Integrative and theoretical research on the architecture of a biological system and its disorder View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-13

AUTHORS

Shinichi Uchida, Yoshiyuki Asai, Yoshiaki Kariya, Kunichika Tsumoto, Hiroshi Hibino, Masashi Honma, Takeshi Abe, Fumiaki Nin, Yasutaka Kurata, Kazuharu Furutani, Hiroshi Suzuki, Hiroaki Kitano, Ryuji Inoue, Yoshihisa Kurachi

ABSTRACT

An organism stems from assemblies of a variety of cells and proteins. This complex system serves as a unit, and it exhibits highly sophisticated functions in response to exogenous stimuli that change over time. The complete sequencing of the entire human genome has allowed researchers to address the enigmas of life and disease at the gene- or molecular-based level. The consequence of such studies is the rapid accumulation of a multitude of data at multiple levels, ranging from molecules to the whole body, that has necessitated the development of entirely new concepts, tools, and methodologies to analyze and integrate these data. This necessity has given birth to systems biology, an advanced theoretical and practical research framework that has totally changed the directions of not only basic life science but also medicine. During the symposium of the 95th Annual Meeting of The Physiological Society of Japan 2018, five researchers reported on their respective studies on systems biology. The topics included reactions of drugs, ion-transport architecture in an epithelial system, multi-omics in renal disease, cardiac electrophysiological systems, and a software platform for computer simulation. In this review article these authors have summarized recent achievements in the field and discuss next-generation studies on health and disease. More... »

PAGES

1-19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12576-019-00667-8

DOI

http://dx.doi.org/10.1007/s12576-019-00667-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112732134

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30868372


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428 schema:name Department of Systems Bioinformatics, Yamaguchi University Graduate School of Medicine, 755-8505, Ube, Yamaguchi, Japan
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430 https://www.grid.ac/institutes/grid.27860.3b schema:alternateName University of California, Davis
431 schema:name Department of Physiology and Membrane Biology, University of California Davis, 95616, Davis, USA
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433 https://www.grid.ac/institutes/grid.411497.e schema:alternateName Fukuoka University
434 schema:name Department of Physiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan
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436 https://www.grid.ac/institutes/grid.411998.c schema:alternateName Kanazawa Medical University
437 schema:name Center for Advanced Medical Engineering and Informatics, Osaka University, Suita, Japan
438 Department of Physiology II, Kanazawa Medical University, 920-0293, Ishikawa, Japan
439 Division of Molecular and Cellular Pharmacology, Department of Pharmacology, Osaka University, Suita, Japan
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441 https://www.grid.ac/institutes/grid.412708.8 schema:alternateName University of Tokyo Hospital
442 schema:name Department of Pharmacy, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan
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444 https://www.grid.ac/institutes/grid.452864.9 schema:alternateName Systems Biology Institute
445 schema:name The Systems Biology Institute, Shinagawa-ku, 108-0071, Tokyo, Japan
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447 https://www.grid.ac/institutes/grid.480536.c schema:alternateName Japan Agency for Medical Research and Development
448 schema:name AMED-CREST, AMED, Niigata, Japan
449 Department of Molecular Physiology, Niigata University School of Medicine, 1-757 Asahimachi-dori, Chuo-ku, 951-8510, Niigata, Niigata, Japan
450 rdf:type schema:Organization
 




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