The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-05

AUTHORS

Laura Brandolini, Marta Grannonico, Gianluca Bianchini, Alessia Colanardi, Pierluigi Sebastiani, Antonella Paladini, Alba Piroli, Marcello Allegretti, Giustino Varrassi, Silvia Di Loreto

ABSTRACT

The central nervous system (CNS) constitutively expresses complement (C) membrane receptors and complement proteins, including the component C5a. This is a crucial terminal effector of the C cascade, mostly involved in pain and neuroinflammatory conditions. Aberrant activation of C5a protein and its receptor C5aR has been reported to play a critical role in neurodegenerative diseases, with important clinical consequences. Here we have investigated the effects of DF3016A, a novel selective C5aR antagonist, able to penetrate the blood-brain barrier (BBB), on cortical neurons exposed to oxygen-glucose deprivation-reoxygenation (OGD/R), a neuroinflammation-related process. We demonstrated that a mild ischemic insult induces an early upregulation of C5aR associated with the over-production of pro-inflammatory cytokines and the over-expression of the transcriptional regulatory factor miR-181. Furthermore, we report the first experimental evidence of the effect of DF3016A, modulating complement component C5a, on neurons in a model of injury. Interestingly, DF3016A protects neuronal viability by restoring intracellular calcium levels, thus opposing the increase in pro-inflammatory cytokine levels and miR-181 expression. Based on our results, we suggest that DF3016A is a novel C5aR antagonist promoting protective effects against OGD/R-induced damage that could be a new therapeutic approach to controlling CNS neuroinflammatory conditions. More... »

Journal

TITLE

Neurotoxicity Research

ISSUE

N/A

VOLUME

N/A

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12640-019-00026-w

DOI

http://dx.doi.org/10.1007/s12640-019-00026-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113261869

