Oxcarbazepine oral suspension in pediatric patients with partial seizures and/or generalized tonic-clonic seizures: a multi-center, single arm, observational study in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12

AUTHORS

Yi Wang, Yin-Bo Chen, Yu-Qin Zhang, Rong Luo, Hua Wang, Jun-Lan Lv, Dong Wang, Sui-Qiang Zhu, Zhong-Dong Lin, Jiong Qin

ABSTRACT

BACKGROUND: To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China. METHODS: This 26-week, single arm, multicenter and observational study recruited patients aged 2-16 years with PS or GTCS suitable for OXC oral suspension treatment. Enrolled patients received OXC oral suspension treatment for 26 weeks. Primary endpoints included mean seizure frequency at the end of the treatment and mean seizure frequency reduction at the end of the treatment vs. baseline. Secondary efficacy-related endpoints and safety parameters were also assessed. RESULTS: Nine hundred and eighty-seven pediatric patients were enrolled and 912 (92.4%) completed the study. The mean seizure frequencies at baseline and the end of week 26 were 13.40±64.92 and 1.62±19.47 times/ month, respectively. The mean seizure frequency reduction was 10.03±63.67 times/month and the mean seizure frequency reduction percentage was 90.02%±5127.0% (P<0.0001). After 26 weeks of treatment, 82.36%, 7.24% and 3.86% of the patients became controlled, significantly improved and improved, respectively. Adverse events (AEs) were reported in 74 (7.65%) patients. Rash was the most common AE. The efficacy of OXC was not affected by seizure types, age or gender. CONCLUSIONS: This study confirms the efficacy and good safety profile of OXC oral suspension in Chinese pediatric patients aged 2-16 years with PS and/or GTCS. More... »

PAGES

551-559

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12519-017-0045-2

DOI

http://dx.doi.org/10.1007/s12519-017-0045-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086121872

