Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-03-31

AUTHORS

Morgan C. Lyon, Courtney Foster, Xinhong Ding, Sharmila Dorbala, Don Spence, Manojeet Bhattacharya, A. Hans Vija, Marcelo F. DiCarli, Stephen C. Moore

ABSTRACT

BackgroundRecent technological advances in myocardial perfusion imaging may warrant the use of lower injected activity. We evaluated whether quantitative measures of stress myocardial perfusion defects using Tc-99m sestamibi and low-energy high-resolution (LEHR) collimators are equivalent to lower dose SPECT-CT with cardiac multifocal collimators and software (IQ·SPECT).Methods93 patients underwent one-day rest-stress gated SPECT-CT. Following conventional rest imaging, 925-1100 MBq (25-30 mCi) of Tc-99m sestamibi was injected during stress testing. Stress SPECT-CT images were acquired two ways: with LEHR (13 minutes) and IQ·SPECT (7 minutes). Low-dose IQ·SPECT stress was simulated by subsampling the full-dose data to half-, quarter-, and eighth-count levels. Abnormalities were quantified using the total perfusion deficit (TPD) score and dose-specific databases.ResultsThe mean ± SD of the differences between LEHR and IQ·SPECT TPD scores were −1.01 ± 5.36%, −0.10 ± 5.81%, 1.78 ± 4.81%, and 1.75 ± 6.05% at full, half, quarter, and eighth doses, respectively. Differences were statistically significant for quarter and eighth doses. Correlation between LEHR and IQ·SPECT was excellent at all doses (R ≥ 0.93). Bland-Altman plots demonstrated minimal bias.ConclusionsWith IQ·SPECT, quantitative stress SPECT-CT imaging is possible with half of the standard injected activity in half the time. More... »

PAGES

657-667

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12350-016-0471-x

DOI

http://dx.doi.org/10.1007/s12350-016-0471-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026494493

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27033352


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54 activity
55 advances
56 bias
57 cardiac multifocal collimators
58 collimation
59 collimator
60 conventional rest imaging
61 correlation
62 data
63 database
64 defects
65 deficit scores
66 differences
67 dose
68 dose reduction
69 dose-specific databases
70 doses
71 eighth doses
72 eighth-count levels
73 full-dose data
74 half
75 half-time myocardial perfusion SPECT-CT
76 high-resolution collimator
77 images
78 imaging
79 injected activity
80 levels
81 low-energy high-resolution (LEHR) collimator
82 lower injected activity
83 measures
84 minimal bias
85 multifocal collimation
86 multifocal collimator
87 myocardial perfusion SPECT-CT
88 myocardial perfusion defects
89 myocardial perfusion imaging
90 one-day
91 patients
92 perfusion SPECT-CT
93 perfusion defects
94 perfusion deficit (TPD) score
95 perfusion imaging
96 plots
97 quantitative measures
98 quantitative stress SPECT-CT imaging
99 quarter
100 reduction
101 rest imaging
102 scores
103 sestamibi
104 software
105 stress
106 stress SPECT-CT imaging
107 stress myocardial perfusion defects
108 stress testing
109 technological advances
110 testing
111 time
112 total perfusion deficit scores
113 use
114 way
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