Immune Modulation Capability of Exopolysaccharides Synthesised by Lactic Acid Bacteria and Bifidobacteria View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-09-29

AUTHORS

Claudio Hidalgo-Cantabrana, Patricia López, Miguel Gueimonde, Clara G. de los Reyes-Gavilán, Ana Suárez, Abelardo Margolles, Patricia Ruas-Madiedo

ABSTRACT

During recent years, the exopolysaccharides (EPS) produced by some strains of lactic acid bacteria and bifidobacteria have attracted the attention of researchers, mainly due to their potential technological applications. However, more recently, it has been observed that some of these EPS present immunomodulatory properties, which suggest a potential effect on human health. Whereas EPS from lactic acid bacteria have been studied in some detail, those of bifidobacteria largely remain uncharacterized in spite of the ubiquity of EPS genes in Bifidobacterium genomes. In this review, we have analysed the data collected in the literature about the potential immune-modulating capability of EPS produced by lactic acid bacteria and bifidobacteria. From this data analysis, as well as from results obtained in our group, a hypothesis relating the physicochemical characteristics of EPS with their immune modulation capability was highlighted. We propose that EPS having negative charge and/or small size (molecular weight) are able to act as mild stimulators of immune cells, whereas those polymers non-charged and with a large size present a suppressive profile. More... »

PAGES

227-237

Journal

TITLE

Probiotics and Antimicrobial Proteins

ISSUE

4

VOLUME

4

Related Patents

  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Pirin Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Composition Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Bacterium For Use As A Probiotic For Nutritional And Medical Applications
  • Compositions Comprising Bacterial Strains
  • Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Pirin Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising A Bacterial Strain Of The Genus Megasphera And Uses Thereof
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strain
  • Lactic Acid Bacterial Strains
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12602-012-9110-2

    DOI

    http://dx.doi.org/10.1007/s12602-012-9110-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053079465

