Physical and mechanical properties of alginate-based hydrogel film as carrier for release of acetylthiocholine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01

AUTHORS

Sung Yun Park, Wan-Joong Kim, Jae Bong Choi, Sanghee Kim

ABSTRACT

The effects of different cross-linkers on mechanical and physical properties of alginate hydrogel films were determined to use prepared films as potential carrier structure for rapid detection system. Xylitol and d-mannitol cross-linked hydrogel films improved mechanical properties and generated more rigid, tough and stretchable film than uncross-linked film. Results exhibited increased tensile strength by 2.3 folds (58.3±5.8 MPa) and 1.8 folds (47.4±4.9MPa) when compared to uncross-linked film (25.8±7.3 MPa) respectively. Young’s modulus of d-mannitol cross-linked film was slightly greater (16.8±2.1 MPa) than that of xylitol (15.7±2.7 MPa) whereas the elongation at break (E%) value of xylitol cross-linking (5.46±1.2%) was greater than d-mannitol (2.72±0.8%) cross-linking. Altered mechanical properties were investigated in terms of different amount of % cumulative release of AchI and DTNB that were immobilized in film matrix. Results showed different release amount depending on types of cross-linkers as following: xylitolcrosslinked (71.5%) > d-mannitol (64.9%) > uncross-linked (58.3%) at 10 min of release period. The exponent value n which determined based on power-law expression was ranged between 0.56 and 0.98, and indicates the release was mediated by anomalous Non-Fickian diffusion. More... »

PAGES

129-135

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12541-018-0015-1

DOI

http://dx.doi.org/10.1007/s12541-018-0015-1

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