Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01

AUTHORS

Yousuke Watanabe, Tomoaki Murakami, Masashi Kawashima, Yasuko Hasegawa-Baba, Sayaka Mizukami, Nobuya Imatanaka, Yumi Akahori, Toshinori Yoshida, Makoto Shibutani

ABSTRACT

Valproic acid (VPA) is used to establish models of experimental autism. The present study investigated the developmental exposure effect of VPA on postnatal hippocampal neurogenesis in accordance with the exposure scheme of OECD Test Guideline 426 adopted for developmental neurotoxicity. Pregnant rats were administered drinking water containing 0, 667, or 2000 ppm VPA from gestational day 6 until day 21 post-delivery. In the subgranular zone (SGZ) and granule cell layer (GCL) of offspring, the number of granule cell lineage subpopulations remained unchanged upon weaning. However, in the hilus of the dentate gyrus, the number of reelin+ interneurons decreased at ≥667 ppm, and the number of PVALB+ or GAD67+ interneurons decreased at 2000 ppm. Conversely, Reln and Gad1 transcript levels increased at 2000 ppm, but Pvalb and Grin2d decreased, in the dentate gyrus. At the adult stage, PCNA+ proliferating SGZ cells, NeuN+ postmitotic SGZ/GCL neurons, and ARC+ or COX2+ GCL neurons increased at ≥667 ppm. In the dentate hilus, decreases in GAD67+ interneuron subpopulations and Grin2d transcript levels sustained at 2000 ppm. These results suggested that VPA primarily targets interneurons by developmental exposure, and this is followed by late effects on granule cell lineages, likely by influencing SGZ cell proliferation and synaptic plasticity. A reduced population of reelin+ or PVALB+ interneurons did not affect distribution of granule cell lineage subpopulations upon weaning. The late effect on neurogenesis, which resulted in increased GCL neurons, might be the result of a sustained decrease in GAD67+ interneurons expressing NR2D encoded by Grin2d. More... »

PAGES

46-62

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12640-016-9660-2

DOI

http://dx.doi.org/10.1007/s12640-016-9660-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021959429

