Stress ulcer prophylaxis in critical illness: a Canadian survey View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-24

AUTHORS

Melissa Shears, Waleed Alhazzani, John C. Marshall, John Muscedere, Richard Hall, Shane W. English, Peter M. Dodek, François Lauzier, Salmaan Kanji, Mark Duffett, Jeffrey Barletta, Mohammed Alshahrani, Yaseen Arabi, Adam Deane, Deborah J. Cook

ABSTRACT

PurposeStress ulcer prophylaxis (SUP) using histamine-2-receptor antagonists has been a standard of care in intensive care units (ICUs) for four decades. Proton pump inhibitors (PPIs) are increasingly used despite apparently lower background rates of gastrointestinal bleeding and growing concerns about PPI-associated complications. Our objective was to understand the views and prescribing habits amongst Canadian physicians regarding SUP in the ICU and to gauge interest in a future randomized-controlled trial (RCT).MethodsWe created a short self-administered survey about SUP for critically ill adults, evaluated its clinical sensibility, and pilot tested the instrument. We surveyed all physician members of the Canadian Critical Care Trials Group (CCCTG) by e-mail and sent reminders three and five weeks later.ResultsWe received 94 of 111 (85%) surveys from the validated respondent pool between May and June, 2015. Respondents reported use of SUP most commonly in patients 1) receiving invasive mechanical ventilation (62, 66%), 2) expected to be ventilated for ≥ two days (25, 27%), or 3) receiving mechanical ventilation but nil per os (NPO) (20, 21%). Stress ulcer prophylaxis is discontinued when patients no longer receive mechanical ventilation (75%), no longer are NPO (22%), or are discharged from the ICU (19%). Stress ulcer prophylaxis involves PPIs in 68% of centres. Most respondents endorsed the need for a large rigorous RCT of PPI vs placebo to understand the risks and benefits of this practice.ConclusionsStress ulcer prophylaxis is reportedly used primarily for the duration of mechanical ventilation. The CCCTG physicians believe that a placebo-controlled RCT is needed to evaluate the effectiveness and safety of contemporary SUP with PPIs. More... »

PAGES

718-724

Journal

TITLE

Journal canadien d'anesthésie

ISSUE

6

VOLUME

63

Author Affiliations

  • Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
  • Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
  • Department of Surgery, Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
  • Department of Critical Care Medicine, Queen’s University, Kingston, ON, Canada
  • Departments of Anesthesia and Critical Care Medicine, Dalhousie University, Halifax, NS, Canada
  • Department of Medicine, University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
  • Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul’s Hospital and University of British Columbia, Vancouver, BC, Canada
  • Departments of Medicine, Anesthesiology & Critical Care, Population Health and Optimal Health Practice Research Unit, CHU de Québec Research Center, Université Laval, Quebec City, QC, Canada
  • Department of Clinical Epidemiology, The Ottawa Hospital Research Institute, Ottawa, ON, Canada
  • Department of Pediatrics, McMaster University, Hamilton, ON, Canada
  • Department of Pharmacy Practice, Midwestern University, College of Pharmacy-Glendale, Glendale, AZ, USA
  • Department of Emergency and Critical Care, King Fahad Hospital of the University of Dammam, Khobar, Saudi Arabia
  • Department of Intensive Care, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  • Department of Intensive Care, University of Adelaide, Adelaide, Australia
  • Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Center, Room 2C11, 1200 Main Street West, L8N 3Z5, Hamilton, ON, Canada
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12630-016-0612-3

    DOI

    http://dx.doi.org/10.1007/s12630-016-0612-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024604523

