Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium–coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-02

AUTHORS

Sunena Srivastava, Kiyoshi Nakagawa, Xin He, Toru Kimura, Toshiyuki Fukutomi, Seiji Miyauchi, Hiroyuki Sakurai, Naohiko Anzai

ABSTRACT

Sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) mediate the high- and low-affinity transport of lactate in the kidney, but their regulatory mechanism is still unknown. Since these two transporters have the PDZ-motif at their C-terminus, the function of SMCTs may be modulated by a protein–protein interaction. To investigate the binding partner(s) of SMCTs in the kidney, we performed yeast two-hybrid (Y2H) screenings of a human kidney cDNA library with the C-terminus of SMCT1 (SMCT1-CT) and SMCT2 (SMCT2-CT) as bait. PDZK1 was identified as a partner for SMCTs. PDZK1 coexpression in SMCT1-expressing HEK293 cells enhanced their nicotinate transport activity. PDZK1, SMCT1, and URAT1 in vitro assembled into a single tri-molecular complex and their colocalization was confirmed in the renal proximal tubule in vivo by immunohistochemistry. These results indicate that the SMCT1-PDZK1 interaction thus plays an important role in both lactate handling as well as urate reabsorption in the human kidney. More... »

PAGES

399-408

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12576-018-00658-1

DOI

http://dx.doi.org/10.1007/s12576-018-00658-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111058637

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30604288


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