Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging View Full Text


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Article Info

DATE

2022-07-07

AUTHORS

Nabeel Mansour, Stephan G. Nekolla, Eliana Reyes, George Angelidis, Panagiotis Georgoulias, Constantinos Anagnostopoulos, Paco Bravo, Isabella Bruno, Albert Flotats, Francisco Fuentes-Ocampo, Roberto Sciagrà, Felix Keng, Lukas Kessler, Maria Papathanasiou, Prem Soman, Christoph Rischpler

ABSTRACT

BackgroundCadmium-zinc-telluride (CZT)-based detectors exhibit higher diagnostic sensitivity in myocardial perfusion imaging (MPI) than conventional Anger-MPI for detection of coronary artery disease (CAD); however, reduced specificity and diagnostic accuracy of CZT-MPI were observed. This study aims to compare these different camera systems and to examine the degree of inter-rater reproducibility among readers with varying experience in MPI.Methods83 patients who underwent double stress/rest examinations using both a CZT and conventional SPECT cameras within one visit were included. Anonymized and randomized MPI-images were distributed to 15 international readers using a standardized questionnaire. Subsequent coronary angiography findings of ten patients served as a reference for analysis of sensitivity and specificity.ResultsImage quality was significantly better in CZT-MPI with significantly lower breast attenuation (P < 0.05). CZT-MPI exhibited higher sensitivity than Anger-MPI (87.5% vs. 62.5%) and significantly reduced specificity (40% vs. 100%). Readers experienced with both camera systems had the highest inter-rater agreement indicating higher reproducibility (CZT 0.54 vs. conv. 0.49, P < 0.05).ConclusionsHigher diagnostic sensitivity of CZT-MPI offers advantages in detection of CAD yet potentially of at the cost of reduced specificity, therefore it requires special training and a differentiated evaluation approach, especially for non-experienced readers with such camera systems. More... »

PAGES

1-12

References to SciGraph publications

  • 2015-09-24. Pitfalls and artifacts using the D-SPECT dedicated cardiac camera in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2004-07. Prognostic validation of a 17-segment score derived from a 20-segment score for myocardial perfusion spect interpretation in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2011-07-15. Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2015-08-21. EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2009-08-18. Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2015-07-02. Comparative analysis of cadmium-zincum-telluride cameras dedicated to myocardial perfusion SPECT: A phantom study in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2013-06-05. High-efficiency SPECT MPI: Comparison of automated quantification, visual interpretation, and coronary angiography in JOURNAL OF NUCLEAR CARDIOLOGY
  • 1998-09. Reproducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2015-01-28. A performance comparison of novel cadmium–zinc–telluride camera and conventional SPECT/CT using anthropomorphic torso phantom and water bags to simulate soft tissue and breast attenuation in ANNALS OF NUCLEAR MEDICINE
  • 2018-05-23. Differences in attenuation pattern in myocardial SPECT between CZT and conventional gamma cameras in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2014-11-08. Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2009-02-26. Advances in technical aspects of myocardial perfusion SPECT imaging in JOURNAL OF NUCLEAR CARDIOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s12350-022-03054-w

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    http://dx.doi.org/10.1007/s12350-022-03054-w

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35799039


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    18 schema:description BackgroundCadmium-zinc-telluride (CZT)-based detectors exhibit higher diagnostic sensitivity in myocardial perfusion imaging (MPI) than conventional Anger-MPI for detection of coronary artery disease (CAD); however, reduced specificity and diagnostic accuracy of CZT-MPI were observed. This study aims to compare these different camera systems and to examine the degree of inter-rater reproducibility among readers with varying experience in MPI.Methods83 patients who underwent double stress/rest examinations using both a CZT and conventional SPECT cameras within one visit were included. Anonymized and randomized MPI-images were distributed to 15 international readers using a standardized questionnaire. Subsequent coronary angiography findings of ten patients served as a reference for analysis of sensitivity and specificity.ResultsImage quality was significantly better in CZT-MPI with significantly lower breast attenuation (P < 0.05). CZT-MPI exhibited higher sensitivity than Anger-MPI (87.5% vs. 62.5%) and significantly reduced specificity (40% vs. 100%). Readers experienced with both camera systems had the highest inter-rater agreement indicating higher reproducibility (CZT 0.54 vs. conv. 0.49, P < 0.05).ConclusionsHigher diagnostic sensitivity of CZT-MPI offers advantages in detection of CAD yet potentially of at the cost of reduced specificity, therefore it requires special training and a differentiated evaluation approach, especially for non-experienced readers with such camera systems.
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