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28646433


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticonvulsants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carbamazepine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epilepsy, Generalized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epilepsy, Tonic-Clonic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxcarbazepine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Single-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Children's Hospital of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.411333.7", 
          "name": [
            "Department of Neurology, Children\u2019s Hospital of Fudan University, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yi", 
        "id": "sg:person.013204012423.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013204012423.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Bethune Hospital of Jilin University", 
          "id": "https://www.grid.ac/institutes/grid.452451.3", 
          "name": [
            "Department of Pediatric Neurology, The First Bethune Hospital of Jilin University, Changchun, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yin-Bo", 
        "id": "sg:person.014001373023.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014001373023.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417022.2", 
          "name": [
            "Department of Neurology, Tianjin Children\u2019s Hospital, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yu-Qin", 
        "id": "sg:person.014576753423.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576753423.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West China Second University Hospital of Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.461863.e", 
          "name": [
            "Department of Pediatric Neurology, West China Second University Hospital of Sichuan University, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Rong", 
        "id": "sg:person.01001732523.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001732523.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sheng Jing Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412467.2", 
          "name": [
            "Department of Pediatric Neurology, Shengjing Hospital of China Medical University, Shenyang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Hua", 
        "id": "sg:person.01231002726.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231002726.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Capital Medical University", 
          "id": "https://www.grid.ac/institutes/grid.24696.3f", 
          "name": [
            "Department of Neurology, Beijing Children\u2019s Hospital, Capital Medical University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lv", 
        "givenName": "Jun-Lan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi\u2019an Children\u2019s Hospital", 
          "id": "https://www.grid.ac/institutes/grid.452902.8", 
          "name": [
            "Department of Neurology, Xi\u2019an Children\u2019s Hospital, Xi\u2019an, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Dong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Neurology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Sui-Qiang", 
        "id": "sg:person.01242210740.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242210740.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Department of Pediatric Neurology, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Zhong-Dong", 
        "id": "sg:person.01142531011.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142531011.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University First Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411472.5", 
          "name": [
            "Department of Pediatrics, Peking University People\u2019s Hospital, No.11 Xizhimen South Str., Xicheng District, 100044, Beijing, China", 
            "Department of Pediatrics, Peking University First Hospital, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qin", 
        "givenName": "Jiong", 
        "id": "sg:person.0732562660.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732562660.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1528-1157.1998.tb01185.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1157.1998.tb01185.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.seizure.2013.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004724868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pediatrneurol.2006.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005636599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2006.00585.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016435719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40263-013-0048-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017619647", 
          "https://doi.org/10.1007/s40263-013-0048-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0887-8994(02)00467-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021278889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0887-8994(02)00467-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021278889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pediatrneurol.2005.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026821952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.2005.02529.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027305324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.2005.02529.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027305324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.seizure.2012.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027733203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/08830738060210061701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028193899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/08830738060210061701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028193899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pediatrneurol.2006.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030409579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00148581-200305080-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030890168", 
          "https://doi.org/10.2165/00148581-200305080-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00148581-200305080-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030890168", 
          "https://doi.org/10.2165/00148581-200305080-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.291.5.605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033065068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0976-3147.165420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034477316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00148581-200810040-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035142509", 
          "https://doi.org/10.2165/00148581-200810040-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40272-013-0049-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037644118", 
          "https://doi.org/10.1007/s40272-013-0049-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40272-013-0049-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037644118", 
          "https://doi.org/10.1007/s40272-013-0049-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.seizure.2006.02.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038553639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/ebeh.2000.0126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039815466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/088307389701200806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040242503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/088307389701200806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040242503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1528-1157.2001.30800.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040605156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00228-007-0308-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049915027", 
          "https://doi.org/10.1007/s00228-007-0308-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00228-007-0308-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049915027", 
          "https://doi.org/10.1007/s00228-007-0308-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11055-007-0051-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051012445", 
          "https://doi.org/10.1007/s11055-007-0051-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0091270004266617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053538674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/08830738020170010201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063853902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/08830738020170010201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063853902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000059867.35547.de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000059867.35547.de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000059867.35547.de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000186800.18456.72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000186800.18456.72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000186800.18456.72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.54.12.2237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064378223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077979904", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078297669", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078349439", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078730292", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078739674", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078843849", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China.\nMETHODS: This 26-week, single arm, multicenter and observational study recruited patients aged 2-16 years with PS or GTCS suitable for OXC oral suspension treatment. Enrolled patients received OXC oral suspension treatment for 26 weeks. Primary endpoints included mean seizure frequency at the end of the treatment and mean seizure frequency reduction at the end of the treatment vs. baseline. Secondary efficacy-related endpoints and safety parameters were also assessed.\nRESULTS: Nine hundred and eighty-seven pediatric patients were enrolled and 912 (92.4%) completed the study. The mean seizure frequencies at baseline and the end of week 26 were 13.40\u00b164.92 and 1.62\u00b119.47 times/ month, respectively. The mean seizure frequency reduction was 10.03\u00b163.67 times/month and the mean seizure frequency reduction percentage was 90.02%\u00b15127.0% (P<0.0001). After 26 weeks of treatment, 82.36%, 7.24% and 3.86% of the patients became controlled, significantly improved and improved, respectively. Adverse events (AEs) were reported in 74 (7.65%) patients. Rash was the most common AE. The efficacy of OXC was not affected by seizure types, age or gender.\nCONCLUSIONS: This study confirms the efficacy and good safety profile of OXC oral suspension in Chinese pediatric patients aged 2-16 years with PS and/or GTCS.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12519-017-0045-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1037176", 
        "issn": [
          "1708-8569", 
          "1867-0687"
        ], 
        "name": "World Journal of Pediatrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Oxcarbazepine oral suspension in pediatric patients with partial seizures and/or generalized tonic-clonic seizures: a multi-center, single arm, observational study in China", 
    "pagination": "551-559", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6a7b85bdab781c1e09cbd63c6e1b20032c2e5795ef65f67349cd70a045686125"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28646433"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101278599"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12519-017-0045-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1086121872"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12519-017-0045-2", 
      "https://app.dimensions.ai/details/publication/pub.1086121872"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87083_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12519-017-0045-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12519-017-0045-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12519-017-0045-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12519-017-0045-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12519-017-0045-2'


 

This table displays all metadata directly associated to this object as RDF triples.

