Type 2 diabetes mellitus correlates with systolic function during myocardial stress perfusion scanning with Nitrogen-13 ammonia PET View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08

AUTHORS

Luis Eduardo Juárez-Orozco, Friso M. van der Zant, Riemer H. J. A. Slart, Sergiy V. Lazarenko, Erick Alexanderson, Rene A. Tio, Remco J. J. Knol

ABSTRACT

BACKGROUND: The influence of type 2 diabetes mellitus (DM2) on systolic function is partially determined by the coronary vasodilator function, nevertheless, an independent effect is suspected. We evaluated the relationship between DM2 and systolic function considering PET quantitative myocardial perfusion. METHODS: We analyzed 585 patients without a previous myocardial infarction referred to a rest and adenosine stress Nitrogen-13 ammonia PET. A bootstrapped multiple linear regression analysis was performed using DM2, stress myocardial blood flow (sMBF), myocardial perfusion reserve (MPR), and clinical risk factors as predictors and LVEF as the outcome variable; an interaction term was additionally investigated. RESULTS: Two hundred and ninety male and 295 female patients (mean age 65.3 ± 9.9 and 67.4 ± 10 years, respectively) were included. 57.1% presented hypertension, 16% smoking, 37.6% hypercholesterolemia, 33.8% family history for CAD, and 15.2% DM2. The mean MPR was 2.13 ± 0.48 and 2.21 ± 0.60, mean sMBF was 2.01 ± 0.51 and 2.15 ± 0.54, and mean LVEF was 63% ± 10.4 and 67% ± 10.1 for diabetics and non-diabetics, respectively. A significant relation was detected for sMBF (B = 5.830 95% CI [3.505, 9.549], P = .001) and DM2 (B = -2.599 95% CI [-5.125, -0.119], P = .03) with LVEF. The interaction (DM2 × sMBF) yielded no significance (P = .512). CONCLUSION: DM2 influences PET-measured systolic function in patients without previous myocardial infarction independently from myocardial perfusion parameters. Our study supports the importance of DM2 as an independent risk factor for deteriorating systolic function. More... »

PAGES

1305-1311

References to SciGraph publications

  • 2013-08. Myocardial perfusion reserve in spared myocardium: correlation with infarct size and left ventricular ejection fraction in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2015-01. Imaging of cardiac and renal perfusion in a rat model with 13N–NH3 micro-PET in THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12350-016-0482-7

    DOI

    http://dx.doi.org/10.1007/s12350-016-0482-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031428328

