Stress-induced alteration of left ventricular eccentricity: An additional marker of multivessel CAD View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Alessia Gimelli, Riccardo Liga, Assuero Giorgetti, Mirta Casagranda, Paolo Marzullo

ABSTRACT

BACKGROUND: Abnormal left ventricular (LV) eccentricity index (EI) is a marker of adverse cardiac remodeling. However, the interaction between stress-induced alterations of EI and major cardiac parameters has not been explored. We sought to evaluate the relationship between LV EI and coronary artery disease (CAD) burden in patients submitted to myocardial perfusion imaging (MPI). METHODS AND RESULTS: Three-hundred and forty-three patients underwent MPI and coronary angiography. LV ejection fraction (EF) and EI were computed from gated stress images as measures of stress-induced functional impairment. One-hundred and thirty-six (40%), 122 (35%), and 85 (25%) patients had normal coronary arteries, single-vessel CAD, and multivessel CAD, respectively. Post-stress EI was lower in patients with multivessel CAD than in those with normal coronary arteries and single-vessel CAD (P = 0.001). This relationship was confirmed only in patients undergoing exercise stress test, where a lower post-stress EI predicted the presence of multivessel CAD (P = 0.039). CONCLUSIONS: Post-stress alterations of LV EI on MPI may unmask the presence of multivessel CAD. More... »

PAGES

227-232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12350-017-0862-7

DOI

http://dx.doi.org/10.1007/s12350-017-0862-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084035131

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28353212


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