Interventions Against Disability in Frail Older Adults: Lessons Learned from Clinical Trials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Bertrand Fougère, J. E. Morley, M. O. Little, P. de Souto Barreto, M. Cesari, B. Vellas

ABSTRACT

As the population ages, the number of older people with frailty is expected to increase worldwide with consequent rising of expenditures for healthcare and long-term care. Effective methods for preventing or delaying the onset of disability are urgently required. Frailty is a common and important geriatric condition characterized by age-associated declines in multiple physiological mechanisms, leading to increased vulnerability to stressors and higher risk for adverse health outcomes. Significant advancements have been made in the understanding of the frailty pathophysiological background. Given its multidimensional nature, reversing frailty requires a comprehensive approach. In this context, several studies testing the effects of pharmacological approach, physical activity, nutritional intervention, or cognitive training showed evidence of efficacy in frail older adults. Important innovations in ongoing trials include the development of multidomain interventions. Challenges include the use of trial designs, the development of standardized, sensitive outcome measures, and the need for interventions that can be implemented in resource-poor settings. In this viewpoint paper, based on recent literature, our aim was to identify relevant studies performed to reverse or delay disability in frail older adults. More... »

PAGES

676-688

References to SciGraph publications

  • 2013-12. Embrace, a model for integrated elderly care: study protocol of a randomized controlled trial on the effectiveness regarding patient outcomes, service use, costs, and quality of care in BMC GERIATRICS
  • 2012-07-19. A randomized controlled Alzheimer’s disease Prevention trial’s evolution into an exposure trial: The Preadvise trial in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2017-02. The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project: advancing the care of physically frail and sarcopenic older people in AGING CLINICAL AND EXPERIMENTAL RESEARCH
  • 2013-12. Measures of frailty in population-based studies: an overview in BMC GERIATRICS
  • 2012-12. Effect of a multifactorial interdisciplinary intervention on mobility-related disability in frail older people: randomised controlled trial in BMC MEDICINE
  • 2010-12. Physical activity and functional limitations in older adults: a systematic review related to Canada's Physical Activity Guidelines in INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
  • 2013-12. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial in BMC MEDICINE
  • 2017-12. Emerging biomarkers and screening for cognitive frailty in AGING CLINICAL AND EXPERIMENTAL RESEARCH
  • 2013-12. Impact of geriatric consultation teams on clinical outcome in acute hospitals: a systematic review and meta-analysis in BMC MEDICINE
  • 2008-12. Frailty Intervention Trial (FIT) in BMC GERIATRICS
  • 2013-05. The new metabolic treatments for sarcopenia in AGING CLINICAL AND EXPERIMENTAL RESEARCH
  • 2012-12. A pilot randomized controlled trial to improve geriatric frailty in BMC GERIATRICS
  • 2014-04. Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians in GEROSCIENCE
  • 2006-12. Cost effectiveness of preventive home visits to the elderly in THE EUROPEAN JOURNAL OF HEALTH ECONOMICS
  • 2013-01. A randomized controlled Alzheimer’s disease prevention trial’s evolution into an exposure trial: The preadvise trial in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2010-12. A Frailty Instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE) in BMC GERIATRICS
  • 2008-01. The I.A.N.A. task force on frailty assessment of older people in clinical practice in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2012-12. A systematic review of interventions in primary care to improve health literacy for chronic disease behavioral risk factors in BMC FAMILY PRACTICE
  • 2002-12. Frailty, fitness and late-life mortality in relation to chronological and biological age in BMC GERIATRICS
  • 2011-08-05. The Impact of Physical and Mental Activity on Cognitive Aging in BEHAVIORAL NEUROBIOLOGY OF AGING
  • 2014-12. An evaluation of the effectiveness of a multi-modal intervention in frail and pre-frail older people with type 2 diabetes - the MID-Frail study: study protocol for a randomised controlled trial in TRIALS
  • 2014-12. Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies in BMC PUBLIC HEALTH
  • 2013-12. High protein intake is associated with low prevalence of frailty among old Japanese women: a multicenter cross-sectional study in NUTRITION JOURNAL
  • 2014-12. Effectiveness of a primary care based multifactorial intervention to improve frailty parameters in the elderly: a randomised clinical trial: rationale and study design in BMC GERIATRICS
  • 2010-12. Elderly persons in the risk zone. Design of a multidimensional, health-promoting, randomised three-armed controlled trial for "prefrail" people of 80+ years living at home in BMC GERIATRICS
  • 2009-12. Multi-component health promotion and disease prevention for community-dwelling frail elderly persons: a systematic review in EUROPEAN JOURNAL OF AGEING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12603-017-0987-z

    DOI

    http://dx.doi.org/10.1007/s12603-017-0987-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092347490

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29806856


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