Unzureichender Tetanusimpfschutz bei Psoriasis und systemischer Immunsuppression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-08

AUTHORS

W. Sondermann, L. Leister, N. Rompoti, J. Dissemond, J. Klode, A. Körber

ABSTRACT

BackgroundWith a prevalence of approximately 3 % worldwide, psoriasis is one of the most frequent chronic inflammatory skin diseases. Patients with moderate to severe psoriasis are treated guideline-conform with immunomodulatory or immunosuppressive agents. According to current guidelines physicians should be vigilant about the vaccination status of immunosuppressed patients.ObjectiveThe aim of the study was to serologically objectify the tetanus vaccination status in systemically treated patients with moderate to severe psoriasis in Germany.Material and methodsWithin the context of this retrospective study the concentration of immunoglobulin G antibodies against Clostridium tetani was determined in 101 patients with systemic immunosuppression suffering from psoriasis.ResultsIn a total of 27.7% (n = 28; 11 male, 17 female) of the patients, insufficient immunoglobulin G antibody concentrations were detected, corresponding to a higher risk of an infection with C. tetani. Group subanalyses indicated an insufficient tetanus protection especially in patients ≥65 years old (50%).ConclusionThe tetanus immune status of psoriasis patients was shown to be comparable with the general population. The results of our investigation underline that people suffering from psoriasis have to be tested for tetanus protection and if necessary, vaccinations have to be renewed. More... »

PAGES

141-146

References to SciGraph publications

  • 2016-05-25. Komorbidität bei Psoriasis vulgaris in DER HAUTARZT
  • 2009-09-10. Aktuelle Entwicklung von Impfquoten und Impflücken bei Kindern und Jugendlichen in Deutschland in BUNDESGESUNDHEITSBLATT - GESUNDHEITSFORSCHUNG - GESUNDHEITSSCHUTZ
  • 2014-12-02. Impfquoten unter Erwachsenen in Deutschland für die Impfungen gegen saisonale Influenza, Tetanus und Pertussis in BUNDESGESUNDHEITSBLATT - GESUNDHEITSFORSCHUNG - GESUNDHEITSSCHUTZ
  • 1997-06. A peptide antibiotic from human skin in NATURE
  • 2013-05-25. Impfstatus von Erwachsenen in Deutschland in BUNDESGESUNDHEITSBLATT - GESUNDHEITSFORSCHUNG - GESUNDHEITSSCHUTZ
  • 2014-02-20. Managing Moderate-to-Severe Psoriasis in the Elderly in DRUGS & AGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12326-019-0325-9

    DOI

    http://dx.doi.org/10.1007/s12326-019-0325-9

    DIMENSIONS

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