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27566479


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebellar Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dentate Gyrus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drinking Water", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interneurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maternal Exposure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prenatal Exposure Delayed Effects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Random Allocation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cell Niche", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Valproic Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan", 
            "Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, 501-1193, Gifu-Shi, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Yousuke", 
        "id": "sg:person.0727004747.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727004747.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murakami", 
        "givenName": "Tomoaki", 
        "id": "sg:person.0635756642.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635756642.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawashima", 
        "givenName": "Masashi", 
        "id": "sg:person.015023035541.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015023035541.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasegawa-Baba", 
        "givenName": "Yasuko", 
        "id": "sg:person.0615010501.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615010501.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan", 
            "Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, 501-1193, Gifu-Shi, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizukami", 
        "givenName": "Sayaka", 
        "id": "sg:person.0617153567.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617153567.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chemicals Evaluation and Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418471.f", 
          "name": [
            "Chemicals Evaluation and Research Institute, Japan, 1-4-25 Koraku, 112-0004, Bunkyo-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imatanaka", 
        "givenName": "Nobuya", 
        "id": "sg:person.01002644154.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002644154.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chemicals Evaluation and Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418471.f", 
          "name": [
            "Chemicals Evaluation and Research Institute, Japan, 1-4-25 Koraku, 112-0004, Bunkyo-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akahori", 
        "givenName": "Yumi", 
        "id": "sg:person.0625335456.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625335456.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Toshinori", 
        "id": "sg:person.01233546434.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233546434.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Agriculture and Technology", 
          "id": "https://www.grid.ac/institutes/grid.136594.c", 
          "name": [
            "Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shibutani", 
        "givenName": "Makoto", 
        "id": "sg:person.01055675151.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055675151.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.stemcr.2015.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000838804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1993.tb03206.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000960319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2012.10.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007048839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.05.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007530112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12311-013-0459-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007555873", 
          "https://doi.org/10.1007/s12311-013-0459-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6123(08)61304-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009317356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2013.06.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010028125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012850894", 
          "https://doi.org/10.1038/nn.2156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1461145712001216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012904115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15622975.2015.1085597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013350279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00016489509125218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013737298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.10010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013915477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainresbull.2012.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014961202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2005.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015114205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2005.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015114205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2014.07.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015522986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2008.09.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015641211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2014.12.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016894480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2015.01.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017156742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2131/jts.38.431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018925108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019548304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019548304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijdevneu.2009.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021397424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9861(19960624)370:2<247::aid-cne8>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021821807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0892-0362(99)00083-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022497638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms1670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022919518", 
          "https://doi.org/10.1038/ncomms1670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024407396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2014.07.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027041634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1811-14.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032039935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.22225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033306778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0407643101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035479407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00287.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035881637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yfrne.2009.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036842251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.102608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038103199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039762019", 
          "https://doi.org/10.1038/nn.2447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039762019", 
          "https://doi.org/10.1038/nn.2447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2004.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040177859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.6.3221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040221269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2009.06212.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040427550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.901240303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041194014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2004.12.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042149358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/361031a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042608618", 
          "https://doi.org/10.1038/361031a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2007.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043346248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fped.2014.00070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044644479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2015.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045663321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/14734220310022289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045950258", 
          "https://doi.org/10.1080/14734220310022289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jat.3086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046059417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kft092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047308024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1996.66031240.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048539965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3111-06.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049685387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052326210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/epi.5.8.13053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072303053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.2002.87.6.2851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075061038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.15-06-04687.1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082509055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082936094", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-01", 
    "datePublishedReg": "2017-01-01", 
    "description": "Valproic acid (VPA) is used to establish models of experimental autism. The present study investigated the developmental exposure effect of VPA on postnatal hippocampal neurogenesis in accordance with the exposure scheme of OECD Test Guideline 426 adopted for developmental neurotoxicity. Pregnant rats were administered drinking water containing 0, 667, or 2000\u00a0ppm VPA from gestational day 6 until day 21 post-delivery. In the subgranular zone (SGZ) and granule cell layer (GCL) of offspring, the number of granule cell lineage subpopulations remained unchanged upon weaning. However, in the hilus of the dentate gyrus, the number of reelin+ interneurons decreased at\u00a0\u2265667\u00a0ppm, and the number of PVALB+ or GAD67+ interneurons decreased at 2000\u00a0ppm. Conversely, Reln and Gad1 transcript levels increased at 2000\u00a0ppm, but Pvalb and Grin2d decreased, in the dentate gyrus. At the adult stage, PCNA+ proliferating SGZ cells, NeuN+ postmitotic SGZ/GCL neurons, and ARC+ or COX2+ GCL neurons increased at\u00a0\u2265667\u00a0ppm. In the dentate hilus, decreases in GAD67+ interneuron subpopulations and Grin2d transcript levels sustained at 2000\u00a0ppm. These results suggested that VPA primarily targets interneurons by developmental exposure, and this is followed by late effects on granule cell lineages, likely by influencing SGZ cell proliferation and synaptic plasticity. A reduced population of reelin+ or PVALB+ interneurons did not affect distribution of granule cell lineage subpopulations upon weaning. The late effect on neurogenesis, which resulted in increased GCL neurons, might be the result of a sustained decrease in GAD67+ interneurons expressing NR2D encoded by Grin2d.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12640-016-9660-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1022448", 
        "issn": [
          "1029-8428", 
          "1476-3524"
        ], 
        "name": "Neurotoxicity Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring", 
    "pagination": "46-62", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "689e5202b9860e74f72da23b283fc89e2a752d602b86a2f06765f5bae47b3b2c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27566479"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100929017"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12640-016-9660-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021959429"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12640-016-9660-2", 
      "https://app.dimensions.ai/details/publication/pub.1021959429"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87088_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12640-016-9660-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12640-016-9660-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12640-016-9660-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12640-016-9660-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12640-016-9660-2'


 

This table displays all metadata directly associated to this object as RDF triples.