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27083442


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coronary Circulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetes Mellitus, Type 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exercise Test", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Linear Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nitrogen Radioisotopes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Positron-Emission Tomography", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Systole", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ventricular Function, Left", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Autonomous University of Mexico", 
              "id": "https://www.grid.ac/institutes/grid.9486.3", 
              "name": [
                "Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Hanzeplein 1, Internal Post: EB50, 9700RB, Groningen, The Netherlands", 
                "PET/CT Cyclotron Unit, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ju\u00e1rez-Orozco", 
            "givenName": "Luis Eduardo", 
            "id": "sg:person.01150506107.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150506107.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medisch Centrum Alkmaar", 
              "id": "https://www.grid.ac/institutes/grid.414828.3", 
              "name": [
                "Department of Nuclear Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van der Zant", 
            "givenName": "Friso M.", 
            "id": "sg:person.0712750304.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712750304.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Twente", 
              "id": "https://www.grid.ac/institutes/grid.6214.1", 
              "name": [
                "Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Hanzeplein 1, Internal Post: EB50, 9700RB, Groningen, The Netherlands", 
                "Biomedical Photonic Imaging Group, University of Twente, Enschede, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Slart", 
            "givenName": "Riemer H. J. A.", 
            "id": "sg:person.01007720736.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007720736.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medisch Centrum Alkmaar", 
              "id": "https://www.grid.ac/institutes/grid.414828.3", 
              "name": [
                "Department of Nuclear Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lazarenko", 
            "givenName": "Sergiy V.", 
            "id": "sg:person.01357657443.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357657443.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Autonomous University of Mexico", 
              "id": "https://www.grid.ac/institutes/grid.9486.3", 
              "name": [
                "PET/CT Cyclotron Unit, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alexanderson", 
            "givenName": "Erick", 
            "id": "sg:person.0722177072.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722177072.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tio", 
            "givenName": "Rene A.", 
            "id": "sg:person.01343364655.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343364655.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medisch Centrum Alkmaar", 
              "id": "https://www.grid.ac/institutes/grid.414828.3", 
              "name": [
                "Department of Nuclear Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knol", 
            "givenName": "Remco J. J.", 
            "id": "sg:person.0666373154.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666373154.18"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.amjmed.2008.03.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003248367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10554-014-0538-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011961668", 
              "https://doi.org/10.1007/s10554-014-0538-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ehjci/jet274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013844719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.110.084954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014122478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/dc12-2147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016919722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2014.05.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017554357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-013-2394-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018175341", 
              "https://doi.org/10.1007/s00259-013-2394-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0735-1097(90)90237-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018875251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.105.574400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022576693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/ehv134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028056659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.108.054395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035639750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.114.002400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036068024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.114.002400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036068024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9149(72)90595-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042047864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.112.120402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045265724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.112.120402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045265724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-11-0687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052760055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2003-0012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064285781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075213865", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077151743", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-08", 
