FK506 (tacrolimus) causes pain sensation through the activation of transient receptor potential ankyrin 1 (TRPA1) channels View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Tomo Kita, Kunitoshi Uchida, Kenichi Kato, Yoshiro Suzuki, Makoto Tominaga, Jun Yamazaki

ABSTRACT

FK506 (tacrolimus) is an immunosuppressant widely used as an ointment in the treatment of atopic dermatitis. However, local application of FK506 can evoke burning sensations in atopic dermatitis patients, and its mechanisms are unknown. In this study, we found that FK506 activates transient receptor potential ankyrin 1 (TRPA1) channels. In Ca2+-imaging experiments, increases in intracellular Ca2+ concentrations ([Ca2+]i) by FK506 were observed in HEK293T cells expressing hTRPA1 or hTRPM8. FK506-induced currents were observed in HEK293T cells expressing hTRPA1 or mTRPA1, but less or not at all in cells expressing hTRPV1 or hTRPM8 using a patch-clamp technique. FK506 also evoked single-channel opening of hTRPA1 in an inside-out configuration. FK506-induced [Ca2+]i increases were also observed in TRPA1-expressing mouse primary sensory neurons. Furthermore, injection of FK506 evoked licking or biting behaviors and these behaviors were almost abolished in TRPA1 knockout mice. These results indicate that FK506 might cause pain sensations through TRPA1 activation. More... »

PAGES

305-316

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12576-018-0647-z

DOI

http://dx.doi.org/10.1007/s12576-018-0647-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110203587