373 TRIPLES      21 PREDICATES      101 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12640-016-9660-2 schema:about N224da6a3a402422aa6dec283da02ede7
2 N2f0677162e0845048650796e24d8b3df
3 N3c3f2ad01805445da4caab1f7ab6df90
4 N4655cfb4e8a74a3486302da3a6036444
5 N60454a373ac944fe87b3c74ac093ed59
6 N6111379eddef447e99efe7e5da645a5e
7 N7459ecf65b30414c8440af7683843033
8 N78de58318dea4676934785399aeefe38
9 N7b5641bf296646ca9b9d7772785f618d
10 N7dd7734f5908457d81652a4233e78a53
11 N84194058052842f792259225ce2c33e9
12 N8a5c02317cf740ecb2daf3de99d5d38c
13 N92caa1d7a1834d90a37c73e8741f9e63
14 N94aabe03bed14bedb96cb55767f67f72
15 Na8508e9173fc44b8a5403a5b62b15c9f
16 Nad2140199b3244cbbbdee3f28eeeed8e
17 Nb6fe8509cec645adb7d4395a2cc6c366
18 Nd7078bcb2a0745a28077e1e2d280547b
19 Ndd014a509a934738a60eeaaea65e9486
20 anzsrc-for:11
21 anzsrc-for:1109
22 schema:author N530eec8c33fc4dd593ad148f21baf509
23 schema:citation sg:pub.10.1007/s12311-013-0459-x
24 sg:pub.10.1038/361031a0
25 sg:pub.10.1038/ncomms1670
26 sg:pub.10.1038/nn.2156
27 sg:pub.10.1038/nn.2447
28 sg:pub.10.1080/14734220310022289
29 https://app.dimensions.ai/details/publication/pub.1082936094
30 https://doi.org/10.1002/(sici)1096-9861(19960624)370:2<247::aid-cne8>3.0.co;2-2
31 https://doi.org/10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i
32 https://doi.org/10.1002/cne.901240303
33 https://doi.org/10.1002/glia.20407
34 https://doi.org/10.1002/hipo.10010
35 https://doi.org/10.1002/hipo.22225
36 https://doi.org/10.1002/jat.3086
37 https://doi.org/10.1006/meth.2001.1262
38 https://doi.org/10.1016/j.biopsych.2004.12.018
39 https://doi.org/10.1016/j.biopsych.2012.10.023
40 https://doi.org/10.1016/j.brainres.2013.06.024
41 https://doi.org/10.1016/j.brainresbull.2012.01.011
42 https://doi.org/10.1016/j.cell.2008.05.054
43 https://doi.org/10.1016/j.ijdevneu.2009.01.006
44 https://doi.org/10.1016/j.neuint.2007.05.006
45 https://doi.org/10.1016/j.neulet.2005.05.022
46 https://doi.org/10.1016/j.neulet.2014.07.031
47 https://doi.org/10.1016/j.neulet.2014.07.036
48 https://doi.org/10.1016/j.neuron.2005.08.023
49 https://doi.org/10.1016/j.neuropharm.2008.09.019
50 https://doi.org/10.1016/j.schres.2014.12.026
51 https://doi.org/10.1016/j.stemcr.2015.10.012
52 https://doi.org/10.1016/j.taap.2015.06.005
53 https://doi.org/10.1016/j.tins.2004.05.013
54 https://doi.org/10.1016/j.toxlet.2015.01.022
55 https://doi.org/10.1016/j.yfrne.2009.03.007
56 https://doi.org/10.1016/s0079-6123(08)61304-7
57 https://doi.org/10.1016/s0892-0362(99)00083-5
58 https://doi.org/10.1017/s1461145712001216
59 https://doi.org/10.1046/j.1471-4159.1996.66031240.x
60 https://doi.org/10.1073/pnas.0407643101
61 https://doi.org/10.1073/pnas.95.6.3221
62 https://doi.org/10.1093/toxsci/kft092
63 https://doi.org/10.1111/j.1471-4159.1993.tb03206.x
64 https://doi.org/10.1111/j.1471-4159.2009.06212.x
65 https://doi.org/10.1152/jn.00287.2010
66 https://doi.org/10.1152/jn.2002.87.6.2851
67 https://doi.org/10.1242/dev.102608
68 https://doi.org/10.1523/jneurosci.15-06-04687.1995
69 https://doi.org/10.1523/jneurosci.1811-14.2014
70 https://doi.org/10.1523/jneurosci.3111-06.2007
71 https://doi.org/10.2131/jts.38.431
72 https://doi.org/10.3109/00016489509125218
73 https://doi.org/10.3109/15622975.2015.1085597
74 https://doi.org/10.3389/fped.2014.00070
75 https://doi.org/10.4161/epi.5.8.13053
76 schema:datePublished 2017-01
77 schema:datePublishedReg 2017-01-01
78 schema:description Valproic acid (VPA) is used to establish models of experimental autism. The present study investigated the developmental exposure effect of VPA on postnatal hippocampal neurogenesis in accordance with the exposure scheme of OECD Test Guideline 426 adopted for developmental neurotoxicity. Pregnant rats were administered drinking water containing 0, 667, or 2000 ppm VPA from gestational day 6 until day 21 post-delivery. In the subgranular zone (SGZ) and granule cell layer (GCL) of offspring, the number of granule cell lineage subpopulations remained unchanged upon weaning. However, in the hilus of the dentate gyrus, the number of reelin<sup>+</sup> interneurons decreased at ≥667 ppm, and the number of PVALB<sup>+</sup> or GAD67<sup>+</sup> interneurons decreased at 2000 ppm. Conversely, Reln and Gad1 transcript levels increased at 2000 ppm, but Pvalb and Grin2d decreased, in the dentate gyrus. At the adult stage, PCNA<sup>+</sup> proliferating SGZ cells, NeuN<sup>+</sup> postmitotic SGZ/GCL neurons, and ARC<sup>+</sup> or COX2<sup>+</sup> GCL neurons increased at ≥667 ppm. In the dentate hilus, decreases in GAD67<sup>+</sup> interneuron subpopulations and Grin2d transcript levels sustained at 2000 ppm. These results suggested that VPA primarily targets interneurons by developmental exposure, and this is followed by late effects on granule cell lineages, likely by influencing SGZ cell proliferation and synaptic plasticity. A reduced population of reelin<sup>+</sup> or PVALB<sup>+</sup> interneurons did not affect distribution of granule cell lineage subpopulations upon weaning. The late effect on neurogenesis, which resulted in increased GCL neurons, might be the result of a sustained decrease in GAD67<sup>+</sup> interneurons expressing NR2D encoded by Grin2d.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree false