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30953275


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Domp\u00e9 Farmaceutici SpA, Via Campo di Pile, L'Aquila, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brandolini", 
        "givenName": "Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of MESVA, University of L'Aquila, L'Aquila, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grannonico", 
        "givenName": "Marta", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Domp\u00e9 Farmaceutici SpA, Via Campo di Pile, L'Aquila, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bianchini", 
        "givenName": "Gianluca", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colanardi", 
        "givenName": "Alessia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sebastiani", 
        "givenName": "Pierluigi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of MESVA, University of L'Aquila, L'Aquila, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paladini", 
        "givenName": "Antonella", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of MESVA, University of L'Aquila, L'Aquila, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piroli", 
        "givenName": "Alba", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Domp\u00e9 Farmaceutici SpA, Via Campo di Pile, L'Aquila, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allegretti", 
        "givenName": "Marcello", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Paolo Procacci Foundation, Via Tacito 7, 00193, Rome, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varrassi", 
        "givenName": "Giustino", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy. silvia.diloreto@cnr.it."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Loreto", 
        "givenName": "Silvia", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.nbd.2011.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000117808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1999.7273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000186845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:nere.0000018853.30131.4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002714001", 
          "https://doi.org/10.1023/b:nere.0000018853.30131.4d"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2007.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003667351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phrs.2016.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007587929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008718799", 
          "https://doi.org/10.1038/nrd3845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0500419102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010085235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.124388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010419513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/dna.2015.2800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010471296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-1136(199905)26:3<201::aid-glia2>3.0.co;2-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011287918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-5728(00)00209-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014992274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2012.02.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015986935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2005.05.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016012989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2005.05.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016012989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2008.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017726445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2008.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017726445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-015-0464-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017772299", 
          "https://doi.org/10.1186/s12974-015-0464-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/papr.12254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018299325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.08-2868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018457045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.10.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019924563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-9-r68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020602210", 
          "https://doi.org/10.1186/gb-2004-5-9-r68"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ir:26:1-3:007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020613788", 
          "https://doi.org/10.1385/ir:26:1-3:007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2009.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020616367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12975-013-0280-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021392092", 
          "https://doi.org/10.1007/s12975-013-0280-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12975-013-0280-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021392092", 
          "https://doi.org/10.1007/s12975-013-0280-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07853899509002465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021830523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.1998.679bs.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023786602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-016-2179-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023935827", 
