Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08

AUTHORS

Maria C. Ziadi, Robert A. deKemp, Kathryn Williams, Ann Guo, Jennifer M. Renaud, Benjamin J. W. Chow, Ran Klein, Terrence D. Ruddy, May Aung, Linda Garrard, Rob S. B. Beanlands

ABSTRACT

BACKGROUND: Relative myocardial perfusion imaging (MPI) is the standard imaging approach for the diagnosis and prognostic work-up of coronary artery disease (CAD). However, this technique may underestimate the extent of disease in patients with 3-vessel CAD. Positron emission tomography (PET) is also able to quantify myocardial blood flow. Rubidium-82 ((82)Rb) is a valid PET tracer alternative in centers that lack a cyclotron. The aim of this study was to assess whether assessment of myocardial flow reserve (MFR) measured with (82)Rb PET is an independent predictor of severe obstructive 3-vessel CAD. METHODS: We enrolled a cohort of 120 consecutive patients referred to a dipyridamole (82)Rb PET MPI for evaluation of ischemia neither with prior coronary artery bypass graft nor with recent percutaneous coronary intervention that also underwent coronary angiogram within 6 months of the PET study. Patients with and without 3-vessel CAD were compared. RESULTS: Among patients with severe 3-vessel CAD, MFR was globally reduced (<2) in 88% (22/25). On the adjusted logistic Cox model, MFR was an independent predictor of 3-vessel CAD [.5 unit decrease, HR: 2.1, 95% CI (1.2-3.8); P = .015]. The incremental value of (82)Rb MFR over the SSS was also shown by comparing the adjusted SSS models with and without (82)Rb MFR (P = .005). CONCLUSION: (82)Rb MFR is an independent predictor of 3-vessel CAD and provided added value to relative MPI. Clinical integration of this approach should be considered to enhance detection and risk assessment of patients with known or suspected CAD. More... »

PAGES

670-680

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12350-011-9506-5

    DOI

    http://dx.doi.org/10.1007/s12350-011-9506-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047664879

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22415819


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