Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile View Full Text


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Article Info

DATE

2018-10

AUTHORS

Boris Martinac, Navid Bavi, Pietro Ridone, Yury A. Nikolaev, Adam D. Martinac, Yoshitaka Nakayama, Paul R. Rohde, Omid Bavi

ABSTRACT

Mechanical stimuli acting on the cellular membrane are linked to intracellular signaling events and downstream effectors via different mechanoreceptors. Mechanosensitive (MS) ion channels are the fastest known primary mechano-electrical transducers, which convert mechanical stimuli into meaningful intracellular signals on a submillisecond time scale. Much of our understanding of the biophysical principles that underlie and regulate conversion of mechanical force into conformational changes in MS channels comes from studies based on MS channel reconstitution into lipid bilayers. The bilayer reconstitution methods have enabled researchers to investigate the structure-function relationship in MS channels and probe their specific interactions with their membrane lipid environment. This brief review focuses on close interactions between MS channels and the lipid bilayer and emphasizes the central role that the transbilayer pressure profile plays in mechanosensitivity and gating of these fascinating membrane proteins. More... »

PAGES

1-8

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12551-018-0450-3

    DOI

    http://dx.doi.org/10.1007/s12551-018-0450-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106650236

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30182202


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