82 schema:isPartOf N1b2241c2895348829c97ea3b2d7f72e2
83 Na56ce0548b964a21a773c07ace063c21
84 sg:journal.1022448
85 schema:name Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring
86 schema:pagination 46-62
87 schema:productId N2637b0b70bc940b7a5453987934e7c6d
88 N30fd7227641f4b7eb717a82e3a7d2d99
89 N923f9f9cd68641859eacd2d1c3625f14
90 Nd426e3f58c884141bf4e80ab33d0c759
91 Ne3bc014d69eb46a8ad27fc9d442a7cbd
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021959429
93 https://doi.org/10.1007/s12640-016-9660-2
94 schema:sdDatePublished 2019-04-11T12:22
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N12930bde4d81424091130ae202dcb449
97 schema:url https://link.springer.com/10.1007%2Fs12640-016-9660-2
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N12930bde4d81424091130ae202dcb449 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N1b2241c2895348829c97ea3b2d7f72e2 schema:issueNumber 1
104 rdf:type schema:PublicationIssue
105 N224da6a3a402422aa6dec283da02ede7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Drinking Water
107 rdf:type schema:DefinedTerm
108 N2637b0b70bc940b7a5453987934e7c6d schema:name pubmed_id
109 schema:value 27566479
110 rdf:type schema:PropertyValue
111 N2f0677162e0845048650796e24d8b3df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Valproic Acid
113 rdf:type schema:DefinedTerm
114 N30fd7227641f4b7eb717a82e3a7d2d99 schema:name nlm_unique_id
115 schema:value 100929017
116 rdf:type schema:PropertyValue
117 N3bb0fd46027e4fc093682efaadcb8684 rdf:first sg:person.01055675151.61
118 rdf:rest rdf:nil
119 N3c3f2ad01805445da4caab1f7ab6df90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cell Movement
121 rdf:type schema:DefinedTerm
122 N4655cfb4e8a74a3486302da3a6036444 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Neurogenesis
124 rdf:type schema:DefinedTerm
125 N530eec8c33fc4dd593ad148f21baf509 rdf:first sg:person.0727004747.35
126 rdf:rest Nb69e2ef8624a45e9bd64fc8fd3864e85
127 N60076cbec4e441408caaf518b7c935fe rdf:first sg:person.0617153567.04
128 rdf:rest Nde063e001b024f62aa0e5d119c30c6ad
129 N60454a373ac944fe87b3c74ac093ed59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cerebellar Cortex
131 rdf:type schema:DefinedTerm
132 N6111379eddef447e99efe7e5da645a5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Pregnancy
134 rdf:type schema:DefinedTerm
135 N625f4687b5a946358bce577f7e4c9c80 rdf:first sg:person.0615010501.36
136 rdf:rest N60076cbec4e441408caaf518b7c935fe
137 N70f7b217cf7c484b90d006686d39e3c9 rdf:first sg:person.015023035541.05
138 rdf:rest N625f4687b5a946358bce577f7e4c9c80
139 N7459ecf65b30414c8440af7683843033 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Interneurons
141 rdf:type schema:DefinedTerm
142 N78de58318dea4676934785399aeefe38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Male
144 rdf:type schema:DefinedTerm
145 N7b5641bf296646ca9b9d7772785f618d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cerebral Cortex
147 rdf:type schema:DefinedTerm
148 N7dd7734f5908457d81652a4233e78a53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Maternal Exposure
150 rdf:type schema:DefinedTerm
151 N84194058052842f792259225ce2c33e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Animals
153 rdf:type schema:DefinedTerm
154 N8a5c02317cf740ecb2daf3de99d5d38c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Dentate Gyrus
156 rdf:type schema:DefinedTerm
157 N923f9f9cd68641859eacd2d1c3625f14 schema:name doi
158 schema:value 10.1007/s12640-016-9660-2
159 rdf:type schema:PropertyValue
160 N92caa1d7a1834d90a37c73e8741f9e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Rats
162 rdf:type schema:DefinedTerm
163 N94aabe03bed14bedb96cb55767f67f72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Prenatal Exposure Delayed Effects
165 rdf:type schema:DefinedTerm
166 Na56ce0548b964a21a773c07ace063c21 schema:volumeNumber 31
167 rdf:type schema:PublicationVolume
168 Na8508e9173fc44b8a5403a5b62b15c9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Apoptosis
170 rdf:type schema:DefinedTerm
171 Nad2140199b3244cbbbdee3f28eeeed8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Female
173 rdf:type schema:DefinedTerm
174 Nb69e2ef8624a45e9bd64fc8fd3864e85 rdf:first sg:person.0635756642.08
175 rdf:rest N70f7b217cf7c484b90d006686d39e3c9
176 Nb6fe8509cec645adb7d4395a2cc6c366 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Disease Models, Animal
178 rdf:type schema:DefinedTerm
179 Nbe716c889d7040d1b86e772ba2462519 rdf:first sg:person.01233546434.23
180 rdf:rest N3bb0fd46027e4fc093682efaadcb8684
181 Nc29f9a35bded486fa3557618839e0a75 rdf:first sg:person.0625335456.13
182 rdf:rest Nbe716c889d7040d1b86e772ba2462519
183 Nd426e3f58c884141bf4e80ab33d0c759 schema:name readcube_id
184 schema:value 689e5202b9860e74f72da23b283fc89e2a752d602b86a2f06765f5bae47b3b2c
185 rdf:type schema:PropertyValue
186 Nd7078bcb2a0745a28077e1e2d280547b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Random Allocation
188 rdf:type schema:DefinedTerm
189 Ndd014a509a934738a60eeaaea65e9486 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Stem Cell Niche
191 rdf:type schema:DefinedTerm
