Effects of single and repeated heat stress on anxiety-like behavior and locomotor activity in medaka fish View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-10-25

AUTHORS

Airi Otsuka, Yuki Shimomura, Honoka Sakikubo, Kensuke Miura, Nao Kagawa

ABSTRACT

In this study, we examined whether a single heat stress incident and long-term repeated heat stress could affect behavioral and neural responses in male medaka fish Oryzias latipes. By using the novel tank diving test, we found that 7-day repeated heat stress led to anxiety-like behaviors and suppressed locomotor activity, whereas fluoxetine treatment during repeated heat stress led to anxiolytic behaviors. Furthermore, a single heat stress incident increased hyper-locomotor activity. A single heat stress incident decreased mRNA expression of tryptophan hydroxylase 2 (tph2), a rate-limiting enzyme in serotonin biosynthesis, while a single heat stress increased mRNA expression of tyrosine hydroxylase 1 (th1) and tyrosine hydroxylase 2 (th2), catalyzing dopamine biosynthesis in the brain. Plasma cortisol concentration increased after a single stress, repeated stress, and fluoxetine treatment during repeated stress. These results suggest that medaka fish are a good model for assessing anxiety-like behavior induced by long-term repeated stress. Moreover, th1, th2, and tph2 in the brain would be key factors in the exploration of the central regulation of behavioral responses to a single and repeated stress in fish. More... »

PAGES

45-54

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12562-021-01561-2

DOI

http://dx.doi.org/10.1007/s12562-021-01561-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142173457


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