Three patients treated with sofosbuvir plus ledipasvir for recurrent hepatitis C after liver transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-21

AUTHORS

Tomokazu Kawaoka, Michio Imamura, Kei Morio, Yuki Nakamura, Masataka Tsuge, Clair Nelson Hayes, Yoshiiku Kawakami, Hiroshi Aikata, Hidenori Ochi, Kouhei Ishiyama, Hideki Ohdan, Kazuaki Chayama

ABSTRACT

We previously reported results of interferon (IFN)-free daclatasvir and asunaprevir for the treatment of recurrent hepatitis C virus (HCV) genotype 1 infection after liver transplantation (LT). Here we report three patients who achieved viral response with no effect on the blood concentrations of immunosuppressive agents following sofosbuvir plus ledipasvir treatment. The first patient was a 68-year-old female with HCV-related liver cirrhosis who failed to respond to pegylated-IFN and ribavirin (PEG-IFN/RBV) after living donor LT. She had been treated with 50 mg/day of cyclosporine. The second was a 63-year-old male with HCV-related liver cirrhosis and hepatocellular carcinoma who failed to respond to PEG-IFN/RBV after living donor LT. He had been treated with 50 mg/day of cyclosporine. The third was a 63-year-old female with HCV-related liver cirrhosis. She had been treated with tacrolimus. High alanine aminotransferase levels persisted after LT. Liver biopsy examination revealed active hepatitis or chronic rejection. Therefore, sofosbuvir plus ledipasvir therapy was started. However, the combination treatment was stopped at 4 weeks due to development of interstitial pneumonia. Serum HCV RNA became negative at the time treatment was discontinued and remained negative 12 weeks after cessation of therapy in all three cases. Sofosbuvir plus ledipasvir treatment showed a remarkable viral response with little effect on blood levels of immunosuppressive agents for recurrent HCV genotype 1 infection after LT. More... »

PAGES

179-184

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12328-017-0722-7

DOI

http://dx.doi.org/10.1007/s12328-017-0722-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083855333

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28224470


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27 schema:description We previously reported results of interferon (IFN)-free daclatasvir and asunaprevir for the treatment of recurrent hepatitis C virus (HCV) genotype 1 infection after liver transplantation (LT). Here we report three patients who achieved viral response with no effect on the blood concentrations of immunosuppressive agents following sofosbuvir plus ledipasvir treatment. The first patient was a 68-year-old female with HCV-related liver cirrhosis who failed to respond to pegylated-IFN and ribavirin (PEG-IFN/RBV) after living donor LT. She had been treated with 50 mg/day of cyclosporine. The second was a 63-year-old male with HCV-related liver cirrhosis and hepatocellular carcinoma who failed to respond to PEG-IFN/RBV after living donor LT. He had been treated with 50 mg/day of cyclosporine. The third was a 63-year-old female with HCV-related liver cirrhosis. She had been treated with tacrolimus. High alanine aminotransferase levels persisted after LT. Liver biopsy examination revealed active hepatitis or chronic rejection. Therefore, sofosbuvir plus ledipasvir therapy was started. However, the combination treatment was stopped at 4 weeks due to development of interstitial pneumonia. Serum HCV RNA became negative at the time treatment was discontinued and remained negative 12 weeks after cessation of therapy in all three cases. Sofosbuvir plus ledipasvir treatment showed a remarkable viral response with little effect on blood levels of immunosuppressive agents for recurrent HCV genotype 1 infection after LT.
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34 HCV RNA
35 HCV genotype 1 infection
36 IFN
37 PEG-IFN/RBV
38 RBV
39 RNA
40 active hepatitis
41 agents
42 alanine aminotransferase levels
43 aminotransferase levels
44 asunaprevir
45 biopsy examination
46 blood concentrations
47 blood levels
48 carcinoma
49 cases
50 cessation
51 cessation of therapy
52 chronic rejection
53 cirrhosis
54 combination treatment
55 concentration
56 cyclosporine
57 daclatasvir
58 days
59 development
60 donor liver transplantation
61 effect
62 examination
63 females
64 first patient
65 genotype 1 infection
66 hepatitis
67 hepatitis C
68 hepatitis C virus genotype 1 infection
69 hepatocellular carcinoma
70 higher alanine aminotransferase levels
71 immunosuppressive agents
72 infection
73 interferon
74 interstitial pneumonia
75 ledipasvir
76 ledipasvir treatment
77 levels
78 little effect
79 liver biopsy examination
80 liver cirrhosis
81 liver transplantation
82 males
83 patients
84 pneumonia
85 recurrent HCV genotype 1 infection
86 recurrent hepatitis C
87 rejection
88 response
89 results
90 results of interferon
91 ribavirin
92 serum HCV RNA
93 sofosbuvir
94 tacrolimus
95 therapy
96 time treatment
97 transplantation
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99 viral response
100 weeks
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