Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-07-17

AUTHORS

Maria Grönman, Miikka Tarkia, Christoffer Stark, Tommi Vähäsilta, Tuomas Kiviniemi, Mark Lubberink, Paavo Halonen, Antti Kuivanen, Virva Saunavaara, Tuula Tolvanen, Jarmo Teuho, Mika Teräs, Timo Savunen, Mikko Pietilä, Seppo Ylä-Herttuala, Anne Roivainen, Juhani Knuuti, Antti Saraste

ABSTRACT

BackgroundAssessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and perfusable tissue index (PTI) in the assessment of myocardial viability in a pig model of myocardial infarction (MI).Methods and resultsPigs underwent resting [15O]water PET perfusion study 12 weeks after surgical (n = 16) or 2 weeks after catheter-based (n = 4) occlusion of the proximal left anterior descending coronary artery. MBF, PTF, and PTI were compared with volume fraction of MI in matched segments as assessed by triphenyl tetrazolium chloride staining of LV slices. MBF and PTF were lower in infarcted than non-infarcted segments. Segmental analysis of MBF showed similar area under the curve (AUC) of 0.85, 0.86, and 0.90 with relative MBF, PTF, and PTI for the detection of viable myocardium defined as infarct volume fraction of < 75%. Cut-off values of relative MBF of ≥ 67% and PTF of ≥ 66% resulted in accuracies of 90% and 81%, respectively.ConclusionsOur results indicate that resting MBF, PTF, and PTI based on [15O]water PET perfusion imaging are useful for the assessment of myocardial viability. More... »

PAGES

1271-1280

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12350-019-01818-5

DOI

http://dx.doi.org/10.1007/s12350-019-01818-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1118064640

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31317328


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22 schema:description BackgroundAssessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and perfusable tissue index (PTI) in the assessment of myocardial viability in a pig model of myocardial infarction (MI).Methods and resultsPigs underwent resting [15O]water PET perfusion study 12 weeks after surgical (n = 16) or 2 weeks after catheter-based (n = 4) occlusion of the proximal left anterior descending coronary artery. MBF, PTF, and PTI were compared with volume fraction of MI in matched segments as assessed by triphenyl tetrazolium chloride staining of LV slices. MBF and PTF were lower in infarcted than non-infarcted segments. Segmental analysis of MBF showed similar area under the curve (AUC) of 0.85, 0.86, and 0.90 with relative MBF, PTF, and PTI for the detection of viable myocardium defined as infarct volume fraction of < 75%. Cut-off values of relative MBF of ≥ 67% and PTF of ≥ 66% resulted in accuracies of 90% and 81%, respectively.ConclusionsOur results indicate that resting MBF, PTF, and PTI based on [15O]water PET perfusion imaging are useful for the assessment of myocardial viability.
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29 schema:keywords BackgroundAssessment
30 ConclusionsOur results
31 LV slices
32 MBF
33 PET
34 PET perfusion imaging
35 accuracy
36 analysis
37 area
38 artery
39 assessment
40 catheter-based occlusion
41 chest pain
42 chloride staining
43 coronary artery
44 curves
45 detection
46 ejection fraction
47 experimental myocardial infarction
48 fraction
49 imaging
50 index
51 infarction
52 method
53 model
54 myocardial infarction
55 myocardial viability
56 myocardium
57 non-infarcted segments
58 occlusion
59 pain
60 patients
61 performance
62 perfusable tissue fraction
63 perfusable tissue index
64 perfusion imaging
65 pig model
66 reduced ejection fraction
67 results
68 segmental analysis
69 segments
70 similar areas
71 slices
72 staining
73 study
74 tetrazolium chloride staining
75 tissue fractions
76 tissue index
77 triphenyl tetrazolium chloride staining
78 validation study
79 values
80 viability
81 viable myocardium
82 volume fraction
83 weeks
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