Corticosteroid use in the intensive care unit: a survey of intensivists View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04-19

AUTHORS

François Lamontagne, Hector Quiroz Martinez, Neill K. J. Adhikari, Deborah J. Cook, Karen K. Y. Koo, François Lauzier, Alexis F. Turgeon, Michelle E. Kho, Karen E. A. Burns, Clarence Chant, Rob Fowler, Ivor Douglas, Yannick Poulin, Karen Choong, Niall D. Ferguson, Maureen O. Meade

ABSTRACT

ObjectiveThe efficacy of systemic corticosteroids in many critical illnesses remains uncertain. Our primary objective was to survey intensivists in North America about their perceived use of corticosteroids in clinical practice.DesignSelf-administered paper survey.PopulationIntensivists in academic hospitals with clinical trial expertise in critical illness.MeasurementsWe generated questionnaire items in focus groups and refined them after assessments of clinical sensibility and test-retest reliability and pilot testing. We administered the survey to experienced intensivists practicing in selected North American centres actively enrolling patients in the multicentre Oscillation for ARDS Treated Early (OSCILLATE) Trial (ISRCTN87124254). Respondents used a four-point scale to grade how frequently they would administer corticosteroids in 14 clinical settings. They also reported their opinions on 16 potential near-absolute indications or contraindications for the use of corticosteroids.Main resultsOur response rate was 82% (103/125). Respondents were general internists (50%), respirologists (22%), anesthesiologists (21%), and surgeons (7%) who practiced in mixed medical-surgical units. A majority of respondents reported almost always prescribing corticosteroids in the setting of significant bronchospasm in a mechanically ventilated patient (94%), recent corticosteroid use and low blood pressure (93%), and vasopressor-refractory septic shock (52%). Although more than half of respondents stated they would almost never prescribe corticosteroids in severe community-acquired pneumonia (81%), acute lung injury (ALI, 76%), acute respiratory distress syndrome (ARDS, 65%), and severe ARDS (51%), variability increased with severity of acute lung injury. Near-absolute indications selected by most respondents included known adrenal insufficiency (99%) and suspicion of cryptogenic organizing pneumonia (89%), connective tissue disease (85%), or other potentially corticosteroid-responsive illnesses (85%).ConclusionsRespondents reported rarely prescribing corticosteroids for ALI, but accepted them for bronchospasm, suspected adrenal insufficiency due to previous corticosteroid use, and vasopressor-refractory septic shock. These competing indications will complicate the design and interpretation of any future large-scale trial of corticosteroids in critical illness. More... »

PAGES

652-659

Journal

TITLE

Journal canadien d'anesthésie

ISSUE

7

VOLUME

60

Author Affiliations

  • Centre de Recherche Clinique Étienne-Le Bel, Université de Sherbrooke, Sherbrooke, QC, Canada
  • Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada
  • Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
  • Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
  • Department of Medicine, University of Western Ontario, Toronto, ON, Canada
  • Centre de Recherche FRQ-S du CHU de Québec, Division of Critical Care, Departments of Anesthesiology and Medicine, Université Laval, Québec City, QC, Canada
  • Centre de Recherche FRQ-S du CHU de Québec, Division of Critical Care, Department of Anesthesiology, Université Laval, Québec City, QC, Canada
  • Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA
  • Department of Critical Care and the Keenan Research Centre/Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada
  • Pharmacy Department, St Michael’s Hospital, Keenan Research Centre at Li Ka Shing Knowledge Institute, Toronto, ON, Canada
  • Pulmonary Sciences & Critical Care Medicine, Denver Health and University of Colorado, School of Medicine, Denver, CO, USA
  • Departments of Pediatrics and Critical Care, McMaster University, Hamilton, ON, Canada
  • Interdepartmental Division of Critical Care, and Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12630-013-9929-3

    DOI

    http://dx.doi.org/10.1007/s12630-013-9929-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008222283