332 TRIPLES      21 PREDICATES      81 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12519-017-0045-2 schema:about N06943051bcaf439c9de695d1f5e6020d
2 N275a0dfea67843a59fba39c069f3c294
3 N37aecd060d274cbd82cffa745fc7e0b8
4 N37c6f335994d45018b4fc4671622d394
5 N3885bb7b1c0a43f2a445f6be76840775
6 N402f1900d0b04ef5ac3ce6df5098c475
7 N56dbd439e23d4c8390854be7e1156b05
8 N5ad73b20e18f462398c1f1c6704332c4
9 N9126d59cedac4b90a704f1bd9fda870f
10 N927a5873542d4cbfb088b4cabc19c816
11 Na760568b35884612b90c7e6f4ed0043e
12 Nb7c8e426dfcd45b9a969288819fc7881
13 Nbecbb393ac8f4ecc81471d468e02de30
14 Nc4c9ce6e39974df39d6285347f00bd2d
15 Nd98657606db94b6f9a048de0fd64942b
16 Ne691fd26d77d468fa18dae19cd81a1cb
17 Ne737ab32a64f4542a652ed65fcc6752d
18 Nef658eb956014113aa8fa0a0661441ef
19 Nfd2e9d060fec4da9a1583e586872a338
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author Nc8a8db7036af49dabe008edfa0a6d7bb
23 schema:citation sg:pub.10.1007/s00228-007-0308-2
24 sg:pub.10.1007/s11055-007-0051-2
25 sg:pub.10.1007/s40263-013-0048-z
26 sg:pub.10.1007/s40272-013-0049-x
27 sg:pub.10.2165/00148581-200305080-00006
28 sg:pub.10.2165/00148581-200810040-00003
29 https://app.dimensions.ai/details/publication/pub.1077979904
30 https://app.dimensions.ai/details/publication/pub.1078297669
31 https://app.dimensions.ai/details/publication/pub.1078349439
32 https://app.dimensions.ai/details/publication/pub.1078730292
33 https://app.dimensions.ai/details/publication/pub.1078739674
34 https://app.dimensions.ai/details/publication/pub.1078843849
35 https://doi.org/10.1001/jama.291.5.605
36 https://doi.org/10.1006/ebeh.2000.0126
37 https://doi.org/10.1016/j.pediatrneurol.2005.05.011
38 https://doi.org/10.1016/j.pediatrneurol.2006.02.009
39 https://doi.org/10.1016/j.pediatrneurol.2006.03.003
40 https://doi.org/10.1016/j.seizure.2006.02.017
41 https://doi.org/10.1016/j.seizure.2012.07.007
42 https://doi.org/10.1016/j.seizure.2013.12.001
43 https://doi.org/10.1016/s0887-8994(02)00467-8
44 https://doi.org/10.1046/j.1528-1157.2001.30800.x
45 https://doi.org/10.1111/j.1365-2125.2005.02529.x
46 https://doi.org/10.1111/j.1528-1157.1998.tb01185.x
47 https://doi.org/10.1111/j.1528-1167.2006.00585.x
48 https://doi.org/10.1177/0091270004266617
49 https://doi.org/10.1177/08830738020170010201
50 https://doi.org/10.1177/08830738060210061701
51 https://doi.org/10.1177/088307389701200806
52 https://doi.org/10.1212/01.wnl.0000059867.35547.de
53 https://doi.org/10.1212/01.wnl.0000186800.18456.72
54 https://doi.org/10.1212/wnl.54.12.2237
55 https://doi.org/10.4103/0976-3147.165420
56 schema:datePublished 2017-12
57 schema:datePublishedReg 2017-12-01
58 schema:description BACKGROUND: To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China. METHODS: This 26-week, single arm, multicenter and observational study recruited patients aged 2-16 years with PS or GTCS suitable for OXC oral suspension treatment. Enrolled patients received OXC oral suspension treatment for 26 weeks. Primary endpoints included mean seizure frequency at the end of the treatment and mean seizure frequency reduction at the end of the treatment vs. baseline. Secondary efficacy-related endpoints and safety parameters were also assessed. RESULTS: Nine hundred and eighty-seven pediatric patients were enrolled and 912 (92.4%) completed the study. The mean seizure frequencies at baseline and the end of week 26 were 13.40±64.92 and 1.62±19.47 times/ month, respectively. The mean seizure frequency reduction was 10.03±63.67 times/month and the mean seizure frequency reduction percentage was 90.02%±5127.0% (P<0.0001). After 26 weeks of treatment, 82.36%, 7.24% and 3.86% of the patients became controlled, significantly improved and improved, respectively. Adverse events (AEs) were reported in 74 (7.65%) patients. Rash was the most common AE. The efficacy of OXC was not affected by seizure types, age or gender. CONCLUSIONS: This study confirms the efficacy and good safety profile of OXC oral suspension in Chinese pediatric patients aged 2-16 years with PS and/or GTCS.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf N329ef33f8acf4c0386df2dcf77634c92
63 N8494f3513e294210a7ccd37141bd0d4d
64 sg:journal.1037176
65 schema:name Oxcarbazepine oral suspension in pediatric patients with partial seizures and/or generalized tonic-clonic seizures: a multi-center, single arm, observational study in China
66 schema:pagination 551-559
67 schema:productId N07d4852e38a44ec49b450ab3277a053c
68 N09330a1cfc9d46f88fe1d1a766ceced9
69 N126833bc7f234577b0056a61a755eb16
70 N17ebaa98b4e84a30b223ad62be8336fb
71 Nf0fa74ff446649a18b81ff6fa9854535
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086121872
73 https://doi.org/10.1007/s12519-017-0045-2
