Proteases from dengue, West Nile and Zika viruses as drug targets View Full Text


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Article Info

DATE

2019-04

AUTHORS

Christoph Nitsche

ABSTRACT

Proteases from flaviviruses have gained substantial interest as potential drug targets to combat infectious diseases caused by dengue, West Nile, Zika and related viruses. Despite nearly two decades of drug discovery campaigns, promising lead compounds for clinical trials have not yet been identified. The main challenges for successful lead compound development are associated with limited drug-likeness of inhibitors and structural ambiguity of the protease target. This brief review focuses on the available information on the structure of flavivirus proteases and their interactions with inhibitors and attempts to point the way forward for successful identification of future lead compounds. More... »

PAGES

157-165

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12551-019-00508-3

DOI

http://dx.doi.org/10.1007/s12551-019-00508-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112394625

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30806881


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12551-019-00508-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12551-019-00508-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12551-019-00508-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12551-019-00508-3'


 

This table displays all metadata directly associated to this object as RDF triples.

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