Effect of iloprost inhalation on postoperative outcome in high-risk cardiac surgical patients: a prospective randomized-controlled multicentre trial (ILOCARD) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-12

AUTHORS

Michael Winterhalter, Steffen Rex, Christian Stoppe, Peter Kienbaum, Hans-Helge Müller, Ines Kaufmann, Hermann Kuppe, Aristidis Dongas, Bernhard Zwissler, ILOCARD Investigators

ABSTRACT

PURPOSE: Perioperative right ventricular (RV) failure due to pressure overload from pulmonary hypertension (PH) worsens postoperative outcomes after cardiac surgery. Inhaled iloprost is a potent pulmonary vasodilator improving RV performance, ameliorating myocardial and pulmonary ischemia-reperfusion injury and attenuating inflammation. We hypothesized that the prophylactic inhalation of iloprost would reduce postoperative ventilation times after cardiac surgery. METHODS: In this phase III, multicentre, randomized, double-blind, placebo-controlled trial, we randomly assigned 253 cardiac surgical patients at high risk of perioperative RV failure to the prophylactic inhalation of 20 µg iloprost or placebo before and during weaning from extracorporeal circulation. The primary endpoint was the duration of postoperative ventilation. Secondary endpoints included perioperative hemodynamics, intensive care unit and hospital length of stay, and 90-day mortality. Safety was assessed by the incidence of adverse events. RESULTS: Iloprost had no significant effect on the median [interquartile range] duration of postoperative ventilation compared with placebo (720 [470-1170] min vs 778 [541-1219] min, respectively; median decrease, 65 min; 95% confidence interval [CI], - 77 to 210; P = 0.37). While the nebulization of iloprost decreased RV afterload and improved cardiac index, major secondary endpoints were not significantly affected. Ninety-day mortality occurred in 14% of the iloprost patients compared with 14% of the placebo patients (hazard ratio, 0.97; 95% CI, 0.50 to 1.89; P = 0.93). The incidence of adverse events was comparable in both groups. CONCLUSIONS: The prophylactic inhalation of iloprost did not meaningfully improve the outcome in high-risk cardiac surgical patients. TRIAL REGISTRATION: www.clinicaltrials.gov (NCT00927654); registered 25 June, 2009. More... »

PAGES

1-14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12630-019-01309-8

DOI

http://dx.doi.org/10.1007/s12630-019-01309-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112089398