74 schema:sdDatePublished 2019-04-11T12:22
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher Nbe799a2ed46d445292004f0b450bcdb5
77 schema:url https://link.springer.com/10.1007%2Fs12519-017-0045-2
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N06943051bcaf439c9de695d1f5e6020d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Treatment Outcome
83 rdf:type schema:DefinedTerm
84 N07d4852e38a44ec49b450ab3277a053c schema:name pubmed_id
85 schema:value 28646433
86 rdf:type schema:PropertyValue
87 N09330a1cfc9d46f88fe1d1a766ceced9 schema:name readcube_id
88 schema:value 6a7b85bdab781c1e09cbd63c6e1b20032c2e5795ef65f67349cd70a045686125
89 rdf:type schema:PropertyValue
90 N126833bc7f234577b0056a61a755eb16 schema:name nlm_unique_id
91 schema:value 101278599
92 rdf:type schema:PropertyValue
93 N17ebaa98b4e84a30b223ad62be8336fb schema:name dimensions_id
94 schema:value pub.1086121872
95 rdf:type schema:PropertyValue
96 N1853a6c192b249b28f643055abc353b2 rdf:first sg:person.01242210740.78
97 rdf:rest Ne36e9535e44d4bfb87640975d67a60ba
98 N275a0dfea67843a59fba39c069f3c294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Anticonvulsants
100 rdf:type schema:DefinedTerm
101 N3220c94dcfcd47f2a28497dfeb9a6cae rdf:first sg:person.01231002726.22
102 rdf:rest N6293a9fc5034434a96658f9cd9fb1560
103 N329ef33f8acf4c0386df2dcf77634c92 schema:volumeNumber 13
104 rdf:type schema:PublicationVolume
105 N37aecd060d274cbd82cffa745fc7e0b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Epilepsy, Generalized
107 rdf:type schema:DefinedTerm
108 N37c6f335994d45018b4fc4671622d394 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Single-Blind Method
110 rdf:type schema:DefinedTerm
111 N3885bb7b1c0a43f2a445f6be76840775 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Child, Preschool
113 rdf:type schema:DefinedTerm
114 N402f1900d0b04ef5ac3ce6df5098c475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Oxcarbazepine
116 rdf:type schema:DefinedTerm
117 N56dbd439e23d4c8390854be7e1156b05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adolescent
119 rdf:type schema:DefinedTerm
120 N5ad73b20e18f462398c1f1c6704332c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 N6293a9fc5034434a96658f9cd9fb1560 rdf:first Nf1c8db2814b64f86be28f2498366d7b2
124 rdf:rest N67f5544558b5471f8d7d7cc23847afb3
125 N67f5544558b5471f8d7d7cc23847afb3 rdf:first Nea71572984d34be2b1b587b39f0176cb
126 rdf:rest N1853a6c192b249b28f643055abc353b2
127 N6f7198f39e6e4d0dbe2aa48649aaff9e rdf:first sg:person.014001373023.50
128 rdf:rest Ndc6f48d040b1490fb2b623f3dd7294b9
129 N8494f3513e294210a7ccd37141bd0d4d schema:issueNumber 6
130 rdf:type schema:PublicationIssue
131 N9126d59cedac4b90a704f1bd9fda870f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Time Factors
133 rdf:type schema:DefinedTerm
134 N927a5873542d4cbfb088b4cabc19c816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Epilepsy, Tonic-Clonic
136 rdf:type schema:DefinedTerm
137 N9b958b3e372e4b37beb562264cb090ba rdf:first sg:person.01001732523.87
138 rdf:rest N3220c94dcfcd47f2a28497dfeb9a6cae
139 Na760568b35884612b90c7e6f4ed0043e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Carbamazepine
141 rdf:type schema:DefinedTerm
142 Nb7c8e426dfcd45b9a969288819fc7881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Severity of Illness Index
144 rdf:type schema:DefinedTerm
145 Nbe799a2ed46d445292004f0b450bcdb5 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Nbecbb393ac8f4ecc81471d468e02de30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Administration, Oral
149 rdf:type schema:DefinedTerm
150 Nc4c9ce6e39974df39d6285347f00bd2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Child
152 rdf:type schema:DefinedTerm
153 Nc8a8db7036af49dabe008edfa0a6d7bb rdf:first sg:person.013204012423.84
154 rdf:rest N6f7198f39e6e4d0dbe2aa48649aaff9e
155 Nccc920184d2c42449b8843e4826f2d61 schema:name Department of Neurology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China
156 rdf:type schema:Organization
157 Nd98657606db94b6f9a048de0fd64942b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Follow-Up Studies
159 rdf:type schema:DefinedTerm
160 Ndc6f48d040b1490fb2b623f3dd7294b9 rdf:first sg:person.014576753423.26
161 rdf:rest N9b958b3e372e4b37beb562264cb090ba
162 Ne36e9535e44d4bfb87640975d67a60ba rdf:first sg:person.01142531011.34
163 rdf:rest Nf79502ed6fd440339e3795ae208aeaa2
164 Ne691fd26d77d468fa18dae19cd81a1cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Prospective Studies
166 rdf:type schema:DefinedTerm
167 Ne737ab32a64f4542a652ed65fcc6752d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Humans
169 rdf:type schema:DefinedTerm
170 Nea71572984d34be2b1b587b39f0176cb schema:affiliation https://www.grid.ac/institutes/grid.452902.8
171 schema:familyName Wang
