Quantitation of myocardial 99mTc-HMDP uptake with new SPECT/CT cadmium zinc telluride (CZT) camera in patients with transthyretin-related cardiac amyloidosis: Ready ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-07-26

AUTHORS

Dimitri Bellevre, Alban Bailliez, François Delelis, Tanguy Blaire, Denis Agostini, Frédéric Mouquet, Sylvestre Maréchaux, Alain Manrique

ABSTRACT

BackgroundThe aim of this study was to investigate the feasibility of assessing absolute myocardial 99mTc-HMDP uptake in patients with suspected cardiac ATTR using SUV with a whole-body CZT SPECT-CT camera (DNM670CZT).MethodsFifteen patients with suspected cardiac ATTR (Perugini ≥ 2) underwent a conventional 99mTc-HMDP planar imaging and a thoracic SPECT/CT using a DNM 670CZT. A control group consisted of 15 patients with negative scintigraphy (Perugini < 2). SUVmax (mg·L−1) and percentage of injected dose (%ID) were calculated in a cardiac volume of interest (VOI) encompassing the left ventricle. VOIs were also placed in the lung, the right pectoris major, and the sternum. A heart-to-lung SUVmax ratio (HLR) was calculated.ResultsAll ATTR patients demonstrated an increased cardiac HMDP SUVmax (12.2 ± 3.7 mg·L−1) vs controls (3.5 ± 1.2, P < .0001). Percentage of ID, pectoral uptake and HLR were significantly higher in the ATTR group (1.1 ± 0.3 vs 0.15 ± 0.8, P < .0001; 1.5 ± 0.3 vs 0.9 ± 0.3, P < .0001; 9.7 ± 3 vs 4.3 ± 2.2, P < .0001). Bone uptake was not statistically different between the two groups.ConclusionThis study demonstrated the feasibility of quantitative 99mTc-HMDP SUVmax measurement using a whole-body SPECT/CT CZT camera in patients with suspected cardiac ATTR. More... »

PAGES

506-514

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12350-020-02274-2

DOI

http://dx.doi.org/10.1007/s12350-020-02274-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1129668042

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32715418


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