192 Nde063e001b024f62aa0e5d119c30c6ad rdf:first sg:person.01002644154.32
193 rdf:rest Nc29f9a35bded486fa3557618839e0a75
194 Ne3bc014d69eb46a8ad27fc9d442a7cbd schema:name dimensions_id
195 schema:value pub.1021959429
196 rdf:type schema:PropertyValue
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
201 schema:name Neurosciences
202 rdf:type schema:DefinedTerm
203 sg:journal.1022448 schema:issn 1029-8428
204 1476-3524
205 schema:name Neurotoxicity Research
206 rdf:type schema:Periodical
207 sg:person.01002644154.32 schema:affiliation https://www.grid.ac/institutes/grid.418471.f
208 schema:familyName Imatanaka
209 schema:givenName Nobuya
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002644154.32
211 rdf:type schema:Person
212 sg:person.01055675151.61 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
213 schema:familyName Shibutani
214 schema:givenName Makoto
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055675151.61
216 rdf:type schema:Person
217 sg:person.01233546434.23 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
218 schema:familyName Yoshida
219 schema:givenName Toshinori
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233546434.23
221 rdf:type schema:Person
222 sg:person.015023035541.05 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
223 schema:familyName Kawashima
224 schema:givenName Masashi
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015023035541.05
226 rdf:type schema:Person
227 sg:person.0615010501.36 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
228 schema:familyName Hasegawa-Baba
229 schema:givenName Yasuko
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615010501.36
231 rdf:type schema:Person
232 sg:person.0617153567.04 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
233 schema:familyName Mizukami
234 schema:givenName Sayaka
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617153567.04
236 rdf:type schema:Person
237 sg:person.0625335456.13 schema:affiliation https://www.grid.ac/institutes/grid.418471.f
238 schema:familyName Akahori
239 schema:givenName Yumi
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625335456.13
241 rdf:type schema:Person
242 sg:person.0635756642.08 schema:affiliation https://www.grid.ac/institutes/grid.136594.c
243 schema:familyName Murakami
244 schema:givenName Tomoaki
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635756642.08
246 rdf:type schema:Person
247 sg:person.0727004747.35 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
248 schema:familyName Watanabe
249 schema:givenName Yousuke
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727004747.35
251 rdf:type schema:Person
252 sg:pub.10.1007/s12311-013-0459-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007555873
253 https://doi.org/10.1007/s12311-013-0459-x
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/361031a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042608618
256 https://doi.org/10.1038/361031a0
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/ncomms1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022919518
259 https://doi.org/10.1038/ncomms1670
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nn.2156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012850894
262 https://doi.org/10.1038/nn.2156
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/nn.2447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039762019
265 https://doi.org/10.1038/nn.2447
266 rdf:type schema:CreativeWork
267 sg:pub.10.1080/14734220310022289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045950258
268 https://doi.org/10.1080/14734220310022289
269 rdf:type schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1082936094 schema:CreativeWork
271 https://doi.org/10.1002/(sici)1096-9861(19960624)370:2<247::aid-cne8>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021821807
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1052326210
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/cne.901240303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041194014
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/glia.20407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024407396
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/hipo.10010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013915477
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/hipo.22225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033306778
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1002/jat.3086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046059417
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.biopsych.2004.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042149358
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.biopsych.2012.10.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007048839
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.brainres.2013.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010028125
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.brainresbull.2012.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014961202
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.cell.2008.05.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007530112