172 schema:givenName Dong
173 rdf:type schema:Person
174 Nef658eb956014113aa8fa0a0661441ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Drug Administration Schedule
176 rdf:type schema:DefinedTerm
177 Nf0fa74ff446649a18b81ff6fa9854535 schema:name doi
178 schema:value 10.1007/s12519-017-0045-2
179 rdf:type schema:PropertyValue
180 Nf1c8db2814b64f86be28f2498366d7b2 schema:affiliation https://www.grid.ac/institutes/grid.24696.3f
181 schema:familyName Lv
182 schema:givenName Jun-Lan
183 rdf:type schema:Person
184 Nf79502ed6fd440339e3795ae208aeaa2 rdf:first sg:person.0732562660.52
185 rdf:rest rdf:nil
186 Nfd2e9d060fec4da9a1583e586872a338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Male
188 rdf:type schema:DefinedTerm
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
193 schema:name Clinical Sciences
194 rdf:type schema:DefinedTerm
195 sg:journal.1037176 schema:issn 1708-8569
196 1867-0687
197 schema:name World Journal of Pediatrics
198 rdf:type schema:Periodical
199 sg:person.01001732523.87 schema:affiliation https://www.grid.ac/institutes/grid.461863.e
200 schema:familyName Luo
201 schema:givenName Rong
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001732523.87
203 rdf:type schema:Person
204 sg:person.01142531011.34 schema:affiliation https://www.grid.ac/institutes/grid.268099.c
205 schema:familyName Lin
206 schema:givenName Zhong-Dong
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142531011.34
208 rdf:type schema:Person
209 sg:person.01231002726.22 schema:affiliation https://www.grid.ac/institutes/grid.412467.2
210 schema:familyName Wang
211 schema:givenName Hua
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231002726.22
213 rdf:type schema:Person
214 sg:person.01242210740.78 schema:affiliation Nccc920184d2c42449b8843e4826f2d61
215 schema:familyName Zhu
216 schema:givenName Sui-Qiang
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242210740.78
218 rdf:type schema:Person
219 sg:person.013204012423.84 schema:affiliation https://www.grid.ac/institutes/grid.411333.7
220 schema:familyName Wang
221 schema:givenName Yi
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013204012423.84
223 rdf:type schema:Person
224 sg:person.014001373023.50 schema:affiliation https://www.grid.ac/institutes/grid.452451.3
225 schema:familyName Chen
226 schema:givenName Yin-Bo
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014001373023.50
228 rdf:type schema:Person
229 sg:person.014576753423.26 schema:affiliation https://www.grid.ac/institutes/grid.417022.2
230 schema:familyName Zhang
231 schema:givenName Yu-Qin
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576753423.26
233 rdf:type schema:Person
234 sg:person.0732562660.52 schema:affiliation https://www.grid.ac/institutes/grid.411472.5
235 schema:familyName Qin
236 schema:givenName Jiong
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732562660.52
238 rdf:type schema:Person
239 sg:pub.10.1007/s00228-007-0308-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049915027
240 https://doi.org/10.1007/s00228-007-0308-2
241 rdf:type schema:CreativeWork
242 sg:pub.10.1007/s11055-007-0051-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051012445
243 https://doi.org/10.1007/s11055-007-0051-2
244 rdf:type schema:CreativeWork
245 sg:pub.10.1007/s40263-013-0048-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1017619647
246 https://doi.org/10.1007/s40263-013-0048-z
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s40272-013-0049-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037644118
249 https://doi.org/10.1007/s40272-013-0049-x
250 rdf:type schema:CreativeWork
251 sg:pub.10.2165/00148581-200305080-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030890168
252 https://doi.org/10.2165/00148581-200305080-00006
253 rdf:type schema:CreativeWork
254 sg:pub.10.2165/00148581-200810040-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035142509
255 https://doi.org/10.2165/00148581-200810040-00003
256 rdf:type schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1077979904 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1078297669 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1078349439 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1078730292 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1078739674 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1078843849 schema:CreativeWork
263 https://doi.org/10.1001/jama.291.5.605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033065068
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1006/ebeh.2000.0126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039815466
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.pediatrneurol.2005.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026821952