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23606231


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acute Lung Injury", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adrenal Cortex Hormones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adrenal Insufficiency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anesthesiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Attitude of Health Personnel", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bronchial Spasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Community-Acquired Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Connective Tissue Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Contraindications", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Critical Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Critical Illness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cryptogenic Organizing Pneumonia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "General Surgery", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypotension", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Internal Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pneumonia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pulmonary Disease, Chronic Obstructive", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pulmonary Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiration, Artificial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiratory Distress Syndrome, Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Self Report", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Shock, Septic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Surveys and Questionnaires", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Centre de Recherche Clinique \u00c9tienne-Le Bel, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.86715.3d", 
              "name": [
                "Department of Medicine, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada", 
                "Centre de Recherche Clinique \u00c9tienne-Le Bel, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lamontagne", 
            "givenName": "Fran\u00e7ois", 
            "id": "sg:person.01321064225.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321064225.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.86715.3d", 
              "name": [
                "Department of Medicine, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Quiroz Martinez", 
            "givenName": "Hector", 
            "id": "sg:person.01014724324.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014724324.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada", 
                "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adhikari", 
            "givenName": "Neill K. J.", 
            "id": "sg:person.01205364112.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205364112.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cook", 
            "givenName": "Deborah J.", 
            "id": "sg:person.01372124736.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372124736.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Western Ontario, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Medicine, University of Western Ontario, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koo", 
            "givenName": "Karen K. Y.", 
            "id": "sg:person.015720567657.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015720567657.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre de Recherche FRQ-S du CHU de Qu\u00e9bec, Division of Critical Care, Departments of Anesthesiology and Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche FRQ-S du CHU de Qu\u00e9bec, Division of Critical Care, Departments of Anesthesiology and Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lauzier", 
            "givenName": "Fran\u00e7ois", 
            "id": "sg:person.01066142337.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre de Recherche FRQ-S du CHU de Qu\u00e9bec, Division of Critical Care, Department of Anesthesiology, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche FRQ-S du CHU de Qu\u00e9bec, Division of Critical Care, Department of Anesthesiology, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turgeon", 
            "givenName": "Alexis F.", 
            "id": "sg:person.01253006352.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253006352.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kho", 
            "givenName": "Michelle E.", 
            "id": "sg:person.01202370737.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202370737.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Critical Care and the Keenan Research Centre/Li Ka Shing Knowledge Institute, St Michael\u2019s Hospital, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "Department of Critical Care and the Keenan Research Centre/Li Ka Shing Knowledge Institute, St Michael\u2019s Hospital, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burns", 
            "givenName": "Karen E. A.", 