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.ijdevneu.2009.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021397424
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.neuint.2007.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043346248
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.neulet.2005.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015114205
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.neulet.2014.07.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027041634
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.neulet.2014.07.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015522986
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.neuron.2005.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019548304
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.neuropharm.2008.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015641211
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.schres.2014.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016894480
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.stemcr.2015.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000838804
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.taap.2015.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045663321
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.tins.2004.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040177859
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.toxlet.2015.01.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017156742
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.yfrne.2009.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036842251
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0079-6123(08)61304-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009317356
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0892-0362(99)00083-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022497638
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1017/s1461145712001216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012904115
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1046/j.1471-4159.1996.66031240.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048539965
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1073/pnas.0407643101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035479407
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1073/pnas.95.6.3221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040221269
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/toxsci/kft092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047308024
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1471-4159.1993.tb03206.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000960319
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1111/j.1471-4159.2009.06212.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040427550
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1152/jn.00287.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035881637
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1152/jn.2002.87.6.2851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075061038
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1242/dev.102608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038103199
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1523/jneurosci.15-06-04687.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082509055
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1523/jneurosci.1811-14.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032039935
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1523/jneurosci.3111-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049685387
352 rdf:type schema:CreativeWork
353 https://doi.org/10.2131/jts.38.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018925108
354 rdf:type schema:CreativeWork
355 https://doi.org/10.3109/00016489509125218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013737298
356 rdf:type schema:CreativeWork
357 https://doi.org/10.3109/15622975.2015.1085597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013350279
358 rdf:type schema:CreativeWork
359 https://doi.org/10.3389/fped.2014.00070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044644479
360 rdf:type schema:CreativeWork
361 https://doi.org/10.4161/epi.5.8.13053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072303053
362 rdf:type schema:CreativeWork
363 https://www.grid.ac/institutes/grid.136594.c schema:alternateName Tokyo University of Agriculture and Technology
364 schema:name Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan
365 Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.256342.4 schema:alternateName Gifu University
368 schema:name Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, 183-8509, Fuchu-Shi, Tokyo, Japan
369 Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, 501-1193, Gifu-Shi, Gifu, Japan
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.418471.f schema:alternateName Chemicals Evaluation and Research Institute
372 schema:name Chemicals Evaluation and Research Institute, Japan, 1-4-25 Koraku, 112-0004, Bunkyo-Ku, Tokyo, Japan
373 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...