Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease View Full Text


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Article Info

DATE

2017-09-04

AUTHORS

Lorenzo Alamo, Antonio Pinto, Guidenn Sulbarán, Jesús Mavárez, Raúl Padrón

ABSTRACT

Tarantula’s leg muscle thick filament is the ideal model for the study of the structure and function of skeletal muscle thick filaments. Its analysis has given rise to a series of structural and functional studies, leading, among other things, to the discovery of the myosin interacting-heads motif (IHM). Further electron microscopy (EM) studies have shown the presence of IHM in frozen-hydrated and negatively stained thick filaments of striated, cardiac, and smooth muscle of bilaterians, most showing the IHM parallel to the filament axis. EM studies on negatively stained heavy meromyosin of different species have shown the presence of IHM on sponges, animals that lack muscle, extending the presence of IHM to metazoans. The IHM evolved about 800 MY ago in the ancestor of Metazoa, and independently with functional differences in the lineage leading to the slime mold Dictyostelium discoideum (Mycetozoa). This motif conveys important functional advantages, such as Ca2+ regulation and ATP energy-saving mechanisms. Recent interest has focused on human IHM structure in order to understand the structural basis underlying various conditions and situations of scientific and medical interest: the hypertrophic and dilated cardiomyopathies, overfeeding control, aging and hormone deprival muscle weakness, drug design for schistosomiasis control, and conditioning exercise physiology for the training of power athletes. More... »

PAGES

1465-1477

References to SciGraph publications

  • 2017-09-04. Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function in BIOPHYSICAL REVIEWS
  • 1954-05. Changes in the Cross-Striations of Muscle during Contraction and Stretch and their Structural Interpretation in NATURE
  • 2014-07-22. Post activation potentiation can be induced without impairing tendon stiffness in EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
  • 2011-03-23. The role of the myosin ATPase activity in adaptive thermogenesis by skeletal muscle in BIOPHYSICAL REVIEWS
  • 2008. Myosins, A Superfamily of Molecular Motors in NONE
  • 2005-08. Atomic model of a myosin filament in the relaxed state in NATURE
  • 1954-05. Structural Changes in Muscle During Contraction: Interference Microscopy of Living Muscle Fibres in NATURE
  • 1992. Mutations in cardiac myosin heavy-chain genes cause familial hypertrophic cardiomyopathy in CELLULAR AND MOLECULAR ALTERATIONS IN THE FAILING HUMAN HEART
  • 2017-05-08. The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2017-04. Myosin II sequences for Lethocerusindicus in JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
  • 2012-06-27. Independent evolution of striated muscles in cnidarians and bilaterians in NATURE
  • 2017-03-28. Controlling schistosomiasis with praziquantel: How much longer without a viable alternative? in INFECTIOUS DISEASES OF POVERTY
  • 1994-12. Role of myosin light chains in JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12551-017-0292-4

    DOI

    http://dx.doi.org/10.1007/s12551-017-0292-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091477877

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28871552


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