Ontology type: schema:ScholarlyArticle Open Access: True
2021-05-04
AUTHORSReetta Siekkinen, Anna K. Kirjavainen, Kalle Koskensalo, Nadia A. S. Smith, Andrew Fenwick, Virva Saunavaara, Tuula Tolvanen, Hidehiro Iida, Antti Saraste, Mika Teräs, Jarmo Teuho
ABSTRACTIn Myocardial Perfusion Imaging (MPI) with Positron Emission Tomography/Computed Tomography (PET/CT) systems, accurate quantification is essential. We assessed flow quantification accuracy over various injected activities using a flow phantom.MethodsThe study was performed on the digital 4-ring Discovery MI (DMI-20) and analog Discovery 690 (D690) PET/CT systems, using 325-1257 MBq of [15O]H2O. PET performance and flow quantification accuracy were assessed in terms of count-rates, dead-time factors (DTF), scatter fractions (SF), time-activity curves (TACs), areas-under-the-curves (AUCs) and flow values.ResultsOn DMI-20, prompts of 12.8 Mcps, DTF of 2.06 and SF of 46.1% were measured with 1257 MBq of activity. On the D690, prompts of 6.85 Mcps, DTF of 1.57 and SF of 32.5% were measured with 1230 MBq of activity. AUC values were linear over all activities. Mean wash-in flow error was − 9% for both systems whereas wash-out flow error was − 5% and − 6% for DMI-20 and D690. With the highest activity, wash-out flow error was − 12% and − 7% for the DMI-20 and D690.ConclusionDMI-20 and D690 preserved accurate flow quantification over all injected activities, with maximum error of − 12%. In the future, flow quantification accuracy over the activities and count-rates evaluated in this study should be assessed. More... »
PAGES1-9
http://scigraph.springernature.com/pub.10.1007/s12350-021-02631-9
DOIhttp://dx.doi.org/10.1007/s12350-021-02631-9
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/33948894
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