Late Effect of Developmental Exposure to 3,3′-Iminodipropionitrile on Neurogenesis in the Hippocampal Dentate Gyrus of Mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07

AUTHORS

Yasuko Hasegawa-Baba, Takeshi Tanaka, Yousuke Watanabe, Liyun Wang, Megu Itahashi, Toshinori Yoshida, Makoto Shibutani

ABSTRACT

The effects of developmental exposure to 3,3'-iminodipropionitrile (IDPN), a neurotoxicant that causes proximal axonopathy, on mouse hippocampal neurogenesis was examined. Pregnant mice were exposed to IDPN at 0, 600, or 1200 ppm in their drinking water from gestational day 6 to postnatal day (PND) 21. On PND 21, male offspring showed increased postmitotic neuron-specific NeuN-immunoreactive(+) granule cell numbers in the dentate subgranular zone (SGZ) and granule cell layer (GCL) and decreased glutamate receptor gene Grin2d levels in the dentate gyrus at 1200 ppm. On PND 77, decreased numbers were observed for TBR2+ progenitor cells in the SGZ at ≥600 ppm and GFAP+ stem cells, DCX+ progenitor cells and immature granule cells, NeuN+ immature and mature granule cells, PCNA+ proliferating cells in the SGZ and/or GCL, and immunoreactive cells for ARC or FOS, immediate-early gene products related to neuronal and synaptic plasticity, in the GCL at 1200 ppm. Additionally, at 1200 ppm of IDPN, downregulation of Kit, the gene encoding the stem cell factor (SCF) receptor, and upregulation of Kitl, encoding SCF, were observed in the dentate gyrus. Therefore, maternal IDPN exposure in mice affects neurogenesis involving glutamatergic signals at the end of developmental exposure, with late effects suppressing SGZ cell proliferation, reducing the broad range of granule cell lineage population, which may be responsible for SCF receptor downregulation. The upregulated SCF was likely a feedback response to the decreased receptor level. These results suggest that reduced SCF signaling may cause suppressed neuronal and synaptic plasticity. More... »

PAGES

27-40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12640-017-9703-3

DOI

http://dx.doi.org/10.1007/s12640-017-9703-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083688008