            "id": "sg:person.013535244737.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013535244737.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pharmacy Department, St Michael\u2019s Hospital, Keenan Research Centre at Li Ka Shing Knowledge Institute, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "Pharmacy Department, St Michael\u2019s Hospital, Keenan Research Centre at Li Ka Shing Knowledge Institute, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chant", 
            "givenName": "Clarence", 
            "id": "sg:person.0673055064.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673055064.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada", 
                "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fowler", 
            "givenName": "Rob", 
            "id": "sg:person.0710200124.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710200124.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pulmonary Sciences & Critical Care Medicine, Denver Health and University of Colorado, School of Medicine, Denver, CO, USA", 
              "id": "http://www.grid.ac/institutes/grid.241116.1", 
              "name": [
                "Pulmonary Sciences & Critical Care Medicine, Denver Health and University of Colorado, School of Medicine, Denver, CO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Douglas", 
            "givenName": "Ivor", 
            "id": "sg:person.01204356253.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204356253.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.86715.3d", 
              "name": [
                "Department of Medicine, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poulin", 
            "givenName": "Yannick", 
            "id": "sg:person.013655176271.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013655176271.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Pediatrics and Critical Care, McMaster University, Hamilton, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Departments of Pediatrics and Critical Care, McMaster University, Hamilton, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choong", 
            "givenName": "Karen", 
            "id": "sg:person.01072003437.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072003437.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Interdepartmental Division of Critical Care, and Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Interdepartmental Division of Critical Care, and Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferguson", 
            "givenName": "Niall D.", 
            "id": "sg:person.0673455705.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673455705.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meade", 
            "givenName": "Maureen O.", 
            "id": "sg:person.01316617337.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316617337.49"
            ], 
            "type": "Person"
          }
        ], 
        "datePublished": "2013-04-19", 
        "datePublishedReg": "2013-04-19", 
        "description": "ObjectiveThe efficacy of systemic corticosteroids in many critical illnesses remains uncertain. Our primary objective was to survey intensivists in North America about their perceived use of corticosteroids in clinical practice.DesignSelf-administered paper survey.PopulationIntensivists in academic hospitals with clinical trial expertise in critical illness.MeasurementsWe generated questionnaire items in focus groups and refined them after assessments of clinical sensibility and test-retest reliability and pilot testing. We administered the survey to experienced intensivists practicing in selected North American centres actively enrolling patients in the multicentre Oscillation for ARDS Treated Early (OSCILLATE) Trial (ISRCTN87124254). Respondents used a four-point scale to grade how frequently they would administer corticosteroids in 14 clinical settings. They also reported their opinions on 16 potential near-absolute indications or contraindications for the use of corticosteroids.Main resultsOur response rate was 82% (103/125). Respondents were general internists (50%), respirologists (22%), anesthesiologists (21%), and surgeons (7%) who practiced in mixed medical-surgical units. A majority of respondents reported almost always prescribing corticosteroids in the setting of significant bronchospasm in a mechanically ventilated patient (94%), recent corticosteroid use and low blood pressure (93%), and vasopressor-refractory septic shock (52%). Although more than half of respondents stated they would almost never prescribe corticosteroids in severe community-acquired pneumonia (81%), acute lung injury (ALI, 76%), acute respiratory distress syndrome (ARDS, 65%), and severe ARDS (51%), variability increased with severity of acute lung injury. Near-absolute indications selected by most respondents included known adrenal insufficiency (99%) and suspicion of cryptogenic organizing pneumonia (89%), connective tissue disease (85%), or other potentially corticosteroid-responsive illnesses (85%).ConclusionsRespondents reported rarely prescribing corticosteroids for ALI, but accepted them for bronchospasm, suspected adrenal insufficiency due to previous corticosteroid use, and vasopressor-refractory septic shock. These competing indications will complicate the design and interpretation of any future large-scale trial of corticosteroids in critical illness.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12630-013-9929-3", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1017152", 
