Souvenaid®: A new approach to management of early Alzheimer’s disease View Full Text


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Article Info

DATE

2013-11-04

AUTHORS

C. W. Ritchie, J. Bajwa, G. Coleman, K. Hope, R. W. Jones, M. Lawton, M. Marven, P. Passmore

ABSTRACT

Synaptic loss correlates closely with cognitive deficits in Alzheimer’s disease and represents a new target for intervention. Souvenaid® is the first medical nutrition product to be designed to support synapse formation and function in early Alzheimer’s disease, and has undergone an extensive, 12-year development programme. The relatively large amount of clinical data available for Souvenaid® is unusual for a medical nutrition product. Souvenaid® contains omega-3 polyunsaturated fatty acids (docosahexaenoic acid and eicosapentaenoic acid), uridine (as uridine monophosphate) and choline which are nutritional precursors required for synaptic membrane phospholipid synthesis, together with phospholipids and other cofactors. Souvenaid® has demonstrated cognitive benefits in patients with mild Alzheimer’s disease but not in patients with mild-to-moderate Alzheimer’s disease. Two randomised, double-blind, controlled trials (duration 12 and 24 weeks) in patients with mild Alzheimer’s disease untreated with acetylcholinesterase inhibitors and/or memantine have demonstrated that Souvenaid® is well tolerated and improves episodic memory performance. The daily intake of Souvenaid® has not been associated with any harmful effects or interactions with medications and none are anticipated. The ongoing, 24-month, European Union-funded LipiDiDiet trial in subjects with prodromal Alzheimer’s disease is evaluating the potential benefits of Souvenaid® on memory and in slowing progression to Alzheimer’s dementia. If Souvenaid® induces synaptogenesis and improved synaptic function, it may provide benefits in other clinical conditions characterised by neurodegeneration. A number of trials are ongoing and planned to evaluate the potential wider benefits of Souvenaid®. More... »

PAGES

291-299

References to SciGraph publications

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  • 2012-09-28. Challenges in managing the diet of older adults with early-stage Alzheimer dementia: A caregiver perspective in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2013-05-28. Caregiver Health: Health of Caregivers of Alzheimer’s and Other Dementia Patients in CURRENT PSYCHIATRY REPORTS
  • 2006-04. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3 in NATURE
  • 2006-11. Vitamin B12, a chlorophyll-related analog to pheophytin a from marine brown algae, promotes neurite outgrowth and stimulates differentiation in PC12 cells in CYTOTECHNOLOGY
  • 2003-08. Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer’s disease in JOURNAL OF NEURAL TRANSMISSION
  • 1998-05. Effects of Marine Fish Oils on the Anticoagulation Status of Patients Receiving Chronic Warfarin Therapy in JOURNAL OF THROMBOSIS AND THROMBOLYSIS
  • 2007-05-07. Synapse formation on neurons born in the adult hippocampus in NATURE NEUROSCIENCE
  • 1998-09. Differential Diagnosis of the Major Progressive Dementias and Depression in Middle and Late Adulthood: A Summary of the Literature of the Early 1990s in NEUROPSYCHOLOGY REVIEW
  • 2012-08. Fruit, vegetables and prevention of cognitive decline or dementia: A systematic review of cohort studies in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2001-07. Brain Membrane Phospholipid Alterations in Alzheimer's Disease in NEUROCHEMICAL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12603-013-0411-2

    DOI

    http://dx.doi.org/10.1007/s12603-013-0411-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034591338

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24626757


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