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26911559


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Canada", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Critical Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Critical Illness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histamine H2 Antagonists", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptic Ulcer", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proton Pump Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiration, Artificial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stress, Physiological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ulcer", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shears", 
            "givenName": "Melissa", 
            "id": "sg:person.0713604665.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713604665.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alhazzani", 
            "givenName": "Waleed", 
            "id": "sg:person.01316634110.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316634110.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Department of Surgery, Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marshall", 
            "givenName": "John C.", 
            "id": "sg:person.01064471126.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064471126.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Critical Care Medicine, Queen\u2019s University, Kingston, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.410356.5", 
              "name": [
                "Department of Critical Care Medicine, Queen\u2019s University, Kingston, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muscedere", 
            "givenName": "John", 
            "id": "sg:person.01015756545.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015756545.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Anesthesia and Critical Care Medicine, Dalhousie University, Halifax, NS, Canada", 
              "id": "http://www.grid.ac/institutes/grid.55602.34", 
              "name": [
                "Departments of Anesthesia and Critical Care Medicine, Dalhousie University, Halifax, NS, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hall", 
            "givenName": "Richard", 
            "id": "sg:person.0756636512.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756636512.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Department of Medicine, University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "English", 
            "givenName": "Shane W.", 
            "id": "sg:person.01036166574.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036166574.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul\u2019s Hospital and University of British Columbia, Vancouver, BC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul\u2019s Hospital and University of British Columbia, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dodek", 
            "givenName": "Peter M.", 
            "id": "sg:person.01010333011.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010333011.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Medicine, Anesthesiology & Critical Care, Population Health and Optimal Health Practice Research Unit, CHU de Qu\u00e9bec Research Center, Universit\u00e9 Laval, Quebec City, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Departments of Medicine, Anesthesiology & Critical Care, Population Health and Optimal Health Practice Research Unit, CHU de Qu\u00e9bec Research Center, Universit\u00e9 Laval, Quebec City, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lauzier", 
            "givenName": "Fran\u00e7ois", 
            "id": "sg:person.01066142337.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Epidemiology, The Ottawa Hospital Research Institute, Ottawa, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Department of Pharmacy, The Ottawa Hospital, Ottawa, ON, Canada", 
                "Department of Clinical Epidemiology, The Ottawa Hospital Research Institute, Ottawa, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanji", 
            "givenName": "Salmaan", 
            "id": "sg:person.01207613372.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207613372.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, McMaster University, Hamilton, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Department of Pediatrics, McMaster University, Hamilton, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duffett", 
            "givenName": "Mark", 
            "id": "sg:person.01023553027.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023553027.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacy Practice, Midwestern University, College of Pharmacy-Glendale, Glendale, AZ, USA", 
              "id": "http://www.grid.ac/institutes/grid.260024.2", 
              "name": [