          "https://doi.org/10.1007/s00018-016-2179-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2012.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025024013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1417365111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025158231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.12.6.723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028754301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2950679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030461242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2950679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030461242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1999.0722426.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030705697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2003.tb03138.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030792230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2003.tb03138.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030792230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0402090101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033161934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.11-202382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033209063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2008.05668.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034249123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.16.1.545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039521935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2014.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043613177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2012.11.097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043788837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0162-3109(00)80303-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044232248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12017-009-8085-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046196243", 
          "https://doi.org/10.1007/s12017-009-8085-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12017-009-8085-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046196243", 
          "https://doi.org/10.1007/s12017-009-8085-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-5728(99)00261-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046361094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0361-9230(01)00428-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046746069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/papr.12551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048681050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2001.00167.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050355431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.kint.2016.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052576351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.kint.2016.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052576351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.22483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052771669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074670911", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.6.4154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074780186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.170.11.5764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075289403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079159861", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079217801", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.13-08-03510.1993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082651646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083036416", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/cia.s113576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084955569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40122-017-0076-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090324391", 
          "https://doi.org/10.1007/s40122-017-0076-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40122-017-0076-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090324391", 
          "https://doi.org/10.1007/s40122-017-0076-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1100624595", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40122-018-0094-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101845426", 
          "https://doi.org/10.1007/s40122-018-0094-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40122-018-0094-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101845426", 
          "https://doi.org/10.1007/s40122-018-0094-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2018.00949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103686708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2018.00949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103686708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2018.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107707680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2018.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107707680"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-05", 
    "datePublishedReg": "2019-04-05", 
    "description": "The central nervous system (CNS) constitutively expresses complement (C) membrane receptors and complement proteins, including the component C5a. This is a crucial terminal effector of the C cascade, mostly involved in pain and neuroinflammatory conditions. Aberrant activation of C5a protein and its receptor C5aR has been reported to play a critical role in neurodegenerative diseases, with important clinical consequences. Here we have investigated the effects of DF3016A, a novel selective C5aR antagonist, able to penetrate the blood-brain barrier (BBB), on cortical neurons exposed to oxygen-glucose deprivation-reoxygenation (OGD/R), a neuroinflammation-related process. We demonstrated that a mild ischemic insult induces an early upregulation of C5aR associated with the over-production of pro-inflammatory cytokines and the over-expression of the transcriptional regulatory factor miR-181. Furthermore, we report the first experimental evidence of the effect of DF3016A, modulating complement component C5a, on neurons in a model of injury. Interestingly, DF3016A protects neuronal viability by restoring intracellular calcium levels, thus opposing the increase in pro-inflammatory cytokine levels and miR-181 expression. Based on our results, we suggest that DF3016A is a novel C5aR antagonist promoting protective effects against OGD/R-induced damage that could be a new therapeutic approach to controlling CNS neuroinflammatory conditions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12640-019-00026-w", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1022448", 
        "issn": [
          "1029-8428", 
          "1476-3524"
        ], 
        "name": "Neurotoxicity Research", 
        "type": "Periodical"
      }
    ], 
