Association between myocardial ischemia and plaque characteristics in chronic total occlusion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-14

AUTHORS

Sang-Geon Cho, Jong Eun Lee, Hyung Yoon Kim, Ho-Chun Song, Yun-Hyeon Kim

ABSTRACT

BackgroundMyocardial ischemia varies in chronic total occlusion (CTO) despite the occluded artery. We analyzed whether it is associated with the plaque characteristics of the occluded segment. MethodsWe retrospectively enrolled 100 patients with CTO who underwent myocardial perfusion single-photon emission computed tomography (SPECT) and coronary computed tomography angiography (CCTA) within 2 months. CTO-related ischemia was classified as moderate to severe (summed difference score [SDS] of the CTO territory ≥ 5) or mild or none (SDS < 5) on SPECT. Using CCTA, the atherosclerotic plaques of the occluded segment were subdivided into low-density (− 100-30 HU), intermediate-density (31-350 HU), and high-density (351-1000 HU) plaques. The plaque composition was compared according to the severity of CTO-related ischemia.ResultsModerate-to-severe CTO-related ischemia (n = 23) showed significantly higher proportion of intermediate-density plaques (72.4% vs. 64.0%), intermediate/low-density (7.10 vs. 3.65) and intermediate-to-high/low-density (7.78 vs. 3.80) plaque ratios, frequent shorter occlusion (30% vs. 6%), and lower volume (26.5 mm3 vs. 58.8 mm3) and proportion (11.4% vs. 20.8%) of low-density plaques. Multivariable analysis revealed significant associations between higher proportion of intermediate-density plaques and moderate-to-severe CTO-related ischemia, independent of occlusion length.ConclusionHigher proportion of intermediate-density plaques in the occluded segment was associated with the moderate-to-severe CTO-related ischemia. More... »

PAGES

1-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12350-022-03020-6

DOI

http://dx.doi.org/10.1007/s12350-022-03020-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149472260

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35836093


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