                "Department of Pharmacy Practice, Midwestern University, College of Pharmacy-Glendale, Glendale, AZ, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barletta", 
            "givenName": "Jeffrey", 
            "id": "sg:person.0662444541.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662444541.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Emergency and Critical Care, King Fahad Hospital of the University of Dammam, Khobar, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.411975.f", 
              "name": [
                "Department of Emergency and Critical Care, King Fahad Hospital of the University of Dammam, Khobar, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alshahrani", 
            "givenName": "Mohammed", 
            "id": "sg:person.0744127135.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744127135.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.412149.b", 
              "name": [
                "Department of Intensive Care, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arabi", 
            "givenName": "Yaseen", 
            "id": "sg:person.01233210151.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233210151.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, University of Adelaide, Adelaide, Australia", 
              "id": "http://www.grid.ac/institutes/grid.1010.0", 
              "name": [
                "Department of Intensive Care, University of Adelaide, Adelaide, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deane", 
            "givenName": "Adam", 
            "id": "sg:person.01042764756.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042764756.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Center, Room 2C11, 1200 Main Street West, L8N 3Z5, Hamilton, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Center, Room 2C11, 1200 Main Street West, L8N 3Z5, Hamilton, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cook", 
            "givenName": "Deborah J.", 
            "id": "sg:person.01372124736.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372124736.59"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-015-3785-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051097199", 
              "https://doi.org/10.1007/s00134-015-3785-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-3725-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003982986", 
              "https://doi.org/10.1007/s00134-015-3725-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004832676", 
              "https://doi.org/10.1186/cc368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc1831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029007281", 
              "https://doi.org/10.1186/cc1831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-012-2769-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031148336", 
              "https://doi.org/10.1007/s00134-012-2769-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2197-425x-3-s1-a41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041250182", 
              "https://doi.org/10.1186/2197-425x-3-s1-a41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-013-3125-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022557876", 
              "https://doi.org/10.1007/s00134-013-3125-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc1071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013596440", 
              "https://doi.org/10.1186/cc1071"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-02-24", 
        "datePublishedReg": "2016-02-24", 
        "description": "PurposeStress ulcer prophylaxis (SUP) using histamine-2-receptor antagonists has been a standard of care in intensive care units (ICUs) for four decades. Proton pump inhibitors (PPIs) are increasingly used despite apparently lower background rates of gastrointestinal bleeding and growing concerns about PPI-associated complications. Our objective was to understand the views and prescribing habits amongst Canadian physicians regarding SUP in the ICU and to gauge interest in a future randomized-controlled trial (RCT).MethodsWe created a short self-administered survey about SUP for critically ill adults, evaluated its clinical sensibility, and pilot tested the instrument. We surveyed all physician members of the Canadian Critical Care Trials Group (CCCTG) by e-mail and sent reminders three and five weeks later.ResultsWe received 94 of 111 (85%) surveys from the validated respondent pool between May and June, 2015. Respondents reported use of SUP most commonly in patients 1) receiving invasive mechanical ventilation (62, 66%), 2) expected to be ventilated for \u2265 two days (25, 27%), or 3) receiving mechanical ventilation but nil per os (NPO) (20, 21%). Stress ulcer prophylaxis is discontinued when patients no longer receive mechanical ventilation (75%), no longer are NPO (22%), or are discharged from the ICU (19%). Stress ulcer prophylaxis involves PPIs in 68% of centres. Most respondents endorsed the need for a large rigorous RCT of PPI vs placebo to understand the risks and benefits of this practice.ConclusionsStress ulcer prophylaxis is reportedly used primarily for the duration of mechanical ventilation. The CCCTG physicians believe that a placebo-controlled RCT is needed to evaluate the effectiveness and safety of contemporary SUP with PPIs.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12630-016-0612-3", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1017152", 