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26782182


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/grid.419120.f", 
              "name": [
                "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hidalgo-Cantabrana", 
            "givenName": "Claudio", 
            "id": "sg:person.01270323165.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270323165.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Functional Biology, University of Oviedo, Immunology Area, Oviedo, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/grid.10863.3c", 
              "name": [
                "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain", 
                "Department of Functional Biology, University of Oviedo, Immunology Area, Oviedo, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f3pez", 
            "givenName": "Patricia", 
            "id": "sg:person.0617365355.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617365355.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/grid.419120.f", 
              "name": [
                "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gueimonde", 
            "givenName": "Miguel", 
            "id": "sg:person.01052067103.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052067103.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/grid.419120.f", 
              "name": [
                "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de los Reyes-Gavil\u00e1n", 
            "givenName": "Clara G.", 
            "id": "sg:person.01302544103.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302544103.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Functional Biology, University of Oviedo, Immunology Area, Oviedo, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/grid.10863.3c", 
              "name": [
                "Department of Functional Biology, University of Oviedo, Immunology Area, Oviedo, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Su\u00e1rez", 
            "givenName": "Ana", 
            "id": "sg:person.015560755322.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015560755322.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/grid.419120.f", 
              "name": [
                "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Margolles", 
            "givenName": "Abelardo", 
            "id": "sg:person.01030457452.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030457452.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/grid.419120.f", 
              "name": [
                "Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s/n, 33300, Villaviciosa, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruas-Madiedo", 
            "givenName": "Patricia", 
            "id": "sg:person.01216541753.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216541753.07"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrc2651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016070520", 
              "https://doi.org/10.1038/nrc2651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004447638", 
              "https://doi.org/10.1038/nri2515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049344936", 
              "https://doi.org/10.1038/nrmicro2695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006761326", 
              "https://doi.org/10.1038/nature07008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-006-0469-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012848237", 
              "https://doi.org/10.1007/s00253-006-0469-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00166915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044666811", 
              "https://doi.org/10.1007/bf00166915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040773999", 
              "https://doi.org/10.1038/nrmicro2354"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-09-29", 
        "datePublishedReg": "2012-09-29", 
        "description": "During recent years, the exopolysaccharides (EPS) produced by some strains of lactic acid bacteria and bifidobacteria have attracted the attention of researchers, mainly due to their potential technological applications. However, more recently, it has been observed that some of these EPS present immunomodulatory properties, which suggest a potential effect on human health. Whereas EPS from lactic acid bacteria have been studied in some detail, those of bifidobacteria largely remain uncharacterized in spite of the ubiquity of EPS genes in Bifidobacterium genomes. In this review, we have analysed the data collected in the literature about the potential immune-modulating capability of EPS produced by lactic acid bacteria and bifidobacteria. From this data analysis, as well as from results obtained in our group, a hypothesis relating the physicochemical characteristics of EPS with their immune modulation capability was highlighted. We propose that EPS having negative charge and/or small size (molecular weight) are able to act as mild stimulators of immune cells, whereas those polymers non-charged and with a large size present a suppressive profile.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12602-012-9110-2", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1040556", 
            "issn": [
              "1867-1306", 
              "1867-1314"
            ], 
            "name": "Probiotics and Antimicrobial Proteins", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "keywords": [
          "immune cells", 
          "immunomodulatory properties", 
          "lactic acid bacteria", 
          "suppressive profile", 
          "acid bacteria", 
          "bifidobacteria", 
          "potential effects", 
          "mild stimulators", 
          "stimulator", 