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30756339


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "D\u00fcsseldorf University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.14778.3d", 
          "name": [
            "Klinik f\u00fcr An\u00e4sthesiologie und Schmerztherapie, Klinikum Bremen-Mitte gGmbH, Bremen, Germany", 
            "Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winterhalter", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Anesthesiology & Department of Cardiovascular Sciences, University Hospitals Leuven, KU Leuven, Herestraat 49, 3000, Leuven, Belgium", 
            "Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4tsklinikum der RWTH Aachen, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rex", 
        "givenName": "Steffen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4tsklinikum der RWTH Aachen, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stoppe", 
        "givenName": "Christian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00fcsseldorf University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.14778.3d", 
          "name": [
            "Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kienbaum", 
        "givenName": "Peter", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Philipp University of Marburg", 
          "id": "https://www.grid.ac/institutes/grid.10253.35", 
          "name": [
            "Klinische Forschung, IBE - Institut f\u00fcr Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany", 
            "Institut f\u00fcr Medizinische Biometrie und Epidemiologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "Hans-Helge", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St\u00e4dtisches Klinikum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.419595.5", 
          "name": [
            "Klinik f\u00fcr An\u00e4sthesiologie, LMU Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany", 
            "Klinik f\u00fcr An\u00e4sthesiologie, Operative Intensivmedizin und Schmerztherapie, St\u00e4dtisches Klinikum M\u00fcnchen, Neuperlach, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaufmann", 
        "givenName": "Ines", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Deutsches Herzzentrum Berlin", 
          "id": "https://www.grid.ac/institutes/grid.418209.6", 
          "name": [
            "Institut f\u00fcr An\u00e4sthesiologie, Deutsches Herzzentrum Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuppe", 
        "givenName": "Hermann", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evangelisches Krankenhaus Bielefeld", 
          "id": "https://www.grid.ac/institutes/grid.414649.a", 
          "name": [
            "Institut f\u00fcr An\u00e4sthesiologie, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Bad Oeynhausen, Germany", 
            "Klinik f\u00fcr An\u00e4sthesiologie und operative Intensivmedizin, Franziskus Hospital Bielefeld, Bielefeld, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dongas", 
        "givenName": "Aristidis", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum der Universit\u00e4t M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.411095.8", 
          "name": [
            "Klinik f\u00fcr An\u00e4sthesiologie, LMU Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zwissler", 
        "givenName": "Bernhard", 
        "type": "Person"
      }, 
      {
        "familyName": "ILOCARD Investigators", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jtcvs.2011.02.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001555149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.006974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003889260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.006974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003889260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.006974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003889260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.jvca.2013.01.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004085692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bmc.3123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005581464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-002-1445-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005970471", 
          "https://doi.org/10.1007/s00134-002-1445-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc4301.098058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006793042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000056104.49686.4b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007031194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc7005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007787080", 
          "https://doi.org/10.1186/cc7005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc7005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007787080", 
          "https://doi.org/10.1186/cc7005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/679725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012947274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/679725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012947274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12630-016-0709-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014033475", 
          "https://doi.org/10.1007/s12630-016-0709-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12630-016-0709-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014033475", 
          "https://doi.org/10.1007/s12630-016-0709-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200309000-00033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015101812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200309000-00033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015101812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-016-1570-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015411986", 
          "https://doi.org/10.1186/s13054-016-1570-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-016-1570-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015411986", 
          "https://doi.org/10.1186/s13054-016-1570-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.healun.2014.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016342107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.1987.tb11367.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017147249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.prostaglandins.2006.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017261435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340050044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020259954", 