            "issn": [
              "0832-610X", 
              "1496-8975"
            ], 
            "name": "Journal canadien d'anesth\u00e9sie", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "63"
          }
        ], 
        "keywords": [
          "randomized-controlled trials", 
          "proton pump inhibitors", 
          "intensive care unit", 
          "stress ulcer prophylaxis", 
          "Canadian Critical Care Trials Group", 
          "ulcer prophylaxis", 
          "mechanical ventilation", 
          "invasive mechanical ventilation", 
          "future randomized-controlled trials", 
          "standard of care", 
          "gastrointestinal bleeding", 
          "self-administered survey", 
          "critical illness", 
          "ill adults", 
          "care unit", 
          "Patient 1", 
          "prescribing habits", 
          "pump inhibitors", 
          "trial group", 
          "prophylaxis", 
          "physician members", 
          "Canadian physicians", 
          "clinical sensibility", 
          "ventilation", 
          "Canadian survey", 
          "Most respondents", 
          "physicians", 
          "placebo", 
          "bleeding", 
          "complications", 
          "patients", 
          "antagonist", 
          "MethodsWe", 
          "illness", 
          "trials", 
          "weeks", 
          "care", 
          "low background rate", 
          "respondents", 
          "adults", 
          "background rate", 
          "ResultsWe", 
          "risk", 
          "survey", 
          "duration", 
          "inhibitors", 
          "days", 
          "safety", 
          "respondent pool", 
          "sup", 
          "group", 
          "habits", 
          "center", 
          "benefits", 
          "nil", 
          "rate", 
          "pilot", 
          "mail", 
          "objective", 
          "use", 
          "need", 
          "practice", 
          "concern", 
          "pool", 
          "NPO", 
          "members", 
          "three", 
          "effectiveness", 
          "units", 
          "standards", 
          "decades", 
          "instrument", 
          "sensibility", 
          "interest", 
          "view", 
          "PurposeStress ulcer prophylaxis", 
          "short self-administered survey", 
          "Critical Care Trials Group", 
          "Care Trials Group", 
          "reminders three", 
          "use of SUP", 
          "large rigorous RCT", 
          "rigorous RCT", 
          "ConclusionsStress ulcer prophylaxis", 
          "CCCTG physicians", 
          "placebo-controlled RCT", 
          "contemporary SUP"
        ], 
        "name": "Stress ulcer prophylaxis in critical illness: a Canadian survey", 
        "pagination": "718-724", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024604523"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12630-016-0612-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26911559"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12630-016-0612-3", 
          "https://app.dimensions.ai/details/publication/pub.1024604523"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_690.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12630-016-0612-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12630-016-0612-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12630-016-0612-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12630-016-0612-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12630-016-0612-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    378 TRIPLES      22 PREDICATES      136 URIs      120 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12630-016-0612-3 schema:about N1f4f7929d5bf4d3e8907aa54a8948d09
    2 N244baf71c7a4430d930ab6b1f201beca
    3 N433e2f9c39ab46508790e9c9a3fa5b79
    4 N45b098c6810a4039a88df93feefff62a
    5 N63d4fd925d9e412a81801a9cc5b41d01
    6 N770481d78b564718903e6cb5e30f11af
    7 N8161fc0c3e054b20ba3417c337c1fcd4
    8 N8540aed9e14043ffa78625b550d89f39
    9 N8d536927716144fd8d019ab6afdb79e9
    10 N8f39c3f59ab7494089ce9aaa22b6b896
    11 N988a162ea6b54eaeb2c77cc02f2620ae
    12 Nd4f0849df6a942f7aad6e04ec9a830b6
    13 Ne0ab450551fb4533b977b73a830e1b40
    14 Nea588afd6eb74238816f5b158e648e3c
    15 Nf78dedd2cea749c8a160e53129d64c36