            "issn": [
              "0832-610X", 
              "1496-8975"
            ], 
            "name": "Journal canadien d'anesth\u00e9sie", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "60"
          }
        ], 
        "keywords": [
          "use of corticosteroids", 
          "acute lung injury", 
          "corticosteroid use", 
          "critical illness", 
          "adrenal insufficiency", 
          "lung injury", 
          "septic shock", 
          "absolute indication", 
          "severe community-acquired pneumonia", 
          "future large-scale trials", 
          "community-acquired pneumonia", 
          "acute respiratory distress syndrome", 
          "medical-surgical units", 
          "recent corticosteroid use", 
          "previous corticosteroid use", 
          "survey of intensivists", 
          "lower blood pressure", 
          "respiratory distress syndrome", 
          "cryptogenic organizing pneumonia", 
          "intensive care unit", 
          "connective tissue disease", 
          "large-scale trials", 
          "North American centers", 
          "four-point scale", 
          "test-retest reliability", 
          "significant bronchospasm", 
          "systemic corticosteroids", 
          "severe ARDS", 
          "blood pressure", 
          "organizing pneumonia", 
          "half of respondents", 
          "distress syndrome", 
          "care unit", 
          "tissue disease", 
          "academic hospital", 
          "corticosteroids", 
          "experienced intensivists", 
          "general internists", 
          "response rate", 
          "clinical practice", 
          "clinical setting", 
          "majority of respondents", 
          "illness", 
          "intensivists", 
          "American centers", 
          "clinical sensibility", 
          "ARDS", 
          "bronchospasm", 
          "pneumonia", 
          "patients", 
          "insufficiency", 
          "injury", 
          "Most respondents", 
          "trials", 
          "pilot testing", 
          "focus groups", 
          "indications", 
          "questionnaire items", 
          "primary objective", 
          "respondents", 
          "contraindications", 
          "respirologists", 
          "syndrome", 
          "hospital", 
          "internists", 
          "setting", 
          "disease", 
          "suspicion", 
          "surgeons", 
          "severity", 
          "efficacy", 
          "shock", 
          "survey", 
          "use", 
          "grade", 
          "group", 
          "majority", 
          "assessment", 
          "half", 
          "testing", 
          "center", 
          "units", 
          "rate", 
          "pressure", 
          "objective", 
          "practice", 
          "items", 
          "opinion", 
          "Ali", 
          "expertise", 
          "variability", 
          "North America", 
          "scale", 
          "sensibility", 
          "paper surveys", 
          "reliability", 
          "interpretation", 
          "America", 
          "design", 
          "oscillations", 
          "DesignSelf", 
          "PopulationIntensivists", 
          "clinical trial expertise", 
          "trial expertise", 
          "MeasurementsWe", 
          "multicentre Oscillation", 
          "Main resultsOur response rate", 
          "resultsOur response rate", 
          "mixed medical-surgical units", 
          "vasopressor-refractory septic shock", 
          "corticosteroid-responsive illnesses", 
          "ConclusionsRespondents", 
          "prescribing corticosteroids"
        ], 
        "name": "Corticosteroid use in the intensive care unit: a survey of intensivists", 
        "pagination": "652-659", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1008222283"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12630-013-9929-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23606231"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12630-013-9929-3", 
          "https://app.dimensions.ai/details/publication/pub.1008222283"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_591.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12630-013-9929-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12630-013-9929-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12630-013-9929-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12630-013-9929-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12630-013-9929-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    408 TRIPLES      21 PREDICATES      163 URIs      155 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12630-013-9929-3 schema:about N08e818e27e1d43c0aa64d14dfdc098a3
    2 N185b1b6117b1423a9537c1334491296a
    3 N29cace1752674aa7a5cfbbe8d7162dc7
    4 N2b7e4b72d70d402fab2d1ae3d95d4fbd
    5 N2d13d119954d4fbeb226f344d467cc62
    6 N5208c0654ef3452dacfbf1534b80f27b
    7 N525350996106441eabbb7fbe68d3582c
    8 N6ae8ac00982d452a8e9bb8ee8132869b
    9 N7f377f0610964372b463ba5b1388ac55
    10 N8df7f06f95014808a61617957e82bb0b
    11 N9429a93bce2a425ab51a2d295960616e
    12 N98b39846437d4c609500497ea9978a9f
    13 Na015ba8d14d044bf97935e659443b369
