Computational analysis of the effect of the type of LVAD flow on coronary perfusion and ventricular afterload View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-07

AUTHORS

Ki Moo Lim, In Su Kim, Seong Wook Choi, Byung Goo Min, Yong Soon Won, Heon Young Kim, Eun Bo Shim

ABSTRACT

We developed a computational model to investigate the hemodynamic effects of a pulsatile left ventricular assist device (LVAD) on the cardiovascular system. The model consisted of 16 compartments for the cardiovascular system, including coronary circulation and LVAD, and autonomic nervous system control. A failed heart was modeled by decreasing the end-systolic elastance of the ventricle and blocking the mechanism controlling heart contractility. We assessed the physiological effect of the LVAD on the cardiovascular system for three types of LVAD flow: co-pulsation, counter-pulsation, and continuous flow modes. The results indicated that the pulsatile LVAD with counter-pulsation mode gave the most physiological coronary blood perfusion. In addition, the counter-pulsation mode resulted in a lower peak pressure of the left ventricle than the other modes, aiding cardiac recovery by reducing the ventricular afterload. In conclusion, these results indicate that, from the perspective of cardiovascular physiology, a pulsatile LVAD with counter-pulsation operation is a plausible alternative to the existing LVAD with continuous flow mode. More... »

PAGES

307-316

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12576-009-0037-7

DOI

http://dx.doi.org/10.1007/s12576-009-0037-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007361520

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19387788


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