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28168441


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dentate Gyrus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acid-Binding Protein 7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred ICR", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitriles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins v-fos", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proliferating Cell Nuclear Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Box Domain Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasegawa-Baba", 
        "givenName": "Yasuko", 
        "id": "sg:person.0615010501.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615010501.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan", 
            "Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu-shi, 501-1193, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Takeshi", 
        "id": "sg:person.0770705436.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770705436.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan", 
            "Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu-shi, 501-1193, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Yousuke", 
        "id": "sg:person.0727004747.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727004747.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Liyun", 
        "id": "sg:person.0706160162.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706160162.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itahashi", 
        "givenName": "Megu", 
        "id": "sg:person.01367127434.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367127434.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Toshinori", 
        "id": "sg:person.01233546434.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233546434.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shibutani", 
        "givenName": "Makoto", 
        "id": "sg:person.01055675151.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055675151.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/lm.33900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000407619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-012-0801-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004115330", 
          "https://doi.org/10.1007/s00204-012-0801-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncel.2014.00166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004908562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2012.10.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007048839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.reprotox.2013.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007057058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6123(08)61304-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009317356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.5.1808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011350345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-011-8207-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012670579", 
          "https://doi.org/10.1007/s12035-011-8207-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.10010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013915477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2005.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015114205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2005.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015114205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-198001000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016058304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14252/foodsafetyfscj.2014038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017314614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.reprotox.2010.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017399859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-3623(81)90108-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018583885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-3623(81)90108-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018583885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2131/jts.38.431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018925108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0053569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020694006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fendo.2011.00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021686876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms1670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022919518", 
          "https://doi.org/10.1038/ncomms1670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psyneuen.2014.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023726781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024407396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1768-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026701173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(97)00261-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027696071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(92)90553-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029786372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(92)90553-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029786372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bht035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030441417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfs110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030555567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4280-07.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030862841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1811-14.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032039935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/382107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033077574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.22225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033306778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(94)90104-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034225593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(94)90104-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034225593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.reprotox.2012.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035112602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00287.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035881637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00004.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036073633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yfrne.2009.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036842251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.12.5734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037219839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(93)90111-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038899242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(93)90111-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038899242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2004.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040177859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0953-816x.2004.03327.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041632743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/gbb.12065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042027967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042390930", 
          "https://doi.org/10.1038/nature02553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042390930", 
          "https://doi.org/10.1038/nature02553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncel.2015.00095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043977209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jat.3086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046059417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kft092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047308024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.21683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048282788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3111-06.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049685387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0028-3908(95)00109-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051808483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052326210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.reprotox.2012.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053296689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci15251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063415350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci20001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.2001.85.6.2423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074829027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5114/aoms.2015.54871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079173510"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-07", 
    "datePublishedReg": "2017-07-01", 
    "description": "The effects of developmental exposure to 3,3'-iminodipropionitrile (IDPN), a neurotoxicant that causes proximal axonopathy, on mouse hippocampal neurogenesis was examined. Pregnant mice were exposed to IDPN at 0, 600, or 1200\u00a0ppm in their drinking water from gestational day 6 to postnatal day (PND) 21. On PND 21, male offspring showed increased postmitotic neuron-specific NeuN-immunoreactive(+)\u00a0granule cell numbers in the dentate subgranular zone (SGZ) and granule cell layer (GCL) and decreased glutamate receptor gene Grin2d levels in the dentate gyrus at 1200\u00a0ppm. On PND 77, decreased numbers were observed for TBR2+ progenitor cells in the SGZ at \u2265600\u00a0ppm and GFAP+ stem cells, DCX+ progenitor cells and immature granule cells, NeuN+ immature and mature granule cells, PCNA+ proliferating cells in the SGZ and/or GCL, and immunoreactive cells for ARC or FOS, immediate-early gene products related to neuronal and synaptic plasticity, in the GCL at 1200\u00a0ppm. Additionally, at 1200\u00a0ppm of IDPN, downregulation of Kit, the gene encoding the stem cell factor (SCF) receptor, and upregulation of Kitl, encoding SCF, were observed in the dentate gyrus. Therefore, maternal IDPN exposure in mice affects neurogenesis involving glutamatergic signals at the end of developmental exposure, with late effects suppressing SGZ cell proliferation, reducing the broad range of granule cell lineage population, which may be responsible for SCF receptor downregulation. The upregulated SCF was likely a feedback response to the decreased receptor level. These results suggest that reduced SCF signaling may cause suppressed neuronal and synaptic plasticity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12640-017-9703-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6106978", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1022448", 
        "issn": [
          "1029-8428", 
          "1476-3524"
        ], 
        "name": "Neurotoxicity Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "Late Effect of Developmental Exposure to 3,3\u2032-Iminodipropionitrile on Neurogenesis in the Hippocampal Dentate Gyrus of Mice", 
    "pagination": "27-40", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fee91335642fce0f9d9ba733d64ad2b115999bdfbbe99b61268e622f93d685a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28168441"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100929017"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12640-017-9703-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1083688008"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12640-017-9703-3", 
      "https://app.dimensions.ai/details/publication/pub.1083688008"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113647_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12640-017-9703-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12640-017-9703-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12640-017-9703-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12640-017-9703-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12640-017-9703-3'


 

This table displays all metadata directly associated to this object as RDF triples.