    14 Nb3db134b5567410fb62e95d0c75156d9
    15 Nba81e867c0e1431bb2a7c1c5da868bb6
    16 Nbbd8bd7817e3480984dd7e224b148740
    17 Nc0be1e4eee42405bbf279c7f8a6a62ce
    18 Nc410711c259946e2bd1b8ede81214374
    19 Nd05a156558434ba9a9ead3fa223e874f
    20 Ne7526b58dfeb4f30b1ca2183e9058b50
    21 Nee1d4057433544af9d58e953984712e4
    22 Nf7d3db32648841768065d157c885296e
    23 Nfcb568ba16be4241880595a8427cb910
    24 Nff108cef2c9b4df195a4f0c1742dec3d
    25 anzsrc-for:11
    26 anzsrc-for:1103
    27 schema:author N110edf65867246b4ac275e451e57abaa
    28 schema:datePublished 2013-04-19
    29 schema:datePublishedReg 2013-04-19
    30 schema:description ObjectiveThe efficacy of systemic corticosteroids in many critical illnesses remains uncertain. Our primary objective was to survey intensivists in North America about their perceived use of corticosteroids in clinical practice.DesignSelf-administered paper survey.PopulationIntensivists in academic hospitals with clinical trial expertise in critical illness.MeasurementsWe generated questionnaire items in focus groups and refined them after assessments of clinical sensibility and test-retest reliability and pilot testing. We administered the survey to experienced intensivists practicing in selected North American centres actively enrolling patients in the multicentre Oscillation for ARDS Treated Early (OSCILLATE) Trial (ISRCTN87124254). Respondents used a four-point scale to grade how frequently they would administer corticosteroids in 14 clinical settings. They also reported their opinions on 16 potential near-absolute indications or contraindications for the use of corticosteroids.Main resultsOur response rate was 82% (103/125). Respondents were general internists (50%), respirologists (22%), anesthesiologists (21%), and surgeons (7%) who practiced in mixed medical-surgical units. A majority of respondents reported almost always prescribing corticosteroids in the setting of significant bronchospasm in a mechanically ventilated patient (94%), recent corticosteroid use and low blood pressure (93%), and vasopressor-refractory septic shock (52%). Although more than half of respondents stated they would almost never prescribe corticosteroids in severe community-acquired pneumonia (81%), acute lung injury (ALI, 76%), acute respiratory distress syndrome (ARDS, 65%), and severe ARDS (51%), variability increased with severity of acute lung injury. Near-absolute indications selected by most respondents included known adrenal insufficiency (99%) and suspicion of cryptogenic organizing pneumonia (89%), connective tissue disease (85%), or other potentially corticosteroid-responsive illnesses (85%).ConclusionsRespondents reported rarely prescribing corticosteroids for ALI, but accepted them for bronchospasm, suspected adrenal insufficiency due to previous corticosteroid use, and vasopressor-refractory septic shock. These competing indications will complicate the design and interpretation of any future large-scale trial of corticosteroids in critical illness.
    31 schema:genre article
    32 schema:inLanguage en
    33 schema:isAccessibleForFree false
    34 schema:isPartOf N610cb932340541aeb0737851d500e940
    35 N88530123700c47079b992745a8386901
    36 sg:journal.1017152
    37 schema:keywords ARDS
    38 Ali
    39 America
    40 American centers
    41 ConclusionsRespondents
    42 DesignSelf
    43 Main resultsOur response rate
    44 MeasurementsWe
    45 Most respondents
    46 North America
    47 North American centers
    48 PopulationIntensivists
    49 absolute indication
    50 academic hospital
    51 acute lung injury
    52 acute respiratory distress syndrome
    53 adrenal insufficiency
    54 assessment
    55 blood pressure
    56 bronchospasm
    57 care unit
    58 center
    59 clinical practice
    60 clinical sensibility
    61 clinical setting
    62 clinical trial expertise
    63 community-acquired pneumonia
    64 connective tissue disease
    65 contraindications
    66 corticosteroid use
    67 corticosteroid-responsive illnesses
    68 corticosteroids
    69 critical illness
    70 cryptogenic organizing pneumonia
    71 design
    72 disease
    73 distress syndrome
    74 efficacy
    75 experienced intensivists
    76 expertise
    77 focus groups
    78 four-point scale
    79 future large-scale trials
    80 general internists
    81 grade
    82 group
    83 half
    84 half of respondents
    85 hospital
    86 illness
    87 indications
    88 injury
    89 insufficiency
    90 intensive care unit
    91 intensivists
    92 internists
    93 interpretation
    94 items
    95 large-scale trials
    96 lower blood pressure
    97 lung injury
    98 majority
    99 majority of respondents
    100 medical-surgical units
    101 mixed medical-surgical units
    102 multicentre Oscillation
    103 objective
    104 opinion
    105 organizing pneumonia
    106 oscillations
    107 paper surveys
    108 patients
    109 pilot testing
    110 pneumonia
    111 practice
    112 prescribing corticosteroids
    113 pressure
    114 previous corticosteroid use
    115 primary objective
    116 questionnaire items
    117 rate
    118 recent corticosteroid use
    119 reliability
    120 respiratory distress syndrome
    121 respirologists