          "https://doi.org/10.1007/s001340050044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000156792.40298.5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022362214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000156792.40298.5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022362214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.90.6.2780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023663603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa020204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024765279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(99)00494-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026367884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/aei027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027768538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.jvca.2007.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030276335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-6576.2007.01476.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031829166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtcvs.2016.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032164335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ctr.12577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032876962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ejhf.478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035131574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jcan.2000.9451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037124579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.24017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037501736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.healun.2004.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037952659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.healun.2004.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037952659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.124.4.1294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041254242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.124.4.1294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041254242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aco.0000000000000310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041622390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aco.0000000000000310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041622390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aco.0000000000000310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041622390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0831-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043557714", 
          "https://doi.org/10.1007/s00134-007-0831-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0831-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043557714", 
          "https://doi.org/10.1007/s00134-007-0831-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mtc.2003.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045804337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mtc.2003.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045804337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-003-1891-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049177858", 
          "https://doi.org/10.1007/s00134-003-1891-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753465815599345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053951603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753465815599345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053951603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199902000-00041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060173886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199902000-00041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060173886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199902000-00041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060173886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th10-07-0499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063292507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/ane.0000000000002138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085964924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/ane.0000000000002138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085964924"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-12", 
    "datePublishedReg": "2019-02-12", 
    "description": "PURPOSE: Perioperative right ventricular (RV) failure due to pressure overload from pulmonary hypertension (PH) worsens postoperative outcomes after cardiac surgery. Inhaled iloprost is a potent pulmonary vasodilator improving RV performance, ameliorating myocardial and pulmonary ischemia-reperfusion injury and attenuating inflammation. We hypothesized that the prophylactic inhalation of iloprost would reduce postoperative ventilation times after cardiac surgery.\nMETHODS: In this phase III, multicentre, randomized, double-blind, placebo-controlled trial, we randomly assigned 253 cardiac surgical patients at high risk of perioperative RV failure to the prophylactic inhalation of 20 \u00b5g iloprost or placebo before and during weaning from extracorporeal circulation. The primary endpoint was the duration of postoperative ventilation. Secondary endpoints included perioperative hemodynamics, intensive care unit and hospital length of stay, and 90-day mortality. Safety was assessed by the incidence of adverse events.\nRESULTS: Iloprost had no significant effect on the median [interquartile range] duration of postoperative ventilation compared with placebo (720 [470-1170] min vs 778 [541-1219] min, respectively; median decrease, 65 min; 95% confidence interval [CI], -\u200977 to 210; P = 0.37). While the nebulization of iloprost decreased RV afterload and improved cardiac index, major secondary endpoints were not significantly affected. Ninety-day mortality occurred in 14% of the iloprost patients compared with 14% of the placebo patients (hazard ratio, 0.97; 95% CI, 0.50 to 1.89; P = 0.93). The incidence of adverse events was comparable in both groups.\nCONCLUSIONS: The prophylactic inhalation of iloprost did not meaningfully improve the outcome in high-risk cardiac surgical patients.\nTRIAL REGISTRATION: www.clinicaltrials.gov (NCT00927654); registered 25 June, 2009.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12630-019-01309-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017152", 
        "issn": [
          "0832-610X", 
          "1496-8975"
        ], 
        "name": "Journal canadien d'anesth\u00e9sie", 
        "type": "Periodical"
      }
    ], 
    "name": "Effect of iloprost inhalation on postoperative outcome in high-risk cardiac surgical patients: a prospective randomized-controlled multicentre trial (ILOCARD)", 
    "pagination": "1-14", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "615ed2f11fe725d0a4c42076a8132f9f7b5f24da61f12d19e4bef1bc726510b6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30756339"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8701709"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12630-019-01309-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112089398"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12630-019-01309-8", 
      "https://app.dimensions.ai/details/publication/pub.1112089398"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000335_0000000335/records_125267_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12630-019-01309-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12630-019-01309-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12630-019-01309-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12630-019-01309-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12630-019-01309-8'