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.pediatrneurol.2006.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030409579
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.pediatrneurol.2006.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005636599
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.seizure.2006.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038553639
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.seizure.2012.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027733203
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.seizure.2013.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004724868
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0887-8994(02)00467-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021278889
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1046/j.1528-1157.2001.30800.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040605156
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/j.1365-2125.2005.02529.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027305324
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1111/j.1528-1157.1998.tb01185.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002695013
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1111/j.1528-1167.2006.00585.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016435719
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1177/0091270004266617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053538674
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1177/08830738020170010201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063853902
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1177/08830738060210061701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028193899
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1177/088307389701200806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040242503
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1212/01.wnl.0000059867.35547.de schema:sameAs https://app.dimensions.ai/details/publication/pub.1064345093
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1212/01.wnl.0000186800.18456.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347623
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1212/wnl.54.12.2237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064378223
302 rdf:type schema:CreativeWork
303 https://doi.org/10.4103/0976-3147.165420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034477316
304 rdf:type schema:CreativeWork
305 https://www.grid.ac/institutes/grid.24696.3f schema:alternateName Capital Medical University
306 schema:name Department of Neurology, Beijing Children’s Hospital, Capital Medical University, Beijing, China
307 rdf:type schema:Organization
308 https://www.grid.ac/institutes/grid.268099.c schema:alternateName Wenzhou Medical College
309 schema:name Department of Pediatric Neurology, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.411333.7 schema:alternateName Children's Hospital of Fudan University
312 schema:name Department of Neurology, Children’s Hospital of Fudan University, Shanghai, China
313 rdf:type schema:Organization
314 https://www.grid.ac/institutes/grid.411472.5 schema:alternateName Peking University First Hospital
315 schema:name Department of Pediatrics, Peking University First Hospital, Beijing, China
316 Department of Pediatrics, Peking University People’s Hospital, No.11 Xizhimen South Str., Xicheng District, 100044, Beijing, China
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.412467.2 schema:alternateName Sheng Jing Hospital
319 schema:name Department of Pediatric Neurology, Shengjing Hospital of China Medical University, Shenyang, China
320 rdf:type schema:Organization
321 https://www.grid.ac/institutes/grid.417022.2 schema:alternateName Tianjin Children's Hospital
322 schema:name Department of Neurology, Tianjin Children’s Hospital, Tianjin, China
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.452451.3 schema:alternateName First Bethune Hospital of Jilin University
325 schema:name Department of Pediatric Neurology, The First Bethune Hospital of Jilin University, Changchun, China
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.452902.8 schema:alternateName Xi’an Children’s Hospital
328 schema:name Department of Neurology, Xi’an Children’s Hospital, Xi’an, China
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.461863.e schema:alternateName West China Second University Hospital of Sichuan University
331 schema:name Department of Pediatric Neurology, West China Second University Hospital of Sichuan University, Chengdu, China
332 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...