Cytotoxic Effects of Environmental Toxins on Human Glial Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02

AUTHORS

Fiona D‘Mello, Nady Braidy, Helder Marçal, Gilles Guillemin, Fanny Rossi, Mirielle Chinian, Dominique Laurent, Charles Teo, Brett A. Neilan

ABSTRACT

Toxins produced by cyanobacteria and dinoflagellates have increasingly become a public health concern due to their degenerative effects on mammalian tissue and cells. In particular, emerging evidence has called attention to the neurodegenerative effects of the cyanobacterial toxin β-N-methylamino-L-alanine (BMAA). Other toxins such as the neurotoxins saxitoxin and ciguatoxin, as well as the hepatotoxic microcystin, have been previously shown to have a range of effects upon the nervous system. However, the capacity of these toxins to cause neurodegeneration in human cells has not, to our knowledge, been previously investigated. This study aimed to examine the cytotoxic effects of BMAA, microcystin-LR (MC-LR), saxitoxin (STX) and ciguatoxin (CTX-1B) on primary adult human astrocytes. We also demonstrated that α-lipoate attenuated MC-LR toxicity in primary astrocytes and characterised changes in gene expression which could potentially be caused by these toxins in primary astrocytes. Herein, we are the first to show that all of these toxins are capable of causing physiological changes consistent with neurodegeneration in glial cells, via oxidative stress and excitotoxicity, leading to a reduction in cell proliferation culminating in cell death. In addition, MC-LR toxicity was reduced significantly in astrocytes-treated α-lipoic acid. While there were no significant changes in gene expression, many of the probes that were altered were associated with neurodegenerative disease pathogenesis. Overall, this is important in advancing our current understanding of the mechanism of toxicity of MC-LR on human brain function in vitro, particularly in the context of neurodegeneration. More... »

PAGES

245-258

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12640-016-9678-5

DOI

http://dx.doi.org/10.1007/s12640-016-9678-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010246211

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27796937


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