Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-24

AUTHORS

Satoko Nakamura, Yuhei Kawano, Kenichi Nakajima, Hiroki Hase, Nobuhiko Joki, Tsuguru Hatta, Shigeyuki Nishimura, Masao Moroi, Susumu Nakagawa, Tokuo Kasai, Hideo Kusuoka, Yasuchika Takeishi, Mitsuru Momose, Kazuya Takehana, Mamoru Nanasato, Syunichi Yoda, Hidetaka Nishina, Naoya Matsumoto, Tsunehiko Nishimura

ABSTRACT

BackgroundMyocardial perfusion imaging (MPI) is considered useful for risk stratification among patients with chronic kidney disease (CKD), without renal deterioration by contrast media. Methods and ResultsThe Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS 3) is a multicenter, prospective cohort study investigating the ability of MPI to predict cardiac events in 529 CKD patients without a definitive coronary artery disease. All patients were assessed by stress and rest MPI with 99mTc-tetrofosmin and data were analyzed using a defect scoring method and QGS software. Major cardiac events were analyzed for 3 years after registration. The mean eGFR was 29.0 ± 12.8 (mL/minute/1.73 m2). The mean summed stress/rest/difference (SSS, SRS, SDS) scores were 1.9 ± 3.8, 1.1 ± 3.0, and 0.8 ± 1.8, respectively. A total of 60 cardiac events (three cardiac deaths, six sudden deaths, five nonfatal myocardial infarctions, 46 hospitalization cases for heart failure) occurred. The event-free survival rate was lower among patients with kidney dysfunction, higher SSS, and higher CRP values. Multivariate Cox regression analysis independently associated SSS ≥8, eGFR <15 (mL/minute/1.73 m2), and CRP ≥0.3 (mg/dL) with cardiac events.ConclusionsTogether with eGFR and CRP, MPI can predict cardiac events in patients with CKD. More... »

PAGES

431-440

Journal

TITLE

Journal of Nuclear Cardiology

ISSUE

2

VOLUME

26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12350-017-0880-5

DOI

http://dx.doi.org/10.1007/s12350-017-0880-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085054646

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28439760


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    "description": "BackgroundMyocardial perfusion imaging (MPI) is considered useful for risk stratification among patients with chronic kidney disease (CKD), without renal deterioration by contrast media.\nMethods and ResultsThe Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS 3) is a multicenter, prospective cohort study investigating the ability of MPI to predict cardiac events in 529 CKD patients without a definitive coronary artery disease. All patients were assessed by stress and rest MPI with 99mTc-tetrofosmin and data were analyzed using a defect scoring method and QGS software. Major cardiac events were analyzed for 3\u00a0years after registration. The mean eGFR was 29.0\u00a0\u00b1\u00a012.8 (mL/minute/1.73\u00a0m2). The mean summed stress/rest/difference (SSS, SRS, SDS) scores were 1.9\u00a0\u00b1\u00a03.8, 1.1\u00a0\u00b1\u00a03.0, and 0.8\u00a0\u00b1\u00a01.8, respectively. A total of 60 cardiac events (three cardiac deaths, six sudden deaths, five nonfatal myocardial infarctions, 46 hospitalization cases for heart failure) occurred. The event-free survival rate was lower among patients with kidney dysfunction, higher SSS, and higher CRP values. Multivariate Cox regression analysis independently associated SSS\u00a0\u22658, eGFR\u00a0<15 (mL/minute/1.73\u00a0m2), and CRP\u00a0\u22650.3 (mg/dL) with cardiac events.ConclusionsTogether with eGFR and CRP, MPI can predict cardiac events in patients with CKD.", 
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