Effects of proNGF on Neuronal Viability, Neurite Growth and Amyloid-beta Metabolism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-08-13

AUTHORS

Yan-Jiang Wang, Deborah Valadares, Ying Sun, Xin Wang, Jin-Hua Zhong, Xiao-Hong Liu, Shohreh Majd, Li Chen, Chang-Yue Gao, Si Chen, Yoon Lim, Anthony Pollard, Ernest Aguilar, Wei-Ping Gai, Miao Yang, Xin-Fu Zhou

ABSTRACT

Alzheimer’s disease (AD) is characterized pathologically by the deposition of amyloid-β peptides (Aβ), neurofibrillary tangles, distinctive neuronal loss and neurite dystrophy. Nerve growth factor (NGF) has been suggested to be involved in the pathogenesis of AD, however, the role of its precursor (proNGF) in AD remains unknown. In this study, we investigated the effect of proNGF on neuron death, neurite growth and Aβ production, in vitro and in vivo. We found that proNGF promotes the death of different cell lines and primary neurons in culture, likely dependent on the expression of p75NTR. We for the first time found that proNGF has an opposite role in neurite growth to that of mature NGF, retarding neurite growth in both cell lines and primary neurons. proNGF is localized to the Aβ plaques in AD mice brain, however, it had no significant effect on Aβ production in vitro and in vivo. Our findings suggest that proNGF is an important factor involving AD pathogenesis. More... »

PAGES

257-267

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12640-009-9098-x

DOI

http://dx.doi.org/10.1007/s12640-009-9098-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034289949

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19680737


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33 schema:description Alzheimer’s disease (AD) is characterized pathologically by the deposition of amyloid-β peptides (Aβ), neurofibrillary tangles, distinctive neuronal loss and neurite dystrophy. Nerve growth factor (NGF) has been suggested to be involved in the pathogenesis of AD, however, the role of its precursor (proNGF) in AD remains unknown. In this study, we investigated the effect of proNGF on neuron death, neurite growth and Aβ production, in vitro and in vivo. We found that proNGF promotes the death of different cell lines and primary neurons in culture, likely dependent on the expression of p75NTR. We for the first time found that proNGF has an opposite role in neurite growth to that of mature NGF, retarding neurite growth in both cell lines and primary neurons. proNGF is localized to the Aβ plaques in AD mice brain, however, it had no significant effect on Aβ production in vitro and in vivo. Our findings suggest that proNGF is an important factor involving AD pathogenesis.
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42 Alzheimer's disease
43 Aβ plaques
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45 amyloid
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47 brain
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59 expression
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64 growth
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67 lines
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71 mouse brain
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81 p75NTR
82 pathogenesis
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84 peptides
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