    "name": "The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury.", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30953275"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100929017"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12640-019-00026-w"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113261869"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12640-019-00026-w", 
      "https://app.dimensions.ai/details/publication/pub.1113261869"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117103_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s12640-019-00026-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12640-019-00026-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12640-019-00026-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12640-019-00026-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12640-019-00026-w'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      20 PREDICATES      83 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12640-019-00026-w schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N36180b9e7b3e4a9683949ea0e7b4025f
4 schema:citation sg:pub.10.1007/s00018-016-2179-0
5 sg:pub.10.1007/s12017-009-8085-y
6 sg:pub.10.1007/s12975-013-0280-3
7 sg:pub.10.1007/s40122-017-0076-3
8 sg:pub.10.1007/s40122-018-0094-9
9 sg:pub.10.1023/b:nere.0000018853.30131.4d
10 sg:pub.10.1038/nrd3845
11 sg:pub.10.1186/gb-2004-5-9-r68
12 sg:pub.10.1186/s12974-015-0464-8
13 sg:pub.10.1385/ir:26:1-3:007
14 https://app.dimensions.ai/details/publication/pub.1074670911
15 https://app.dimensions.ai/details/publication/pub.1079159861
16 https://app.dimensions.ai/details/publication/pub.1079217801
17 https://app.dimensions.ai/details/publication/pub.1083036416
18 https://app.dimensions.ai/details/publication/pub.1100624595
19 https://doi.org/10.1002/(sici)1098-1136(199905)26:3<201::aid-glia2>3.0.co;2-m
20 https://doi.org/10.1002/glia.22483
21 https://doi.org/10.1006/exnr.1999.7273
22 https://doi.org/10.1006/meth.2001.1262
23 https://doi.org/10.1016/j.bbrc.2012.11.097
24 https://doi.org/10.1016/j.brainres.2005.05.063
25 https://doi.org/10.1016/j.cell.2007.10.036
26 https://doi.org/10.1016/j.kint.2016.04.023
27 https://doi.org/10.1016/j.molimm.2012.09.001
28 https://doi.org/10.1016/j.molmed.2009.12.001
29 https://doi.org/10.1016/j.nbd.2011.09.012
30 https://doi.org/10.1016/j.neuint.2007.09.014
31 https://doi.org/10.1016/j.neuint.2012.02.024
32 https://doi.org/10.1016/j.neuropharm.2014.10.027
33 https://doi.org/10.1016/j.neuroscience.2018.10.018
34 https://doi.org/10.1016/j.phrs.2016.02.004
35 https://doi.org/10.1016/s0162-3109(00)80303-3
36 https://doi.org/10.1016/s0165-5728(00)00209-5
37 https://doi.org/10.1016/s0165-5728(99)00261-1
38 https://doi.org/10.1016/s0361-9230(01)00428-2
39 https://doi.org/10.1038/jcbfm.2008.157
40 https://doi.org/10.1042/bj2950679
41 https://doi.org/10.1046/j.1471-4159.1999.0722426.x
42 https://doi.org/10.1046/j.1471-4159.2001.00167.x
43 https://doi.org/10.1073/pnas.0402090101
44 https://doi.org/10.1073/pnas.0500419102
45 https://doi.org/10.1073/pnas.1417365111
46 https://doi.org/10.1089/dna.2015.2800
47 https://doi.org/10.1096/fj.11-202382
48 https://doi.org/10.1111/j.1469-7793.1998.679bs.x
49 https://doi.org/10.1111/j.1471-4159.2008.05668.x
50 https://doi.org/10.1111/j.1749-6632.2003.tb03138.x
51 https://doi.org/10.1111/papr.12254
52 https://doi.org/10.1111/papr.12551
53 https://doi.org/10.1146/annurev.immunol.16.1.545
54 https://doi.org/10.1161/01.str.12.6.723
55 https://doi.org/10.1167/iovs.08-2868
56 https://doi.org/10.1242/jcs.124388
57 https://doi.org/10.1523/jneurosci.13-08-03510.1993
58 https://doi.org/10.2147/cia.s113576
59 https://doi.org/10.3109/07853899509002465
60 https://doi.org/10.3389/fimmu.2018.00949
61 https://doi.org/10.4049/jimmunol.166.6.4154
62 https://doi.org/10.4049/jimmunol.170.11.5764
63 schema:datePublished 2019-04-05
64 schema:datePublishedReg 2019-04-05
65 schema:description The central nervous system (CNS) constitutively expresses complement (C) membrane receptors and complement proteins, including the component C5a. This is a crucial terminal effector of the C cascade, mostly involved in pain and neuroinflammatory conditions. Aberrant activation of C5a protein and its receptor C5aR has been reported to play a critical role in neurodegenerative diseases, with important clinical consequences. Here we have investigated the effects of DF3016A, a novel selective C5aR antagonist, able to penetrate the blood-brain barrier (BBB), on cortical neurons exposed to oxygen-glucose deprivation-reoxygenation (OGD/R), a neuroinflammation-related process. We demonstrated that a mild ischemic insult induces an early upregulation of C5aR associated with the over-production of pro-inflammatory cytokines and the over-expression of the transcriptional regulatory factor miR-181. Furthermore, we report the first experimental evidence of the effect of DF3016A, modulating complement component C5a, on neurons in a model of injury. Interestingly, DF3016A protects neuronal viability by restoring intracellular calcium levels, thus opposing the increase in pro-inflammatory cytokine levels and miR-181 expression. Based on our results, we suggest that DF3016A is a novel C5aR antagonist promoting protective effects against OGD/R-induced damage that could be a new therapeutic approach to controlling CNS neuroinflammatory conditions.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree false
69 schema:isPartOf sg:journal.1022448
70 schema:name The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury.
71 schema:productId N8ef31a81e5bf475aa6b0554c576aff09
72 N8f2943df09d04fdba79e1885150cd8b1
73 N9d10792923474aa890986b47faf7891e
74 Nea2c0caaf22a47b1a1c237c945363b93
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113261869
76 https://doi.org/10.1007/s12640-019-00026-w
77 schema:sdDatePublished 2019-04-11T14:18
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Ne90cd69707c84d4789de2b1d9e7f4346
80 schema:url http://link.springer.com/10.1007/s12640-019-00026-w
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N1afd92eebebd4163a77cb14ad73640b9 rdf:first N4e2e2054c2c14732af601a6e7ce2d096
85 rdf:rest N40771de8b1554fc28f2b3794988d88d8
86 N28b8d3c2da1644bfb93c5ca7dbe22af8 schema:affiliation N3ca5ad67773f424a8359517a23933063
87 schema:familyName Brandolini
88 schema:givenName Laura
89 rdf:type schema:Person