        "datePublishedReg": "2017-08-01", 
        "description": "BACKGROUND: The influence of type 2 diabetes mellitus (DM2) on systolic function is partially determined by the coronary vasodilator function, nevertheless, an independent effect is suspected. We evaluated the relationship between DM2 and systolic function considering PET quantitative myocardial perfusion.\nMETHODS: We analyzed 585 patients without a previous myocardial infarction referred to a rest and adenosine stress Nitrogen-13 ammonia PET. A bootstrapped multiple linear regression analysis was performed using DM2, stress myocardial blood flow (sMBF), myocardial perfusion reserve (MPR), and clinical risk factors as predictors and LVEF as the outcome variable; an interaction term was additionally investigated.\nRESULTS: Two hundred and ninety male and 295 female patients (mean age 65.3\u00a0\u00b1\u00a09.9 and 67.4\u00a0\u00b1\u00a010\u00a0years, respectively) were included. 57.1% presented hypertension, 16% smoking, 37.6% hypercholesterolemia, 33.8% family history for CAD, and 15.2% DM2. The mean MPR was 2.13\u00a0\u00b1\u00a00.48 and 2.21\u00a0\u00b1\u00a00.60, mean sMBF was 2.01\u00a0\u00b1\u00a00.51 and 2.15\u00a0\u00b1\u00a00.54, and mean LVEF was 63%\u00a0\u00b1\u00a010.4 and 67%\u00a0\u00b1\u00a010.1 for diabetics and non-diabetics, respectively. A significant relation was detected for sMBF (B\u00a0=\u00a05.830 95% CI [3.505, 9.549], P\u00a0=\u00a0.001) and DM2 (B\u00a0=\u00a0-2.599 95% CI [-5.125, -0.119], P\u00a0=\u00a0.03) with LVEF. The interaction (DM2\u00a0\u00d7\u00a0sMBF) yielded no significance (P\u00a0=\u00a0.512).\nCONCLUSION: DM2 influences PET-measured systolic function in patients without previous myocardial infarction independently from myocardial perfusion parameters. Our study supports the importance of DM2 as an independent risk factor for deteriorating systolic function.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12350-016-0482-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1106202", 
            "issn": [
              "1071-3581", 
              "1532-6551"
            ], 
            "name": "Journal of Nuclear Cardiology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "24"
          }
        ], 
        "name": "Type 2 diabetes mellitus correlates with systolic function during myocardial stress perfusion scanning with Nitrogen-13 ammonia PET", 
        "pagination": "1305-1311", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "95b7cbed34792f390b5f7c120fa09ea5dea137b396de8fc0e9dbee1a6c1ccdd8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27083442"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9423534"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12350-016-0482-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031428328"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12350-016-0482-7", 
          "https://app.dimensions.ai/details/publication/pub.1031428328"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88221_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs12350-016-0482-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12350-016-0482-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12350-016-0482-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12350-016-0482-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12350-016-0482-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    228 TRIPLES      21 PREDICATES      60 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12350-016-0482-7 schema:about N1474c276cb4b497691d98474a0efedcb
    2 N1e3563b1d6d34a51bd17f22dc7abc755
    3 N202c16ff5c0a42aa87d902b752cb9d4c
    4 N23577dac0461465ab40623c05bc19503
    5 N271a157701be42208718d03324605c6b
    6 N2ef422d7165b44aaa586264b4588647c
    7 N35f3de274fbb4b26b416d09245c798f8
    8 N3f6a8783bb274bbeba7b08f41dfa3184
    9 N402ec654532949fd95a6dfbe03748ff9
    10 N42a2abea843a46cd8d5fe5384068538f
    11 N54788add6e9b40ffad81d21ed0d9bdd5
    12 Nbedb7acba2814ec8bfb449e813c42042
    13 Ncc6a8098c9d142eaadbdc9d7c02790bf
    14 anzsrc-for:11
    15 anzsrc-for:1102
    16 schema:author Na8738756ed444b5080ea9c5e9c39cbe7
    17 schema:citation sg:pub.10.1007/s00259-013-2394-y
    18 sg:pub.10.1007/s10554-014-0538-1
    19 https://app.dimensions.ai/details/publication/pub.1075213865
    20 https://app.dimensions.ai/details/publication/pub.1077151743
    21 https://doi.org/10.1016/0002-9149(72)90595-4
    22 https://doi.org/10.1016/0735-1097(90)90237-j
    23 https://doi.org/10.1016/j.amjmed.2008.03.046
    24 https://doi.org/10.1016/j.jacc.2014.05.069
    25 https://doi.org/10.1093/ehjci/jet274
    26 https://doi.org/10.1093/eurheartj/ehv134
    27 https://doi.org/10.1161/circimaging.114.002400
    28 https://doi.org/10.1161/circulationaha.105.574400
    29 https://doi.org/10.1161/circulationaha.112.120402
    30 https://doi.org/10.1210/er.2003-0012
    31 https://doi.org/10.1530/eje-11-0687
    32 https://doi.org/10.2337/dc12-2147
    33 https://doi.org/10.2967/jnumed.108.054395
    34 https://doi.org/10.2967/jnumed.110.084954
    35 schema:datePublished 2017-08
    36 schema:datePublishedReg 2017-08-01
