Diet intervention reduces uptake of αvβ3 integrin-targeted PET tracer 18F-galacto-RGD in mouse atherosclerotic plaques View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08

AUTHORS

Antti Saraste, Iina Laitinen, Eliane Weidl, Moritz Wildgruber, Axel W. Weber, Stephan G. Nekolla, Gabriele Hölzlwimmer, Irene Esposito, Axel Walch, Pia Leppänen, Irina Lisinen, Peter B. Luppa, Seppo Ylä-Herttuala, Hans-Jürgen Wester, Juhani Knuuti, Markus Schwaiger

ABSTRACT

BACKGROUND: Expression of α(v)β(3) integrin has been proposed as a marker for atherosclerotic lesion inflammation. We studied whether diet intervention reduces uptake of α(v)β(3) integrin-targeted positron emission tomography tracer (18)F-galacto-RGD in mouse atherosclerotic plaques. METHODS AND RESULTS: Hypercholesterolemic LDLR(-/-) ApoB(100/100) mice on high-fat diet for 4 months were randomized to further 3 months on high-fat diet (high-fat group, n = 8) or regular mouse chow (intervention group, n = 7). Intima-media ratio describing plaque burden was comparable between intervention and high-fat groups (2.0 ± 0.5 vs 2.3 ± 0.8, P = .5). Uptake of (18)F-galacto-RGD in the aorta was lower in the intervention than high-fat group (%ID/g 0.16 vs 0.23, P < .01). Autoradiography showed 35% lower uptake of (18)F-galacto-RGD in the atherosclerotic plaques in the intervention than high-fat group (P = .007). Uptake of (18)F-galacto-RGD in plaques correlated with uptake of (3)H-deoxyglucose and nuclear density, which was lower in the intervention than high-fat group (P = .01). Flow cytometry demonstrated macrophages expressing α(v) and β(3) integrins in the aorta. CONCLUSIONS: Uptake of (18)F-galacto-RGD in mouse atherosclerotic lesions was reduced by lipid-lowering diet intervention. Expression of α(v)β(3) integrin is a potential target for evaluation of therapy response in atherosclerosis. More... »

PAGES

775-784

References to SciGraph publications

  • 2009-12. 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2008-08. Arithmetic of vulnerable plaques for noninvasive imaging in NATURE REVIEWS CARDIOLOGY
  • 2009-03. In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis in THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12350-012-9554-5

    DOI

    http://dx.doi.org/10.1007/s12350-012-9554-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041513203

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22527796


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