360 TRIPLES      21 PREDICATES      102 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12640-017-9703-3 schema:about N0f577255194a47d19136645eb34ff079
2 N259b8a9d6d004ebb8d9ac25462355c78
3 N2d289a7eb4ff4701b1165861f40deae2
4 N38acc6de5de34686a1284444d1f0630e
5 N3eaf664f0d7b48f59af540fcd8930f1b
6 N4a8d69dfc7d44ca8a29e7d79bf466e3a
7 N6cf57d7a9c58473a968e7fe132d24f73
8 N6f1050c200b648998e1f5fce77bdc71c
9 N6ff9b2ffa7c84057bd461a05f2008f5d
10 N853c03214d02493ead7464687dbcc737
11 N88c3e9082988494eb1632d9a6884c9b4
12 N8aaba7370400411492209e80168ae97b
13 N8f9cf3cc3db44b9b80b809f04a7b477f
14 N99ef4a9c958942bd8dbf1d97e8869d03
15 Nb3b40fa3fa5148018d763118fe7bd29b
16 Nb82efff6fa6c4a7bbd9af7a4b924f854
17 Nc877b2ce4f2e4c45a227c96f8ef9991d
18 Nd8d2d8afeb96437d8ae88f94ab1152c1
19 Nddf6f9b2301d488aad3168750cf5895d
20 Nf437d976c38145a5a7e1334c776eb75b
21 anzsrc-for:11
22 anzsrc-for:1109
23 schema:author N35356355cec545e8bcd9127a0fbecf83
24 schema:citation sg:pub.10.1007/s00204-012-0801-y
25 sg:pub.10.1007/s12035-011-8207-z
26 sg:pub.10.1038/nature02553
27 sg:pub.10.1038/ncomms1670
28 https://doi.org/10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i
29 https://doi.org/10.1002/glia.20407
30 https://doi.org/10.1002/hipo.10010
31 https://doi.org/10.1002/hipo.22225
32 https://doi.org/10.1002/jat.3086
33 https://doi.org/10.1002/syn.21683
34 https://doi.org/10.1006/meth.2001.1262
35 https://doi.org/10.1016/0006-8993(92)90553-l
36 https://doi.org/10.1016/0028-3908(95)00109-j
37 https://doi.org/10.1016/0306-3623(81)90108-7
38 https://doi.org/10.1016/0378-5955(93)90111-d
39 https://doi.org/10.1016/0378-5955(94)90104-x
40 https://doi.org/10.1016/j.biopsych.2012.10.023
41 https://doi.org/10.1016/j.neulet.2005.05.022
42 https://doi.org/10.1016/j.psyneuen.2014.03.016
43 https://doi.org/10.1016/j.reprotox.2010.08.009
44 https://doi.org/10.1016/j.reprotox.2012.04.009
45 https://doi.org/10.1016/j.reprotox.2012.10.008
46 https://doi.org/10.1016/j.reprotox.2013.02.004
47 https://doi.org/10.1016/j.tins.2004.05.013
48 https://doi.org/10.1016/j.yfrne.2009.03.007
49 https://doi.org/10.1016/s0079-6123(08)61304-7
50 https://doi.org/10.1016/s0306-4522(97)00261-3
51 https://doi.org/10.1073/pnas.92.12.5734
52 https://doi.org/10.1073/pnas.93.5.1808
53 https://doi.org/10.1093/cercor/bht035
54 https://doi.org/10.1093/toxsci/kfs110
55 https://doi.org/10.1093/toxsci/kft092
56 https://doi.org/10.1097/00005072-198001000-00004
57 https://doi.org/10.1101/lm.33900
58 https://doi.org/10.1111/gbb.12065
59 https://doi.org/10.1111/j.0953-816x.2004.03327.x
60 https://doi.org/10.1152/jn.00287.2010
61 https://doi.org/10.1152/jn.2001.85.6.2423
62 https://doi.org/10.1152/physrev.00004.2014
63 https://doi.org/10.1155/2012/382107
64 https://doi.org/10.1172/jci15251
65 https://doi.org/10.1172/jci20001
66 https://doi.org/10.1371/journal.pone.0053569
67 https://doi.org/10.14252/foodsafetyfscj.2014038
68 https://doi.org/10.1523/jneurosci.1768-09.2009
69 https://doi.org/10.1523/jneurosci.1811-14.2014
70 https://doi.org/10.1523/jneurosci.3111-06.2007
71 https://doi.org/10.1523/jneurosci.4280-07.2008
72 https://doi.org/10.2131/jts.38.431
73 https://doi.org/10.3389/fendo.2011.00018
74 https://doi.org/10.3389/fncel.2014.00166
75 https://doi.org/10.3389/fncel.2015.00095
76 https://doi.org/10.5114/aoms.2015.54871
77 schema:datePublished 2017-07
78 schema:datePublishedReg 2017-07-01
79 schema:description The effects of developmental exposure to 3,3'-iminodipropionitrile (IDPN), a neurotoxicant that causes proximal axonopathy, on mouse hippocampal neurogenesis was examined. Pregnant mice were exposed to IDPN at 0, 600, or 1200 ppm in their drinking water from gestational day 6 to postnatal day (PND) 21. On PND 21, male offspring showed increased postmitotic neuron-specific NeuN-immunoreactive<sup>(+)</sup> granule cell numbers in the dentate subgranular zone (SGZ) and granule cell layer (GCL) and decreased glutamate receptor gene Grin2d levels in the dentate gyrus at 1200 ppm. On PND 77, decreased numbers were observed for TBR2<sup>+</sup> progenitor cells in the SGZ at ≥600 ppm and GFAP<sup>+</sup> stem cells, DCX<sup>+</sup> progenitor cells and immature granule cells, NeuN<sup>+</sup> immature and mature granule cells, PCNA<sup>+</sup> proliferating cells in the SGZ and/or GCL, and immunoreactive cells for ARC or FOS, immediate-early gene products related to neuronal and synaptic plasticity, in the GCL at 1200 ppm. Additionally, at 1200 ppm of IDPN, downregulation of Kit, the gene encoding the stem cell factor (SCF) receptor, and upregulation of Kitl, encoding SCF, were observed in the dentate gyrus. Therefore, maternal IDPN exposure in mice affects neurogenesis involving glutamatergic signals at the end of developmental exposure, with late effects suppressing SGZ cell proliferation, reducing the broad range of granule cell lineage population, which may be responsible for SCF receptor downregulation. The upregulated SCF was likely a feedback response to the decreased receptor level. These results suggest that reduced SCF signaling may cause suppressed neuronal and synaptic plasticity.