    16 anzsrc-for:11
    17 anzsrc-for:1103
    18 schema:author N0c33147a623842c18edcf1e7c106ebde
    19 schema:citation sg:pub.10.1007/s00134-012-2769-8
    20 sg:pub.10.1007/s00134-013-3125-3
    21 sg:pub.10.1007/s00134-015-3725-1
    22 sg:pub.10.1007/s00134-015-3785-2
    23 sg:pub.10.1186/2197-425x-3-s1-a41
    24 sg:pub.10.1186/cc1071
    25 sg:pub.10.1186/cc1831
    26 sg:pub.10.1186/cc368
    27 schema:datePublished 2016-02-24
    28 schema:datePublishedReg 2016-02-24
    29 schema:description PurposeStress ulcer prophylaxis (SUP) using histamine-2-receptor antagonists has been a standard of care in intensive care units (ICUs) for four decades. Proton pump inhibitors (PPIs) are increasingly used despite apparently lower background rates of gastrointestinal bleeding and growing concerns about PPI-associated complications. Our objective was to understand the views and prescribing habits amongst Canadian physicians regarding SUP in the ICU and to gauge interest in a future randomized-controlled trial (RCT).MethodsWe created a short self-administered survey about SUP for critically ill adults, evaluated its clinical sensibility, and pilot tested the instrument. We surveyed all physician members of the Canadian Critical Care Trials Group (CCCTG) by e-mail and sent reminders three and five weeks later.ResultsWe received 94 of 111 (85%) surveys from the validated respondent pool between May and June, 2015. Respondents reported use of SUP most commonly in patients 1) receiving invasive mechanical ventilation (62, 66%), 2) expected to be ventilated for ≥ two days (25, 27%), or 3) receiving mechanical ventilation but nil per os (NPO) (20, 21%). Stress ulcer prophylaxis is discontinued when patients no longer receive mechanical ventilation (75%), no longer are NPO (22%), or are discharged from the ICU (19%). Stress ulcer prophylaxis involves PPIs in 68% of centres. Most respondents endorsed the need for a large rigorous RCT of PPI vs placebo to understand the risks and benefits of this practice.ConclusionsStress ulcer prophylaxis is reportedly used primarily for the duration of mechanical ventilation. The CCCTG physicians believe that a placebo-controlled RCT is needed to evaluate the effectiveness and safety of contemporary SUP with PPIs.
    30 schema:genre article
    31 schema:inLanguage en
    32 schema:isAccessibleForFree true
    33 schema:isPartOf N15e721415ab5464086bc3053aec45a9f
    34 N80f601a15f504238b800c6f1912d9e19
    35 sg:journal.1017152
    36 schema:keywords CCCTG physicians
    37 Canadian Critical Care Trials Group
    38 Canadian physicians
    39 Canadian survey
    40 Care Trials Group
    41 ConclusionsStress ulcer prophylaxis
    42 Critical Care Trials Group
    43 MethodsWe
    44 Most respondents
    45 NPO
    46 Patient 1
    47 PurposeStress ulcer prophylaxis
    48 ResultsWe
    49 adults
    50 antagonist
    51 background rate
    52 benefits
    53 bleeding
    54 care
    55 care unit
    56 center
    57 clinical sensibility
    58 complications
    59 concern
    60 contemporary SUP
    61 critical illness
    62 days
    63 decades
    64 duration
    65 effectiveness
    66 future randomized-controlled trials
    67 gastrointestinal bleeding
    68 group
    69 habits
    70 ill adults
    71 illness
    72 inhibitors
    73 instrument
    74 intensive care unit
    75 interest
    76 invasive mechanical ventilation
    77 large rigorous RCT
    78 low background rate
    79 mail
    80 mechanical ventilation
    81 members
    82 need
    83 nil
    84 objective
    85 patients
    86 physician members
    87 physicians
    88 pilot
    89 placebo
    90 placebo-controlled RCT
    91 pool
    92 practice
    93 prescribing habits
    94 prophylaxis
    95 proton pump inhibitors
    96 pump inhibitors
    97 randomized-controlled trials
    98 rate
    99 reminders three
    100 respondent pool
    101 respondents
    102 rigorous RCT
    103 risk
    104 safety
    105 self-administered survey
    106 sensibility
    107 short self-administered survey
    108 standard of care
    109 standards
    110 stress ulcer prophylaxis
    111 sup
    112 survey
    113 three
    114 trial group
    115 trials
    116 ulcer prophylaxis
    117 units
    118 use
    119 use of SUP
    120 ventilation
    121 view
    122 weeks
    123 schema:name Stress ulcer prophylaxis in critical illness: a Canadian survey
    124 schema:pagination 718-724
    125 schema:productId N3ea4ca4ed53b4849844b4e69f4ce53db
    126 N650d0d0c3d9848bfb206032e6bb398e6
    127 Nf1307d7d73574c609881c791849a1310
    128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024604523
    129 https://doi.org/10.1007/s12630-016-0612-3
    130 schema:sdDatePublished 2021-12-01T19:35
    131 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    132 schema:sdPublisher N43fd8dcb18d2449d9994d94aa86306c9