    122 respondents
    123 response rate
    124 resultsOur response rate
    125 scale
    126 sensibility
    127 septic shock
    128 setting
    129 severe ARDS
    130 severe community-acquired pneumonia
    131 severity
    132 shock
    133 significant bronchospasm
    134 surgeons
    135 survey
    136 survey of intensivists
    137 suspicion
    138 syndrome
    139 systemic corticosteroids
    140 test-retest reliability
    141 testing
    142 tissue disease
    143 trial expertise
    144 trials
    145 units
    146 use
    147 use of corticosteroids
    148 variability
    149 vasopressor-refractory septic shock
    150 schema:name Corticosteroid use in the intensive care unit: a survey of intensivists
    151 schema:pagination 652-659
    152 schema:productId N40c6d363b9c04ba1bc1fe12f54070424
    153 Nc0b027d888584db5a45f382caa11d22b
    154 Nf005597bc7424a1aab00f897cfa832eb
    155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008222283
    156 https://doi.org/10.1007/s12630-013-9929-3
    157 schema:sdDatePublished 2021-12-01T19:28
    158 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    159 schema:sdPublisher Nbd200365cbec49ab85e658de73d56a8e
    160 schema:url https://doi.org/10.1007/s12630-013-9929-3
    161 sgo:license sg:explorer/license/
    162 sgo:sdDataset articles
    163 rdf:type schema:ScholarlyArticle
    164 N08e818e27e1d43c0aa64d14dfdc098a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Community-Acquired Infections
    166 rdf:type schema:DefinedTerm
    167 N110edf65867246b4ac275e451e57abaa rdf:first sg:person.01321064225.67
    168 rdf:rest N60d1e539077d406daafc26451549b1e3
    169 N185b1b6117b1423a9537c1334491296a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Connective Tissue Diseases
    171 rdf:type schema:DefinedTerm
    172 N18b17f57432247f4a20cda66741ea242 rdf:first sg:person.013655176271.89
    173 rdf:rest Ne168d2e499074d89bce5ffbd492c01c6
    174 N29cace1752674aa7a5cfbbe8d7162dc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Anesthesiology
    176 rdf:type schema:DefinedTerm
    177 N2b7e4b72d70d402fab2d1ae3d95d4fbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Contraindications
    179 rdf:type schema:DefinedTerm
    180 N2d13d119954d4fbeb226f344d467cc62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Bronchial Spasm
    182 rdf:type schema:DefinedTerm
    183 N3d50902f9b644336979bd6bb407aa1f8 rdf:first sg:person.01372124736.59
    184 rdf:rest Nf5260874535741ebaecaed82f54891ac
    185 N40c6d363b9c04ba1bc1fe12f54070424 schema:name doi
    186 schema:value 10.1007/s12630-013-9929-3
    187 rdf:type schema:PropertyValue
    188 N5208c0654ef3452dacfbf1534b80f27b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name General Surgery
    190 rdf:type schema:DefinedTerm
    191 N525350996106441eabbb7fbe68d3582c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Surveys and Questionnaires
    193 rdf:type schema:DefinedTerm
    194 N57621ca076c04510a9909eb0496b4c29 rdf:first sg:person.0673455705.49
    195 rdf:rest Ndbba74ac6a8a48b18124cbc46ad7d267
    196 N57b5256484484a7991a42b53e3178e08 rdf:first sg:person.013535244737.13
    197 rdf:rest Ndff769c9e2544916b10dbdac97621897
    198 N5f2c900c5b8d453abc92e9d95dfe4cc9 rdf:first sg:person.01253006352.94
    199 rdf:rest Nb49e28e6e5e843fbbf2ee9288594d7b6
    200 N60d1e539077d406daafc26451549b1e3 rdf:first sg:person.01014724324.39
    201 rdf:rest Na025802c27d94338bcf153c7983c0709
    202 N610cb932340541aeb0737851d500e940 schema:issueNumber 7
    203 rdf:type schema:PublicationIssue
    204 N6ae8ac00982d452a8e9bb8ee8132869b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Pulmonary Medicine
    206 rdf:type schema:DefinedTerm
    207 N7dd9228d758e4d2c902d54cfdf43186c rdf:first sg:person.0710200124.41
    208 rdf:rest N903417c8a8e549f9aeabdbe1754de096
    209 N7f377f0610964372b463ba5b1388ac55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Adrenal Cortex Hormones
    211 rdf:type schema:DefinedTerm
    212 N88530123700c47079b992745a8386901 schema:volumeNumber 60
    213 rdf:type schema:PublicationVolume
    214 N8df7f06f95014808a61617957e82bb0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Pneumonia
    216 rdf:type schema:DefinedTerm
    217 N903417c8a8e549f9aeabdbe1754de096 rdf:first sg:person.01204356253.41
    218 rdf:rest N18b17f57432247f4a20cda66741ea242
    219 N9429a93bce2a425ab51a2d295960616e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Attitude of Health Personnel
    221 rdf:type schema:DefinedTerm
    222 N98b39846437d4c609500497ea9978a9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Respiration, Artificial
    224 rdf:type schema:DefinedTerm
    225 Na015ba8d14d044bf97935e659443b369 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Shock, Septic
    227 rdf:type schema:DefinedTerm
    228 Na025802c27d94338bcf153c7983c0709 rdf:first sg:person.01205364112.01
    229 rdf:rest N3d50902f9b644336979bd6bb407aa1f8
    230 Nb3db134b5567410fb62e95d0c75156d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Humans
    232 rdf:type schema:DefinedTerm
    233 Nb49e28e6e5e843fbbf2ee9288594d7b6 rdf:first sg:person.01202370737.50
    234 rdf:rest N57b5256484484a7991a42b53e3178e08
    235 Nba81e867c0e1431bb2a7c1c5da868bb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Critical Illness