    37 schema:description BACKGROUND: The influence of type 2 diabetes mellitus (DM2) on systolic function is partially determined by the coronary vasodilator function, nevertheless, an independent effect is suspected. We evaluated the relationship between DM2 and systolic function considering PET quantitative myocardial perfusion. METHODS: We analyzed 585 patients without a previous myocardial infarction referred to a rest and adenosine stress Nitrogen-13 ammonia PET. A bootstrapped multiple linear regression analysis was performed using DM2, stress myocardial blood flow (sMBF), myocardial perfusion reserve (MPR), and clinical risk factors as predictors and LVEF as the outcome variable; an interaction term was additionally investigated. RESULTS: Two hundred and ninety male and 295 female patients (mean age 65.3 ± 9.9 and 67.4 ± 10 years, respectively) were included. 57.1% presented hypertension, 16% smoking, 37.6% hypercholesterolemia, 33.8% family history for CAD, and 15.2% DM2. The mean MPR was 2.13 ± 0.48 and 2.21 ± 0.60, mean sMBF was 2.01 ± 0.51 and 2.15 ± 0.54, and mean LVEF was 63% ± 10.4 and 67% ± 10.1 for diabetics and non-diabetics, respectively. A significant relation was detected for sMBF (B = 5.830 95% CI [3.505, 9.549], P = .001) and DM2 (B = -2.599 95% CI [-5.125, -0.119], P = .03) with LVEF. The interaction (DM2 × sMBF) yielded no significance (P = .512). CONCLUSION: DM2 influences PET-measured systolic function in patients without previous myocardial infarction independently from myocardial perfusion parameters. Our study supports the importance of DM2 as an independent risk factor for deteriorating systolic function.
    38 schema:genre research_article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N4f62cad4144543f08d93422915b406ad
    42 Nb2fd7b2757f745b29c59653e835099a4
    43 sg:journal.1106202
    44 schema:name Type 2 diabetes mellitus correlates with systolic function during myocardial stress perfusion scanning with Nitrogen-13 ammonia PET
    45 schema:pagination 1305-1311
    46 schema:productId N4e56973c8dff4d4e97a1bc16f0e19407
    47 N5aa9a19fb3264d4ca285695ad25600a9
    48 N87e401f9c3b14d28b1b118efc4b0ba42
    49 Naea737e4d5ba456ebb196168413f5a58
    50 Nd2f84299f9934fd38f747fe947ef74ee
    51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031428328
    52 https://doi.org/10.1007/s12350-016-0482-7
    53 schema:sdDatePublished 2019-04-11T13:07
    54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    55 schema:sdPublisher Nff0bf6df5c4647818a2763dc9eb2955e
    56 schema:url https://link.springer.com/10.1007%2Fs12350-016-0482-7
    57 sgo:license sg:explorer/license/
    58 sgo:sdDataset articles
    59 rdf:type schema:ScholarlyArticle
    60 N1474c276cb4b497691d98474a0efedcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    61 schema:name Coronary Circulation
    62 rdf:type schema:DefinedTerm
    63 N1e3563b1d6d34a51bd17f22dc7abc755 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    64 schema:name Diabetes Mellitus, Type 2
    65 rdf:type schema:DefinedTerm
    66 N202c16ff5c0a42aa87d902b752cb9d4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    67 schema:name Nitrogen Radioisotopes
    68 rdf:type schema:DefinedTerm
    69 N23577dac0461465ab40623c05bc19503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    70 schema:name Aged
    71 rdf:type schema:DefinedTerm
    72 N271a157701be42208718d03324605c6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    73 schema:name Humans
    74 rdf:type schema:DefinedTerm
    75 N29118041b1d443fbbf071e53be21bca9 rdf:first sg:person.0722177072.42
    76 rdf:rest N4ea578ce3a584982a7663d226abd5ef5
    77 N2cd2218f28be49f0b4468ce9ba3f3093 rdf:first sg:person.01357657443.13
    78 rdf:rest N29118041b1d443fbbf071e53be21bca9
    79 N2ef422d7165b44aaa586264b4588647c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Ventricular Function, Left
    81 rdf:type schema:DefinedTerm
    82 N3259a1047c5e41e58e2200f76eebe8dc rdf:first sg:person.0712750304.72
    83 rdf:rest N36a081bfb2a742248e0961af4ec19845
    84 N35f3de274fbb4b26b416d09245c798f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Female
    86 rdf:type schema:DefinedTerm
    87 N36a081bfb2a742248e0961af4ec19845 rdf:first sg:person.01007720736.90
    88 rdf:rest N2cd2218f28be49f0b4468ce9ba3f3093
    89 N3f6a8783bb274bbeba7b08f41dfa3184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Middle Aged
    91 rdf:type schema:DefinedTerm
    92 N402ec654532949fd95a6dfbe03748ff9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Systole
    94 rdf:type schema:DefinedTerm
    95 N42a2abea843a46cd8d5fe5384068538f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Exercise Test
    97 rdf:type schema:DefinedTerm
    98 N4e56973c8dff4d4e97a1bc16f0e19407 schema:name readcube_id
    99 schema:value 95b7cbed34792f390b5f7c120fa09ea5dea137b396de8fc0e9dbee1a6c1ccdd8
    100 rdf:type schema:PropertyValue
    101 N4ea578ce3a584982a7663d226abd5ef5 rdf:first sg:person.01343364655.02
    102 rdf:rest N63bc0eab292a4325b8f20cd3c78cd4f6
    103 N4f62cad4144543f08d93422915b406ad schema:volumeNumber 24
    104 rdf:type schema:PublicationVolume
    105 N54788add6e9b40ffad81d21ed0d9bdd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Linear Models
    107 rdf:type schema:DefinedTerm
    108 N5aa9a19fb3264d4ca285695ad25600a9 schema:name dimensions_id
    109 schema:value pub.1031428328
    110 rdf:type schema:PropertyValue
    111 N63bc0eab292a4325b8f20cd3c78cd4f6 rdf:first sg:person.0666373154.18
    112 rdf:rest rdf:nil
    113 N87e401f9c3b14d28b1b118efc4b0ba42 schema:name nlm_unique_id
    114 schema:value 9423534
    115 rdf:type schema:PropertyValue
    116 Na8738756ed444b5080ea9c5e9c39cbe7 rdf:first sg:person.01150506107.01
    117 rdf:rest N3259a1047c5e41e58e2200f76eebe8dc
    118 Naea737e4d5ba456ebb196168413f5a58 schema:name doi
    119 schema:value 10.1007/s12350-016-0482-7
    120 rdf:type schema:PropertyValue
    121 Nb2fd7b2757f745b29c59653e835099a4 schema:issueNumber 4
    122 rdf:type schema:PublicationIssue
    123 Nbedb7acba2814ec8bfb449e813c42042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Male
    125 rdf:type schema:DefinedTerm
    126 Ncc6a8098c9d142eaadbdc9d7c02790bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Positron-Emission Tomography
    128 rdf:type schema:DefinedTerm
    129 Nd2f84299f9934fd38f747fe947ef74ee schema:name pubmed_id
    130 schema:value 27083442
    131 rdf:type schema:PropertyValue
    132 Nff0bf6df5c4647818a2763dc9eb2955e schema:name Springer Nature - SN SciGraph project