 

This table displays all metadata directly associated to this object as RDF triples.

258 TRIPLES      21 PREDICATES      64 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12630-019-01309-8 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N58ccc12512344999b3d988c0264fd859
4 schema:citation sg:pub.10.1007/s00134-002-1445-9
5 sg:pub.10.1007/s00134-003-1891-z
6 sg:pub.10.1007/s00134-007-0831-8
7 sg:pub.10.1007/s001340050044
8 sg:pub.10.1007/s12630-016-0709-8
9 sg:pub.10.1186/cc7005
10 sg:pub.10.1186/s13054-016-1570-4
11 https://doi.org/10.1002/ajh.24017
12 https://doi.org/10.1002/bmc.3123
13 https://doi.org/10.1002/ejhf.478
14 https://doi.org/10.1016/j.healun.2004.11.014
15 https://doi.org/10.1016/j.healun.2014.04.010
16 https://doi.org/10.1016/j.jtcvs.2011.02.028
17 https://doi.org/10.1016/j.jtcvs.2016.08.020
18 https://doi.org/10.1016/j.prostaglandins.2006.12.004
19 https://doi.org/10.1016/s0735-1097(99)00494-5
20 https://doi.org/10.1053/j.jvca.2007.10.015
21 https://doi.org/10.1053/j.jvca.2013.01.023
22 https://doi.org/10.1053/jcan.2000.9451
23 https://doi.org/10.1056/nejmoa020204
24 https://doi.org/10.1067/mtc.2003.107
25 https://doi.org/10.1086/679725
26 https://doi.org/10.1093/bja/aei027
27 https://doi.org/10.1097/00000542-200309000-00033
28 https://doi.org/10.1097/00003246-199902000-00041
29 https://doi.org/10.1097/01.ccm.0000156792.40298.5a
30 https://doi.org/10.1097/aco.0000000000000310
31 https://doi.org/10.1111/ctr.12577
32 https://doi.org/10.1111/j.1399-6576.2007.01476.x
33 https://doi.org/10.1111/j.1476-5381.1987.tb11367.x
34 https://doi.org/10.1160/th10-07-0499
35 https://doi.org/10.1161/01.cir.0000056104.49686.4b
36 https://doi.org/10.1161/01.cir.90.6.2780
37 https://doi.org/10.1161/circulationaha.114.006974
38 https://doi.org/10.1161/hc4301.098058
39 https://doi.org/10.1177/1753465815599345
40 https://doi.org/10.1213/ane.0000000000002138
41 https://doi.org/10.1378/chest.124.4.1294
42 schema:datePublished 2019-02-12
43 schema:datePublishedReg 2019-02-12
44 schema:description PURPOSE: Perioperative right ventricular (RV) failure due to pressure overload from pulmonary hypertension (PH) worsens postoperative outcomes after cardiac surgery. Inhaled iloprost is a potent pulmonary vasodilator improving RV performance, ameliorating myocardial and pulmonary ischemia-reperfusion injury and attenuating inflammation. We hypothesized that the prophylactic inhalation of iloprost would reduce postoperative ventilation times after cardiac surgery. METHODS: In this phase III, multicentre, randomized, double-blind, placebo-controlled trial, we randomly assigned 253 cardiac surgical patients at high risk of perioperative RV failure to the prophylactic inhalation of 20 µg iloprost or placebo before and during weaning from extracorporeal circulation. The primary endpoint was the duration of postoperative ventilation. Secondary endpoints included perioperative hemodynamics, intensive care unit and hospital length of stay, and 90-day mortality. Safety was assessed by the incidence of adverse events. RESULTS: Iloprost had no significant effect on the median [interquartile range] duration of postoperative ventilation compared with placebo (720 [470-1170] min vs 778 [541-1219] min, respectively; median decrease, 65 min; 95% confidence interval [CI], - 77 to 210; P = 0.37). While the nebulization of iloprost decreased RV afterload and improved cardiac index, major secondary endpoints were not significantly affected. Ninety-day mortality occurred in 14% of the iloprost patients compared with 14% of the placebo patients (hazard ratio, 0.97; 95% CI, 0.50 to 1.89; P = 0.93). The incidence of adverse events was comparable in both groups. CONCLUSIONS: The prophylactic inhalation of iloprost did not meaningfully improve the outcome in high-risk cardiac surgical patients. TRIAL REGISTRATION: www.clinicaltrials.gov (NCT00927654); registered 25 June, 2009.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf sg:journal.1017152
49 schema:name Effect of iloprost inhalation on postoperative outcome in high-risk cardiac surgical patients: a prospective randomized-controlled multicentre trial (ILOCARD)
50 schema:pagination 1-14
51 schema:productId N1918c584e5704a91be8bda763f554930
52 N67c4be8711124c5dadedf2f69b81b911
53 Nb570e97845374db887b526d28f849552
54 Nd31c35975df5492fa75aee87be26d7aa
55 Ne66a89253fc14e969305dc912f50e19f
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112089398
57 https://doi.org/10.1007/s12630-019-01309-8
58 schema:sdDatePublished 2019-04-11T09:05
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Na8c8b5692abb4a7697e6f02390a4b619
61 schema:url https://link.springer.com/10.1007%2Fs12630-019-01309-8
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N0ccc705c365748c4b38e34663170ca6d rdf:first Nd44d7b82f1fe4b83827a9bba250e16fd
66 rdf:rest rdf:nil
67 N0f22c6c5e7db4fcdbe2bfbfc744b0e07 rdf:first Nb6e938a161b14e41a5c9597e8770c1cf
68 rdf:rest N0ccc705c365748c4b38e34663170ca6d
69 N18a089c04f5f4ec291d10034149d03f9 schema:affiliation https://www.grid.ac/institutes/grid.418209.6
70 schema:familyName Kuppe
71 schema:givenName Hermann
72 rdf:type schema:Person
73 N1918c584e5704a91be8bda763f554930 schema:name readcube_id
74 schema:value 615ed2f11fe725d0a4c42076a8132f9f7b5f24da61f12d19e4bef1bc726510b6
75 rdf:type schema:PropertyValue
76 N19d05860ebaf4ec09dd337b3100efdeb rdf:first Nf286c3aebc304bd8b84e673134f8c770
77 rdf:rest N4978be4fdff94660b080b1618d455f15