    133 schema:url https://doi.org/10.1007/s12630-016-0612-3
    134 sgo:license sg:explorer/license/
    135 sgo:sdDataset articles
    136 rdf:type schema:ScholarlyArticle
    137 N024226610b7a4b76ab2bcebd51add4d4 rdf:first sg:person.0756636512.82
    138 rdf:rest N55fec09878b94db6b205547aaf952506
    139 N084d694423ff47eb91dceeb46e85a43c rdf:first sg:person.01372124736.59
    140 rdf:rest rdf:nil
    141 N0c33147a623842c18edcf1e7c106ebde rdf:first sg:person.0713604665.34
    142 rdf:rest N3b2681053fd34bb599b2b7ab59636219
    143 N0cd2460bf36c4b4ca7a5ed538a4af2b1 rdf:first sg:person.01066142337.60
    144 rdf:rest Nbf3fdaa2ca7e4bd4bf365607ccc5e828
    145 N15e721415ab5464086bc3053aec45a9f schema:issueNumber 6
    146 rdf:type schema:PublicationIssue
    147 N1dcccea65791442d93a87f322100ab34 rdf:first sg:person.01064471126.24
    148 rdf:rest Ncf850e03e12447db942c1271ce97bbe2
    149 N1f4f7929d5bf4d3e8907aa54a8948d09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Female
    151 rdf:type schema:DefinedTerm
    152 N2025d4dc20eb4d91933048eb84d9b75a rdf:first sg:person.01042764756.89
    153 rdf:rest N084d694423ff47eb91dceeb46e85a43c
    154 N244baf71c7a4430d930ab6b1f201beca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Adult
    156 rdf:type schema:DefinedTerm
    157 N33a333cbfb8e47e9b333bf7ef3aca3b9 rdf:first sg:person.01010333011.45
    158 rdf:rest N0cd2460bf36c4b4ca7a5ed538a4af2b1
    159 N36585c63a38349caa08f016da24bfa3e rdf:first sg:person.01023553027.63
    160 rdf:rest Nb6e525a476164b99adf3df07837df76e
    161 N3b2681053fd34bb599b2b7ab59636219 rdf:first sg:person.01316634110.07
    162 rdf:rest N1dcccea65791442d93a87f322100ab34
    163 N3ea4ca4ed53b4849844b4e69f4ce53db schema:name dimensions_id
    164 schema:value pub.1024604523
    165 rdf:type schema:PropertyValue
    166 N433e2f9c39ab46508790e9c9a3fa5b79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Respiration, Artificial
    168 rdf:type schema:DefinedTerm
    169 N43fd8dcb18d2449d9994d94aa86306c9 schema:name Springer Nature - SN SciGraph project
    170 rdf:type schema:Organization
    171 N45b098c6810a4039a88df93feefff62a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Risk Factors
    173 rdf:type schema:DefinedTerm
    174 N55fec09878b94db6b205547aaf952506 rdf:first sg:person.01036166574.42
    175 rdf:rest N33a333cbfb8e47e9b333bf7ef3aca3b9
    176 N5b377bf13e1549b081b2eb5cad5495ec rdf:first sg:person.01233210151.86
    177 rdf:rest N2025d4dc20eb4d91933048eb84d9b75a
    178 N63d4fd925d9e412a81801a9cc5b41d01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Proton Pump Inhibitors
    180 rdf:type schema:DefinedTerm
    181 N650d0d0c3d9848bfb206032e6bb398e6 schema:name doi
    182 schema:value 10.1007/s12630-016-0612-3
    183 rdf:type schema:PropertyValue
    184 N770481d78b564718903e6cb5e30f11af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Critical Illness
    186 rdf:type schema:DefinedTerm
    187 N77f07f92a5d54cb7a97d1e5a9dc4d684 rdf:first sg:person.0744127135.25
    188 rdf:rest N5b377bf13e1549b081b2eb5cad5495ec
    189 N80f601a15f504238b800c6f1912d9e19 schema:volumeNumber 63
    190 rdf:type schema:PublicationVolume
    191 N8161fc0c3e054b20ba3417c337c1fcd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Male
    193 rdf:type schema:DefinedTerm
    194 N8540aed9e14043ffa78625b550d89f39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Critical Care
    196 rdf:type schema:DefinedTerm
    197 N8d536927716144fd8d019ab6afdb79e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Treatment Outcome
    199 rdf:type schema:DefinedTerm
    200 N8f39c3f59ab7494089ce9aaa22b6b896 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Stress, Physiological
    202 rdf:type schema:DefinedTerm
    203 N988a162ea6b54eaeb2c77cc02f2620ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Humans
    205 rdf:type schema:DefinedTerm
    206 Nb6e525a476164b99adf3df07837df76e rdf:first sg:person.0662444541.33
    207 rdf:rest N77f07f92a5d54cb7a97d1e5a9dc4d684
    208 Nbf3fdaa2ca7e4bd4bf365607ccc5e828 rdf:first sg:person.01207613372.27
    209 rdf:rest N36585c63a38349caa08f016da24bfa3e
    210 Ncf850e03e12447db942c1271ce97bbe2 rdf:first sg:person.01015756545.95
    211 rdf:rest N024226610b7a4b76ab2bcebd51add4d4
    212 Nd4f0849df6a942f7aad6e04ec9a830b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Ulcer
    214 rdf:type schema:DefinedTerm
    215 Ne0ab450551fb4533b977b73a830e1b40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Canada
    217 rdf:type schema:DefinedTerm
    218 Nea588afd6eb74238816f5b158e648e3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Peptic Ulcer
    220 rdf:type schema:DefinedTerm
    221 Nf1307d7d73574c609881c791849a1310 schema:name pubmed_id
    222 schema:value 26911559
    223 rdf:type schema:PropertyValue
    224 Nf78dedd2cea749c8a160e53129d64c36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Histamine H2 Antagonists
