0acaee44997a83a415adef860d7
    110 N0f60f404c48348dbb14b9c7cb7c35b4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Adolescent
    112 rdf:type schema:DefinedTerm
    113 N1426097cad64427fa96098ee3fb44be0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Interferon-alpha
    115 rdf:type schema:DefinedTerm
    116 N183a1317e0fb4f7a8f7ec45ab5224ec3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Recombinant Proteins
    118 rdf:type schema:DefinedTerm
    119 N1c9ebb54bf554e4c86cc85acd7ea934a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Drug Therapy, Combination
    121 rdf:type schema:DefinedTerm
    122 N1faed0acaee44997a83a415adef860d7 rdf:first sg:person.01227657050.94
    123 rdf:rest rdf:nil
    124 N2ce081d12420415f826571c793571518 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Prospective Studies
    126 rdf:type schema:DefinedTerm
    127 N3051550223144b0291c3b8135c2e3023 schema:name pubmed_id
    128 schema:value 28656492
    129 rdf:type schema:PropertyValue
    130 N41c0fe11e0ef45a7b2ae33235b98ce0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Interferon alpha-2
    132 rdf:type schema:DefinedTerm
    133 N4461ccb181f347dcaca0581561412961 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Cohort Studies
    135 rdf:type schema:DefinedTerm
    136 N4559b404868646e8b9e48798532f35f3 schema:name Springer Nature - SN SciGraph project
    137 rdf:type schema:Organization
    138 N56f80b0eafef4e1caeb59bc55480d817 rdf:first sg:person.0633741372.14
    139 rdf:rest Nbedd3a0ecf8a402496f74799fd58aff8
    140 N5a82bafc956a4f1cb9aa226d7da7eff6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Antiviral Agents
    142 rdf:type schema:DefinedTerm
    143 N62f200da0adb427dba21514778ffd4b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Pyrrolidines
    145 rdf:type schema:DefinedTerm
    146 N67c15cf9ee9a4017b99eaac29826c8bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Aged
    148 rdf:type schema:DefinedTerm
    149 N6ef538a5a9f84580b5ac57436396bf59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Polyethylene Glycols
    151 rdf:type schema:DefinedTerm
    152 N7163f9202b8043c88ea3bccef34525d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Hepatitis C, Chronic
    154 rdf:type schema:DefinedTerm
    155 N7c61f66fe317405db6350afef67cb535 schema:issueNumber 3
    156 rdf:type schema:PublicationIssue
    157 N8f750f670d554892a262867ada120fba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Female
    159 rdf:type schema:DefinedTerm
    160 N92cf6570a58a4f25bb702398edfd9e00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Genotype
    162 rdf:type schema:DefinedTerm
    163 N9581d8e1fea7448490ff61297b936d06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Liver Cirrhosis
    165 rdf:type schema:DefinedTerm
    166 N9bfc4a8090cd4e398009aa368f8893db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Male
    168 rdf:type schema:DefinedTerm
    169 N9ca7e22fe14045eb8f3a44b94c5ac678 schema:name doi
    170 schema:value 10.1007/s12664-017-0763-3
    171 rdf:type schema:PropertyValue
    172 N9e17b312d9554169b4d1e87b0071f9fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name India
    174 rdf:type schema:DefinedTerm
    175 Na32cfa803e1e4999b774eeafb1f2c2f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Sofosbuvir
    177 rdf:type schema:DefinedTerm
    178 Na632523ef18349fd9343fdb7c294e2c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Young Adult
    180 rdf:type schema:DefinedTerm
    181 Nad3a9832c248484a9e038019b14129f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Valine
    183 rdf:type schema:DefinedTerm
    184 Nada229f72b26400797d443cc3d24a1a4 schema:volumeNumber 36
    185 rdf:type schema:PublicationVolume
    186 Nb39121cab907450cacbd88ab64b95d79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Ribavirin
    188 rdf:type schema:DefinedTerm
    189 Nbd8a380e986143c088d239a3b78e5ecd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Carbamates
    191 rdf:type schema:DefinedTerm
    192 Nbedd3a0ecf8a402496f74799fd58aff8 rdf:first sg:person.011650233217.65
    193 rdf:rest N0218fac2b6f646d8a407cb9701ddc360
    194 Nc24790bf335e4bb5b1a8765a0993d185 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Hepacivirus
    196 rdf:type schema:DefinedTerm
    197 Nc60f9edab5324cc1952bcc4b6e71fda8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Middle Aged
    199 rdf:type schema:DefinedTerm
    200 Nd4a83641c59a4a149bdd06db538d435e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Imidazoles
    202 rdf:type schema:DefinedTerm
    203 Nda82af29deaa477b8e275efeb3b655a2 schema:name dimensions_id
    204 schema:value pub.1090276888
    205 rdf:type schema:PropertyValue
    206 Ndfa0b84653e9496ead487527fc6ecb5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Adult
    208 rdf:type schema:DefinedTerm
    209 Neba70a55375f49fc817fb3d6d4aa7341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Humans
    211 rdf:type schema:DefinedTerm
    212 Nfd8cdb45c6cd4c19b58fb88affa56b45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Treatment Outcome
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Medical and Health Sciences
    217 rdf:type schema:DefinedTerm
    218 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Clinical Sciences
    220 rdf:type schema:DefinedTerm
    221 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    222 schema:name Medical Microbiology
    223 rdf:type schema:DefinedTerm
    224 sg:journal.1094828 schema:issn 0254-8860
    225 0975-0711
    226 schema:name Indian Journal of Gastroenterology
    227 schema:publisher Springer Nature
    228 rdf:type schema:Periodical
    229 sg:person.011650233217.65 schema:affiliation grid-institutes:grid.263138.d
    230 schema:familyName Bhargava
    231 schema:givenName Rajat
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011650233217.65
    233 rdf:type schema:Person
    234 sg:person.01227657050.94 schema:affiliation grid-institutes:grid.263138.d
    235 schema:familyName Aggarwal
    236 schema:givenName Rakesh
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227657050.94
    238 rdf:type schema:Person
    239 sg:person.01336570760.60 schema:affiliation grid-institutes:grid.263138.d
    240 schema:familyName Rai
    241 schema:givenName Praveer
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336570760.60
    243 rdf:type schema:Person
    244 sg:person.0633741372.14 schema:affiliation grid-institutes:grid.263138.d
    245 schema:familyName Goel
    246 schema:givenName Amit
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633741372.14
    248 rdf:type schema:Person
    249 sg:pub.10.1007/s12664-016-0713-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044521490
    250 https://doi.org/10.1007/s12664-016-0713-5
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1111/j.1572-0241.2008.01825.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001725308
    253 https://doi.org/10.1111/j.1572-0241.2008.01825.x
    254 rdf:type schema:CreativeWork
    255 grid-institutes:grid.263138.d schema:alternateName Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India
    256 schema:name Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226 014, Lucknow, India
    257 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...