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30478741


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fukuoka Dental College", 
          "id": "https://www.grid.ac/institutes/grid.418046.f", 
          "name": [
            "Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, 814-0193, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kita", 
        "givenName": "Tomo", 
        "id": "sg:person.015124651634.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015124651634.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fukuoka Dental College", 
          "id": "https://www.grid.ac/institutes/grid.418046.f", 
          "name": [
            "Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, 814-0193, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchida", 
        "givenName": "Kunitoshi", 
        "id": "sg:person.01112227760.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112227760.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fukuoka Dental College", 
          "id": "https://www.grid.ac/institutes/grid.418046.f", 
          "name": [
            "Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, 814-0193, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Kenichi", 
        "id": "sg:person.01170076217.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170076217.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Physiological Sciences", 
          "id": "https://www.grid.ac/institutes/grid.467811.d", 
          "name": [
            "Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8787, Okazaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Yoshiro", 
        "id": "sg:person.0727733377.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727733377.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Natural Sciences", 
          "id": "https://www.grid.ac/institutes/grid.250358.9", 
          "name": [
            "Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8787, Okazaki, Japan", 
            "Thermal Biology Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 444-8787, Okazaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tominaga", 
        "givenName": "Makoto", 
        "id": "sg:person.01054150551.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054150551.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fukuoka Dental College", 
          "id": "https://www.grid.ac/institutes/grid.418046.f", 
          "name": [
            "Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, 814-0193, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamazaki", 
        "givenName": "Jun", 
        "id": "sg:person.07377331431.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07377331431.68"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2008.06030.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001602723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/352803a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002286064", 
          "https://doi.org/10.1038/352803a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaad.2005.04.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002660635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaad.2005.04.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002660635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1201/9781420005844.ch20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002664032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2010.09757.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004421368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2010.09757.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004421368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1085/jgp.200810136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004838233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.20794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005391224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.20794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005391224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1115387108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005569380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.11154/pain.14.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009786904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007995.2011.582483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011473009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00001.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012369863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(92)90111-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014675299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci35957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015779631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015824551", 
          "https://doi.org/10.1038/nn1843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1297-319x(03)00095-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016292467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2007.08177.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016389679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0707219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016491438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2006.03.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017268716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neures.2004.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017790820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018899702", 
          "https://doi.org/10.1038/nrn2149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2005.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019323662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2005.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019323662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.143958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020049535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(94)00780-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022023830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.21351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022033916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(04)00150-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022676499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd009864.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026711897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1271/bbb.90964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027002765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m401156200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027848383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0801375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028257170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030343202", 
          "https://doi.org/10.1038/nchembio.640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0809769105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030981686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.02.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031363619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2004.06269.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031701747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2007.05743.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033887985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1567-5769(01)00059-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036651008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0808487106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037274847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.136.8.999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037362876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037386936", 
