Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis ... View Full Text


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Article Info

DATE

2022-07-11

AUTHORS

Tim Wollenweber, Elisabeth Kretschmer-Chott, Raphael Wurm, Sazan Rasul, Oana Kulterer, Rene Rettl, Franz Duca, Diana Bonderman, Kurt-Wolfram Sühs, Marcus Hacker, Tatjana Traub-Weidinger

ABSTRACT

BackgroundWith the introduction of several drugs for the therapy of transthyretin-related amyloidosis (ATTR) which slow down the disease, early detection of polyneuropathy (PNP) is becoming increasingly of interest. [99mTc]-3,3-Diphosphono-1,2-Propanodicarboxylic Acid (DPD) bone scintigraphy, which is used for the diagnosis of cardiac (c)ATTR, can possibly make an important contribution in the identification of patients at risk for PNP.MethodsFifty patients with cATTR, who underwent both planar whole-body DPD scintigraphy and nerve conduction studies (NCS) were retrospectively evaluated. A subgroup of 22 patients also underwent quantitative SPECT/CT of the thorax from which Standardized Uptake Values (SUVpeak) in the subcutaneous fat tissue of the left axillar region were evaluated.ResultsThe Perugini score was significantly increased in patients with cATTR and additional diagnosis of PNP compared to patients without (2.51 ± 0.51 vs 2.13 ± 0.52; P = 0.03). Quantitative SPECT/CT revealed that DPD uptake in the subcutaneous fat of the left axillar region was significantly increased in cATTR patients with compared to patients without (1.36 ± 0.60 vs 0.74 ± 0.52; P = 0.04).ConclusionThis study suggests that DPD bone scintigraphy is a useful tool for identification of patients with cATTR and a risk for PNP due to increased DPD soft tissue uptake. More... »

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References to SciGraph publications

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    http://scigraph.springernature.com/pub.10.1007/s12350-022-02986-7

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    http://dx.doi.org/10.1007/s12350-022-02986-7

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35817943


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