Fixed-Dose Combinations of Long-Acting Bronchodilators for the Management of COPD: Global and Asian Perspectives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Chin Kook Rhee, Hajime Yoshisue, Rahul Lad

ABSTRACT

Maintenance bronchodilator therapy with long-acting β-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) is the cornerstone treatment for patients with stable chronic obstructive pulmonary disease (COPD). Fixed-dose combinations (FDCs) of LABA/LAMA are recommended for the majority of symptomatic COPD patients by global guidelines; regional guidelines such as the Japanese and Korean guidelines also provide similar recommendations for the use of LABA/LAMA FDCs. This review comprehensively describes the latest clinical evidence from key studies on the efficacy and safety of four approved LABA/LAMA fixed-dose combinations: indacaterol/glycopyrronium, vilanterol/umeclidinium, formoterol/aclidinium, and olodaterol/tiotropium. Additionally, in this review we describe the rationale behind the use of LABA/LAMA FDC therapy, key findings from the preclinical and clinical trial evaluation of respective LABA and LAMA monocomponents, and the efficacy and safety of LABA/LAMA FDCs. Special emphasis is placed on the clinical evidence for the monocomponents and LABA/LAMA FDCs from the Asian population. This detailed overview of the efficacy and safety of LABA/LAMA FDCs in global and Asian COPD patients is envisaged to provide a better understanding of the benefits of these therapies and to inform healthcare providers and patients on their appropriate use.Funding: Novartis Pharma K.K. More... »

PAGES

495-519

References to SciGraph publications

  • 2014-12. Safety and tolerability of once-daily umeclidinium/vilanterol 125/25 mcg and umeclidinium 125 mcg in patients with chronic obstructive pulmonary disease: results from a 52-week, randomized, double-blind, placebo-controlled study in RESPIRATORY RESEARCH
  • 2014-12. Efficacy and safety of aclidinium bromide/formoterol fumarate fixed-dose combinations compared with individual components and placebo in patients with COPD (ACLIFORM-COPD): a multicentre, randomised study in BMC PULMONARY MEDICINE
  • 2014-03. QVA149 (Indacaterol/Glycopyrronium Fixed-Dose Combination): A Review of Its Use in Patients with Chronic Obstructive Pulmonary Disease in DRUGS
  • 2015-12. The importance of inhaler devices in the treatment of COPD in COPD RESEARCH AND PRACTICE
  • 2014-12. Efficacy and safety of fixed-dose combinations of aclidinium bromide/formoterol fumarate: the 24-week, randomized, placebo-controlled AUGMENT COPD study in RESPIRATORY RESEARCH
  • 2011-12. Efficacy and safety of inhaled formoterol 4.5 and 9 μg twice daily in Japanese and European COPD patients: Phase III study results in BMC PULMONARY MEDICINE
  • 2011-04. Efficacy,Safety and Pharmacokinetics of Indacaterol in Caucasian and Japanese Patients with Chronic Obstructive Pulmonary Disease in CLINICAL DRUG INVESTIGATION
  • 2015-12. Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month, multicentre, randomised studies (ACLIFORM and AUGMENT) in RESPIRATORY RESEARCH
  • 2014-02. Cardiovascular Safety of Long Acting Beta Agonist-Inhaled Corticosteroid Combination Products in Adult Patients with Asthma: A Systematic Review in LUNG
  • 2015-12. Umeclidinium/vilanterol versus fluticasone propionate/salmeterol in COPD: a randomised trial in BMC PULMONARY MEDICINE
  • 2015-12. Impact of chronic obstructive pulmonary disease (COPD) in the Asia-Pacific region: the EPIC Asia population-based survey in ASIA PACIFIC FAMILY MEDICINE
  • 2014-09. Turning a Molecule into a Medicine: the Development of Indacaterol as a Novel Once-Daily Bronchodilator Treatment for Patients with COPD in DRUGS
  • 2016. Pathogenesis of COPD and Asthma in PHARMACOLOGY AND THERAPEUTICS OF ASTHMA AND COPD
  • 2017-12. Efficacy and safety of indacaterol/glycopyrronium fixed-dose combination in mild-to-moderate COPD patients symptomatic on tiotropium in Korea: study protocol for a randomized controlled trial in TRIALS
  • 2013-12. Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease in RESPIRATORY RESEARCH
  • 2013-04. Aclidinium Bromide Twice Daily for the Treatment of Chronic Obstructive Pulmonary Disease: A Review in ADVANCES IN THERAPY
  • 2016-03. Inhaled Umeclidinium in COPD Patients: A Review and Meta-Analysis in DRUGS
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s12325-019-0893-3

    DOI

    http://dx.doi.org/10.1007/s12325-019-0893-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112062570

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30742242


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