          "human health", 
          "bacteria", 
          "health", 
          "cells", 
          "review", 
          "group", 
          "years", 
          "Bifidobacterium genomes", 
          "data analysis", 
          "genes", 
          "effect", 
          "recent years", 
          "strains", 
          "hypothesis", 
          "profile", 
          "spite", 
          "data", 
          "literature", 
          "exopolysaccharide", 
          "analysis", 
          "present", 
          "physicochemical characteristics", 
          "results", 
          "characteristics", 
          "small size", 
          "attention", 
          "size", 
          "genome", 
          "attention of researchers", 
          "researchers", 
          "size present", 
          "detail", 
          "capability", 
          "negative charge", 
          "ubiquity", 
          "properties", 
          "applications", 
          "modulation capability", 
          "charge", 
          "EPS genes", 
          "polymers", 
          "technological applications", 
          "potential technological applications"
        ], 
        "name": "Immune Modulation Capability of Exopolysaccharides Synthesised by Lactic Acid Bacteria and Bifidobacteria", 
        "pagination": "227-237", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053079465"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12602-012-9110-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26782182"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12602-012-9110-2", 
          "https://app.dimensions.ai/details/publication/pub.1053079465"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_572.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12602-012-9110-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12602-012-9110-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12602-012-9110-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12602-012-9110-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12602-012-9110-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    187 TRIPLES      21 PREDICATES      84 URIs      69 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12602-012-9110-2 schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author N3eed6fc880574d799d5145e9be48fc33
    4 schema:citation sg:pub.10.1007/bf00166915
    5 sg:pub.10.1007/s00253-006-0469-4
    6 sg:pub.10.1038/nature07008
    7 sg:pub.10.1038/nrc2651
    8 sg:pub.10.1038/nri2515
    9 sg:pub.10.1038/nrmicro2354
    10 sg:pub.10.1038/nrmicro2695
    11 schema:datePublished 2012-09-29
    12 schema:datePublishedReg 2012-09-29
    13 schema:description During recent years, the exopolysaccharides (EPS) produced by some strains of lactic acid bacteria and bifidobacteria have attracted the attention of researchers, mainly due to their potential technological applications. However, more recently, it has been observed that some of these EPS present immunomodulatory properties, which suggest a potential effect on human health. Whereas EPS from lactic acid bacteria have been studied in some detail, those of bifidobacteria largely remain uncharacterized in spite of the ubiquity of EPS genes in Bifidobacterium genomes. In this review, we have analysed the data collected in the literature about the potential immune-modulating capability of EPS produced by lactic acid bacteria and bifidobacteria. From this data analysis, as well as from results obtained in our group, a hypothesis relating the physicochemical characteristics of EPS with their immune modulation capability was highlighted. We propose that EPS having negative charge and/or small size (molecular weight) are able to act as mild stimulators of immune cells, whereas those polymers non-charged and with a large size present a suppressive profile.
    14 schema:genre article
    15 schema:isAccessibleForFree true
    16 schema:isPartOf N0784f8e0c0584949bc0f462383dcff59
    17 Nf6adc5e0799b4ee7a91ae223cd47aa48
    18 sg:journal.1040556
    19 schema:keywords Bifidobacterium genomes
    20 EPS genes
    21 acid bacteria
    22 analysis
    23 applications
    24 attention
    25 attention of researchers
    26 bacteria
    27 bifidobacteria
    28 capability
    29 cells
    30 characteristics
    31 charge
    32 data
    33 data analysis
    34 detail
    35 effect
    36 exopolysaccharide
    37 genes
    38 genome
    39 group
    40 health
    41 human health
    42 hypothesis
    43 immune cells
    44 immunomodulatory properties
    45 lactic acid bacteria
    46 literature
    47 mild stimulators
    48 modulation capability
    49 negative charge
    50 physicochemical characteristics
    51 polymers
    52 potential effects
    53 potential technological applications
    54 present
    55 profile
    56 properties
    57 recent years
    58 researchers
    59 results
    60 review
    61 size
    62 size present
    63 small size
    64 spite
    65 stimulator
    66 strains
    67 suppressive profile
    68 technological applications
    69 ubiquity
    70 years
    71 schema:name Immune Modulation Capability of Exopolysaccharides Synthesised by Lactic Acid Bacteria and Bifidobacteria
    72 schema:pagination 227-237
    73 schema:productId N3a79589f75684cbf970835896b5e6075
    74 N4b24bde4fe69422ea889de94de490d7f
    75 Nd3591065f06e458989ea0d4a565f55c9
    76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053079465
    77 https://doi.org/10.1007/s12602-012-9110-2
    78 schema:sdDatePublished 2022-12-01T06:30
    79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    80 schema:sdPublisher N22b6518a8b4345ec9d48db23e3ca2386
    81 schema:url https://doi.org/10.1007/s12602-012-9110-2
    82 sgo:license sg:explorer/license/
    83 sgo:sdDataset articles
    84 rdf:type schema:ScholarlyArticle