90 N2e830f55969a44fd89ca4162250ae32f schema:name Paolo Procacci Foundation, Via Tacito 7, 00193, Rome, Italy.
91 rdf:type schema:Organization
92 N331b6e97660f41d5af54ee6a53d24182 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
93 schema:familyName Paladini
94 schema:givenName Antonella
95 rdf:type schema:Person
96 N36180b9e7b3e4a9683949ea0e7b4025f rdf:first N28b8d3c2da1644bfb93c5ca7dbe22af8
97 rdf:rest Na8295f834fc74a0685dcecddb8756d14
98 N3722ee1eb08447fb8b67a6fb8e212c04 schema:name Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy.
99 rdf:type schema:Organization
100 N3ca5ad67773f424a8359517a23933063 schema:name Dompé Farmaceutici SpA, Via Campo di Pile, L'Aquila, Italy.
101 rdf:type schema:Organization
102 N40771de8b1554fc28f2b3794988d88d8 rdf:first Ne405f6dd41cb4e60bef67aae0b1753df
103 rdf:rest rdf:nil
104 N4e2e2054c2c14732af601a6e7ce2d096 schema:affiliation N2e830f55969a44fd89ca4162250ae32f
105 schema:familyName Varrassi
106 schema:givenName Giustino
107 rdf:type schema:Person
108 N5561dd56cbab4c23a881ef57e60a3bcb schema:affiliation N3722ee1eb08447fb8b67a6fb8e212c04
109 schema:familyName Sebastiani
110 schema:givenName Pierluigi
111 rdf:type schema:Person
112 N5e2f4bff7d4c4c89a75b608aa611d122 rdf:first N5561dd56cbab4c23a881ef57e60a3bcb
113 rdf:rest N6634a23f4a52464e8cf2d1b1b7afc0cd
114 N6634a23f4a52464e8cf2d1b1b7afc0cd rdf:first N331b6e97660f41d5af54ee6a53d24182
115 rdf:rest Ndb6da17f8b0642ceaf3b2d8cabe7aa46
116 N6915736367574fe98f3fcc3b9a965224 schema:affiliation Nddc9d9f45dca43059f2d73520917cceb
117 schema:familyName Allegretti
118 schema:givenName Marcello
119 rdf:type schema:Person
120 N8b7be9d7cd6c42c09539cb2c11b65583 rdf:first Naca8e1dfa5d5454487730c91a15315b2
121 rdf:rest Ne08128a5ee0c4dc3afa75371eee4f7a1
122 N8ef31a81e5bf475aa6b0554c576aff09 schema:name pubmed_id
123 schema:value 30953275
124 rdf:type schema:PropertyValue
125 N8f2943df09d04fdba79e1885150cd8b1 schema:name doi
126 schema:value 10.1007/s12640-019-00026-w
127 rdf:type schema:PropertyValue
128 N8fd155baafe74e45aa675e67721ef964 schema:name Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy.
129 rdf:type schema:Organization
130 N9d10792923474aa890986b47faf7891e schema:name dimensions_id
131 schema:value pub.1113261869
132 rdf:type schema:PropertyValue
133 N9d6fabc72c274af6b6bde9b6d5720893 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
134 schema:familyName Grannonico
135 schema:givenName Marta
136 rdf:type schema:Person
137 N9dd8e13b7f0c40858b4f4f4dc50a169a schema:name Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy. silvia.diloreto@cnr.it.
138 rdf:type schema:Organization
139 Na42a3b4f09f44a62b2e9c6b03851c9f6 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
140 schema:familyName Piroli
141 schema:givenName Alba
142 rdf:type schema:Person
143 Na5952d3cec904519b61f365a382ce250 rdf:first N6915736367574fe98f3fcc3b9a965224
144 rdf:rest N1afd92eebebd4163a77cb14ad73640b9
145 Na8295f834fc74a0685dcecddb8756d14 rdf:first N9d6fabc72c274af6b6bde9b6d5720893
146 rdf:rest N8b7be9d7cd6c42c09539cb2c11b65583
147 Naca8e1dfa5d5454487730c91a15315b2 schema:affiliation Nef8facecd53348e6ab3b44bf99a4b32a
148 schema:familyName Bianchini
149 schema:givenName Gianluca
150 rdf:type schema:Person
151 Nbcd6c2a9765d41ad97afc5b686d07205 schema:affiliation N8fd155baafe74e45aa675e67721ef964
152 schema:familyName Colanardi
153 schema:givenName Alessia
154 rdf:type schema:Person
155 Ndb6da17f8b0642ceaf3b2d8cabe7aa46 rdf:first Na42a3b4f09f44a62b2e9c6b03851c9f6
156 rdf:rest Na5952d3cec904519b61f365a382ce250
157 Nddc9d9f45dca43059f2d73520917cceb schema:name Dompé Farmaceutici SpA, Via Campo di Pile, L'Aquila, Italy.
158 rdf:type schema:Organization
159 Ne08128a5ee0c4dc3afa75371eee4f7a1 rdf:first Nbcd6c2a9765d41ad97afc5b686d07205
160 rdf:rest N5e2f4bff7d4c4c89a75b608aa611d122
161 Ne405f6dd41cb4e60bef67aae0b1753df schema:affiliation N9dd8e13b7f0c40858b4f4f4dc50a169a
162 schema:familyName Di Loreto
163 schema:givenName Silvia
164 rdf:type schema:Person
165 Ne90cd69707c84d4789de2b1d9e7f4346 schema:name Springer Nature - SN SciGraph project
166 rdf:type schema:Organization
167 Nea2c0caaf22a47b1a1c237c945363b93 schema:name nlm_unique_id
168 schema:value 100929017
169 rdf:type schema:PropertyValue
170 Nef8facecd53348e6ab3b44bf99a4b32a schema:name Dompé Farmaceutici SpA, Via Campo di Pile, L'Aquila, Italy.
171 rdf:type schema:Organization
172 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
173 schema:name Medical and Health Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
176 schema:name Neurosciences
177 rdf:type schema:DefinedTerm
178 sg:journal.1022448 schema:issn 1029-8428
179 1476-3524
180 schema:name Neurotoxicity Research
181 rdf:type schema:Periodical
182 sg:pub.10.1007/s00018-016-2179-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023935827
183 https://doi.org/10.1007/s00018-016-2179-0
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/s12017-009-8085-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1046196243
186 https://doi.org/10.1007/s12017-009-8085-y
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/s12975-013-0280-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021392092
189 https://doi.org/10.1007/s12975-013-0280-3
190 rdf:type schema:CreativeWork
191 sg:pub.10.1007/s40122-017-0076-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090324391
192 https://doi.org/10.1007/s40122-017-0076-3
193 rdf:type schema:CreativeWork
194 sg:pub.10.1007/s40122-018-0094-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101845426
195 https://doi.org/10.1007/s40122-018-0094-9
196 rdf:type schema:CreativeWork
197 sg:pub.10.1023/b:nere.0000018853.30131.4d schema:sameAs https://app.dimensions.ai/details/publication/pub.1002714001
198 https://doi.org/10.1023/b:nere.0000018853.30131.4d
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/nrd3845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008718799
201 https://doi.org/10.1038/nrd3845
202 rdf:type schema:CreativeWork
203 sg:pub.10.1186/gb-2004-5-9-r68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020602210
204 https://doi.org/10.1186/gb-2004-5-9-r68
205 rdf:type schema:CreativeWork
206 sg:pub.10.1186/s12974-015-0464-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017772299
207 https://doi.org/10.1186/s12974-015-0464-8
208 rdf:type schema:CreativeWork
209 sg:pub.10.1385/ir:26:1-3:007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020613788
210 https://doi.org/10.1385/ir:26:1-3:007