    226 rdf:type schema:DefinedTerm
    227 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    228 schema:name Medical and Health Sciences
    229 rdf:type schema:DefinedTerm
    230 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Clinical Sciences
    232 rdf:type schema:DefinedTerm
    233 sg:journal.1017152 schema:issn 0832-610X
    234 1496-8975
    235 schema:name Journal canadien d'anesthésie
    236 schema:publisher Springer Nature
    237 rdf:type schema:Periodical
    238 sg:person.01010333011.45 schema:affiliation grid-institutes:grid.17091.3e
    239 schema:familyName Dodek
    240 schema:givenName Peter M.
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010333011.45
    242 rdf:type schema:Person
    243 sg:person.01015756545.95 schema:affiliation grid-institutes:grid.410356.5
    244 schema:familyName Muscedere
    245 schema:givenName John
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015756545.95
    247 rdf:type schema:Person
    248 sg:person.01023553027.63 schema:affiliation grid-institutes:grid.25073.33
    249 schema:familyName Duffett
    250 schema:givenName Mark
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023553027.63
    252 rdf:type schema:Person
    253 sg:person.01036166574.42 schema:affiliation grid-institutes:grid.412687.e
    254 schema:familyName English
    255 schema:givenName Shane W.
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036166574.42
    257 rdf:type schema:Person
    258 sg:person.01042764756.89 schema:affiliation grid-institutes:grid.1010.0
    259 schema:familyName Deane
    260 schema:givenName Adam
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042764756.89
    262 rdf:type schema:Person
    263 sg:person.01064471126.24 schema:affiliation grid-institutes:grid.17063.33
    264 schema:familyName Marshall
    265 schema:givenName John C.
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064471126.24
    267 rdf:type schema:Person
    268 sg:person.01066142337.60 schema:affiliation grid-institutes:grid.23856.3a
    269 schema:familyName Lauzier
    270 schema:givenName François
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60
    272 rdf:type schema:Person
    273 sg:person.01207613372.27 schema:affiliation grid-institutes:grid.412687.e
    274 schema:familyName Kanji
    275 schema:givenName Salmaan
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207613372.27
    277 rdf:type schema:Person
    278 sg:person.01233210151.86 schema:affiliation grid-institutes:grid.412149.b
    279 schema:familyName Arabi
    280 schema:givenName Yaseen
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233210151.86
    282 rdf:type schema:Person
    283 sg:person.01316634110.07 schema:affiliation grid-institutes:grid.25073.33
    284 schema:familyName Alhazzani
    285 schema:givenName Waleed
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316634110.07
    287 rdf:type schema:Person
    288 sg:person.01372124736.59 schema:affiliation grid-institutes:grid.25073.33
    289 schema:familyName Cook
    290 schema:givenName Deborah J.
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372124736.59
    292 rdf:type schema:Person
    293 sg:person.0662444541.33 schema:affiliation grid-institutes:grid.260024.2
    294 schema:familyName Barletta
    295 schema:givenName Jeffrey
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662444541.33
    297 rdf:type schema:Person
    298 sg:person.0713604665.34 schema:affiliation grid-institutes:grid.25073.33
    299 schema:familyName Shears
    300 schema:givenName Melissa
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713604665.34
    302 rdf:type schema:Person
    303 sg:person.0744127135.25 schema:affiliation grid-institutes:grid.411975.f
    304 schema:familyName Alshahrani
    305 schema:givenName Mohammed
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744127135.25
    307 rdf:type schema:Person
    308 sg:person.0756636512.82 schema:affiliation grid-institutes:grid.55602.34
    309 schema:familyName Hall
    310 schema:givenName Richard
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756636512.82
    312 rdf:type schema:Person
    313 sg:pub.10.1007/s00134-012-2769-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031148336
    314 https://doi.org/10.1007/s00134-012-2769-8
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1007/s00134-013-3125-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022557876
    317 https://doi.org/10.1007/s00134-013-3125-3
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1007/s00134-015-3725-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003982986
    320 https://doi.org/10.1007/s00134-015-3725-1
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1007/s00134-015-3785-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051097199
    323 https://doi.org/10.1007/s00134-015-3785-2