    85 N0784f8e0c0584949bc0f462383dcff59 schema:issueNumber 4
    86 rdf:type schema:PublicationIssue
    87 N22b6518a8b4345ec9d48db23e3ca2386 schema:name Springer Nature - SN SciGraph project
    88 rdf:type schema:Organization
    89 N32b709c25468477f942a1613c07c14cb rdf:first sg:person.01052067103.36
    90 rdf:rest N4d65a23ecb6d40c49e4f096304492543
    91 N3a79589f75684cbf970835896b5e6075 schema:name doi
    92 schema:value 10.1007/s12602-012-9110-2
    93 rdf:type schema:PropertyValue
    94 N3eed6fc880574d799d5145e9be48fc33 rdf:first sg:person.01270323165.16
    95 rdf:rest N8e15db7c6db34f5ea67ed5d5c0a38e3f
    96 N4b24bde4fe69422ea889de94de490d7f schema:name dimensions_id
    97 schema:value pub.1053079465
    98 rdf:type schema:PropertyValue
    99 N4d65a23ecb6d40c49e4f096304492543 rdf:first sg:person.01302544103.58
    100 rdf:rest Ndbe880d7a75b46a0ae44a29195378cf2
    101 N8e15db7c6db34f5ea67ed5d5c0a38e3f rdf:first sg:person.0617365355.29
    102 rdf:rest N32b709c25468477f942a1613c07c14cb
    103 Nd3591065f06e458989ea0d4a565f55c9 schema:name pubmed_id
    104 schema:value 26782182
    105 rdf:type schema:PropertyValue
    106 Nd35aa05220d24f51b706c548b9dec5bb rdf:first sg:person.01030457452.60
    107 rdf:rest Nd746f9d33be445e79a37d5a74f9fc693
    108 Nd746f9d33be445e79a37d5a74f9fc693 rdf:first sg:person.01216541753.07
    109 rdf:rest rdf:nil
    110 Ndbe880d7a75b46a0ae44a29195378cf2 rdf:first sg:person.015560755322.46
    111 rdf:rest Nd35aa05220d24f51b706c548b9dec5bb
    112 Nf6adc5e0799b4ee7a91ae223cd47aa48 schema:volumeNumber 4
    113 rdf:type schema:PublicationVolume
    114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    115 schema:name Medical and Health Sciences
    116 rdf:type schema:DefinedTerm
    117 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    118 schema:name Immunology
    119 rdf:type schema:DefinedTerm
    120 sg:journal.1040556 schema:issn 1867-1306
    121 1867-1314
    122 schema:name Probiotics and Antimicrobial Proteins
    123 schema:publisher Springer Nature
    124 rdf:type schema:Periodical
    125 sg:person.01030457452.60 schema:affiliation grid-institutes:grid.419120.f
    126 schema:familyName Margolles
    127 schema:givenName Abelardo
    128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030457452.60
    129 rdf:type schema:Person
    130 sg:person.01052067103.36 schema:affiliation grid-institutes:grid.419120.f
    131 schema:familyName Gueimonde
    132 schema:givenName Miguel
    133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052067103.36
    134 rdf:type schema:Person
    135 sg:person.01216541753.07 schema:affiliation grid-institutes:grid.419120.f
    136 schema:familyName Ruas-Madiedo
    137 schema:givenName Patricia
    138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216541753.07
    139 rdf:type schema:Person
    140 sg:person.01270323165.16 schema:affiliation grid-institutes:grid.419120.f
    141 schema:familyName Hidalgo-Cantabrana
    142 schema:givenName Claudio
    143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270323165.16
    144 rdf:type schema:Person
    145 sg:person.01302544103.58 schema:affiliation grid-institutes:grid.419120.f
    146 schema:familyName de los Reyes-Gavilán
    147 schema:givenName Clara G.
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302544103.58
    149 rdf:type schema:Person
    150 sg:person.015560755322.46 schema:affiliation grid-institutes:grid.10863.3c
    151 schema:familyName Suárez
    152 schema:givenName Ana
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015560755322.46
    154 rdf:type schema:Person
    155 sg:person.0617365355.29 schema:affiliation grid-institutes:grid.10863.3c
    156 schema:familyName López
    157 schema:givenName Patricia
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617365355.29
    159 rdf:type schema:Person
    160 sg:pub.10.1007/bf00166915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044666811
    161 https://doi.org/10.1007/bf00166915
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1007/s00253-006-0469-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012848237
    164 https://doi.org/10.1007/s00253-006-0469-4
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1038/nature07008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006761326
    167 https://doi.org/10.1038/nature07008
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/nrc2651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016070520
    170 https://doi.org/10.1038/nrc2651
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/nri2515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004447638
    173 https://doi.org/10.1038/nri2515
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/nrmicro2354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040773999
    176 https://doi.org/10.1038/nrmicro2354
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/nrmicro2695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049344936
    179 https://doi.org/10.1038/nrmicro2695
    180 rdf:type schema:CreativeWork
    181 grid-institutes:grid.10863.3c schema:alternateName Department of Functional Biology, University of Oviedo, Immunology Area, Oviedo, Asturias, Spain
    182 schema:name Department of Functional Biology, University of Oviedo, Immunology Area, Oviedo, Asturias, Spain
    183 Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n, 33300, Villaviciosa, Asturias, Spain
    184 rdf:type schema:Organization
    185 grid-institutes:grid.419120.f schema:alternateName Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n, 33300, Villaviciosa, Asturias, Spain
    186 schema:name Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n, 33300, Villaviciosa, Asturias, Spain
    187 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...