211 rdf:type schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1074670911 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1079159861 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1079217801 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1083036416 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1100624595 schema:CreativeWork
217 https://doi.org/10.1002/(sici)1098-1136(199905)26:3<201::aid-glia2>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1011287918
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/glia.22483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052771669
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1006/exnr.1999.7273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000186845
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.bbrc.2012.11.097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043788837
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.brainres.2005.05.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016012989
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.cell.2007.10.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019924563
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.kint.2016.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052576351
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.molimm.2012.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025024013
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.molmed.2009.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020616367
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.nbd.2011.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000117808
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.neuint.2007.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003667351
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.neuint.2012.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015986935
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.neuropharm.2014.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043613177
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.neuroscience.2018.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107707680
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.phrs.2016.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007587929
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0162-3109(00)80303-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044232248
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0165-5728(00)00209-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014992274
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0165-5728(99)00261-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046361094
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0361-9230(01)00428-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046746069
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1038/jcbfm.2008.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017726445
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1042/bj2950679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030461242
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1046/j.1471-4159.1999.0722426.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030705697
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1046/j.1471-4159.2001.00167.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050355431
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1073/pnas.0402090101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033161934
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1073/pnas.0500419102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010085235
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1073/pnas.1417365111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025158231
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1089/dna.2015.2800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010471296
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1096/fj.11-202382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033209063
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1469-7793.1998.679bs.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023786602
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/j.1471-4159.2008.05668.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034249123
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/j.1749-6632.2003.tb03138.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030792230
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/papr.12254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018299325
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/papr.12551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048681050
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1146/annurev.immunol.16.1.545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039521935
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1161/01.str.12.6.723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028754301
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1167/iovs.08-2868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457045
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1242/jcs.124388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419513
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1523/jneurosci.13-08-03510.1993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082651646
294 rdf:type schema:CreativeWork
295 https://doi.org/10.2147/cia.s113576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084955569
296 rdf:type schema:CreativeWork
297 https://doi.org/10.3109/07853899509002465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021830523
298 rdf:type schema:CreativeWork
299 https://doi.org/10.3389/fimmu.2018.00949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103686708
300 rdf:type schema:CreativeWork
301 https://doi.org/10.4049/jimmunol.166.6.4154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074780186
302 rdf:type schema:CreativeWork
303 https://doi.org/10.4049/jimmunol.170.11.5764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075289403
304 rdf:type schema:CreativeWork
305 https://www.grid.ac/institutes/grid.158820.6 schema:alternateName University of L'Aquila
306 schema:name Department of MESVA, University of L'Aquila, L'Aquila, Italy.
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...