          "https://doi.org/10.1038/nature02282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037386936", 
          "https://doi.org/10.1038/nature02282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90124-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037884644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2014.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038231825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1346-8138.2009.00706.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038962520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1346-8138.2009.00706.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038962520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/chemse/bjs065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039213871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2221-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039455984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039689814", 
          "https://doi.org/10.1038/nature03066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039689814", 
          "https://doi.org/10.1038/nature03066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature19074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040626845", 
          "https://doi.org/10.1038/nature19074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00158-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041856635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.107.042663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043054185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mai.2002.121832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044371613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.12.183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048251264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.transproceed.2016.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048787171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049357132", 
          "https://doi.org/10.1038/nchembio.146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1374-10.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053214255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aab3376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062688789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076887910", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000454816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084233084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1272/jnms.84.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084258418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12576-017-0545-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086046677", 
          "https://doi.org/10.1007/s12576-017-0545-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12576-017-0545-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086046677", 
          "https://doi.org/10.1007/s12576-017-0545-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12576-017-0545-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086046677", 
          "https://doi.org/10.1007/s12576-017-0545-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12576-017-0545-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086046677", 
          "https://doi.org/10.1007/s12576-017-0545-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2017.06.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086062518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2017.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092292937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2017.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092292937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jdermsci.2017.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092461236"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03", 
    "datePublishedReg": "2019-03-01", 
    "description": "FK506 (tacrolimus) is an immunosuppressant widely used as an ointment in the treatment of atopic dermatitis. However, local application of FK506 can evoke burning sensations in atopic dermatitis patients, and its mechanisms are unknown. In this study, we found that FK506 activates transient receptor potential ankyrin 1 (TRPA1) channels. In Ca2+-imaging experiments, increases in intracellular Ca2+ concentrations ([Ca2+]i) by FK506 were observed in HEK293T cells expressing hTRPA1 or hTRPM8. FK506-induced currents were observed in HEK293T cells expressing hTRPA1 or mTRPA1, but less or not at all in cells expressing hTRPV1 or hTRPM8 using a patch-clamp technique. FK506 also evoked single-channel opening of hTRPA1 in an inside-out configuration. FK506-induced [Ca2+]i increases were also observed in TRPA1-expressing mouse primary sensory neurons. Furthermore, injection of FK506 evoked licking or biting behaviors and these behaviors were almost abolished in TRPA1 knockout mice. These results indicate that FK506 might cause pain sensations through TRPA1 activation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12576-018-0647-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294916", 
        "issn": [
          "1880-6546", 
          "1880-6562"
        ], 
        "name": "The Journal of Physiological Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "69"
      }
    ], 
    "name": "FK506 (tacrolimus) causes pain sensation through the activation of transient receptor potential ankyrin 1 (TRPA1) channels", 
    "pagination": "305-316", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9b644a14c4456f050db323f9242062e4efe26c4abd957743d2937e6620de062f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30478741"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101262417"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12576-018-0647-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110203587"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12576-018-0647-z", 
      "https://app.dimensions.ai/details/publication/pub.1110203587"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47994_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12576-018-0647-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12576-018-0647-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12576-018-0647-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12576-018-0647-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12576-018-0647-z'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      89 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12576-018-0647-z schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N08e949aa6d144029b1e7502a97221e30
4 schema:citation sg:pub.10.1007/s12576-017-0545-9
5 sg:pub.10.1038/352803a0
6 sg:pub.10.1038/nature02282
7 sg:pub.10.1038/nature03066
8 sg:pub.10.1038/nature19074
9 sg:pub.10.1038/nchembio.146
10 sg:pub.10.1038/nchembio.640
11 sg:pub.10.1038/nn1843
12 sg:pub.10.1038/nrn2149
13 https://app.dimensions.ai/details/publication/pub.1076887910
14 https://doi.org/10.1001/archderm.136.8.999
15 https://doi.org/10.1002/14651858.cd009864.pub2
16 https://doi.org/10.1002/cne.20794
17 https://doi.org/10.1002/cne.21351
18 https://doi.org/10.1016/0014-2999(94)00780-b
19 https://doi.org/10.1016/0092-8674(91)90124-h
20 https://doi.org/10.1016/0167-5699(92)90111-j
21 https://doi.org/10.1016/j.bbi.2017.10.015
22 https://doi.org/10.1016/j.bbrc.2008.12.183
23 https://doi.org/10.1016/j.cub.2005.04.018
24 https://doi.org/10.1016/j.gene.2017.06.029
25 https://doi.org/10.1016/j.jaad.2005.04.062
26 https://doi.org/10.1016/j.jdermsci.2017.10.012
27 https://doi.org/10.1016/j.neures.2004.07.005
28 https://doi.org/10.1016/j.neuron.2006.03.042
29 https://doi.org/10.1016/j.neuron.2011.02.051
30 https://doi.org/10.1016/j.neuroscience.2014.02.005
31 https://doi.org/10.1016/j.transproceed.2016.11.007
32 https://doi.org/10.1016/s0092-8674(03)00158-2
33 https://doi.org/10.1016/s0896-6273(04)00150-3
34 https://doi.org/10.1016/s1297-319x(03)00095-2
