A probiotics-containing biscuit modulates the intestinal microbiota in the elderly View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02

AUTHORS

S. Rampelli, M. Candela, M. Severgnini, E. Biagi, S. Turroni, M. Roselli, P. Carnevali, L. Donini, P. Brigidi

ABSTRACT

OBJECTIVES: Evaluation of the impact of a biscuit containing the probiotics Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 on the intestinal microbiota in the elderly. DESIGN: Randomized double-blind placebo-controlled trial. PARTICIPANTS: Thirty-two elderly volunteers living in Italy. The group was composed of 19 women and 13 men aged between 71 and 88 years (mean 76). INTERVENTION: Subjects were randomized in two groups consuming one dose of the probiotics-containing biscuit or placebo once a day for 30 days. MEASUREMENTS: For each subject the intestinal microbiota was characterized using the phylogenetic microarray platform HTF-Microbi.Array before and after intervention. RESULTS: Our data demonstrated that one-month consumption of a probiotics-containing biscuit was effective in redressing some of the age-related dysbioses of the intestinal microbiota. In particular, the probiotic treatment reverted the age-related increase of the opportunistic pathogens Clostridium cluster XI, Clostridium difficile, Clostridium perfringens, Enterococcus faecium and the enteropathogenic genus Campylobacter. CONCLUSION: The present study opens the way to the development of elderly-tailored probiotic-based functional foods to counteract the age-related dysbioses of the intestinal microbiota. More... »

PAGES

166-172

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12603-012-0372-x

    DOI

    http://dx.doi.org/10.1007/s12603-012-0372-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033033534

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23364497


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