Ontology type: schema:ScholarlyArticle
2009-05
AUTHORSR. S. Chung, Y. K. Leung, C. W. Butler, Y. Chen, E. D. Eaton, M. W. Pankhurst, A. K. West, G. J. Guillemin
ABSTRACTThe kynurenine pathway has been implicated as a major component of the neuroinflammatory response to brain injury and neurodegeneration. We found that the neurotoxic kynurenine pathway intermediate quinolinic acid (QUIN) is rapidly expressed, within 24 h, by reactive microglia following traumatic injury to the rodent neocortex. Furthermore, administration of the astrocytic protein metallothionein attenuated this neuroinflammatory response by reducing microglial activation (by approximately 30%) and QUIN expression. The suppressive effect of MT was confirmed upon cultured cortical microglia, with 1 mug/ml MT almost completely blocking interferon-gamma induced activation of microglia and QUIN expression. These results demonstrate the neuroimmunomodulatory properties of MT, which may have therapeutic applications for the treatment of traumatic brain injury. More... »
PAGES381-389
http://scigraph.springernature.com/pub.10.1007/s12640-009-9044-y
DOIhttp://dx.doi.org/10.1007/s12640-009-9044-y
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12640-009-9044-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12640-009-9044-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12640-009-9044-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12640-009-9044-y'
This table displays all metadata directly associated to this object as RDF triples.
320 TRIPLES
21 PREDICATES
84 URIs
41 LITERALS
29 BLANK NODES