80 schema:genre research_article
81 schema:inLanguage en
82 schema:isAccessibleForFree false
83 schema:isPartOf N4f9a5d9abe3a48c28b7a2e5a0dbcfcc0
84 N6d11420ac0fb468ba9c20d287675b295
85 sg:journal.1022448
86 schema:name Late Effect of Developmental Exposure to 3,3′-Iminodipropionitrile on Neurogenesis in the Hippocampal Dentate Gyrus of Mice
87 schema:pagination 27-40
88 schema:productId N373b592fe5c241eb92f091cdda854362
89 Nbc8ff5be52aa4b33a8f667aaac683a4f
90 Nc3b205f769bc4d7ea8ad0c7b6fb162b2
91 Nc690f86dcc6e415b9b047e7f4219a1d5
92 Ne6af4d12d7be498a9d778cf17e660966
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083688008
94 https://doi.org/10.1007/s12640-017-9703-3
95 schema:sdDatePublished 2019-04-11T10:30
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N286ea4fa9e0e4515809d10bbfdd8ad73
98 schema:url https://link.springer.com/10.1007%2Fs12640-017-9703-3
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N0f577255194a47d19136645eb34ff079 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Oncogene Proteins v-fos
104 rdf:type schema:DefinedTerm
105 N259b8a9d6d004ebb8d9ac25462355c78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Cytoskeletal Proteins
107 rdf:type schema:DefinedTerm
108 N286ea4fa9e0e4515809d10bbfdd8ad73 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N2d289a7eb4ff4701b1165861f40deae2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Apoptosis
112 rdf:type schema:DefinedTerm
113 N35356355cec545e8bcd9127a0fbecf83 rdf:first sg:person.0615010501.36
114 rdf:rest N506703b3b84941059588b20d2ef77b2e
115 N373b592fe5c241eb92f091cdda854362 schema:name readcube_id
116 schema:value fee91335642fce0f9d9ba733d64ad2b115999bdfbbe99b61268e622f93d685a0
117 rdf:type schema:PropertyValue
118 N38acc6de5de34686a1284444d1f0630e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Age Factors
120 rdf:type schema:DefinedTerm
121 N3eaf664f0d7b48f59af540fcd8930f1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Proliferating Cell Nuclear Antigen
123 rdf:type schema:DefinedTerm
124 N4a8d69dfc7d44ca8a29e7d79bf466e3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Cell Proliferation
126 rdf:type schema:DefinedTerm
127 N4f9a5d9abe3a48c28b7a2e5a0dbcfcc0 schema:issueNumber 1
128 rdf:type schema:PublicationIssue
129 N506703b3b84941059588b20d2ef77b2e rdf:first sg:person.0770705436.71
130 rdf:rest N974a4fc06e364a71a1f76786a4a66ad2
131 N64e52e8d29c742a1a59ff21f4af7acbc rdf:first sg:person.01055675151.61
132 rdf:rest rdf:nil
133 N6542796ecdc547a38286d0f584429cd5 rdf:first sg:person.01233546434.23
134 rdf:rest N64e52e8d29c742a1a59ff21f4af7acbc
135 N6cf57d7a9c58473a968e7fe132d24f73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name T-Box Domain Proteins
137 rdf:type schema:DefinedTerm
138 N6d11420ac0fb468ba9c20d287675b295 schema:volumeNumber 32
139 rdf:type schema:PublicationVolume
140 N6f1050c200b648998e1f5fce77bdc71c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Dentate Gyrus
142 rdf:type schema:DefinedTerm
143 N6ff9b2ffa7c84057bd461a05f2008f5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Expression Regulation, Developmental
145 rdf:type schema:DefinedTerm
146 N853c03214d02493ead7464687dbcc737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Body Weight
148 rdf:type schema:DefinedTerm
149 N88c3e9082988494eb1632d9a6884c9b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Fatty Acid-Binding Protein 7
151 rdf:type schema:DefinedTerm
152 N8aaba7370400411492209e80168ae97b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Animals, Newborn
154 rdf:type schema:DefinedTerm
155 N8f9cf3cc3db44b9b80b809f04a7b477f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Necrosis
157 rdf:type schema:DefinedTerm
158 N974a4fc06e364a71a1f76786a4a66ad2 rdf:first sg:person.0727004747.35
159 rdf:rest Nb83f2c04ca994b96856fc2738daa10fb
160 N99ef4a9c958942bd8dbf1d97e8869d03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Mice, Inbred ICR
162 rdf:type schema:DefinedTerm
163 Nb3b40fa3fa5148018d763118fe7bd29b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Nerve Tissue Proteins
165 rdf:type schema:DefinedTerm
166 Nb82efff6fa6c4a7bbd9af7a4b924f854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Mice
168 rdf:type schema:DefinedTerm
169 Nb83f2c04ca994b96856fc2738daa10fb rdf:first sg:person.0706160162.51
170 rdf:rest Nffc73ce48dab429e850c852e90c653ab
171 Nbc8ff5be52aa4b33a8f667aaac683a4f schema:name nlm_unique_id
172 schema:value 100929017
173 rdf:type schema:PropertyValue
174 Nc3b205f769bc4d7ea8ad0c7b6fb162b2 schema:name dimensions_id
175 schema:value pub.1083688008
176 rdf:type schema:PropertyValue
177 Nc690f86dcc6e415b9b047e7f4219a1d5 schema:name pubmed_id
178 schema:value 28168441
179 rdf:type schema:PropertyValue
180 Nc877b2ce4f2e4c45a227c96f8ef9991d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Embryo, Mammalian
182 rdf:type schema:DefinedTerm
183 Nd8d2d8afeb96437d8ae88f94ab1152c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Nitriles