35 https://doi.org/10.1016/s1567-5769(01)00059-5
36 https://doi.org/10.1038/sj.bjp.0707219
37 https://doi.org/10.1067/mai.2002.121832
38 https://doi.org/10.1073/pnas.0808487106
39 https://doi.org/10.1073/pnas.0809769105
40 https://doi.org/10.1073/pnas.1115387108
41 https://doi.org/10.1074/jbc.m110.143958
42 https://doi.org/10.1074/jbc.m401156200
43 https://doi.org/10.1085/jgp.200810136
44 https://doi.org/10.1093/chemse/bjs065
45 https://doi.org/10.1111/j.1346-8138.2009.00706.x
46 https://doi.org/10.1111/j.1365-2133.2004.06269.x
47 https://doi.org/10.1111/j.1365-2133.2007.08177.x
48 https://doi.org/10.1111/j.1365-2133.2010.09757.x
49 https://doi.org/10.1111/j.1460-9568.2007.05743.x
50 https://doi.org/10.1111/j.1460-9568.2008.06030.x
51 https://doi.org/10.11154/pain.14.53
52 https://doi.org/10.1124/mol.107.042663
53 https://doi.org/10.1126/scitranslmed.aab3376
54 https://doi.org/10.1152/physrev.00001.2002
55 https://doi.org/10.1159/000454816
56 https://doi.org/10.1172/jci35957
57 https://doi.org/10.1185/03007995.2011.582483
58 https://doi.org/10.1201/9781420005844.ch20
59 https://doi.org/10.1271/bbb.90964
60 https://doi.org/10.1272/jnms.84.2
61 https://doi.org/10.1523/jneurosci.1374-10.2011
62 https://doi.org/10.1523/jneurosci.2221-07.2007
63 https://doi.org/10.4049/jimmunol.0801375
64 schema:datePublished 2019-03
65 schema:datePublishedReg 2019-03-01
66 schema:description FK506 (tacrolimus) is an immunosuppressant widely used as an ointment in the treatment of atopic dermatitis. However, local application of FK506 can evoke burning sensations in atopic dermatitis patients, and its mechanisms are unknown. In this study, we found that FK506 activates transient receptor potential ankyrin 1 (TRPA1) channels. In Ca<sup>2+</sup>-imaging experiments, increases in intracellular Ca<sup>2+</sup> concentrations ([Ca<sup>2+</sup>]<sub>i</sub>) by FK506 were observed in HEK293T cells expressing hTRPA1 or hTRPM8. FK506-induced currents were observed in HEK293T cells expressing hTRPA1 or mTRPA1, but less or not at all in cells expressing hTRPV1 or hTRPM8 using a patch-clamp technique. FK506 also evoked single-channel opening of hTRPA1 in an inside-out configuration. FK506-induced [Ca<sup>2+</sup>]<sub>i</sub> increases were also observed in TRPA1-expressing mouse primary sensory neurons. Furthermore, injection of FK506 evoked licking or biting behaviors and these behaviors were almost abolished in TRPA1 knockout mice. These results indicate that FK506 might cause pain sensations through TRPA1 activation.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf N44b918e9d7ae4132b71b5ea0a65c7c8d
71 Na927cf0198444bf399bbc071c6b47a16
72 sg:journal.1294916
73 schema:name FK506 (tacrolimus) causes pain sensation through the activation of transient receptor potential ankyrin 1 (TRPA1) channels
74 schema:pagination 305-316
75 schema:productId N01dbe502196742459e6fdaab9ee57c15
76 N354c9a99b9ea46c88476fbf1bde0677b
77 N8062b415e59c443aa1863dada87e0654
78 Nc034883ecfb94de185c15461a4c0ef2d
79 Nc0db002cf61642dca5dea35c77b30a59
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110203587
81 https://doi.org/10.1007/s12576-018-0647-z
82 schema:sdDatePublished 2019-04-11T09:13
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N451bbaae38ee41c2b5423d7e921d7b60
85 schema:url https://link.springer.com/10.1007%2Fs12576-018-0647-z
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N01dbe502196742459e6fdaab9ee57c15 schema:name dimensions_id
90 schema:value pub.1110203587
91 rdf:type schema:PropertyValue
92 N08e949aa6d144029b1e7502a97221e30 rdf:first sg:person.015124651634.27
93 rdf:rest N4bb896598d674d23ac627a82bb7d9ceb
94 N354c9a99b9ea46c88476fbf1bde0677b schema:name readcube_id
95 schema:value 9b644a14c4456f050db323f9242062e4efe26c4abd957743d2937e6620de062f
96 rdf:type schema:PropertyValue
97 N44b918e9d7ae4132b71b5ea0a65c7c8d schema:volumeNumber 69
98 rdf:type schema:PublicationVolume
99 N451bbaae38ee41c2b5423d7e921d7b60 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N4bb896598d674d23ac627a82bb7d9ceb rdf:first sg:person.01112227760.27
102 rdf:rest Nbd60195bebe242a59b1df417b5a7847b
103 N515cc22bef4f4cdda994d4a7fe40eaf2 rdf:first sg:person.01054150551.73
104 rdf:rest N594e991d40594e7181be42a6e195606e
105 N594e991d40594e7181be42a6e195606e rdf:first sg:person.07377331431.68
106 rdf:rest rdf:nil
107 N8062b415e59c443aa1863dada87e0654 schema:name pubmed_id
108 schema:value 30478741
109 rdf:type schema:PropertyValue
110 Na927cf0198444bf399bbc071c6b47a16 schema:issueNumber 2
111 rdf:type schema:PublicationIssue
112 Nb1fa7871a41141b99b686a529e1195a8 rdf:first sg:person.0727733377.31
113 rdf:rest N515cc22bef4f4cdda994d4a7fe40eaf2
114 Nbd60195bebe242a59b1df417b5a7847b rdf:first sg:person.01170076217.53
115 rdf:rest Nb1fa7871a41141b99b686a529e1195a8
116 Nc034883ecfb94de185c15461a4c0ef2d schema:name nlm_unique_id
117 schema:value 101262417
118 rdf:type schema:PropertyValue
119 Nc0db002cf61642dca5dea35c77b30a59 schema:name doi
120 schema:value 10.1007/s12576-018-0647-z
121 rdf:type schema:PropertyValue
122 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
123 schema:name Medical and Health Sciences
124 rdf:type schema:DefinedTerm
125 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
126 schema:name Neurosciences
127 rdf:type schema:DefinedTerm
128 sg:journal.1294916 schema:issn 1880-6546
129 1880-6562
130 schema:name The Journal of Physiological Sciences
131 rdf:type schema:Periodical
132 sg:person.01054150551.73 schema:affiliation https://www.grid.ac/institutes/grid.250358.9
133 schema:familyName Tominaga
134 schema:givenName Makoto
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054150551.73
136 rdf:type schema:Person
137 sg:person.01112227760.27 schema:affiliation https://www.grid.ac/institutes/grid.418046.f
138 schema:familyName Uchida
139 schema:givenName Kunitoshi
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112227760.27
141 rdf:type schema:Person
142 sg:person.01170076217.53 schema:affiliation https://www.grid.ac/institutes/grid.418046.f
143 schema:familyName Kato
144 schema:givenName Kenichi
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170076217.53
146 rdf:type schema:Person
147 sg:person.015124651634.27 schema:affiliation https://www.grid.ac/institutes/grid.418046.f
148 schema:familyName Kita
149 schema:givenName Tomo
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015124651634.27
151 rdf:type schema:Person
152 sg:person.0727733377.31 schema:affiliation https://www.grid.ac/institutes/grid.467811.d
153 schema:familyName Suzuki
154 schema:givenName Yoshiro
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727733377.31
156 rdf:type schema:Person
157 sg:person.07377331431.68 schema:affiliation https://www.grid.ac/institutes/grid.418046.f
158 schema:familyName Yamazaki
159 schema:givenName Jun
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07377331431.68
161 rdf:type schema:Person
162 sg:pub.10.1007/s12576-017-0545-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086046677
163 https://doi.org/10.1007/s12576-017-0545-9
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/352803a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002286064
166 https://doi.org/10.1038/352803a0
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/nature02282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037386936
169 https://doi.org/10.1038/nature02282
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/nature03066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039689814
172 https://doi.org/10.1038/nature03066
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/nature19074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040626845
175 https://doi.org/10.1038/nature19074
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/nchembio.146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049357132
178 https://doi.org/10.1038/nchembio.146
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/nchembio.640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030343202