78 N1d6bb01edad6447eb793679c9c23af14 rdf:first N18a089c04f5f4ec291d10034149d03f9
79 rdf:rest Nd83cf5236e1d42ca89c516f26facd7c3
80 N3eb9f1f51d0e416a83744299018f905a rdf:first N8c565aa8fd644819b2e0550c9363e670
81 rdf:rest Nc0963c2d6bf940a5bbea45438ba31b6c
82 N468582568c2940cfb3a1986a0c9e6c5b schema:affiliation https://www.grid.ac/institutes/grid.10253.35
83 schema:familyName Müller
84 schema:givenName Hans-Helge
85 rdf:type schema:Person
86 N4978be4fdff94660b080b1618d455f15 rdf:first N468582568c2940cfb3a1986a0c9e6c5b
87 rdf:rest Nbab1ce5d5e084a6f914897d9eedef687
88 N58ccc12512344999b3d988c0264fd859 rdf:first Ncca964279fac4966a8a7766227a0424e
89 rdf:rest N3eb9f1f51d0e416a83744299018f905a
90 N5b5a173f75734aa7ae6c69cbb3097301 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
91 schema:familyName Stoppe
92 schema:givenName Christian
93 rdf:type schema:Person
94 N67c4be8711124c5dadedf2f69b81b911 schema:name nlm_unique_id
95 schema:value 8701709
96 rdf:type schema:PropertyValue
97 N72e485c45ee84b22878182f6d12fe89b schema:affiliation https://www.grid.ac/institutes/grid.414649.a
98 schema:familyName Dongas
99 schema:givenName Aristidis
100 rdf:type schema:Person
101 N8c565aa8fd644819b2e0550c9363e670 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
102 schema:familyName Rex
103 schema:givenName Steffen
104 rdf:type schema:Person
105 Na8c8b5692abb4a7697e6f02390a4b619 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 Nb570e97845374db887b526d28f849552 schema:name pubmed_id
108 schema:value 30756339
109 rdf:type schema:PropertyValue
110 Nb6e938a161b14e41a5c9597e8770c1cf schema:affiliation https://www.grid.ac/institutes/grid.411095.8
111 schema:familyName Zwissler
112 schema:givenName Bernhard
113 rdf:type schema:Person
114 Nbab1ce5d5e084a6f914897d9eedef687 rdf:first Ne7fac3b91cac4647a2fc0f37a27f8a27
115 rdf:rest N1d6bb01edad6447eb793679c9c23af14
116 Nc0963c2d6bf940a5bbea45438ba31b6c rdf:first N5b5a173f75734aa7ae6c69cbb3097301
117 rdf:rest N19d05860ebaf4ec09dd337b3100efdeb
118 Ncca964279fac4966a8a7766227a0424e schema:affiliation https://www.grid.ac/institutes/grid.14778.3d
119 schema:familyName Winterhalter
120 schema:givenName Michael
121 rdf:type schema:Person
122 Nd31c35975df5492fa75aee87be26d7aa schema:name doi
123 schema:value 10.1007/s12630-019-01309-8
124 rdf:type schema:PropertyValue
125 Nd44d7b82f1fe4b83827a9bba250e16fd schema:familyName ILOCARD Investigators
126 rdf:type schema:Person
127 Nd83cf5236e1d42ca89c516f26facd7c3 rdf:first N72e485c45ee84b22878182f6d12fe89b
128 rdf:rest N0f22c6c5e7db4fcdbe2bfbfc744b0e07
129 Ne66a89253fc14e969305dc912f50e19f schema:name dimensions_id
130 schema:value pub.1112089398
131 rdf:type schema:PropertyValue
132 Ne7fac3b91cac4647a2fc0f37a27f8a27 schema:affiliation https://www.grid.ac/institutes/grid.419595.5
133 schema:familyName Kaufmann
134 schema:givenName Ines
135 rdf:type schema:Person
136 Nf286c3aebc304bd8b84e673134f8c770 schema:affiliation https://www.grid.ac/institutes/grid.14778.3d
137 schema:familyName Kienbaum
138 schema:givenName Peter
139 rdf:type schema:Person
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
144 schema:name Clinical Sciences
145 rdf:type schema:DefinedTerm
146 sg:journal.1017152 schema:issn 0832-610X
147 1496-8975
148 schema:name Journal canadien d'anesthésie
149 rdf:type schema:Periodical
150 sg:pub.10.1007/s00134-002-1445-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005970471
151 https://doi.org/10.1007/s00134-002-1445-9
152 rdf:type schema:CreativeWork
153 sg:pub.10.1007/s00134-003-1891-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1049177858
154 https://doi.org/10.1007/s00134-003-1891-z
155 rdf:type schema:CreativeWork
156 sg:pub.10.1007/s00134-007-0831-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043557714
157 https://doi.org/10.1007/s00134-007-0831-8
158 rdf:type schema:CreativeWork
159 sg:pub.10.1007/s001340050044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020259954
160 https://doi.org/10.1007/s001340050044
161 rdf:type schema:CreativeWork
162 sg:pub.10.1007/s12630-016-0709-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014033475
163 https://doi.org/10.1007/s12630-016-0709-8
164 rdf:type schema:CreativeWork
165 sg:pub.10.1186/cc7005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007787080
166 https://doi.org/10.1186/cc7005
167 rdf:type schema:CreativeWork
168 sg:pub.10.1186/s13054-016-1570-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015411986
169 https://doi.org/10.1186/s13054-016-1570-4
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1002/ajh.24017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037501736
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1002/bmc.3123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005581464
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1002/ejhf.478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035131574
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.healun.2004.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037952659
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.healun.2014.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016342107
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.jtcvs.2011.02.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001555149
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.jtcvs.2016.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032164335
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.prostaglandins.2006.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017261435
