The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic ... View Full Text


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Article Info

DATE

2022-07-14

AUTHORS

Anna I. Mishkina, Victor V. Saushkin, Tariel A. Atabekov, Svetlana I. Sazonova, Vladimir V. Shipulin, Samia Massalha, Roman E. Batalov, Sergey V. Popov, Konstantin V. Zavadovsky

ABSTRACT

BackgroundImpaired cardiac sympathetic activity and mechanical dyssynchrony (MD) are associated with poor prognosis in patients with heart failure (HF) after cardiac resynchronization therapy (CRT). The study aims to assess the significance of scintigraphic evaluation of cardiac sympathetic innervation and contractility in predicting response to CRT in patients with ischemic and non-ischemic chronic HF.Methods and resultsThe study includes 58 HF patients, who were referred for CRT. Prior to CRT all patients underwent 123I-metaiodobenzylguanidine (123I-MIBG) imaging and gated myocardial perfusion imaging (MPI) using a cadmium-zinc-telluride (CZT) SPECT/CT device. At a one-year follow-up post-CRT, the delayed heart-to-mediastinum 123I-MIBG uptake ratio was an independent predictor of CRT response in non-ischemic HF patients (OR 1.469; 95% CI 1.076-2.007, p = .003). In ischemic HF patients the MD index histogram bandwidth (HBW) obtained by CZT-gated MPI had a predictive value (OR 1.06, 95% CI 1.001-1.112, p = .005) to CRT response.ConclusionCRT response can be predicted by cardiac 123I-MIBG scintigraphy, specifically by the heart-to-mediastinum ratio in non-ischemic HF and by the MD index HBW in ischemic HF. These results suggest the value of a potentially useful algorithm to improve outcomes in HF patients who are candidates for CRT. More... »

PAGES

1-12

References to SciGraph publications

  • 2017-08-14. Interactions between myocardial sympathetic denervation and left ventricular mechanical dyssynchrony: A CZT analysis in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2018-03-08. Mechanical dyssynchrony and diastolic dysfunction are common in LVH: a pilot correlation study using Doppler echocardiography and CZT gated-SPECT MPI in SCIENTIFIC REPORTS
  • 2020-05-13. Left ventricular systolic and diastolic dyssynchrony to improve cardiac resynchronization therapy response in heart failure patients with dilated cardiomyopathy in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2018-07-10. Prognostic effect and modulation of cardiac sympathetic function in heart failure patients treated with cardiac resynchronization therapy in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2016-02-25. ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2019-07-02. EANM procedural guidelines for myocardial perfusion scintigraphy using cardiac-centered gamma cameras in EUROPEAN JOURNAL OF HYBRID IMAGING
  • 2019-01-25. Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT) in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2020-11-01. Spotlight on left ventricular dyssynchrony: Part 1—Performance, variability, and mechanisms in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2010-06-17. Ultrafast assessment of left ventricular dyssynchrony from nuclear myocardial perfusion imaging on a new high-speed gamma camera in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013-11-09. Impact of scar on SPECT assay of left ventricular contraction dyssynchrony in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2010-06-25. Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2018-04-25. Iodine-123-metaiodobenzylguanidine cardiac SPECT imaging in the qualification of heart failure patients for ICD implantation in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2021-05-21. Left-ventricular dyssynchrony in viable myocardium by myocardial perfusion SPECT is predictive of mechanical response to CRT in ANNALS OF NUCLEAR MEDICINE
  • 2015-07-31. First determination of the heart-to-mediastinum ratio using cardiac dual isotope (123I-MIBG/99mTc-tetrofosmin) CZT imaging in patients with heart failure: the ADRECARD study in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2020-08-26. Prediction of appropriate ICD therapy in patients with ischemic heart failure in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2021-09-17. Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2020-01-09. Left ventricular mechanical dyssynchrony assessment in obese patients using the cadmium-zinc telluride SPECT camera in THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
  • 2007-10-18. Cardiac sympathetic activity pre and post resynchronization therapy evaluated by 123I-MIBG myocardial scintigraphy in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2013-12-06. Association between left ventricular regional sympathetic denervation and mechanical dyssynchrony in phase analysis: a cardiac CZT study in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013-06-09. Cardiac sympathetic innervation and cardiac resynchronization therapy in HEART FAILURE REVIEWS
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    PUBMED

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    26 schema:description BackgroundImpaired cardiac sympathetic activity and mechanical dyssynchrony (MD) are associated with poor prognosis in patients with heart failure (HF) after cardiac resynchronization therapy (CRT). The study aims to assess the significance of scintigraphic evaluation of cardiac sympathetic innervation and contractility in predicting response to CRT in patients with ischemic and non-ischemic chronic HF.Methods and resultsThe study includes 58 HF patients, who were referred for CRT. Prior to CRT all patients underwent 123I-metaiodobenzylguanidine (123I-MIBG) imaging and gated myocardial perfusion imaging (MPI) using a cadmium-zinc-telluride (CZT) SPECT/CT device. At a one-year follow-up post-CRT, the delayed heart-to-mediastinum 123I-MIBG uptake ratio was an independent predictor of CRT response in non-ischemic HF patients (OR 1.469; 95% CI 1.076-2.007, p = .003). In ischemic HF patients the MD index histogram bandwidth (HBW) obtained by CZT-gated MPI had a predictive value (OR 1.06, 95% CI 1.001-1.112, p = .005) to CRT response.ConclusionCRT response can be predicted by cardiac 123I-MIBG scintigraphy, specifically by the heart-to-mediastinum ratio in non-ischemic HF and by the MD index HBW in ischemic HF. These results suggest the value of a potentially useful algorithm to improve outcomes in HF patients who are candidates for CRT.
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