Crescentic glomerulonephritis in children: a single centre experience View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12-18

AUTHORS

Sare Gülfem Özlü, Aysun Çaltık, Özlem Aydoğ, Mehmet Bülbül, Gülay Demircin, Evrim Çakıcı, Nilüfer Arda, Ayşe Öner

ABSTRACT

BackgroundCrescentic glomerulonephritis (CsGN) is characterized by crescents in 50% or more of glomeruli and clinically by a sudden and progressive decline in renal function.MethodsWe evaluated the etiology, clinical features, prognostic factors and long-term outcome of CsGN. Between January 2000 and December 2010, 45 children (26 girls, 19 boys) with biopsy-proven CsGN (>50% crescents) were investigated retrospectively.ResultsThe mean age of the patients was 130.86±33.77 months. The mean duration of symptoms prior to diagnosis was 26±12 days (4-40 days). Most of the children had hypertension (62.2%), macroscopic hematuria (73.3%), oligoanuria (44.4%), edema (51.1%) and purpuric rash (40%) at presentation. The final clinical status of the patients was complete remission (n=21), partial remission (n=5) or chronic kidney disease (n=19). Adverse outcomes were significantly associated with a long duration between the onset of symptoms and treatment (P=0.038), the presence of oligoanuria (P=0.006), a severe decreased glomerular filtration rate (GFR <30 mL/min/1.73m²) and the need for dialysis (P=0.003) on admission, the ratio of crescents (>75%) (P=0.03), and the ratio of fibrous crescents (P=0.015).ConclusionThe outcome of CsGN in children continues to be poor, and it should be treated as a renal emergency. More... »

PAGES

225-230

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12519-015-0036-0

DOI

http://dx.doi.org/10.1007/s12519-015-0036-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021287761

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26684304


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