185 rdf:type schema:DefinedTerm
186 Nddf6f9b2301d488aad3168750cf5895d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Neurogenesis
188 rdf:type schema:DefinedTerm
189 Ne6af4d12d7be498a9d778cf17e660966 schema:name doi
190 schema:value 10.1007/s12640-017-9703-3
191 rdf:type schema:PropertyValue
192 Nf437d976c38145a5a7e1334c776eb75b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Animals
194 rdf:type schema:DefinedTerm
195 Nffc73ce48dab429e850c852e90c653ab rdf:first sg:person.01367127434.32
196 rdf:rest N6542796ecdc547a38286d0f584429cd5
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
201 schema:name Neurosciences
202 rdf:type schema:DefinedTerm
203 sg:grant.6106978 http://pending.schema.org/fundedItem sg:pub.10.1007/s12640-017-9703-3
204 rdf:type schema:MonetaryGrant
205 sg:journal.1022448 schema:issn 1029-8428
206 1476-3524
207 schema:name Neurotoxicity Research
208 rdf:type schema:Periodical
209 sg:person.01055675151.61 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
210 schema:familyName Shibutani
211 schema:givenName Makoto
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055675151.61
213 rdf:type schema:Person
214 sg:person.01233546434.23 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
215 schema:familyName Yoshida
216 schema:givenName Toshinori
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233546434.23
218 rdf:type schema:Person
219 sg:person.01367127434.32 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
220 schema:familyName Itahashi
221 schema:givenName Megu
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367127434.32
223 rdf:type schema:Person
224 sg:person.0615010501.36 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
225 schema:familyName Hasegawa-Baba
226 schema:givenName Yasuko
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615010501.36
228 rdf:type schema:Person
229 sg:person.0706160162.51 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
230 schema:familyName Wang
231 schema:givenName Liyun
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706160162.51
233 rdf:type schema:Person
234 sg:person.0727004747.35 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
235 schema:familyName Watanabe
236 schema:givenName Yousuke
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727004747.35
238 rdf:type schema:Person
239 sg:person.0770705436.71 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
240 schema:familyName Tanaka
241 schema:givenName Takeshi
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770705436.71
243 rdf:type schema:Person
244 sg:pub.10.1007/s00204-012-0801-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1004115330
245 https://doi.org/10.1007/s00204-012-0801-y
246 rdf:type schema:CreativeWork
247 sg:pub.10.1007/s12035-011-8207-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1012670579
248 https://doi.org/10.1007/s12035-011-8207-z
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nature02553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042390930
251 https://doi.org/10.1038/nature02553
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/ncomms1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022919518
254 https://doi.org/10.1038/ncomms1670
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1052326210
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1002/glia.20407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024407396
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/hipo.10010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013915477
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/hipo.22225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033306778
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/jat.3086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046059417
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/syn.21683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048282788
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/0006-8993(92)90553-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1029786372
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/0028-3908(95)00109-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1051808483
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/0306-3623(81)90108-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018583885
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/0378-5955(93)90111-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1038899242
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/0378-5955(94)90104-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034225593
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.biopsych.2012.10.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007048839
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.neulet.2005.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015114205
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.psyneuen.2014.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023726781
