The role of randomized cluster crossover trials for comparative effectiveness testing in anesthesia: design of the Benzodiazepine-Free Cardiac Anesthesia for ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Jessica Spence, Emilie Belley-Côté, Shun Fu Lee, Shrikant Bangdiwala, Richard Whitlock, Yannick LeManach, Summer Syed, Andre Lamy, Eric Jacobsohn, Sarah MacIsaac, P. J. Devereaux, Stuart Connolly

ABSTRACT

Increasingly, clinicians and researchers recognize that studies of interventions need to evaluate not only their therapeutic efficacy (i.e., the effect on an outcome in ideal, controlled settings) but also their real-world effectiveness in broad, unselected patient groups. Effectiveness trials inform clinical practice by comparing variations in therapeutic approaches that fall within the standard of care. In this article, we discuss the need for studies of comparative effectiveness in anesthesia and the limitations of individual patient randomized-controlled trials in determining comparative effectiveness. We introduce the concept of randomized cluster crossover trials as a means of answering questions of comparative effectiveness in anesthesia, using the design of the Benzodiazepine-Free Cardiac Anesthesia for Reduction in Postoperative Delirium (B-Free) trial (Clinicaltrials.gov identifier NCT03053869). More... »

PAGES

813-821

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12630-018-1130-2

DOI

http://dx.doi.org/10.1007/s12630-018-1130-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103458075

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29671186


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270 Departments of Anesthesia and Critical Care and Health Research Methods, Evidence, and Impact, Population Health Research Institute (PHRI), McMaster University, 2V9 – 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada
271 Departments of Anesthesia and Critical Care, Medicine (Cardiology), and Health Research Methods, Evidence, and Impact, Population Health Research Institute (PHRI), McMaster University, Hamilton, ON, Canada
272 Departments of Medicine (Cardiology) and Health Research Methods, Evidence, and Impact, Population Health Research Institute (PHRI), McMaster University, Hamilton, ON, Canada
273 Departments of Surgery (Cardiac Surgery) and Health Research Methods, Evidence, and Impact, Population Health Research Institute (PHRI), McMaster University, Hamilton, ON, Canada
274 rdf:type schema:Organization
275 https://www.grid.ac/institutes/grid.415102.3 schema:alternateName Population Health Research Institute
276 schema:name Population Health Research Institute (PHRI), Hamilton, ON, Canada
277 rdf:type schema:Organization
 




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