    133 rdf:type schema:Organization
    134 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    135 schema:name Medical and Health Sciences
    136 rdf:type schema:DefinedTerm
    137 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Cardiorespiratory Medicine and Haematology
    139 rdf:type schema:DefinedTerm
    140 sg:journal.1106202 schema:issn 1071-3581
    141 1532-6551
    142 schema:name Journal of Nuclear Cardiology
    143 rdf:type schema:Periodical
    144 sg:person.01007720736.90 schema:affiliation https://www.grid.ac/institutes/grid.6214.1
    145 schema:familyName Slart
    146 schema:givenName Riemer H. J. A.
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007720736.90
    148 rdf:type schema:Person
    149 sg:person.01150506107.01 schema:affiliation https://www.grid.ac/institutes/grid.9486.3
    150 schema:familyName Juárez-Orozco
    151 schema:givenName Luis Eduardo
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150506107.01
    153 rdf:type schema:Person
    154 sg:person.01343364655.02 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
    155 schema:familyName Tio
    156 schema:givenName Rene A.
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343364655.02
    158 rdf:type schema:Person
    159 sg:person.01357657443.13 schema:affiliation https://www.grid.ac/institutes/grid.414828.3
    160 schema:familyName Lazarenko
    161 schema:givenName Sergiy V.
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357657443.13
    163 rdf:type schema:Person
    164 sg:person.0666373154.18 schema:affiliation https://www.grid.ac/institutes/grid.414828.3
    165 schema:familyName Knol
    166 schema:givenName Remco J. J.
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666373154.18
    168 rdf:type schema:Person
    169 sg:person.0712750304.72 schema:affiliation https://www.grid.ac/institutes/grid.414828.3
    170 schema:familyName van der Zant
    171 schema:givenName Friso M.
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712750304.72
    173 rdf:type schema:Person
    174 sg:person.0722177072.42 schema:affiliation https://www.grid.ac/institutes/grid.9486.3
    175 schema:familyName Alexanderson
    176 schema:givenName Erick
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722177072.42
    178 rdf:type schema:Person
    179 sg:pub.10.1007/s00259-013-2394-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1018175341
    180 https://doi.org/10.1007/s00259-013-2394-y
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1007/s10554-014-0538-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011961668
    183 https://doi.org/10.1007/s10554-014-0538-1
    184 rdf:type schema:CreativeWork
    185 https://app.dimensions.ai/details/publication/pub.1075213865 schema:CreativeWork
    186 https://app.dimensions.ai/details/publication/pub.1077151743 schema:CreativeWork
    187 https://doi.org/10.1016/0002-9149(72)90595-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042047864
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/0735-1097(90)90237-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1018875251
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/j.amjmed.2008.03.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003248367
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/j.jacc.2014.05.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017554357
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1093/ehjci/jet274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013844719
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1093/eurheartj/ehv134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028056659
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1161/circimaging.114.002400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036068024
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1161/circulationaha.105.574400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022576693
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1161/circulationaha.112.120402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045265724
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1210/er.2003-0012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285781
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1530/eje-11-0687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052760055
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.2337/dc12-2147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016919722
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.2967/jnumed.108.054395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035639750
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.2967/jnumed.110.084954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014122478
    214 rdf:type schema:CreativeWork
    215 https://www.grid.ac/institutes/grid.414828.3 schema:alternateName Medisch Centrum Alkmaar
    216 schema:name Department of Nuclear Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands
    217 rdf:type schema:Organization
    218 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
    219 schema:name Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    220 rdf:type schema:Organization
    221 https://www.grid.ac/institutes/grid.6214.1 schema:alternateName University of Twente
    222 schema:name Biomedical Photonic Imaging Group, University of Twente, Enschede, The Netherlands
    223 Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Hanzeplein 1, Internal Post: EB50, 9700RB, Groningen, The Netherlands
    224 rdf:type schema:Organization
    225 https://www.grid.ac/institutes/grid.9486.3 schema:alternateName National Autonomous University of Mexico
    226 schema:name Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Hanzeplein 1, Internal Post: EB50, 9700RB, Groningen, The Netherlands
    227 PET/CT Cyclotron Unit, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
    228 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...