    237 rdf:type schema:DefinedTerm
    238 Nbbd8bd7817e3480984dd7e224b148740 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Pulmonary Disease, Chronic Obstructive
    240 rdf:type schema:DefinedTerm
    241 Nbd200365cbec49ab85e658de73d56a8e schema:name Springer Nature - SN SciGraph project
    242 rdf:type schema:Organization
    243 Nc0b027d888584db5a45f382caa11d22b schema:name dimensions_id
    244 schema:value pub.1008222283
    245 rdf:type schema:PropertyValue
    246 Nc0be1e4eee42405bbf279c7f8a6a62ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    247 schema:name Hypotension
    248 rdf:type schema:DefinedTerm
    249 Nc410711c259946e2bd1b8ede81214374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    250 schema:name Self Report
    251 rdf:type schema:DefinedTerm
    252 Nd05a156558434ba9a9ead3fa223e874f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    253 schema:name Cryptogenic Organizing Pneumonia
    254 rdf:type schema:DefinedTerm
    255 Ndbba74ac6a8a48b18124cbc46ad7d267 rdf:first sg:person.01316617337.49
    256 rdf:rest rdf:nil
    257 Ndff769c9e2544916b10dbdac97621897 rdf:first sg:person.0673055064.37
    258 rdf:rest N7dd9228d758e4d2c902d54cfdf43186c
    259 Ne168d2e499074d89bce5ffbd492c01c6 rdf:first sg:person.01072003437.36
    260 rdf:rest N57621ca076c04510a9909eb0496b4c29
    261 Ne7526b58dfeb4f30b1ca2183e9058b50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    262 schema:name Adrenal Insufficiency
    263 rdf:type schema:DefinedTerm
    264 Nee1d4057433544af9d58e953984712e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    265 schema:name Critical Care
    266 rdf:type schema:DefinedTerm
    267 Nf005597bc7424a1aab00f897cfa832eb schema:name pubmed_id
    268 schema:value 23606231
    269 rdf:type schema:PropertyValue
    270 Nf15d6043f7244a15ad8df377392c7f5b rdf:first sg:person.01066142337.60
    271 rdf:rest N5f2c900c5b8d453abc92e9d95dfe4cc9
    272 Nf5260874535741ebaecaed82f54891ac rdf:first sg:person.015720567657.32
    273 rdf:rest Nf15d6043f7244a15ad8df377392c7f5b
    274 Nf7d3db32648841768065d157c885296e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    275 schema:name Internal Medicine
    276 rdf:type schema:DefinedTerm
    277 Nfcb568ba16be4241880595a8427cb910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    278 schema:name Acute Lung Injury
    279 rdf:type schema:DefinedTerm
    280 Nff108cef2c9b4df195a4f0c1742dec3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    281 schema:name Respiratory Distress Syndrome, Adult
    282 rdf:type schema:DefinedTerm
    283 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    284 schema:name Medical and Health Sciences
    285 rdf:type schema:DefinedTerm
    286 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    287 schema:name Clinical Sciences
    288 rdf:type schema:DefinedTerm
    289 sg:journal.1017152 schema:issn 0832-610X
    290 1496-8975
    291 schema:name Journal canadien d'anesthésie
    292 schema:publisher Springer Nature
    293 rdf:type schema:Periodical
    294 sg:person.01014724324.39 schema:affiliation grid-institutes:grid.86715.3d
    295 schema:familyName Quiroz Martinez
    296 schema:givenName Hector
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014724324.39
    298 rdf:type schema:Person
    299 sg:person.01066142337.60 schema:affiliation grid-institutes:grid.23856.3a
    300 schema:familyName Lauzier
    301 schema:givenName François
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60
    303 rdf:type schema:Person
    304 sg:person.01072003437.36 schema:affiliation grid-institutes:grid.25073.33
    305 schema:familyName Choong
    306 schema:givenName Karen
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072003437.36
    308 rdf:type schema:Person
    309 sg:person.01202370737.50 schema:affiliation grid-institutes:grid.21107.35
    310 schema:familyName Kho
    311 schema:givenName Michelle E.
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202370737.50
    313 rdf:type schema:Person
    314 sg:person.01204356253.41 schema:affiliation grid-institutes:grid.241116.1
    315 schema:familyName Douglas
    316 schema:givenName Ivor
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204356253.41
    318 rdf:type schema:Person
    319 sg:person.01205364112.01 schema:affiliation grid-institutes:grid.17063.33
    320 schema:familyName Adhikari
    321 schema:givenName Neill K. J.
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205364112.01
    323 rdf:type schema:Person
    324 sg:person.01253006352.94 schema:affiliation grid-institutes:grid.23856.3a
    325 schema:familyName Turgeon
    326 schema:givenName Alexis F.
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253006352.94
    328 rdf:type schema:Person
    329 sg:person.01316617337.49 schema:affiliation grid-institutes:grid.25073.33
    330 schema:familyName Meade
    331 schema:givenName Maureen O.
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316617337.49
    333 rdf:type schema:Person
    334 sg:person.01321064225.67 schema:affiliation grid-institutes:grid.86715.3d
    335 schema:familyName Lamontagne
    336 schema:givenName François
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321064225.67
    338 rdf:type schema:Person