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.reprotox.2010.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017399859
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.reprotox.2012.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035112602
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.reprotox.2012.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053296689
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.reprotox.2013.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007057058
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.tins.2004.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040177859
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.yfrne.2009.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036842251
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s0079-6123(08)61304-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009317356
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0306-4522(97)00261-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027696071
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1073/pnas.92.12.5734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037219839
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1073/pnas.93.5.1808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011350345
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/cercor/bht035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030441417
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/toxsci/kfs110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030555567
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1093/toxsci/kft092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047308024
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1097/00005072-198001000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016058304
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1101/lm.33900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000407619
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1111/gbb.12065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042027967
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1111/j.0953-816x.2004.03327.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041632743
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1152/jn.00287.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035881637
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1152/jn.2001.85.6.2423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074829027
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1152/physrev.00004.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036073633
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1155/2012/382107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033077574
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1172/jci15251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415350
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1172/jci20001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416520
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1371/journal.pone.0053569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020694006
333 rdf:type schema:CreativeWork
334 https://doi.org/10.14252/foodsafetyfscj.2014038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017314614
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1523/jneurosci.1768-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026701173
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1523/jneurosci.1811-14.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032039935
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1523/jneurosci.3111-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049685387
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1523/jneurosci.4280-07.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030862841
343 rdf:type schema:CreativeWork
344 https://doi.org/10.2131/jts.38.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018925108
345 rdf:type schema:CreativeWork
346 https://doi.org/10.3389/fendo.2011.00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021686876
347 rdf:type schema:CreativeWork
348 https://doi.org/10.3389/fncel.2014.00166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004908562
349 rdf:type schema:CreativeWork
350 https://doi.org/10.3389/fncel.2015.00095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043977209
351 rdf:type schema:CreativeWork
352 https://doi.org/10.5114/aoms.2015.54871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079173510
353 rdf:type schema:CreativeWork
354 https://www.grid.ac/institutes/grid.136594.c schema:alternateName Tokyo University of Agriculture and Technology
355 schema:name Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.256342.4 schema:alternateName Gifu University
358 schema:name Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, 183-8509, Tokyo, Japan
359 Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu-shi, 501-1193, Gifu, Japan
360 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...