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1186/2197-425x-3-s1-a41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041250182
    326 https://doi.org/10.1186/2197-425x-3-s1-a41
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1186/cc1071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013596440
    329 https://doi.org/10.1186/cc1071
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1186/cc1831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029007281
    332 https://doi.org/10.1186/cc1831
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1186/cc368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004832676
    335 https://doi.org/10.1186/cc368
    336 rdf:type schema:CreativeWork
    337 grid-institutes:grid.1010.0 schema:alternateName Department of Intensive Care, University of Adelaide, Adelaide, Australia
    338 schema:name Department of Intensive Care, University of Adelaide, Adelaide, Australia
    339 rdf:type schema:Organization
    340 grid-institutes:grid.17063.33 schema:alternateName Department of Surgery, Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    341 schema:name Department of Surgery, Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    342 rdf:type schema:Organization
    343 grid-institutes:grid.17091.3e schema:alternateName Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul’s Hospital and University of British Columbia, Vancouver, BC, Canada
    344 schema:name Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul’s Hospital and University of British Columbia, Vancouver, BC, Canada
    345 rdf:type schema:Organization
    346 grid-institutes:grid.23856.3a schema:alternateName Departments of Medicine, Anesthesiology & Critical Care, Population Health and Optimal Health Practice Research Unit, CHU de Québec Research Center, Université Laval, Quebec City, QC, Canada
    347 schema:name Departments of Medicine, Anesthesiology & Critical Care, Population Health and Optimal Health Practice Research Unit, CHU de Québec Research Center, Université Laval, Quebec City, QC, Canada
    348 rdf:type schema:Organization
    349 grid-institutes:grid.25073.33 schema:alternateName Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
    350 Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    351 Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
    352 Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Center, Room 2C11, 1200 Main Street West, L8N 3Z5, Hamilton, ON, Canada
    353 schema:name Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
    354 Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    355 Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
    356 Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Center, Room 2C11, 1200 Main Street West, L8N 3Z5, Hamilton, ON, Canada
    357 rdf:type schema:Organization
    358 grid-institutes:grid.260024.2 schema:alternateName Department of Pharmacy Practice, Midwestern University, College of Pharmacy-Glendale, Glendale, AZ, USA
    359 schema:name Department of Pharmacy Practice, Midwestern University, College of Pharmacy-Glendale, Glendale, AZ, USA
    360 rdf:type schema:Organization
    361 grid-institutes:grid.410356.5 schema:alternateName Department of Critical Care Medicine, Queen’s University, Kingston, ON, Canada
    362 schema:name Department of Critical Care Medicine, Queen’s University, Kingston, ON, Canada
    363 rdf:type schema:Organization
    364 grid-institutes:grid.411975.f schema:alternateName Department of Emergency and Critical Care, King Fahad Hospital of the University of Dammam, Khobar, Saudi Arabia
    365 schema:name Department of Emergency and Critical Care, King Fahad Hospital of the University of Dammam, Khobar, Saudi Arabia
    366 rdf:type schema:Organization
    367 grid-institutes:grid.412149.b schema:alternateName Department of Intensive Care, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
    368 schema:name Department of Intensive Care, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
    369 rdf:type schema:Organization
    370 grid-institutes:grid.412687.e schema:alternateName Department of Clinical Epidemiology, The Ottawa Hospital Research Institute, Ottawa, ON, Canada
    371 Department of Medicine, University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    372 schema:name Department of Clinical Epidemiology, The Ottawa Hospital Research Institute, Ottawa, ON, Canada
    373 Department of Medicine, University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    374 Department of Pharmacy, The Ottawa Hospital, Ottawa, ON, Canada
    375 rdf:type schema:Organization
    376 grid-institutes:grid.55602.34 schema:alternateName Departments of Anesthesia and Critical Care Medicine, Dalhousie University, Halifax, NS, Canada
    377 schema:name Departments of Anesthesia and Critical Care Medicine, Dalhousie University, Halifax, NS, Canada
    378 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...