181 https://doi.org/10.1038/nchembio.640
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/nn1843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015824551
184 https://doi.org/10.1038/nn1843
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/nrn2149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018899702
187 https://doi.org/10.1038/nrn2149
188 rdf:type schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1076887910 schema:CreativeWork
190 https://doi.org/10.1001/archderm.136.8.999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037362876
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/14651858.cd009864.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026711897
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/cne.20794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005391224
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/cne.21351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022033916
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/0014-2999(94)00780-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1022023830
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0092-8674(91)90124-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1037884644
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0167-5699(92)90111-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1014675299
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.bbi.2017.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092292937
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.bbrc.2008.12.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048251264
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.cub.2005.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019323662
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.gene.2017.06.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086062518
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.jaad.2005.04.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002660635
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.jdermsci.2017.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092461236
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.neures.2004.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017790820
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.neuron.2006.03.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017268716
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.neuron.2011.02.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031363619
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.neuroscience.2014.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038231825
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.transproceed.2016.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048787171
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0092-8674(03)00158-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041856635
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0896-6273(04)00150-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022676499
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s1297-319x(03)00095-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016292467
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s1567-5769(01)00059-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036651008
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1038/sj.bjp.0707219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016491438
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1067/mai.2002.121832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044371613
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1073/pnas.0808487106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037274847
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1073/pnas.0809769105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030981686
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1073/pnas.1115387108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005569380
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1074/jbc.m110.143958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020049535
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1074/jbc.m401156200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027848383
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1085/jgp.200810136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004838233
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/chemse/bjs065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039213871
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/j.1346-8138.2009.00706.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038962520
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/j.1365-2133.2004.06269.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031701747
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/j.1365-2133.2007.08177.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016389679
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1365-2133.2010.09757.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004421368
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1111/j.1460-9568.2007.05743.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033887985
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/j.1460-9568.2008.06030.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001602723
263 rdf:type schema:CreativeWork
264 https://doi.org/10.11154/pain.14.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009786904
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1124/mol.107.042663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043054185
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1126/scitranslmed.aab3376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062688789
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1152/physrev.00001.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012369863
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1159/000454816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084233084
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1172/jci35957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015779631
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1185/03007995.2011.582483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011473009
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1201/9781420005844.ch20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002664032
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1271/bbb.90964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027002765
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1272/jnms.84.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084258418
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1523/jneurosci.1374-10.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053214255
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1523/jneurosci.2221-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039455984
287 rdf:type schema:CreativeWork
288 https://doi.org/10.4049/jimmunol.0801375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028257170
289 rdf:type schema:CreativeWork
290 https://www.grid.ac/institutes/grid.250358.9 schema:alternateName National Institutes of Natural Sciences
291 schema:name Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8787, Okazaki, Japan
292 Thermal Biology Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 444-8787, Okazaki, Japan
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.418046.f schema:alternateName Fukuoka Dental College
295 schema:name Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, 814-0193, Fukuoka, Japan
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.467811.d schema:alternateName National Institute for Physiological Sciences
298 schema:name Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8787, Okazaki, Japan
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...