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/s0735-1097(99)00494-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026367884
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1053/j.jvca.2007.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030276335
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1053/j.jvca.2013.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004085692
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1053/jcan.2000.9451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037124579
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1056/nejmoa020204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024765279
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1067/mtc.2003.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045804337
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1086/679725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012947274
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1093/bja/aei027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027768538
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1097/00000542-200309000-00033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015101812
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1097/00003246-199902000-00041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060173886
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1097/01.ccm.0000156792.40298.5a schema:sameAs https://app.dimensions.ai/details/publication/pub.1022362214
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1097/aco.0000000000000310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041622390
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1111/ctr.12577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032876962
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1111/j.1399-6576.2007.01476.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031829166
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1111/j.1476-5381.1987.tb11367.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017147249
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1160/th10-07-0499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063292507
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1161/01.cir.0000056104.49686.4b schema:sameAs https://app.dimensions.ai/details/publication/pub.1007031194
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1161/01.cir.90.6.2780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023663603
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1161/circulationaha.114.006974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003889260
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1161/hc4301.098058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006793042
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1177/1753465815599345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053951603
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1213/ane.0000000000002138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085964924
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1378/chest.124.4.1294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041254242
232 rdf:type schema:CreativeWork
233 https://www.grid.ac/institutes/grid.10253.35 schema:alternateName Philipp University of Marburg
234 schema:name Institut für Medizinische Biometrie und Epidemiologie, Philipps-Universität Marburg, Marburg, Germany
235 Klinische Forschung, IBE - Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München, Munich, Germany
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.14778.3d schema:alternateName Düsseldorf University Hospital
238 schema:name Klinik für Anästhesiologie und Schmerztherapie, Klinikum Bremen-Mitte gGmbH, Bremen, Germany
239 Klinik für Anästhesiologie, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
240 rdf:type schema:Organization
241 https://www.grid.ac/institutes/grid.411095.8 schema:alternateName Klinikum der Universität München
242 schema:name Klinik für Anästhesiologie, LMU Klinikum der Universität München, Munich, Germany
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.412301.5 schema:alternateName Universitätsklinikum Aachen
245 schema:name Department of Anesthesiology & Department of Cardiovascular Sciences, University Hospitals Leuven, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
246 Klinik für Anästhesiologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany
247 rdf:type schema:Organization
248 https://www.grid.ac/institutes/grid.414649.a schema:alternateName Evangelisches Krankenhaus Bielefeld
249 schema:name Institut für Anästhesiologie, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany
250 Klinik für Anästhesiologie und operative Intensivmedizin, Franziskus Hospital Bielefeld, Bielefeld, Germany
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.418209.6 schema:alternateName Deutsches Herzzentrum Berlin
253 schema:name Institut für Anästhesiologie, Deutsches Herzzentrum Berlin, Berlin, Germany
254 rdf:type schema:Organization
255 https://www.grid.ac/institutes/grid.419595.5 schema:alternateName Städtisches Klinikum München
256 schema:name Klinik für Anästhesiologie, LMU Klinikum der Universität München, Munich, Germany
257 Klinik für Anästhesiologie, Operative Intensivmedizin und Schmerztherapie, Städtisches Klinikum München, Neuperlach, Munich, Germany
258 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...