    339 sg:person.013535244737.13 schema:affiliation grid-institutes:grid.415502.7
    340 schema:familyName Burns
    341 schema:givenName Karen E. A.
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013535244737.13
    343 rdf:type schema:Person
    344 sg:person.013655176271.89 schema:affiliation grid-institutes:grid.86715.3d
    345 schema:familyName Poulin
    346 schema:givenName Yannick
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013655176271.89
    348 rdf:type schema:Person
    349 sg:person.01372124736.59 schema:affiliation grid-institutes:grid.25073.33
    350 schema:familyName Cook
    351 schema:givenName Deborah J.
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372124736.59
    353 rdf:type schema:Person
    354 sg:person.015720567657.32 schema:affiliation grid-institutes:grid.39381.30
    355 schema:familyName Koo
    356 schema:givenName Karen K. Y.
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015720567657.32
    358 rdf:type schema:Person
    359 sg:person.0673055064.37 schema:affiliation grid-institutes:grid.415502.7
    360 schema:familyName Chant
    361 schema:givenName Clarence
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673055064.37
    363 rdf:type schema:Person
    364 sg:person.0673455705.49 schema:affiliation grid-institutes:grid.17063.33
    365 schema:familyName Ferguson
    366 schema:givenName Niall D.
    367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673455705.49
    368 rdf:type schema:Person
    369 sg:person.0710200124.41 schema:affiliation grid-institutes:grid.17063.33
    370 schema:familyName Fowler
    371 schema:givenName Rob
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710200124.41
    373 rdf:type schema:Person
    374 grid-institutes:grid.17063.33 schema:alternateName Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    375 Interdepartmental Division of Critical Care, and Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    376 schema:name Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    377 Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    378 Interdepartmental Division of Critical Care, and Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    379 rdf:type schema:Organization
    380 grid-institutes:grid.21107.35 schema:alternateName Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA
    381 schema:name Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA
    382 rdf:type schema:Organization
    383 grid-institutes:grid.23856.3a schema:alternateName Centre de Recherche FRQ-S du CHU de Québec, Division of Critical Care, Department of Anesthesiology, Université Laval, Québec City, QC, Canada
    384 Centre de Recherche FRQ-S du CHU de Québec, Division of Critical Care, Departments of Anesthesiology and Medicine, Université Laval, Québec City, QC, Canada
    385 schema:name Centre de Recherche FRQ-S du CHU de Québec, Division of Critical Care, Department of Anesthesiology, Université Laval, Québec City, QC, Canada
    386 Centre de Recherche FRQ-S du CHU de Québec, Division of Critical Care, Departments of Anesthesiology and Medicine, Université Laval, Québec City, QC, Canada
    387 rdf:type schema:Organization
    388 grid-institutes:grid.241116.1 schema:alternateName Pulmonary Sciences & Critical Care Medicine, Denver Health and University of Colorado, School of Medicine, Denver, CO, USA
    389 schema:name Pulmonary Sciences & Critical Care Medicine, Denver Health and University of Colorado, School of Medicine, Denver, CO, USA
    390 rdf:type schema:Organization
    391 grid-institutes:grid.25073.33 schema:alternateName Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
    392 Departments of Pediatrics and Critical Care, McMaster University, Hamilton, ON, Canada
    393 schema:name Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada
    394 Departments of Pediatrics and Critical Care, McMaster University, Hamilton, ON, Canada
    395 rdf:type schema:Organization
    396 grid-institutes:grid.39381.30 schema:alternateName Department of Medicine, University of Western Ontario, Toronto, ON, Canada
    397 schema:name Department of Medicine, University of Western Ontario, Toronto, ON, Canada
    398 rdf:type schema:Organization
    399 grid-institutes:grid.415502.7 schema:alternateName Department of Critical Care and the Keenan Research Centre/Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada
    400 Pharmacy Department, St Michael’s Hospital, Keenan Research Centre at Li Ka Shing Knowledge Institute, Toronto, ON, Canada
    401 schema:name Department of Critical Care and the Keenan Research Centre/Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada
    402 Pharmacy Department, St Michael’s Hospital, Keenan Research Centre at Li Ka Shing Knowledge Institute, Toronto, ON, Canada
    403 rdf:type schema:Organization
    404 grid-institutes:grid.86715.3d schema:alternateName Centre de Recherche Clinique Étienne-Le Bel, Université de Sherbrooke, Sherbrooke, QC, Canada
    405 Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada
    406 schema:name Centre de Recherche Clinique Étienne-Le Bel, Université de Sherbrooke, Sherbrooke, QC, Canada
    407 Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada
    408 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...